Heterocyclyl pyrimidines and triazines as novel fungicides

ABSTRACT

The present disclosure relates to heterocyclyl pyrimidine and heterocyclyl triazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

The present invention relates to heterocyclyl pyrimidine and heterocyclyl triazine compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds.

Numerous crop protection agents to combat or prevent microorganisms' infestations have been developed until now. However, the need remains for the development of new compounds as such, so as to provide compounds being effective against a broad spectrum of phytopathogenic microorganisms, such as fungi, having low toxicity, high selectivity or that can be used at low application rate whilst still allowing effective pest control. It may also be desired to have new compounds to prevent the emergence of resistances.

The present invention provides new compounds for controlling phytopathogenic microorganisms such as fungi which have advantages over known compounds and compositions in at least some of these aspects.

WO 2020/127780 describes heterocyclyl-substituted Pyridazines as fungicides.

DETAILED DESCRIPTION Compounds of Formula (I)

The present invention relates to compounds of the formula (I):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   A² is O, S, C(═O), S(═O), S(═O)₂, NR¹ or CR^(2A)R^(R2B),         -   wherein         -   R¹ is hydrogen, formyl, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,         -   R^(2A) and R^(2B) are independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,         -   or         -   R^(2A) and R^(2B) form together with the carbon atom to             which they are attached to a C₃-C₈-cycloalkyl-ring or a 3-             to 7-membered heterocyclyl-ring,     -   m is 0, 1 or 2,     -   T is hydrogen, hydroxyl, C₁-C₆-alkyl, —C(═O)R¹¹, —C(═O)(OR¹²),         —C(═O)N(R¹³)₂, —S(═O)R¹⁴, —S(═O)₂R¹⁴ or —S(═O)₂N(R¹⁴)₂,         -   wherein         -   R¹¹ and R¹² are independently C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₃-C₈-cycloalkyl or C₂-C₆-alkenyl,         -   R¹³ and R¹⁴ are independently hydrogen, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy,         C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,         C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3-         to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,             C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl, and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,             -   wherein             -   L^(SA) is independently halogen, cyano, hydroxyl,                 carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,                 —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   and/or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,                 formyl, carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to                 7-membered heterocyclyl,             -   and/or             -   two L^(SC) substituents form together with the carbon                 atom to which they are attached to a                 C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein

    -   R^(6S) is independently selected from the group consisting of         halogen, cyano, isocyano, nitro, hydroxyl, mercapto,         pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl,         C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,         C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,         C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,         C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),         —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and         —Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted             with one to three substituents independently selected from             the group consisting of halogen, cyano, hydroxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl             and 3- to 7-membered heterocyclyl,         -   or         -   two substituents C₁-C₆-alkyl attached to the same carbon             atom from a C₃-C₈-cycloalkyl-ring,         -   and         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or             6-membered heteroaryl and 3- to 7-membered heterocyclyl are             furthermore optionally substituted with one to four             substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl,             carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,         -   wherein said C₁-C₆-alkyl in turn is optionally substituted             with one to three substituents independently selected from             the group consisting of halogen, cyano, hydroxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl             and 3- to 7-membered heterocyclyl,         -   and         -   wherein said C₃-C₈-cycloalkyl in turn is optionally             substituted with one to four substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, carboxyl, oxo, methylidene,             halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl             and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   as well as N-oxides, salts, hydrates and hydrates of the salts         and N-oxides thereof.

The present invention relates to a composition comprising at least one compound of formula (I) as defined herein and at least one agriculturally suitable auxiliary.

The present invention also relates to the use of a compound of formula (I) as defined herein or a composition as defined herein for controlling phytopathogenic fungi.

The present invention relates to a method for controlling phytopathogenic fungi which comprises the step of applying at least one compound of formula (I) as defined herein or a composition as defined herein to the plants, plant parts, seeds, fruits or to the soil in which the plants grow.

The present invention also relates to processes and intermediates for preparing compounds of formula (I).

Unless otherwise stated, the following definitions apply for the substituents and residues used throughout this specification and claims: The term “halogen” as used herein refers to fluorine, chlorine, bromine or iodine atom.

The term “methylidene” as used herein refers to a CH₂ group connected to a carbon atom via a double bond.

The term “halomethylidene” as used herein refers to a CX₂ group connected to a carbon atom via a double bond, wherein X is halogen.

The term “oxo” as used herein refers to an oxygen atom which is bound to a carbon atom or sulfur atom via a double bound.

The term “C₁-C₆-alkyl” as used herein refers to a saturated, branched or straight hydrocarbon chain having 1, 2, 3, 4, 5 or 6 carbon atoms. Examples of C₁-C₆-alkyl include but are not limited to methyl, ethyl, propyl (n-propyl), 1-methylethyl (iso-propyl), butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-di-methylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl. Particularly, said hydrocarbon chain has 1, 2, 3 or 4 carbon atoms (“C₁-C₄-alkyl”), e.g. methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, iso-butyl or tert-butyl.

The term “C₁-C₆-haloalkyl” as used herein refers to a C₁-C₆-alkyl group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different. Examples of C₁-C₆-haloalkyl include but are not limited to chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl and 1,1,1-trifluoroprop-2-yl. Preferred are fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, 2-fluoroethyl, 2,2-difluoro-ethyl, 2,2,2-trifluoroethyl, pentafluoroethyl and 1,1,1-trifluoroprop-2-yl.

The term “C₁-C₆-fluoroalkyl” as used herein refers to a C₁-C₆-alkyl group as defined above in which one or more hydrogen atoms are replaced with one or more fluorine atoms that may be the same or different. Examples of C₁-C₆-fluoroalkyl include but are not limited to monofluoromethyl, difluoromethyl, trifluoromethyl, 1-fluoroethyl, 1,1-difluoroethyl, 2,2-difluoroethyl and 2,2,2-trifluoroethyl.

The term “C₁-C₆-alkylene” as used herein refers to a divalent C₁-C₆-alkyl group as defined herein. Examples of C₁-C₆-alkylene include but are not limited to methylene, ethylene, propyl-1,3-ene, propyl-1,2-ene, butyl-1,4-ene, butyl-1,3-ene, butyl-1,2-ene, 1,5-pentylene and 1,6-hexylene.

The terms “C₃-C₈-cycloalkyl” and “C₃-C₈-cycloalkyl-ring” as used herein refers to a saturated, monocyclic hydrocarbon ring containing 3, 4, 5, 6, 7 or 8 carbon atoms. Examples of C₃-C₈-cycloalkyl include but are not limited to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl. Particularly, said cycloalkyl has 3 to 6 carbon atoms.

The term “C₃-C₈-halocycloalkyl” as used herein refers to a saturated hydrocarbon ring system in which all of the ring members, which vary from 3 to 8, are carbon atoms and in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₂-C₆-alkenyl” as used herein refers to an unsaturated, branched or straight hydrocarbon chain having 2, 3, 4, 5 or 6 carbon atoms and comprising at least one double bond. Examples of C₂-C₆-alkenyl include but are not limited to ethenyl (or “vinyl”), prop-2-en-1-yl (or “allyl”), prop-1-en-1-yl, but-3-enyl, but-2-enyl, but-1-enyl, pent-4-enyl, pent-3-enyl, pent-2-enyl, pent-1-enyl, hex-5-enyl, hex-4-enyl, hex-3-enyl, hex-2-enyl, hex-1-enyl, prop-1-en-2-yl (or “isopropenyl”), 2-methylprop-2-enyl, 1-methylprop-2-enyl, 2-methylprop-1-enyl, 1-methylprop-1-enyl, 3-methylbut-3-enyl, 2-methylbut-3-enyl, 1-methylbut-3-enyl, 3-methylbut-2-enyl, 2-methylbut-2-enyl, 1-methylbut-2-enyl, 3-methylbut-1-enyl, 2-methylbut-1-enyl, 1-methylbut-1-enyl, 1,1-dimethylprop-2-enyl, 1-ethylprop-1-enyl, 1-propyl-vinyl, 1-isopropylvinyl, 4-methylpent-4-enyl, 3-methylpent-4-enyl, 2-methylpent-4-enyl, 1-methylpent-4-enyl, 4-methylpent-3-enyl, 3-methylpent-3-enyl, 2-methylpent-3-enyl, 1-methylpent-3-enyl, 4-methylpent-2-enyl, 3-methylpent-2-enyl, 2-methylpent-2-enyl, 1-methylpent-2-enyl, 4-methylpent-1-enyl, 3-methylpent-1-enyl, 2-methylpent-1-enyl, 1-methylpent-1-enyl, 3-ethylbut-3-enyl, 2-ethylbut-3-enyl, 1-ethylbut-3-enyl, 3-ethylbut-2-enyl, 2-ethylbut-2-enyl, 1-ethylbut-2-enyl, 3-ethylbut-1-enyl, 2-ethylbut-1-enyl, 1-ethylbut-1-enyl, 2-propylprop-2-enyl, 1-propylprop-2-enyl, 2-isopropylprop-2-enyl, 1-isopropylprop-2-enyl, 2-propylprop-1-enyl, 1-propylprop-1-enyl, 2-isopropylprop-1-enyl, 1-isopropylprop-1-enyl, 3,3-dimethylprop-1-enyl, 1-(1,1-dimethylethyl)ethenyl, buta-1,3-dienyl, penta-1,4-dienyl, hexa-1,5-dienyl or methylhexadienyl group.

The term “C₂-C₆-alkynyl” as used herein refers to a branched or straight hydrocarbon chain having 2, 3, 4, 5 or 6 carbon atoms and comprising at least one triple bond. Examples of C₂-C₆-alkynyl include but are not limited to ethynyl, prop-1-ynyl, prop-2-ynyl (or “propargyl”), but-1-ynyl, but-2-ynyl, but-3-ynyl, pent-1-ynyl, pent-2-ynyl, pent-3-ynyl, pent-4-ynyl, hex-1-ynyl, hex-2-ynyl, hex-3-ynyl, hex-4-ynyl, hex-5-ynyl, 1-methylprop-2-ynyl, 2-methylbut-3-ynyl, 1-methylbut-3-ynyl, 1-methylbut-2-ynyl, 3-methylbut-1-ynyl, 1-ethylprop-2-ynyl, 3-methylpent-4-ynyl, 2-methylpent-4-ynyl, 1-methylpent-4-ynyl, 2-methylpent-3-ynyl, 1-methylpent-3-ynyl, 4-methylpent-2-ynyl, 1-methyl-pent-2-ynyl, 4-methylpent-1-ynyl, 3-methylpent-1-ynyl, 2-ethylbut-3-ynyl, 1-ethylbut-3-ynyl, 1-ethylbut-2-ynyl, 1-propylprop-2-ynyl, 1-isopropylprop-2-ynyl, 2,2-dimethylbut-3-ynyl, 1,1-dimethylbut-3-ynyl, 1,1-dimethylbut-2-ynyl or 3,3-dimethylbut-1-ynyl group.

The term “C₂-C₆-haloalkenyl” as used herein refers to a C₂-C₆-alkenyl group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₂-C₆-haloalkynyl” as used herein refers to a C₂-C₆-alkynyl group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₁-C₆-alkoxy” as used herein refers to a group of formula (C₁-C₆-alkyl)-O—, in which the term “C₁-C₆-alkyl” is as defined herein. Examples of C₁-C₆-alkoxy include but are not limited to methoxy, ethoxy, n-propoxy, 1-methylethoxy, n-butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, n-pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, n-hexyloxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy. This definition also applies to alkoxy as part of a composite substituent, for example alkoxyalkyl, alkoxyalkoxy, unless defined elsewhere.

The term “C₁-C₆-haloalkoxy” as used herein refers to a C₁-C₆-alkoxy group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different. Examples of C₁-C₆-haloalkoxy include but are not limited to chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoro-methoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1-bromoethoxy, 1-fluoro-ethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and 1,1,1-trifluoroprop-2-oxy.

The term “C₁-C₆-hydroxyalkyl” as used herein refers to a C₁-C₆-alkyl group as defined above in which at least one hydrogen atom is replaced with a hydroxyl group. Examples of C₁-C₆-hydroxyalkyl include but are not limited to hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 1-hydroxypropyl, 1-hydroxypropan-2-yl, 2-hydroxypropan-2-yl, 2,3-di-hydroxypropyl and 1,3-dihydroxypropan-2-yl.

The term “C₃-C₈-cycloalkoxy” as used herein refers to a monocyclic, saturated cycloalkoxy radical having 3 to 8 and preferably 3 to 6 carbon ring members, for example (but not limited to) cyclopropyloxy, cyclobutyloxy, cyclopentyloxy and cyclohexyloxy. This definition also applies to cycloalkoxy as part of a composite substituent, for example cycloalkoxyalkyl, unless defined elsewhere.

The term “C₃-C₈-halocycloalkoxy” as used herein refers to a C₃-C₈-cycloalkoxy group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term C₂-C₆-alkenyloxy as used herein refers to a formula (C₂-C₆-alkenyl)-O—, in which the term “C₁-C₆-alkenyl” group is which the as defined herein. Examples of C₂-C₆-alkenyl include but are not limited to ethenyloxy (or “vinyloxy”), prop-2-en-1-yloxy (or “allyl”), prop-1-en-1-yloxy, but-3-enyloxy, but-2-enyloxy, but-1-enyloxy, pent-4-enyloxy, pent-3-enyloxy, pent-2-enyloxy, pent-1-enyloxy, hex-5-enyloxy, hex-4-enyloxy, hex-3-enyloxy, hex-2-enyloxy, hex-1-enyloxy, prop-1-en-2-yloxy (or “iso-propenyloxy”), 2-methylprop-2-enyloxy, 1-methylprop-2-enyloxy, 2-methylprop-1-enyloxy, 1-methylprop-1-enyloxy, 3-methylbut-3-enyloxy, 2-methylbut-3-enyloxy, 1-methylbut-3-enyloxy, 3-methylbut-2-enyloxy, 2-methylbut-2-enyloxy, 1-methylbut-2-enyloxy, 3-methylbut-1-enyloxy, 2-methylbut-1-enyloxy, 1-methylbut-1-enyloxy, 1,1-dimethylprop-2-enyloxy, 1-ethylprop-1-enyloxy, 1-propylvinyloxy, 1-isopropylvinyloxy, 4-methylpent-4-enyloxy, 3-methylpent-4-enyloxy, 2-methylpent-4-enyloxy, 1-methylpent-4-enyloxy, 4-methylpent-3-enyloxy, 3-methylpent-3-enyloxy, 2-methylpent-3-enyloxy, 1-methylpent-3-enyloxy, 4-methylpent-2-enyloxy, 3-methylpent-2-enyloxy, 2-methylpent-2-enyloxy, 1-methylpent-2-enyloxy, 4-methylpent-1-enyloxy, 3-methylpent-1-enyloxy, 2-methylpent-1-enyloxy, 1-methylpent-1-enyloxy, 3-ethylbut-3-enyloxy, 2-ethylbut-3-enyloxy, 1-ethylbut-3-enyloxy, 3-ethylbut-2-enyloxy, 2-ethylbut-2-enyloxy, 1-ethylbut-2-enyloxy, 3-ethylbut-1-enyloxy, 2-ethylbut-1-enyloxy, 1-ethylbut-1-enyloxy, 2-propylprop-2-enyloxy, 1-propylprop-2-enyloxy, 2-isopropylprop-2-enyloxy, 1-isopropylprop-2-enyloxy, 2-propylprop-1-enyloxy, 1-propylprop-1-enyloxy, 2-isopropylprop-1-enyloxy, 1-isopropylprop-1-enyloxy, 3,3-dimethylprop-1-enyloxy, 1-(1,1-dimethylethyl)ethenyloxy, buta-1,3-dienyloxy, penta-1,4-dienyloxy, hexa-1,5-dienyloxy or methylhexadienyloxy group.

The term “C₂-C₆-haloalkenyloxy” as used herein refers to a (C₂-C₆-alkenyl)-O— group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₂-C₆-alkenylene” as used herein refers to a divalent C₂-C₆-alkenyl group as defined herein. Examples of C₂-C₆-alkenylene include but are not limited to ethenylene, 1,3-propenylene, butenylene, pentenylene, hexenylene, heptenylene, octenylene, nonenylene, decenylene, undecenylene, dodecenylene, and the like.

The term “C₂-C₆-haloalkynyloxy” as used herein refers to a (C₂-C₆-alkynyl)-O— group as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₁-C₆-alkylsulfanyl” as used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkyl)-S—, in which the term “C₁-C₆-alkyl” is as defined herein. Examples of C₁-C₆-alkylsulfanyl include but are not limited to methylsulfanyl, ethylsulfanyl, propylsulfanyl, isopropylsulfanyl, butylsulfanyl, sec-butylsulfanyl, isobutylsulfanyl, tert-butylsulfanyl, pentylsulfanyl, isopentylsulfanyl, hexylsulfanyl group.

The term “C₁-C₆-haloalkylsulfanyl” as used herein refers to a C₁-C₆-alkylsulfanyl as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₃-C₈-cycloalkylsulfanyl” as used herein refers to a saturated, monovalent, monocylic hydrocarbon ring which contains 3, 4, 5, 6, 7 or 8 carbon atoms and which is bound to the skeleton via a sulfur atom. Examples of monocyclic C₃-C₈-cycloalkylsulfanyls include but are not limited to cyclopropylsulfanyl, cyclobutylsulfanyl, cyclopentylsulfanyl, cyclohexylsulfanyl, cycloheptylsulfanyl, or cyclooctylsulfanyl.

The term “C₁-C₆-alkylsulfinyl” as used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkyl)-S(═O)—, in which the term “C₁-C₆-alkyl” is as defined herein. Examples of C₁-C₆-alkylsulfinyl include but are not limited to saturated, straight-chain or branched alkylsulfinyl radicals having 1 to 8, preferably 1 to 6 and more preferably 1 to 4 carbon atoms, for example (but not limited to) C₁-C₆-alkylsulfinyl such as methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, hexylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentylsulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3-dimethylbutylsulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3,3-dimethylbutylsulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropylsulfinyl and 1-ethyl-2-methylpropylsulfinyl.

The term “C₁-C₆-haloalkylsulfinyl” as used herein refers to a C₁-C₆-alkylsulfinyl as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₃-C₈-cycloalkylsulfinyl” as used herein refers to a saturated, monovalent, monocylic hydrocarbon ring which contains 3, 4, 5, 6, 7 or 8 carbon atoms and which is bound to the skeleton via a —S(═O)— group. Examples of monocyclic C₃-C₈-cycloalkylsulfinyls include but are not limited to cyclopropylsulfinyl, cyclobutylsulfinyl, cyclopentylsulfinyl, cyclohexylsulfinyl, cycloheptylsulfinyl or cyclooctylsulfinyl.

The term “C₁-C₆-alkylsulfonyl” s used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkyl)-S(═O)₂—, in which the term “C₁-C₆-alkyl” is as defined herein. Examples of C₁-C₆-alkylsulfonyl include but are not limited to methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethyl-sulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl.

The term “C₁-C₆-haloalkylsulfonyl” as used herein refers to a C₁-C₆-alkylsulfonyl as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₃-C₈-cycloalkylsulfonyl” as used herein refers to a saturated, monovalent, monocylic hydrocarbon ring which contains 3, 4, 5, 6, 7 or 8 carbon atoms and which is bound to the skeleton via a —S(═O)₂— group. Examples of monocyclic C₃-C₈-cycloalkylsulfonyls include but are not limited to cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, cycloheptylsulfonyl or cyclooctylsulfonyl.

The term “C₁-C₆-alkylcarbonyl” as used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkyl)-C(═O)—, in which the term “C₁-C₆-alkyl” is as defined herein.

The term “C₁-C₆-haloalkylcarbonyl” as used herein refers to a C₁-C₆-alkylcarbonyl as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “C₁-C₆-alkylcarbonyloxy” as used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkyl)-C(═O)O—, in which the term “C₁-C₆-alkyl” is as defined herein.

The term “C₁-C₆-alkoxycarbonyl” as used herein refers to a saturated, linear or branched group of formula (C₁-C₆-alkoxy)-C(═O)—, in which the term “C₁-C₆-alkoxy” is as defined herein.

The term “C₁-C₆-haloalkoxycarbonyl” as used herein refers to a C₁-C₆-alkoxycarbonyl as defined above in which one or more hydrogen atoms are replaced with one or more halogen atoms that may be the same or different.

The term “mono-(C₁-C₆-alkyl)amino” as used herein refers to an amino radical having one C₁-C₆-alkyl group as defined herein. Examples of mono-(C₁-C₆-alkyl)amino include but are not limited to Nmethylamino, N-ethylamino, N-isopropylamino, N-n-propylamino, N-isopropylamino and N-tert-butylamino.

The term “di-(C₁-C₆)-alkylamino” as used herein refers to an amino radical having two independently selected C₁-C₆-alkyl groups as defined herein. Examples of C₁-C₆-dialkylamino include but are not limited to N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, N-ethyl-N-methylamino, N-methyl-N-n-propylamino, N-isopropyl-N-n-propylamino and N-tert-butyl-N-methylamino.

The term “C₃-C₁₂-carbocyclyl” as used herein refers to a saturated or partially unsaturated hydrocarbon ring system in which all of the ring members, which vary from 3 to 12, are carbon atoms. The ring system may be monocyclic or polycyclic (fused, spiro or bridged). C₃-C₁₂-carbocyclyls include but are not limited to C₃-C₁₂-cycloalkyl (mono or bicyclic), C₃-C₁₂-cycloalkenyl (mono or bicyclic), bicylic system comprising an aryl (e.g. phenyl) fused to a monocyclic C₃-C₈-cycloalkyl (e.g. tetrahydro-naphthalenyl, indanyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl), bicylic system comprising an aryl (e.g. phenyl) fused to a monocyclic C₃-C₈-cycloalkenyl (e.g. indenyl, dihydronaphthalenyl) and tricyclic system comprising a cyclopropyl connected through one carbon atom to a bicylic system comprising an aryl (e.g. phenyl) fused to a C₃-C₈-cycloalkyl or to a C₃-C₈-cycloalkenyl. The C₃-C₁₂-carbocyclyl can be attached to the parent molecular moiety through any carbon atom.

The term “C₃-C₁₂-cycloalkenyl” as used herein refers to an unsaturated, monovalent, mono- or bicylic hydrocarbon ring which contains 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms and one or two double bonds. Examples of monocyclic C₃-C₈-cycloalkenyl group include but are not limited to cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl group. Examples of bicyclic C₆-C₁₂-cycloalkenyl group include but are not limited to 3-bicyclo[4.2.0]octa-1,3,5-trienyl, bicyclo[2.2.1]hept-2-enyl or bicyclo[2.2.2]oct-2-enyl.

The term “C₆-C₁₄-aryl” as used herein refers to an aromatic hydrocarbon ring system in which all of the ring members, which vary from 6 to 14, preferably from 6 to 10, are carbon atoms. The ring system may be monocyclic or fused polycyclic (e.g. bicyclic or tricyclic). Examples of aryl include but are not limited to phenyl, azulenyl and naphthyl.

The term “3- to 14-membered heterocyclyl” as used herein refers to a saturated or partially unsaturated 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-, 13- or 14-membered membered ring system comprising 1 to 4 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur. If the ring system contains more than one oxygen atoms, they are not directly adjacent. Heterocycles include but are not limited to 3- to 7-membered monocyclic heterocycles and 8- to 14-membered polycyclic (e.g. bicyclic or tricyclic) heterocycles. The 3- to 14-membered heterocycle can be connected to the parent molecular moiety through any carbon atom or nitrogen atom contained within the heterocycle. Examples of saturated heterocycles include but are not limited to 3-membered ring such as oxiranyl, aziridinyl, 4-membered ring such as azetidinyl, oxetanyl, thietanyl, 5-membered ring such as tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydrothienyl, pyrrolidinyl, pyrazolidinyl, imidazolidinyl, triazolidinyl, isoxazolidinyl, oxazolidinyl, oxadiazolidinyl, thiazolidinyl, isothiazolidinyl, thiadiazolidinyl, 6-membered ring such as piperidinyl, hexahydropyridazinyl, hexahydropyrimidinyl, piperazinyl, triazinanyl, hexahydrotriazinyl, tetrahydropyranyl, dioxanyl, tetrahydrothiopyranyl, dithianyl, morpholinyl, 1,2-oxazinanyl, oxathianyl, thiomorpholinyl or 7-membered ring such as oxepanyl, azepanyl, 1,4-diazepanyl and 1,4-oxazepanyl.

Examples of unsaturated heterocycles include but are not limited to 5-membered ring such as dihydrofuranyl, 1,3-dioxolyl, dihydrothienyl, pyrrolinyl, dihydroimidazolyl, dihydropyrazolyl, isoxazolinyl, dihydrooxazolyl, dihydrothiazolyl or 6-membered ring such as pyranyl, thiopyranyl, thiazinyl and thiadiazinyl. Bicyclic heterocycles may consist of a monocyclic heteroaryl as defined herein fused to a monocyclic C₃-C₈-cycloalkyl, a monocyclic C₃-C₈-cycloalkenyl or a monocyclic heterocycle or may consist of a monocyclic heterocycle fused either to an aryl (e.g. phenyl), a C₃-C₈-cycloalkyl, a C₃-C₈-cycloalkenyl or a monocyclic heterocycle. When two monocyclic heterocycles or one monocyclic heterocycle and one monocyclic heteroaryl comprising nitrogen atoms are fused, nitrogen atom may be at the bridgehead (e.g. 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinyl). Tricyclic heterocycles may consist of a monocyclic cycloalkyl connected through one common atom to a bicyclic heterocycle.

The terms “3- to 7-membered heterocyclyl” and “3- to 7-membered heterocyclyl-ring” as used herein refers to a saturated 3-, 4-, 5-, 6- or 7-membered ring system comprising 1 or 2 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur. Examples include but are not limited to oxiranyl, aziridinyl, azetidinyl, oxetanyl, thietanyl, tetrahydrofuranyl, 1,3-dioxolanyl, tetrahydrothienyl, pyrrolidinyl, pyrazolidinyl, imidazolidinyl, triazolidinyl, isoxazolidinyl, oxazolidinyl, oxadiazolidinyl, thiazolidinyl, isothiazolidinyl, thiadiazolidinyl, piperidinyl, hexahydropyridazinyl, hexahydropyrimidinyl, piperazinyl, triazinanyl, hexahydrotriazinyl, tetrahydropyranyl, dioxanyl, tetrahydrothiopyranyl, dithianyl, morpholinyl, 1,2-oxazinanyl, oxathianyl, thiomorpholinyl, oxepanyl, azepanyl, 1,4-diazepanyl and 1,4-oxazepanyl. Preferred 3- to 7-membered heterocyclyl are oxiranyl, aziridinyl, azetidinyl, oxetanyl, tetrahydrofuranyl, 1,3-dioxolanyl, pyrrolidinyl, piperidinyl, piperazinyl, tetrahydropyranyl, dioxanyl, morpholinyl and thiomorpholinyl.

The term “5- to 14-membered heteroaryl” as used herein refers to an aromatic ring system comprising 1 to 4 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur. If the ring system contains more than one oxygen atom, they are not directly adjacent. Aromatic heterocycles include 5- or 6-membered monocyclic heteroaryls and 7- to 14-membered polycyclic (e.g. bicyclic or tricyclic) heteroaryls. The 5- to 14-membered heteroaryl can be connected to the parent molecular moiety through any carbon atom or nitrogen atom contained within the heterocycle.

The term “5- or 6-membered heteroaryl” as used herein refers to a 5- or 6-membered aromatic monocyclic ring system containing 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur. Examples of 5-membered monocyclic heteroaryl include but are not limited to furyl (furanyl), thienyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, oxatriazolyl, isothiazolyl, thiazolyl, thiadiazolyl and thiatriazolyl. Examples of 6-membered monocyclic heteroaryl include but are not limited to pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, tetrazinyl.

The term “7- to 14-membered heteroaryl” as used herein refers to a 7-, 8-, 9-, 10-, 11-, 12-, 13- or 14-membered aromatic polycyclic (e.g. bicyclic or tricyclic) ring system containing 1, 2 or 3 heteroatoms independently selected from the group consisting of oxygen, nitrogen and sulfur. Bicyclic heteroaryls may consist of a monocyclic heteroaryl as defined herein fused to an aryl (e.g. phenyl) or to a monocyclic heteroaryl. Examples of bicyclic heteroaryls include but are not limited to 9-membered ring such as indolyl, indolizinyl, isoindolyl, benzimadozolyl, imidazopyridinyl, indazolyl, benzotriazolyl, purinyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl and benzisoxazolyl or 10-membered ring such as quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, naphthyridinyl, pteridinal and benzodioxinyl. In 9- or 10-membered bicyclic heteroaryls comprising two fused 5- or 6-membered monocyclic heteroaryls, nitrogen atom may be at the bridgehead (e.g. imidazo[1,2-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, imidazo[1,2-a]pyridinyl, imidazo[2,1-b]oxazolyl, furo[2,3-d]isoxazolyl). Examples of tricyclic aromatic heterocyle include but are not limited to carbazolyl, acridinyl and phenazinyl.

The terms “C₃-C₁₂-carbocyclyloxy”, “C₃-C₈-cycloalkoxy”, “C₆-C₁₄-aryloxy”, “5- to 14-membered heteroaryloxy”, “3- to 14-membered heterocyclyloxy” as used herein designate a group of formula —O—R wherein R is respectively a C₃-C₁₂-carbocyclyl, a C₃-C₈-cycloalkyl, a C₆-C₁₄-aryl, a 5- to 14-membered heteroaryl or a 3- to 14-membered heterocyclyl group as defined herein.

The terms “C₃-C₁₂-carbocyclylsulfanyl”, “C₆-C₁₄-arylsulfanyl”, “5- to 14-membered heteroarylsulfanyl”, “3- to 14-membered heterocyclylsulfanyl” as used herein designate a group of formula —S—R wherein R is respectively a C₃-C₁₂-carbocyclyl, a C₆-C₁₄-aryl, a 5- to 14-membered heteroaryl or a 3- to 14-membered heterocyclyl group as defined herein.

The terms “C₃-C₁₂-carbocyclylsulfinyl”, “C₆-C₁₄-arylsulfinyl”, “5- to 14-membered heteroarylsulfinyl”, “3- to 14-membered heterocyclylsulfinyl” as used herein designate a group of formula —(S═O)—R wherein R is respectively a C₃-C₁₂-carbocyclyl, a C₆-C₁₄-aryl, a 5- to 14-membered heteroaryl or a 3- to 14-membered heterocyclyl group as defined herein.

The terms “C₃-C₁₂-carbocyclylsulfonyl”, “C₆-C₁₄-arylsulfonyl”, “5- to 14-membered heteroaryl-sulfonyl”, “3- to 14-membered heterocyclylsulfonyl” as used herein designate a group of formula —(S═O)₂—R wherein R is respectively a C₃-C₁₂-carbocyclyl, a C₆-C₁₄-aryl, a 5- to 14-membered heteroaryl or a 3- to 14-membered heterocyclyl group as defined herein.

The term “leaving group” as used herein is to be understood as meaning a group which is displaced from a compound in a substitution or an elimination reaction, for example a halogen atom, a trifluoromethanesulphonate (“triflate”) group, alkoxy, methanesulphonate, p-toluenesulphonate, etc.

The terms “as described herein” when referring to a variable Q, E, T, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ and m incorporates by reference the broad definition of the variable as well as preferred, more preferred and even more preferred definitions, if any.

Not encompassed herein are compounds resulting from combinations which are against natural laws and which the person skilled in the art would therefore exclude based on his/her expert knowledge. For instance, ring structures having three or more adjacent oxygen atoms are excluded.

The compounds of formula (I) can suitably be in their free form, salt form, N-oxide form or solvate form (e.g. hydrate).

Depending on the nature of the substituents, the compound of formula (I) may be present in the form of different stereoisomers. These stereoisomers are, for example, enantiomers, diastereomers, atropisomers or geometric isomers. Accordingly, the invention encompasses both pure stereoisomers and any mixture of these isomers. Where a compound can be present in two or more tautomer forms in equilibrium, reference to the compound by means of one tautomeric description is to be considered to include all tautomer forms.

Any of the compounds of the present invention can also exist in one or more geometric isomer forms depending on the number of double bonds in the compound. Geometric isomers by nature of substituents about a double bond or a ring may be present in cis (═Z—) or trans (=E-) form. The invention thus relates equally to all geometric isomers and to all possible mixtures, in all proportions.

Depending on the nature of the substituents, the compound of formula (I) may be present in the form of the free compound and/or a salt thereof, such as an agrochemically active salt.

Agrochemically active salts include acid addition salts of inorganic and organic acids well as salts of customary bases. Examples of inorganic acids are hydrohalic acids, such as hydrogen fluoride, hydrogen chloride, hydrogen bromide and hydrogen iodide, sulfuric acid, phosphoric acid and nitric acid, and acidic salts, such as sodium bisulfate and potassium bisulfate. Useful organic acids include, for example, formic acid, carbonic acid and alkanoic acids such as acetic acid, trifluoroacetic acid, trichloroacetic acid and propionic acid, and also glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid, oxalic acid, saturated or mono- or diunsaturated fatty acids having 6 to 20 carbon atoms, alkylsulphuric monoesters, alkylsulphonic acids (sulphonic acids having straight-chain or branched alkyl radicals having 1 to 20 carbon atoms), arylsulphonic acids or aryldisulphonic acids (aromatic radicals, such as phenyl and naphthyl, which bear one or two sulphonic acid groups), alkylphosphonic acids (phosphonic acids having straight-chain or branched alkyl radicals having 1 to 20 carbon atoms), arylphosphonic acids or aryldiphosphonic acids (aromatic radicals, such as phenyl and naphthyl, which bear one or two phosphonic acid radicals), where the alkyl and aryl radicals may bear further substituents, for example p-toluenesulphonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid, etc.

Solvates of the compounds of the invention or their salts are stoichiometric compositions of the compounds with solvents.

The compounds of the invention may exist in multiple crystalline and/or amorphous forms. Crystalline forms include unsolvated crystalline forms, solvates and hydrates.

The term “leaving group” as used herein is to be understood as meaning a group which is displaced from a compound in a substitution or an elimination reaction, for example a halogen atom, a trifluoromethanesulphonate (“triflate”) group, alkoxy, methanesulphonate, p-toluenesulphonate, etc.

The terms “as described herein” when referring to a variable A, E, Q, L, m, T, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ incorporates by reference the broad definition of the variable as well as preferred, more preferred and even more preferred definitions, if any.

The present invention also relates to compounds of the formula (I), wherein

-   -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   A² is O, S, C(═O), S(═O), S(═O)₂, NR¹ or CR^(2A)R^(R2B),         -   wherein         -   R¹ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,         -   R^(2A) and R^(2B) are independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,         -   or         -   R^(2A) and R^(2B) form together with the carbon atom to             which they are attached to a C₃-C₈-cycloalkyl-ring or a 3-             to 7-membered heterocyclyl-ring,     -   m is 0, 1 or 2,     -   T is hydrogen, hydroxyl, C₁-C₆-alkyl, —C(═O)R¹¹, —C(═O)(OR¹²),         —C(═O)N(R¹³)₂, —S(═O)R¹⁴, —S(═O)₂R¹⁴ or —S(═O)₂N(R¹⁴)₂,         -   wherein         -   R¹¹ and R¹² are independently C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₃-C₈-cycloalkyl or C₂-C₆-alkenyl,         -   R¹³ and R¹⁴ are independently hydrogen, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))₁, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(SC) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of halogen, cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl in turn is optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to four substituents independently                 selected from the group consisting of halogen, cyano,                 nitro, hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   as well as N-oxides, salts, hydrates and hydrates of the salts         and N-oxides thereof.

Preferably the present invention relates to compounds of formula (I), wherein

-   -   A¹ is CR⁸,         -   wherein         -   R⁸ is hydrogen, fluoro, chloro or methyl     -   A² is O, C(═O), NR¹ or CR^(2A)R^(R2B),         -   wherein         -   R¹ is hydrogen, formyl, C₁-C₄-alkyl or C₃-C₆-cycloalkyl,         -   R^(2A) and R^(2B) are independently hydrogen or C₁-C₄-alkyl,     -   m is 0, 1 or 2,     -   T is hydrogen or C₁-C₄-alkyl     -   R³ and R⁴ are independently hydrogen, fluoro, chloro,         C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy,         C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl,     -   R⁵ is hydrogen or C₁-C₄-alkyl,     -   L is a direct bond, C₁-C₄-alkylene or a group of formula

-   -   -   wherein         -   said C₁-C₄-alkylene is optionally substituted with one to             three substituents L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl and 3- to 7-membered                 heterocyclyl in turn are optionally substituted with one                 to three substituents L^(SC)             -   wherein             -   L^(SA) is independently fluoro, chloroor hydroxyl,             -   or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently fluoro, chloro hydroxyl, oxo,                 C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or                 C₁-C₄-haloalkoxy,

    -   R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered         heterocyclyl or 5- to 10-membered heteroaryl,         C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered         heteroaryloxy, 5- to 10-membered heterocyclyloxy,         C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5-         to 10-membered heteroarylsulfanyl, 5- to 10-membered         heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy,         -   wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted             with one substituent selected from the group consisting of             C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered             heterocyclyl and 5- to 10-membered heteroaryl,             -   wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to                 10-membered heterocyclyl and 5- to 10-membered                 heteroaryl in turn are optionally substituted with one                 to three R^(6S) substituents,         -   wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to             10-membered heterocyclyl or 5- to 10-membered heteroaryl,             C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to             10-membered heteroaryloxy, 5- to 10-membered             heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl,             naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and             5- to 10-membered heterocyclyl-sulfanyl are optionally             substituted with one to three R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl,             oxo, methylidene, halomethylidene, C₁-C₄-alkyl,             C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl,             C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,             C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl,             C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶,             —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂,             -   wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy,                 C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl,                 C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl                 and C₁-C₄-haloalkylsulfanyl are furthermore optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, hydroxyl,                 C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃,                 C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl,             -   and             -   wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl,                 C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of fluoro, chloro, C₁-C₄-alkyl,                 C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy,         -   and wherein         -   R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or             C₁-C₄-haloalkyl,             -   wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl,

    -   R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl,         C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl,         C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl,         C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl,         C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl,         C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl,         C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl,         C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl,         phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂,         —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂,         —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl,             C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl,             C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,             C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl,             C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and             C₁-C₄-haloalkylsulfonyl are optionally substituted with one             to three R^(7Sa) substituents,         -   wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl,             C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl,             C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl,             C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl,             C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3-             to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5-             or 6-membered heteroaryloxy and 3- to 7-membered             heterocyclyloxy are optionally substituted with one to three             R^(7Sc) substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl,             C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl,             C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl,         -   R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl,             C₁-C₄-haloalkyl or C₁-C₄-alkoxy,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl,         -   wherein         -   R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃,         -   R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo,             C₁-C₄-alkyl, C₁-C₄-haloalkyl C₁-C₄-alkoxy, C₁-C₄-haloalkoxy             or C₃-C₈-cycloalkyl,

    -   Q is phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered         heterocyclyl or 5- to 10-membered heteroaryl,         -   wherein phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to             10-membered heterocyclyl and 5- to 10-membered heteroaryl             are optionally substituted with one to three substituents             Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl,             C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl,             C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄haloalkenyl,             C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,             C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl,             C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl,             C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkyl, 3- to 7-membered             heterocyclyl, phenyl, 5- or 6-membered heteroaryl,             —O—C(═O)R³³, and —N(R⁴³)₂,             -   wherein             -   said C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl,                 C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl,                 C₂-C₄-alkenyl, C₂-C₄haloalkenyl, C₂-C₄-alkynyl,                 C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,                 C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl,                 C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and                 C₁-C₄-haloalkylsulfonyl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of cyano, amino,                 nitro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl,                 C₃-C₆-cycloalkyl, C₃-C₆-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   said C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl and                 5- or 6-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen,                 C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy,                 C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl,                 C₁-C₄-haloalkoxycarbonyl and C₃-C₆-cycloalkyl,             -   R³³ is C₁-C₄-alkyl or C₁-C₆-haloalkyl,             -   R⁴³ is independently hydrogen, C₁-C₄-alkyl,                 C₁-C₄-haloalkyl or C₃-C₆-cycloalkyl,

    -   as well as N-oxides, salts, hydrates and hydrates of the salts         and N-oxides thereof.

Preferably the present invention relates to compounds of formula (I), wherein

-   -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   A² is O, S, C(═O), S(═O), S(═O)₂, NR¹ or CR^(2A)R^(R2B),         -   wherein         -   R¹ is hydrogen, C₁-C₄-alkyl or C₃-C₆-cycloalkyl,             -   wherein C₁-C₄-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₆-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,         -   R^(2A) and R^(2B) are independently hydrogen, C₁-C₄-alkyl or             C₃-C₆-cycloalkyl,             -   wherein C₁-C₄-alkyl is optionally substituted with one                 to three substituents independently selected from the                 group consisting of halogen, cyano, amino, nitro,                 hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and             -   wherein C₃-C₆-cycloalkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of halogen, cyano, nitro, hydroxyl,                 formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   m is 0, 1 or 2,     -   T is hydrogen, C₁-C₄-alkyl,     -   R³ and R⁴ are independently hydrogen, fluoro, chloro,         C₁-C₄-alkyl, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl,         -   wherein C₁-C₄-alkyl, C₂-C₄-alkenyl and C₂-C₄-alkynyl are             optionally substituted with one to three substituents             independently selected from the group consisting of fluoro,             chloro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl,         -   and         -   wherein C₃-C₆-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of fluoro, chloro, hydroxyl, oxo, methylidene,             C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy, C₂-C₄ alkenyl, C₃-C₆-cycloalkyl and             C₃-C₆-halocycloalkyl,         -   or     -   R⁵ is hydrogen, hydroxyl, C₁-C₄-alkyl, C₁-C₄-alkoxy or         C₁-C₄-alkylsulfanyl,         -   wherein C₁-C₄-alkyl, C₁-C₄-alkoxy and C₁-C₆-alkylsulfanyl             are optionally substituted with one to three substituents             independently selected from the group consisting of fluoro,             chloro hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl,         -   and         -   wherein C₃-C₆-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of fluoro, chloro, hydroxyl, oxo, methylidene,             C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy, C₂-C₄alkenyl, C₃-C₆-cycloalkyl and             C₃-C₆-halocycloalkyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₆-cycloalkyl-ring,     -   L is a direct bond, C₁-C₆-alkylene or a group of formula

-   -   -   wherein         -   said C₁-C₆-alkylene is optionally substituted with one to             three substituents L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₆-cycloalkyl or 3- to 7-membered heterocyclyl,             -   wherein said C₃-C₆-cycloalkyl and 3- to 7-membered                 heterocyclyl in turn are optionally substituted with one                 to three substituents L^(SC),         -   L^(SA) is independently fluoro, chloro, hydroxyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and             C₃-C₆-halocycloalkyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₆-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(SC) is independently fluoro, chloro, hydroxyl, oxo,             C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy, C₂-C₄alkenyl, C₃-C₆-cycloalkyl or             C₃-C₆-halocycloalkyl,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy,         -   wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to three R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl and 3- to 14-membered             heterocyclylsulfanyl are optionally substituted with one to             three R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₁-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl,             C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryl, 5- or             6-membered heteroaryl, 3- to 7-membered heterocyclyl,             —C(═O)(OR¹⁷) and —C(═O)N(R¹⁸)₂             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl                 and C₁-C₆-haloalkylsulfanyl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of fluoro, chloro,                 hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl             -   and             -   wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl,                 C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl,                 C₁-C₄-alkoxy and C₁-C₄-haloalkoxy,         -   and wherein         -   R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or             C₁-C₄-haloalkyl,             -   wherein said C₁-C₄-alkyl or C₁-C₄-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 fluoro, chloro, hydroxyl, C₁-C₄-alkoxy,                 C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and                 C₃-C₆-halocycloalkyl,

    -   R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl,         C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄haloalkylcarbonyl,         C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl,         C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl,         C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl,         C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl,         C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl,         C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl,         C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or         6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵),         —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹,         -   Wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl,             C₁-C₄haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl,             C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,             C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl and             C₁-C₄-haloalkylsulfinyl are optionally substituted with one             to three R^(7Sa) substituents,         -   wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkylsulfinyl,             C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy and 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl,             C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl,             C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl,             -   wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl,                 C₂-C₄-haloalkenyl, C₂-C₄-alkynyl and C₂-C₄-haloalkynyl                 in turn are optionally substituted with one to three                 substituents R^(7Sa),             -   and             -   wherein C₃-C₆-cycloalkyl in turn is optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl,             C₁-C₄haloalkyl or C₁-C₄-alkoxy,             -   wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₁-C₄-alkoxy in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl,             -   wherein C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are                 optionally substituted with one or two R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₆-cycloalkyl in turn is optionally                 substituted with one or two R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy,             C₁-C₄-haloalkoxy or C₃-C₆-cycloalkyl,         -   R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo,             C₁-C₄-alkyl, C₁-C₄-haloalkyl C₁-C₄-alkoxy, C₁-C₄-haloalkoxy             or C₃-C₆-cycloalkyl,

    -   Q is phenyl, naphthyl, C₃-C₁₀-carbocyclyl, 5- to 10-membered         heterocyclyl or 5- to 10-membered heteroaryl,         -   wherein phenyl, naphthyl, C₃-C₁₀-carbocyclyl, 5- to             10-membered heterocyclyl and 5- to 10-membered heteroaryl             are optionally substituted with one to three substituents             Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, nitro, formyl, carboxyl, C₁-C₄-alkyl,             C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl,             C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl,             C₂-C₄alkenyl, C₂-C₄haloalkenyl, C₂-C₄-alkynyl,             C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,             C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl,             C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl,             C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkyl, 3- to 7-membered             heterocyclyl, phenyl, 5- or 6-membered heteroaryl,             -   wherein             -   said C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl,                 C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl,                 C₂-C₄alkenyl, C₂-C₄haloalkenyl, C₂-C₄-alkynyl,                 C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl,                 C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl,                 C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and                 C₁-C₄-haloalkylsulfonyl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of cyano, amino,                 nitro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 C₃-C₆-cycloalkyl, C₃-C₆-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   said C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl,                 phenyl and 5- or 6-membered heteroaryl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl,                 C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl,                 C₁-C₄-haloalkoxycarbonyl and C₃-C₆-cycloalkyl,

    -   as well as salts, hydrates and hydrates of the salts thereof.

More preferably the present invention relates to compounds of formula (I), wherein

-   -   A¹ is CR⁸,         -   wherein         -   R⁸ is hydrogen,     -   A² is O, C(═O) or CR^(2A)R^(R2B),         -   wherein         -   R^(2A) and R^(2B) are independently hydrogen,     -   m is 1,     -   T is hydrogen,     -   R³ and R⁴ are independently hydrogen, fluoro, chloro,         C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl,         C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or         C₃-C₆-cycloalkyl,     -   R⁵ is hydrogen,     -   L is a direct bond, methylene or ethylene,         -   wherein         -   said methylene and ethylene are optionally substituted with             one or two substituents L^(SA),         -   wherein         -   L^(SA) is independently fluoro,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a cyclopropyl- or a cyclobutyl-ring,     -   R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl,         1,3-benzodioxolyl, 1,2,3,4-tetrahydro-quinolinyl, chromanyl,         isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl,         tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or         pyrimidinyl,         -   wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl,             1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl,             isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl,             tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl             and pyrimidinyl are optionally substituted with one to three             R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl,             trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy,             trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl,             C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl,             trifluoro-methylsulfanyl, C₃-C₆-cycloalkyl, furanyl,             thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl,             thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl,             tetrahydrofuranyl or —C(═O)R¹⁶,             -   wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl,                 C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore                 optionally substituted with one or two substituents                 independently selected from the group consisting of                 hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,                 —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl             -   and wherein             -   R¹⁶ is C₁-C₄-alkyl,     -   R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl,         C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy,         C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl,     -   Q is phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl,         indanyl, tetrahydronaphthalenyl, dihydro-benzofuranyl, indenyl,         dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl,         dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl,         tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl,         pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl,         pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl,         benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl or         quinolinyl,         -   wherein phenyl, naphthyl,             3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl,             tetrahydronaphthalenyl, dihydrobenzofuranyl, indenyl,             dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl,             chromanyl, dihydro-1,4-benzodioxinyl,             [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl,             6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl,             thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl,             pyrimidinyl, indolyl, benzimidazolyl, indazolyl,             benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl             and quinolinyl, are optionally substituted with one to three             substituents Q^(S) wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, nitro, formyl, C₁-C₄-alkyl, difluoromethyl,             trifluoromethyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy,             difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl,             C₂-C₄haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl,             C₁-C₄-alkylsulfanyl, C₃-C₆-cycloalkyl oxetanyl,             pyrrolidinyl, tetrahydrofuranyl, phenyl, thienyl, furanyl,             pyrrolyl, pyridyl, —O(C═O)R³³ and —N(R⁴³)₂,             -   wherein             -   said C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy,                 C₂-C₄-alkenyl, C₂-C₄haloalkenyl, C₂-C₄-alkynyl,                 C₂-C₄-haloalkynyl and C₁-C₄-alkylsulfanyl in turn are                 optionally substituted with one or two substituents                 independently selected from the group consisting of                 hydroxyl, C₁-C₄-alkoxy and C₁-C₄-alkoxycarbonyl             -   R³³ is C₁-C₄-alkyl,             -   R⁴³ is independently hydrogen or C₁-C₄-alkyl,     -   as well as N-oxides, salts, hydrates and hydrates of the salts         and N-oxides thereof.

Even more preferably the present invention relates to compounds of formula (I), wherein

-   -   A¹ CR⁸, wherein R¹ is hydrogen,     -   A² is O,     -   m is 1,     -   T is hydrogen,     -   R³ and R⁴ are independently hydrogen, fluoro or C₁-C₄-alkyl,     -   R⁵ is hydrogen,     -   L is a direct bond or C₁-C₄-alkylene,         -   wherein         -   said C₁-C₄-alkylene is optionally substituted with one or             two substituents L^(SA),         -   L^(SA) is fluoro,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a cyclopropyl or cyclobutyl,     -   R⁶ is indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl, naphthyl,         dihydrobenzofuranyl or dihydro-benzodioxinyl,         -   wherein indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl,             naphthyl, dihydrobenzofuranyl and di-hydrobenzodioxinyl are             optionally substituted with one or two R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl,             trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy,             trifluoromethoxy, C₂-C₄-alkenyl, methylcarbonyl,             ethylcarbonyl, C₂-C₄-alkynyl, cyclopropyl, cyclobutyl,             oxetanyl, tetrahydrofuranyl, pyrazolyl and pyridyl,     -   R⁷ is hydrogen, fluoro, chloro, cyano, C₁-C₄-alkyl,         difluoromethyl, trifluoromethyl, methylcarbonyl, ethylcarbonyl,         C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl, cyclobutyl, oxetanyl,         pyrrolidinyl or tetrahydrofuranyl,     -   Q is phenyl,         -   wherein phenyl is optionally substituted with one or two             substituents Q^(S),         -   wherein         -   Q^(S) is independently selected from the group consisting of             fluoro, chloro, nitro, C₁-C₄-alkyl, difluoromethyl,             trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy,             trifluoromethoxy, C₂-C₄alkenyl, C₂-C₄-alkynyl, cyclopropyl             and cyclobutyl,     -   as well as salts, hydrates and hydrates of the salts thereof.

Not encompassed herein are compounds resulting from combinations which are against natural laws and which the person skilled in the art would therefore exclude based on his/her expert knowledge. For instance, ring structures having three or more adjacent oxygen atoms are excluded.

The compound of formula (I) can suitably be in its free form, salt form, N-oxides form or solvate form (e.g. hydrate).

Depending on the nature of the substituents, the compound of formula (I) may be present in the form of different stereoisomers. These stereoisomers are, for example, enantiomers, diastereomers, atropisomers or geometric isomers. Accordingly, the invention encompasses both pure stereoisomers and any mixture of these isomers. Where a compound can be present in two or more tautomer forms in equilibrium, reference to the compound by means of one tautomeric description is to be considered to include all tautomer forms.

Any of the compounds of the present invention can also exist in one or more geometric isomer forms depending on the number of double bonds in the compound. Geometric isomers by nature of substituents about a double bond or a ring may be present in cis (═Z—) or trans (=E-) form. The invention thus relates equally to all geometric isomers and to all possible mixtures, in all proportions.

Depending on the nature of the substituents, the compound of formula (I) may be present in the form of the free compound and/or a salt thereof, such as an agrochemically active salt.

Agrochemically active salts include acid addition salts of inorganic and organic acids well as salts of customary bases. Examples of inorganic acids are hydrohalic acids, such as hydrogen fluoride, hydrogen chloride, hydrogen bromide and hydrogen iodide, sulfuric acid, phosphoric acid and nitric acid, and acidic salts, such as sodium bisulfate and potassium bisulfate. Useful organic acids include, for example, formic acid, carbonic acid and alkanoic acids such as acetic acid, trifluoroacetic acid, trichloroacetic acid and propionic acid, and also glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid, oxalic acid, saturated or mono- or diunsaturated fatty acids having 6 to 20 carbon atoms, alkylsulphuric monoesters, alkylsulphonic acids (sulphonic acids having straight-chain or branched alkyl radicals having 1 to 20 carbon atoms), arylsulphonic acids or aryldisulphonic acids (aromatic radicals, such as phenyl and naphthyl, which bear one or two sulphonic acid groups), alkylphosphonic acids (phosphonic acids having straight-chain or branched alkyl radicals having 1 to 20 carbon atoms), arylphosphonic acids or aryldiphosphonic acids (aromatic radicals, such as phenyl and naphthyl, which bear one or two phosphonic acid radicals), where the alkyl and aryl radicals may bear further substituents, for example p-toluenesulphonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid, etc.

Solvates of the compounds of the invention or their salts are stoichiometric compositions of the compounds with solvents.

The compounds of the invention may exist in multiple crystalline and/or amorphous forms. Crystalline forms include unsolvated crystalline forms, solvates and hydrates.

Preferably, A¹ is CH (i.e. CR⁸, wherein R¹ is hydrogen).

Preferably, A² is O, C(═O), S(═O)₂, NR¹ or CR^(2A)R^(2B), wherein R¹ is hydrogen or C₁-C₄-alkyl and R^(2A) and R^(2B) are independently hydrogen, halogen or C₁-C₄-alkyl.

More preferably, A² is O, (C═O) or CR^(2A)R^(2B), wherein R^(2A) and R^(2B) are independently hydrogen or methyl. Even more preferably, A² is O.

Likewise more preferably, A² is O, NR¹ or CR^(2A)R^(2B), wherein R¹ is hydrogen or C₁-C₄-alkyl and R^(2A) and R^(2B) are independently hydrogen, halogen or C₁-C₄-alkyl. Even more preferably, A² is O.

Even more preferably, m is 1, A² is O, (C═O) or CR^(2A)R^(2B), wherein R^(2A) and R^(2B) are independently hydrogen or methyl.

More preferably, T is hydrogen and C₁-C₄-alkyl.

Even more preferably, A¹ is CH, A² is O, m is 1 and T is hydrogen.

Preferably, T is hydrogen and C₁-C₄-alkyl.

Preferably, R³ and R⁴ are independently hydrogen, fluorine, chlorine, C₁-C₄-alkyl, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₃-C₆-cycloalkyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a C₃-C₆-cycloalkyl-ring. More preferably, R³ and R⁴ are independently hydrogen, fluorine or C₁-C₄-alkyl.

Preferably R⁵ is hydrogen, hydroxyl, C₁-C₄-alkyl or C₁-C₄-alkoxy. More preferably, R⁵ is hydrogen.

Even more preferably, A¹ is CH, A² is O, m is 1, T is hydrogen, R³ and R⁴ are independently hydrogen, fluorine or C₁-C₄-alkyl and R⁵ is hydrogen.

Preferably, L is a direct bond, C₁-C₆-alkylene or a group of formula

-   -   wherein     -   said C₁-C₆-alkylene is optionally substituted with one to three         substituents L^(SA),     -   # is the point of attachment to the heterocyclyl-moiety,     -   ## is the point of attachment to R⁶,     -   L¹ is a direct bond or C₁-C₆-alkylene,     -   L² is a direct bond or C₁-C₆-alkylene,     -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered         heterocyclyl,         -   wherein said C₃-C₈-cycloalkyl and 3- to 7-membered             heterocyclyl in turn are optionally substituted with one to             three substituents L^(SC),     -   L^(SA) is independently halogen, hydroxyl, C₁-C₄-alkoxy,         C₃-C₆-cycloalkyl or 3- to 7-membered heterocyclyl,     -   or     -   two substituents L^(SA) that are bound to the same carbon atom         form together with the carbon atom which they are attached to a         C₃-C₆-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring,     -   L^(Sc) is independently halogen, hydroxyl, oxo, C₁-C₄-alkyl,         C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄₋haloalkoxy,     -   and/or     -   two L^(Sc) substituents form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring.

Preferably, L is a direct bond C₁-C₆-alkylene or a group of formula

-   -   wherein     -   said C₁-C₆-alkylene is optionally substituted with one to three         substituents L^(SA),     -   # is the point of attachment to the heterocyclyl-moiety,     -   ## is the point of attachment to R⁶,     -   L¹ is a direct bond or C₁-C₆-alkylene,     -   L² is a direct bond or C₁-C₆-alkylene,     -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered         heterocyclyl,         -   wherein said C₃-C₈-cycloalkyl and 3- to 7-membered             heterocyclyl in turn are optionally substituted with one to             three substituents L^(SC),     -   L^(SA) is independently halogen, hydroxyl, C₁-C₄-alkoxy,         C₃-C₆-cycloalkyl or 3- to 7-membered heterocyclyl,     -   or     -   two substituents L^(SA) that are bound to the same carbon atom         form together with the carbon atom which they are attached to a         C₃-C₆-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring,     -   L^(Sc) is independently halogen, hydroxyl, oxo, C₁-C₄-alkyl,         C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy,     -   and/or     -   two L^(Sc) substituents form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring.

More preferably, L is a direct bond or C₁-C₄-alkylene,

-   -   wherein     -   said C₁-C₄-alkylene is optionally substituted with one or two         substituents L^(SA),     -   L^(SA) is fluoro,     -   or     -   two substituents L^(SA) that are bound to the same carbon atom         form together with the carbon atom which they are attached to a         cyclopropyl or cyclobutyl.

Even more preferably, L is a direct bond, methylene, monofluoromethylene or difluoromethylene, particularly preferably L is a direct bond or methylene.

Preferably, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₆-C₁₄-aryloxy, C₁-C₃-alkoxy substituted by a C₆-C₁₄-aryl or C₆-C₁₄-arylsulfanyl, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₆-C₁₄-aryloxy, C₁-C₃-alkoxy substituted by a C₆-C₁₄-aryl and C₆-C₁₄-arylsulfanyl are optionally substituted with one to four substituents R^(6S), wherein

-   -   R^(6S) is independently selected from the group consisting of         halogen, cyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl,         oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,         C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy,         C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, —C(═O)(OR¹⁷) and —C(═O)N(R¹⁸)₂, wherein         C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,         C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl and         C₁-C₆-haloalkylsulfanyl are furthermore optionally substituted         with one to three substituents independently selected from the         group consisting of fluoro, chloro, hydroxyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and         wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl,         C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl         and 3- to 7-membered heterocyclyl are furthermore optionally         substituted with one to three substituents independently         selected from the group consisting of fluoro, chloro,         C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy,     -   and wherein     -   R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or         C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl or C₁-C₄-haloalkyl in         turn are optionally substituted with one to three substituents         independently selected from the group consisting of fluoro,         chloro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,         C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl.

More preferably, R⁶ is indanyl, 1,2,3,4-tetrahydronaphthalenyl, bicyclo[4.2.0]octa-1,3,5-trienyl, bi-cyclo[4.2.0]octa-1(6), 2,4-trienyl, indenyl, 1,2-dihydronaphthalenyl, spiro[cyclopropane-2,1′-indane]-1-yl, spiro[cyclopropane-2,1′-tetralin]-1-yl, phenyl, naphthyl, phenoxy, benzyloxy, OCF₂-phenyl, phenylsulfanyl, 1,3-dihydrobenzofuranyl, 2,3-dihydrobenzothiophenyl, indolinyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, 5,6,7,8-tetrahydroquinolinyl, 4,5,6,7-tetrahydrobenzothiophenyl, 4,5,6,7-tetrahydrobenzofuranyl, 4,5,6,7-tetrahydro-1,3-benzoxazolyl, 4,5,6,7-tetrahydro-1,3-benzothiazolyl, 4,5,6,7-tetrahydro-1H-benzimidazolyl, 4,5,6,7-tetrahydro-1H-indazolyl, 4,5,6,7-tetrahydro-2H-isoindolyl, 4,5,6,7-tetrahydro-2-benzothiophenyl, 5,6-dihydro-4H-cyclopenta[b]thiophenyl, 5,6-dihydro-4H-cyclopenta[d]thiazolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinyl, 6,7-dihydro-5H-thieno[3,2-b]pyranyl, spiro[chromane-3,1′-cyclopropane]-yl, spiro[7,8-dihydro-5H-quinoline-6,1′-cyclopropane]-yl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, pyridinyl, pyridazinyl and pyrimidinyl, indolyl, benzimadazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, quinoxalinyl, pyrrolo[2,3-b]pyridin-3-yl, imidazo[1,2-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[3,2-b]pyrrol-6-yl, thieno[3,2-b]thio-phenyl, imidazo[2,1-b]oxazolyl, furo[2,3-d]isoxazolyl or thieno[2,3-d]isothiazolyl, wherein indanyl, 1,2,3,4-tetrahydronaphthalenyl, bicyclo[4.2.0]octa-1,3,5-trienyl, bicyclo[4.2.0]octa-1(6), 2,4-trienyl, indenyl, 1,2-dihydronaphthalenyl, spiro[cyclopropane-2,1′-indane]-1-yl, spiro[cyclopropane-2,1′-tetralin]-1-yl, phenyl, naphthyl, phenoxy, benzyloxy, OCF₂-phenyl, phenylsulfanyl, 3-dihydro-benzofuranyl, 2,3-dihydrobenzothiophenyl, indolinyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, 5,6,7,8-tetrahydroquinolinyl, 4,5,6,7-tetrahydrobenzothiophenyl, 4,5,6,7-tetrahydro-benzofuranyl, 4,5,6,7-tetrahydro-1,3-benzoxazolyl, 4,5,6,7-tetrahydro-1,3-benzothiazolyl, 4,5,6,7-tetrahydro-1H-benzimidazolyl, 4,5,6,7-tetrahydro-1H-indazolyl, 4,5,6,7-tetrahydro-2H-isoindolyl, 4,5,6,7-tetrahydro-2-benzothiophenyl, 5,6-dihydro-4H-cyclopenta[b]thiophenyl, 5,6-dihydro-4H-cyclopenta[d]thiazolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridinyl, 5,6,7,8-tetrahydroimidazo[1,2-a]pyridinyl, 6,7-dihydro-5H-thieno[3,2-b]pyranyl, spiro[chromane-3,1′-cyclopropane]-yl, spiro[7,8-dihydro-5H-quinoline-6,1′-cyclopropane]-yl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, pyridinyl, pyridazinyl and pyrimidinyl, indolyl, benzimadazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, quinoxalinyl, pyrrolo[2,3-b]pyridin-3-yl, imidazo[1,2-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[3,2-b]pyrrol-6-yl, thieno[3,2-b]thio-phenyl, imidazo[2,1-b]oxazolyl, furo[2,3-d]isoxazolyl and thieno[2,3-d]isothiazolyl are optionally substituted with one to three substituents R^(6S), wherein

-   -   R^(6S) is independently selected from the group consisting of         halogen, cyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl,         oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,         C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy,         C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, —C(═O)(OR¹⁷) and —C(═O)N(R¹⁸)₂, wherein         C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,         C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl and         C₁-C₆-haloalkylsulfanyl are furthermore optionally substituted         with one to three substituents independently selected from the         group consisting of fluoro, chloro, hydroxyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and         wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl,         C₃-C₆-cycloalkyloxy, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl         and 3- to 7-membered heterocyclyl are furthermore optionally         substituted with one to three substituents independently         selected from the group consisting of fluoro, chloro,         C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy,     -   and wherein     -   R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or         C₁-C₄-haloalkyl,         -   wherein said C₁-C₄-alkyl or C₁-C₄-haloalkyl in turn are             optionally substituted with one to three substituents             independently selected from the group consisting of fluoro,             chloro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl.

Even more preferably, R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, dihydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein

-   -   R^(6S) is independently selected from the group consisting of         fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl,         C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl,         C₂-C₄-alkynyl, cyclopropyl and cyclobutyl,         -   wherein said C₂-C₄-alkynyl is optionally substituted with             one substituent —Si(CH₃)₃.

Likewise even more preferably, R⁶ is indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl, naphthyl, dihydrobenzofuranyl or dihydrobenzodioxinyl, wherein indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl, naphthyl, dihydrobenzofuranyl and dihydrobenzodioxinyl are optionally substituted with one or two R^(6S) substituents, wherein

-   -   R^(6S) is independently selected from the group consisting of         fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl,         C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl,         methylcarbonyl, ethylcarbonyl, C₂-C₄-alkynyl, cyclopropyl,         cyclobutyl, oxetanyl, tetrahydrofuranyl, pyrazolyl and pyridyl.

In a still even more preferred embodiment, R⁶ is

-   -   wherein     -   § ¹ is the attachment to L,     -   R^(6S1) and R^(6S2) are independently hydrogen or R^(6S),         -   wherein         -   R^(6S) is halogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl,             C₁-C₄-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,             C₁-C₆-alkylcarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,             C₃-C₆-cycloalkyl,     -   with the proviso that at least one of R^(6S1) and R^(6S2) is         different from hydrogen.

Preferably,

-   -   R^(6S1) and R^(6S2) are independently R^(6S),         -   wherein         -   R^(6S) is halogen, cyano, C₁-C₄-alkyl, C₁-C₄-haloalkyl,             C₁-C₄-alkoxy, cyclopropyl, preferably R^(6S) is chloro,             fluoro, methyl, trifluoromethyl or methoxy, more preferably             methyl.

Preferably R⁷ is hydrogen, halogen, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R²⁰)₂, —C(═NR²¹)R²², —C(═O)(OR²⁵) or —C(═O)N(R²⁶)₂, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and C₁-C₆-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are optionally substituted with one to three

-   -   R^(7Sc) substituents,         -   wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or             C₃-C₆-cycloalkyl,             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one or two substituents independently                 selected from the group consisting of halogen and                 C₁-C₆-alkyl,         -   R²¹ is hydroxyl, C₁-C₆-alkyl or C₁-C₆-alkoxy,         -   R²² is hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl,         -   R²⁵ and R²⁶ are independently hydrogen or C₁-C₆-alkyl,             -   and wherein             -   R^(7Sa) is independently cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₆-cycloalkyl, C₁-C₄-alkoxycarbonyl                 and phenyl,             -   R^(7Sc) is independently halogen, hydroxyl, C₁-C₄-alkyl,                 C₁-C₄-haloalkyl C₁-C₄-alkoxy or C₁-C₄-haloalkoxy.

More preferably R⁷ is hydrogen, halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₃-C₆-cycloalkyl, pyridinyl, imidazolyl, pyrazolyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, —N(R²⁰)₂, —C(═NR²¹)R²² or —C(═O)(OR²⁵), wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl and C₂-C₄-alkynyl are optionally substituted with one or two R^(7Sa) substituents, wherein C₃-C₆-cycloalkyl, pyridinyl, imidazolyl, pyrazolyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl are optionally substituted with one or two R^(7Sc) substituents,

-   -   wherein     -   R²⁰ is hydrogen, C₁-C₄-alkyl or C₃-C₆-cycloalkyl,     -   R²¹ is C₁-C₄-alkyl or C₁-C₄-alkoxy,     -   R²² is C₁-C₄-alkyl,     -   R²⁵ is hydrogen or C₁-C₄-alkyl,         -   and wherein     -   R^(7Sa) is independently C₁-C₄-alkoxy or phenyl,     -   R^(7Sc) is independently halogen or C₁-C₄-alkyl.

Even more preferably R⁷ is chloro, iodo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, methylcarbonyl, ethylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₃-C₆-cycloalkyl, —N(R²⁰)₂ or —C(═NR²¹)R²² wherein C₁-C₄-alkyl, C₂-C₄-alkenyl and C₂-C₄-alkynyl are optionally substituted with one or two R^(7Sa) substituents,

-   -   wherein C₃-C₆-cycloalkyl is optionally substituted with one or         two R^(7Sc) substituents,     -   R²⁰ is hydrogen, cyclopropyl or cyclobutyl,     -   R²¹ is C₁-C₄-alkyl or C₁-C₄-alkoxy,     -   R²² is C₁-C₄-alkyl,     -   and wherein     -   R^(7Sa) is independently C₁-C₄-alkoxy,     -   R^(7Sc) is independently halogen.

Likewise even more preferably R⁷ is chloro, iodo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, methylcarbonyl, ethylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl, cyclobutyl, oxetanyl, tetrahydrofuranyl or pyrrolidinyl. Particularly preferably R⁷ is methyl, ethyl, n-propyl, isopropyl or cyclopropyl.

Still even more preferably R⁷ is methyl, methylsulfanyl or cyclopropyl.

Preferably R¹ is hydrogen or fluoro, more preferably R¹ is hydrogen.

Even more preferably R⁷ is methyl, methylsulfanyl or cyclopropyl and R¹ is hydrogen.

Preferably Q is phenyl, naphthyl, bicyclo[4.2.0]octa-1(6), 2,4-trienyl, indanyl, tetrahydronaphthalenyl, indenyl, dihydronaphthalenyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, dihydrobenzofuranyl, 1,3-dihydroiso-benzofuranyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, furo[3,2-b]pyridinyl, thieno[3,2-b]thiophenyl or thieno[2,3-d]thiazolyl, wherein phenyl, naphthyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, indanyl, tetrahydronaphthalenyl, indenyl, dihydronaphthalenyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, dihydrobenzofuranyl, 1,3-dihydroisobenzofuranyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydro-quinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinolinyl, furo[3,2-b]pyridinyl, thieno[3,2-b]thiophenyl and thieno[2,3-d]thiazolyl are optionally substituted with one to four substituents Q^(S), wherein

-   -   Q^(S) is independently selected from group consisting of         halogen, cyano, nitro, hydroxyl, formyl, C₁-C₆-alkyl,         C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxy-C₁-C₆-alkyl,         C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,         C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,         C₃-C₆-cycloalkyl, oxetanyl and —N(R⁴³)₂, wherein said         C₃-C₆-cycloalkyl and oxetanyl in turn are optionally substituted         with one or two substituents independently selected from the         group consisting of halogen, C₁-C₄-alkyl and C₁-C₄-haloalkyl,         and wherein R⁴³ is hydrogen and C₁-C₆-alkyl.

More preferably Q is phenyl, naphthyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, benzodioxolyl, 2,3-dihydrobenzofuranyl, pyridinyl, thienyl or indolyl, wherein phenyl, naphthyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, benzodioxolyl, 2,3-dihydrobenzofuranyl, pyridinyl, thienyl and indolyl are optionally substituted with one to three substituents Q^(S), wherein

-   -   Q^(S) is independently selected from the group consisting of         halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl,         C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,         C₂-C₄-alkynyl and C₃-C₆-cycloalkyl, wherein said         C₃-C₆-cycloalkyl and oxetanyl are in turn optionally substituted         with one or two substituents independently selected from the         group consisting of fluoro or methyl.

Even more preferably, Q is phenyl, wherein phenyl is substituted with one or two substituents Q^(S) independently selected from the group consisting of halogen, nitro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl.

Likewise even more preferably, Q is phenyl, wherein phenyl is substituted with one or two substituents Q^(S) independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said cyclopropyl and cyclobutyl in turn are optionally substituted with one or two substituents independently selected from the group consisting of fluoro or methyl.

Still even more preferably Q is phenyl substituted with one Q^(S) substituent selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkoxy, wherein said one Q^(S) substituent preferably is in position 3 of the phenyl ring, and preferably Q^(S) is selected from the group consisting of 3-nitro, 3-fluoro, 3-chloro, 3-difluoromethyl or 3-trifluoromethyl. In a particularly preferred embodiment, Q is 3-(trifluoromethyl)phenyl or 3-(nitro)phenyl.

The above specified definitions of A¹, A², Q, T, L, m, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ (broad definition as well as preferred, more preferred, even more preferred definitions) can be combined in various manners. These combinations of definitions thus provide sub-classes of compounds according to the invention, such as for instance the ones disclosed below.

The present invention also relates to the compounds of formula (I) disclosed in Table 1.

The compounds of formula (I) may be used as fungicides (for controlling phytopathogenic fungi), in particular in methods for controlling phytopathogenic fungi which comprises the step of applying one or more compounds of formula (I) to the plants, plant parts, seeds, fruits or to the soil in which the plants grow.

Processes for the Preparation of Compounds of Formula (I) and Intermediates

The present invention relates to processes for the preparation of compounds of formula (I) and their intermediates. Unless indicated otherwise, the radicals A¹, A², Q, T, L, m, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ have the meanings given above for the compounds of formula (I). These definitions apply not only to the end products of formula (I) but also to all intermediates. Likewise, the preferred definitions, the more preferred definitions, the even more preferred definitions and the particularly preferred definitions of A¹, A², Q, T, L, m, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ given above for the compounds of formula (I), apply mutatis mutandis for the compounds of formula (I-a), (I-a-1) and (I-a-2) as well as to all intermediates described in the context of the present invention, in particular the intermediates of formula (1), (2), (3), (4), (5), (6a), (6b), (7), (8), (9), (10), (11), (12), (13) and (14) as defined herein.

Compounds of formula (I-a) is a subset of formula (I). Compounds of formula (I-a-1) and (I-a-2) are various subsets of formula (I-a). All substituents for formula (I-a) and (I-a-1) to (I-a-2) are as defined above for formula (I) unless otherwise noted.

The compounds of formula (I) can be prepared by various routes in analogy to known processes (see e.g. and references therein). Non-limiting examples of suitable processes are herein described.

A compound of formula (I) may be directly obtained by performing any process A to D or may be obtained by conversion or derivatization of another compound of formula (I) prepared in accordance with the processes described herein. For instance, a compound of formula (I) can be converted into another compound of formula (I) by replacing one or more substituents of the starting compound of formula (I) by other substituents.

The processes described herein may be suitably performed using one or more inert organic solvents which is/are customary for the considered reaction. Suitable inert organic solvents can be chosen from the following: aliphatic, alicyclic or aromatic hydrocarbons (e.g. petroleum ether, pentane, hexane, heptane, cyclohexane, methylcyclohexane, ligroin, benzene, toluene, xylene or decalin), halogenated aliphatic, alicyclic or aromatic hydrocarbons (e.g. chlorobenzene, dichlorobenzene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane or trichloroethane), ethers (e.g. diethyl ether, diiso-propyl ether, methyl t-butyl ether, methyl t-amyl ether, dioxane, tetrahydrofuran, 2-methyltetrahydrofuran, 1,2-dimethoxyethane, 1,2-diethoxyethane or anisole), ketones (e.g. acetone, methyl ethyl ketone, methyl isopropyl ketone and methyl isobutyl ketone), esters (e.g. methyl acetate, ethyl acetate or butyl acetate), alcohols (e.g. methanol, ethanol, propanol, iso-propanol, butanol, tert-butanol), nitriles (e.g. acetonitrile, propionitrile, n- or i-butyronitrile or benzonitrile), amides (e.g. N,N-dimethylformamide, N,N-dimethylacetamide, N-methylformanilide, N-methylpyrrolidone, or hexa-methylphosphoric triamide), sulfoxides (e.g. dimethyl sulfoxide) or sulfones (e.g. sulfolane), ureas (e.g. 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone) or any mixture thereof.

Some processes described herein may require or be optionally performed using one or more inorganic or organic bases which are customary for such reactions. Examples of suitable inorganic and organic bases include, but are not limited to, alkaline earth metal or alkali metal carbonates (e.g. sodium carbonate, potassium carbonate, potassium bicarbonate, sodium bicarbonate or cesium carbonate), alkali metal hydrides (e.g. sodium hydride), alkaline earth metal or alkali metal hydroxides (e.g. sodium hydroxide, calcium hydroxide, potassium hydroxide or other ammonium hydroxide derivatives), alkaline earth metal, alkali metal or ammonium fluorides (e.g. potassium fluoride, cesium fluoride or tetrabutylammonium fluoride), alkali metal or alkaline earth metal acetates (e.g. sodium acetate, lithium acetate, potassium acetate or calcium acetate), alkali metal alcoholates (e.g. potassium tert-butoxide or sodium tert-butoxide), alkali metal phosphates (e.g. tri-potassium phosphate), tertiary amines (e.g. trimethylamine, triethylamine, tributylamine, N,N-dimethylaniline, N,N-dicyclohexylmethylamine, N,N-diisopropylethylamine, N-methylpiperidine, N,N-dimethylaminopyridine, diazabicyclooctane (DABCO), diazabicyclononene (DBN), diazabicycloundecene (DBU), quinuclidine, 3-acetoxyquinuclidine, guanidines or aromatic bases (e.g. pyridines, picolines, lutidines or collidines).

Some of the processes described herein may be optionally performed in the presence of a transition metal catalyst, such as a metal (e.g. copper or palladium) salt or complex, if appropriate in the presence of a ligand.

Suitable copper salts or complexes and their hydrates include, but are not limited to, copper metal, copper(I) iodide, copper(I) chloride, copper(I) bromide, copper(II) chloride, copper(II) bromide, copper(II) oxide, copper(I) oxide, copper(II) acetate, copper(I) acetate, copper(I) thiophene-2-carboxylate, copper(I) cyanide, copper(II) sulfate, copper(II) bis(2,2,6,6-tetramethyl-3,5-heptane-dionate), copper(II) trifluoromethanesulfonate, tetrakis(acetonitrile)copper(I) hexafluorophosphate, tetrakis(acetonitrile)-copper(I) tetrafluoroborate.

It is also possible to generate in situ a suitable copper complex in the reaction mixture by separate addition to the reaction of a copper salt and a ligand or salt, such as ethylenediamine, N,N-dimethylethylenediamine, N,N′-dimethylethylenediamine, rac-trans-1,2-diaminocyclohexane, rac-trans-N,N′-dimethylcyclohexane-1,2-diamine, 1,1′-binaphthyl-2,2′-diamine, N,N,N′,N′-tetramethylethylene-diamine, proline, N,N-dimethylglycine, quinolin-8-ol, pyridine, 2-aminopyridine, 4-(dimethyl-amino)pyridine, 2,2′-bipyridyl, 2,6-di(2-pyridyl)pyridine, 2-picolinic acid, 2-(dimethylaminomethyl)-3-hydroxypyridine, 1,10-phenanthroline, 3,4,7,8-tetramethyl-1,10-phenanthroline, 2,9-dimethyl-1,10-phenanthroline, 4,7-dimethoxy-1,10-phenanthroline, N,N′-bis[(E)-pyridin-2-ylmethylidene]cyclohexane-1,2-diamine, N-[(E)-phenylmethylidene], N-[(E)-phenylmethylidene]-cyclohexanamine, 1,1,1-tris(hydroxymethyl)ethane, n-butylimidazol, ethylene glycol, 2,2,6,6-tetramethylheptane-3,5-dione, 2-(2,2-dimethylpropanoyl)cyclohexanone, acetylacetone, dibenzoylmethane, 2-(2-methylpropanoyl)cyclohexanone, biphenyl-2-yl(di-tert-butyl)phosphane, ethylenebis-(diphenylphosphine), N,N-diethylsalicylamide, 2-hydroxybenzaldehyde oxime, oxo[(2,4,6-trimethylphenyl)amino]acetic acid or 1H-pyrrole-2-carboxylic acid.

Suitable palladium salts or complexes include, but are not limited to, palladium chloride, palladium acetate, tetrakis(triphenylphosphine)palladium(0), bis(dibenzylideneacetone)palladium(0), tris(di-benzylideneacetone)dipalladium(0), bis(triphenylphosphine)palladium(II) dichloride, [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), bis(cinnamyl)dichlorodipalladium(II), bis(allyl)-di-chlorodipalladium(II) or [1,1′-Bis(di-tert-butylphosphino)ferrocene]dichloropalladium(II).

It is also possible to generate a palladium complex in the reaction mixture by separate addition to the reaction of a palladium salt and a ligand or salt, such as triethylphosphine, tri-tert-butylphosphine, tri-tert-butylphosphonium tetrafluoroborate, tricyclohexylphosphine, 2-(dicyclohexylphosphino)biphenyl, 2-(di-tert-butylphosphino)biphenyl, 2-(dicyclohexylphosphino)-2′-(N,N-dimethylamino)biphenyl, 2-(tert-butylphosphino)-2′-(N,N-dimethylamino)biphenyl, 2-di-tert-butylphosphino-2′,4′,6′-triisopropyl-biphenyl, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl, 2-dicyclohexylphosphino-2,6′-di-methoxybiphenyl, 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl, triphenyl-phosphine, tris-(o-tolyl)phosphine, sodium 3-(diphenylphosphino)benzenesulfonate, tris-(2-methoxy-phenyl)phosphine, 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 1,4-bis(diphenylphosphino)butane, 1,2-bis(diphenylphosphino) ethane, 1,4-bis(dicyclohexylphosphino)butane, 1,2-bis(dicyclohexylphosphino)-ethane, 2-(di-cyclohexylphosphino)-2′-(N,N-dimethylamino)-biphenyl, 1,1′-bis(diphenylphosphino)-ferrocene, (R)-(−)-1-[(S)-2-diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine, tris-(2,4-tert-butyl-phenyl)phos-phite, di(1-adamantyl)-2-morpholinophenylphosphine or 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride.

The appropriate catalyst and/or ligand may be chosen from commercial catalogues such as “Metal Catalysts for Organic Synthesis” by Strem Chemicals or from reviews (Chemical Society Reviews (2014), 43, 3525, Coordination Chemistry Reviews (2004), 248, 2337 and references therein).

Some of the processes described herein may be performed by metallo-photoredox catalysis according to methods reported in the literature (Nature chemistry review, (2017) 0052 and references therein; Science (2016) 352, 6291, 1304; Org. Lett. 2016, 18, 4012, J. Org. Chem 2016, 81, 6898; J. Am. Chem. Soc. 2016, 138, 12715, J. Am. Chem. Soc. 2016, 138, 13862; J. Am. Chem. Soc. 2016, 138, 8034; J. Org. Chem. 2016, 81, 12525, J. Org. Chem. 2015, 80, 7642). The process is then performed in the presence a photosensitizer, such as Ir and Ru complexes or organic dyes, and a metal catalyst such as Ni complexes. The reaction can be performed in the presence of a ligand and if appropriate in the presence of a base under irradiation with blue or white light.

Suitable photosensitizers include, but are not limited to, Ir(III) photocatalyst such as [Ir(dFCF₃ppy)(bpy)]PF₆ (dFCF₃ppy=2-(2,4-difluorophenyl)-5-trifluoromethylpyridine, bpy=2,2′-bi-pyridine), [Ir(dFCF₃ppy)₂(dtbbpy)]PF₆ (dtbbpy=4,4′-di-tert-butyl-2,2′-bipyridine), Ir(ppy)₂(dtbbpy)PF₆ (ppy=2-phenylpyridine), Ir(ppy)₂(bpy)PF₆, Ir(dFppy)₃PF₆ (dFppy=2-(2,4-difluorophenyl)pyridine), fac-Ir(ppy)₃, (Ir[diF(5-Me)ppy]₂(tetraMePhen)PF₆ (diF(5-Me)ppy=2-(2,4-difluorophenyl)-5-methylpyridine, tetraMePhen=3,4,7,8-tetramethyl-1,10-phenanthroline), Ru(II) photocatalyst such as Ru(bpy)₃Cl₂ or Ru(bpy)₃(PF₆)₂ or organic dyes like 9-mesityl-10-acridinium perchlorate or tetrafluoroborate, or 2,4,5,6-tetra-9H-carbazol-9-yl-1,3-benzenedicarbonitrile, 9-fluorenone and 9,10-phenanthrenequinone.

Suitable nickel catalysts include, but are not limited to, bis(1,5-cyclooctadiene)nickel (0), nickel(II) chloride, nickel(II) bromide, nickel(II) iodide under their anhydrous or hydrate forms or as dimethoxyethane complexes, nickel(II) acetylacetonate, nickel(II) nitrate hexahydrate. These nickel catalysts can be used in combination with bipyridine ligand such as 2,2′-bipyridine, 4,4′-di-tert-butyl-2,2′-bipyridine, 4,4′-dimethoxy-2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine or phenantroline such as 1,10-phenanthroline, 4,7-dimethyl-1,10-phenantroline, 4,7-dimethoxy-1,10-phenantroline or diamines such as N,N,N′,N′-tetramethylethylenediamine or dione such as tetramethylheptanedione.

The processes described herein may be performed at temperature ranging from −105° C. to 250° C., preferably from −78° C. to 185° C.

The reaction time varies as a function of the scale of the reaction and of the reaction temperature, but is generally between a few minutes and 48 hours.

The processes described herein are generally performed under standard pressure. However, it is also possible to work under elevated or reduced pressure.

In the processes described herein, the starting materials are generally used in approximately equimolar amounts. However, it is also possible to use one of the starting materials in a relatively large excess.

Processes for the Preparation of Compounds of Formula (I) Process A

A compound of formula (I-a-1), wherein A¹, Q, L, R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are defined as above and wherein

-   -   A² is O,     -   T is hydrogen,     -   m is 1 or 2,     -   may be prepared     -   either     -   when W is hydrogen, by treating the compound of formula (4) with         a dehydrating agent, optionally in the presence of a base to         obtain directly the compound of formula (I-a-1)     -   or     -   when W is an aminoprotecting group preferably         tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl,         by treating the compound of formula (4) with a dehydrating         agent, optionally in the presence of a base, and then performing         a deprotection step to obtain the compound of formula (I-a-1) as         shown in scheme 1.

The compound of formula (I-a-1) may be obtained by treating a compound of formula (4) with a dehydrating agent such as POCl₃, P₂O₅ or triflic anhydride, optionally in the presence of a base. Such methods to form oxadiazine rings are known and have been described in the literature (J. Med. Chem. 2017, 60, 2383-2400). The reaction may be performed in any customary inert organic solvents. Preference is given to using optionally halogenated aliphatic, alicyclic or aromatic hydrocarbons, such as petroleum ether, hexane, heptane, cyclohexane, methylcyclohexane, benzene, toluene, xylene or decalin, chlorobenzene, dichlorobenzene, dichloromethane, chloroform, carbon tetrachloride, dichloro-ethane or trichlorethane, ethers, such as diisopropyl ether, methyl t-butyl ether, methyl t-amyl ether, dioxane, tetrahydrofuran, 1,2-dimethoxyethane, 1,2-diethoxyethane or anisole, nitriles, such as acetonitrile, propionitrile, n- or i-butyronitrile or benzonitrile; alcohols, such as ethanol or isopropanol.

When W represents an amino protecting group, step 3 is followed by an additional deprotection step using reaction conditions described in the literature (Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; Fifth Edition; 2014; 895-1194). For example, a tert-butoxycarbonyl group can be removed in acidic medium such as hydrochloric acid or trifluoroacetic acid.

Compound of formula (4), wherein Q, L, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are defined as above, may be obtained by first reacting a compound of formula (1), wherein Q, R⁷ and R⁸ are defined as above and

-   -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   with an amine of formula (2), wherein m, L, R³, R⁴, R⁵ and R⁶         are defined as above and     -   W is hydrogen or an aminoprotecting group, preferably         tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl,     -   or a salt thereof, to provide a compound of formula (3), wherein         m, W, Q, L, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R¹ are defined as         above, from which the phthalimide group of compound (3), wherein         m, W, Q, L, R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are defined as         above, is removed to provide a compound of formula (4).

Reaction conditions to remove a phthalimide group are well known and have been reported in the literature (Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; Fifth Edition; 2014; 1012-1014).

Compounds of formula (1) can be prepared by process E described herein.

Amines of formula (2) may be prepared by process G described herein.

Compounds of formula (1) wherein U¹ is a hydroxyl group can be reacted with an amine of formula (2) in the presence of a condensing reagent by means of methods described in the literature (e.g. Tetrahedron 2005, 61, 10827-10852). Examples of suitable condensing reagents include, but are not limited to, halogenating reagents (e.g. phosgene, phosphorous tribromide, phosphorous trichloride, phosphorous pentachloride, phosphorous trichloride oxide, oxalyl chloride or thionyl chloride), dehydrating reagents (e.g. ethyl chloroformate, methyl chloroformate, isopropyl chloroformate, isobutyl chloroformate or methanesulfonyl chloride), carbodiimides (e.g. N,N′-dicyclohexylcarbodiimide (DCC)) or other customary condensing (or peptide coupling) reagents (e.g. phosphorous pentoxide, polyphosphoric acid, bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU), N,N′-carbonyl-diimidazole, 2-ethoxy-N-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ), triphenylphosphine/tetrachloro-methane, 4-(4,6-dimethoxy[1.3.5]-triazin-2-yl)-4-methylmorpholinium chloride hydrate, bromo-tripyrrolidinophos-phoniumhexafluorophosphate or propanephosphonic anhydride (T3P).

Compounds of formula (1) wherein U¹ is a halogen atom can be reacted with an amine of formula (2) in the presence of an acid scavenger by means of well-known methods. Suitable acid scavengers include any inorganic and organic bases, as described herein, which are customary for such reactions. Preference is given to alkali metal carbonates, alkaline earth metal acetates, tertiary amines or aromatic bases.

Compounds of formula (1) wherein U¹ is a C₁-C₆-alkoxy group can be reacted with an excess of amine of formula (2), optionally in the presence of a Lewis acid such as trimethylaluminum.

Process B

A compound of formula (I-a-1), wherein A¹, Q, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above and

-   -   wherein     -   A² is O,     -   T is hydrogen,     -   m is 1 or 2,     -   may be prepared by reacting a compound of formula (7), wherein         m, A¹, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above and     -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,     -   X is halogen, preferably bromo,     -   with a compound of formula (8), wherein Q is defined as above,         in the presence of a base (e.g. organic or inorganic base) and         optionally in the presence of a suitable copper salt or complex,         followed by a deprotection step if W is tert-butoxycarbonyl,         benzyl, allyl or (4-methoxyphenyl)methyl, as shown in scheme 2.

Compounds of formula (7), wherein m, A¹, A², L, T, W, X, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above, may be prepared by reacting a compound of formula (5), wherein X and R⁷ are defined as above and

-   -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   with an amine of formula (2), wherein m, A², L, W, R³, R⁴, R⁵         and R⁶ are defined as above, or a salt thereof, to obtain a         compound of formula (6a), wherein m, A¹, A², L, T, W, X, R³, R⁴,         R⁵, R⁶ and R⁷ are defined as above, and     -   G is phthalimido,     -   or a salt thereof, then removing the phthalimide group of         compound (6a) to obtain a compound of formula (6b), wherein m,         A¹, A², L, T, W, X, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above,         and     -   G is hydrogen,     -   which is then, when W is hydrogen, directly treated with a         dehydrating agent, optionally in the presence of a base to         obtain directly the compound of formula (7),     -   or     -   which is then, when W is an aminoprotecting group, treated with         a dehydrating agent, optionally in the presence of a base, and         finally deprotected to obtain the compound of formula (7), under         the same conditions as described herein for process A.

The reaction of compound of formula (7) with a compound of formula (8) may be performed in the presence of a transition metal catalyst such as a copper salt or complex, and if appropriate in the presence of a ligand as described herein.

Compounds of formula (5) are commercially available or may be prepared by process F described herein.

Compounds of formula (8) are commercially available or may be obtained by conversion or derivatization of another compound of formula (8) in accordance to well-known methods.

Process C

A compound of formula (I-a-1), wherein A¹, Q, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above and

-   -   m is 1 or 2,     -   A² is O or NH,     -   T is hydrogen,     -   may be prepared by first reacting a compound of formula (1),         wherein Q, R⁷ and R⁸ are defined as above     -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   with an amine of formula (9) or one of its salts, wherein m, L,         R³, R⁴, R⁵ and R⁶ are defined as above and     -   E¹ is hydroxyl or halogen,     -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,     -   to provide a compound of formula (10), wherein m, E¹, L, W, R³,         R⁴, R⁵ and R⁶ are defined as above, under the conditions as         described in process A, which is then treated with a dehydrating         agent followed by hydroxylamine or hydrazine (H₂N-E², wherein E²         is hydroxyl or amino), to form a compound of formula (11),         wherein m, E¹, E², L, Q, W, R³, R⁴, R⁵, R⁶ and R⁷ are defined as         above, which is finally converted into a compound of formula         (I-a-1) or (I-a-2) as shown in scheme 3.

When E¹ and E² each are hydroxyl, a compound of formula (11) is converted into a compound of formula (I-a-1) using Mitsunobu reaction conditions known by the skilled person of the art (Strategic Applications of Named Reactions in Organic Synthesis; Laszlo Kürti, Barbara Czako; Elsevier; 2005; 294-295 and reference herein). When E¹ is halogen and E² is hydroxyl or amino, a compound of formula (11) is converted into a compound of formula (I-a-1) or (I-a-2) in the presence of a base.

When W represents an amino protecting group, Step 3 is followed by an additional deprotection step using reaction conditions described in the literature (Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; Fifth Edition; 2014; 895-1194) to provide a compound of formula (I-a-1) or (I-a-2).

Aminoalcohols of formula (9-a, E¹=hydroxyl) are commercially available or can be obtained by methods described in the literature (Molecules, 9 (6), 405-426; 2004; WO2017203474). Compounds of formula (9-b, E¹=halogen) can be obtained from the corresponding aminoalcohol by well-known methods.

Process D

A compound of formula (I-a-1) or (I-a-2), wherein A¹, Q, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above, and

-   -   A² is O or NH,     -   T is hydrogen,     -   m is 1 or 2,     -   may be prepared by reacting a compound of formula (5), wherein         R⁷ is defined as above and     -   X is halogen,     -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   with an amine of formula (9), wherein m, L, R³, R⁴, R⁵ and R⁶         are defined as above and     -   E¹ is hydroxyl or halogen,     -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,     -   to provide a compound of formula (12), wherein m, E¹, L, W, X,         R³, R⁴, R⁵, R⁶ and R⁷ are defined as above, under the conditions         described in process A, which is then treated with a dehydrating         agent followed by hydroxylamine or hydrazine (H₂N-E², wherein E²         is hydroxyl or amino) to form a compound of formula (13),         wherein m, E¹, L, W, X, R³, R⁴, R⁵, R⁶ and R⁷ are defined as         above, which in the following is converted into compound of         formula (7) (A²=O) or of formula (14) (A²=NH),         -   wherein m, A¹, L, W, X, R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are             defined as above, which is finally reacted with a compound             of formula (8), wherein Q is defined as above, in the             presence of a base (e.g. organic or inorganic base) and             optionally in the presence of a suitable copper salt or             complex to provide a compound of formula (I-a-1) or (I-a-2)             as shown in scheme 4.

Step 3 is performed under Mitsunobu reaction conditions when E¹ and E² both are hydroxyl (Strategic Applications of Named Reactions in Organic Synthesis; Laszlo Kürti, Barbara Czako; Elsevier; 2005; 294-295 and reference herein), and in the presence of a base, when E¹ is halogen and E² is hydroxyl or amino.

When W represents an amino protecting group, Step 3 is followed by an additional deprotection step using reaction conditions described in the literature (Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; Fifth Edition; 2014; 895-1194) to provide a compound of formula (I-a-1) or (I-a-2).

Compounds of formula (5) are commercially available or may be prepared by process F described herein.

Processes for the Preparation of a Compound of Formula (1) Process E

A compound of formula (1) may be directly obtained by performing process E described below or may be obtained by conversion or derivatization of another compound of formula (1) prepared in accordance with the processes described herein. Compounds of formula (1-a), (1-a′) and (1-a″) are various subsets of formula (1).

A compound of formula (1-a), wherein A¹, R⁷ and Q are defined as above and

-   -   U¹ is C₁-C₆-alkoxy,     -   can be prepared by a process comprising the step of reacting a         compound of formula (5),     -   wherein A¹, R⁷ and A are defined as above and     -   U¹ is C₁-C₆-alkoxy,     -   X is halogen,     -   with compound of formula (8), wherein Q is defined as above, in         the presence of a transition metal catalyst, optionally in the         presence of a ligand as shown in scheme 5.

Compounds of formula (5) are commercially available or may be prepared by process F described herein.

Compounds of formula (8) are commercially available or may be obtained by conversion or derivatization of another compound of formula (8) in accordance to well-known methods.

Compounds of formula (1-a), wherein U¹ is C₁-C₆-alkoxy can be converted to compounds of formula (1-a′), wherein U¹ is a hydroxyl group by well-known functional group interconversion methods, for example by hydrolysis of an ester group with LiOH in THF/water.

Compounds of formula (1-a′), wherein U¹ is a hydroxyl can be converted to compounds of formula (1-a″), wherein U¹ is a halogen in the presence of halogenating agents by well-known methods. Suitable halogenating reagents include, but are not limited to, phosphorous tribromide, phosphorous trichloride, phosphorous pentachloride, phosphorous trichloride oxide, oxalyl chloride or thionyl chloride.

Processes for the Preparation of a Compound of Formula (5) Process F

A compound of formula (5) as described herein may be directly obtained by performing process F described below or may be obtained by conversion or derivatization of another compound of formula (5) prepared in accordance with the processes described herein. Compounds of formula (5-a), (5-a′), (5-a″) and (5-b), (5-b′), (5-b″) are various subsets of formula (5).

A compound of formula (5-a), wherein A¹ is defined as above and

-   -   U¹ is C₁-C₆-alkoxy,     -   R^(7a) is halogen,     -   X is halogen,     -   can be converted into a compound of formula (5-b), wherein A¹         and R⁸ are defined as above and     -   U¹ is C₁-C₆-alkoxy,     -   X is halogen,     -   R^(7b) is hydrogen, halogen different from R^(7a), cyano,         C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,         C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R²¹)₂         or —C(═O)(OR²¹),         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl,             C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl             and 3- to 7-membered heterocyclyl are optionally substituted             as defined above,     -   as shown in Scheme 6.

Compounds of formula (5-a) are commercially available.

A compound of formula (5-a), wherein R^(7a) is halogen, can be converted into a compound of formula (5-b) wherein R^(7b) is cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R²¹)₂ or —C(═O)(OR²¹) by transition metal catalyzed or metallo-photoredox catalyzed processes as described herein.

Compounds of formula (5-a) and (5-b), wherein U¹ is C₁-C₆-alkoxy can be converted to compounds of formula (5-a′) and (5-b′), wherein U¹ is a hydroxyl group by well-known functional group interconversion methods, for example by hydrolysis of an ester group with LiOH in THF/water.

Compounds of formula (5-a′) and (5-b′), wherein U¹ is a hydroxyl group can be converted to compounds of formula (5-a″) and (5-a″), wherein U¹ is a halogen in the presence of halogenating agents by well-known methods. Suitable halogenating reagents include, but are not limited to, phosphorous tribromide, phosphorous trichloride, phosphorous pentachloride, phosphorous trichloride oxide, oxalyl chloride or thionyl chloride.

Process for the Preparation of Compounds of Formula (2), (9-a) and (9-b)

A compound of formula (9) may be obtained by performing process G described below or may be obtained by conversion or derivatization of another compound of formula (9-a) prepared in accordance with the processes described herein. Compounds of formula (9-a) and (9-b) are various subsets of formula (9).

Process G

A compound of formula (15) may be converted by means of methods described in the literature to the corresponding compounds (9-a) and (2) as shown in scheme 7.

The amino function of compound (15) may be first protected (W=tert-butoxycarbonyl, benzyl, allyl or 4-methoxyphenyl)methyl) in accordance with known methods to provide a compound of formula (9-a) (Greene's Protective Groups in organic Synthesis; Peter G. M. Wuts; Wiley; Fifth Edition; 2014; 895-1194).

Subsequently, the compound of formula (9-a) may be converted by Step 2 of Process G into a compound of formula (2) using classical Mitsunobu reaction conditions known by the skilled person of the art (Strategic Applications of Named Reactions in Organic Synthesis; Laszlo Kürti, Barbara Czako; Elsevier; 2005; 294-295 and references therein).

Compounds of formula (9-a) wherein E¹ is a hydroxyl may be converted to compounds of formula (9-b) wherein E¹ is a halogen in the presence of halogenating agents by well-known methods. Suitable halogenating reagents include, but are not limited to, phosphorous tribromide, phosphorous trichloride, phosphorous pentachloride, phosphorous trichloride oxide, oxalyl chloride or thionyl chloride.

Aminoalcohols of formula (15) are commercially available or may be producible by methods described in the literature (Molecules, 9 (6), 405-426; 2004, WO2017203474).

Alternative Preparation of Compounds of Formula (I) Process H

A compound of formula (I-a-1), wherein A¹, Q, L, R³, R⁴, R⁶ and R⁷ are defined as above and wherein

-   -   m is 1 or 2,     -   A² is O,     -   T is hydrogen,     -   R⁵ is hydrogen, hydroxyl or C₁-C₆-alkoxy,     -   may be prepared by a process, as shown in scheme 8, comprising         the step of adding a reducing agent under acidic conditions to a         compound of formula (19), wherein m, Q, L, T, R³, R⁴, R⁶ and R⁷         are defined as above, to provide a compound of formula (I-a-1).

Compounds of formula (19) can be cyclized under acidic conditions in the presence of a reducing agent such as sodium cyanoborohydride to provide a compound of formula (I-a-1). Reaction conditions to form oxadiazine rings with this methodology are known and have been described in the literature (Heterocycles 2016, 92, 2166-2200).

Compounds of formula (19) can be obtained by reacting a compound of formula (17), wherein A¹ and Q are defined as above, with a compound of formula (18), wherein m, L, R³, R⁴ and R⁶ are defined as above and X¹ is halogen, in the presence of a base. Suitable bases are alkali metal hydrides such as sodium hydride, alkali metal carbonates such as potassium carbonate, alkali metal hydroxides such as potassium hydroxide, or phosphazene bases such as BEMP as described in the literature (Heterocycles 2016, 92, 2166-2200).

Compounds of formula (17), wherein A¹ and Q are defined as above, can be obtained by reacting a compound of formula (16), wherein A¹ and Q are defined as above, with hydroxylamine or a salt thereof. Reaction conditions to perform such transformations are known and have been reported in the literature (WO2010/138600).

Reagents of formula (16) are either commercially available or producible by processes described in the literature (WO2010/099279).

Compounds of formula (18) are either commercially available or can be prepared by processes described in the literature (Eur. J. Med. Chem. 2014, 84, 302, Eur. J. Med. Chem. 2015, 100, 18-23, WO2017031325).

Process I

A compound of formula (I-a), wherein m, A¹, A², L, Q, T, R³, R⁴, R⁵ and R⁷ are defined as above and

-   -   R^(6a) is indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl,         naphthyl, dihydrobenzofuranyl or dihydro-benzodioxinyl,         -   wherein indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl,             naphthyl, dihydrobenzofuranyl and di-hydrobenzodioxinyl are             optionally substituted with one or two R^(6S) substituents,         -   wherein         -   R^(6Sa) is halogen, methylsulfonyloxy or             trifluoromethylsulfonyloxy, may be converted by means of             methods described in the literature to the corresponding             compound of formula (I-b), wherein m, A¹, A², L, Q, T, R³,             R⁴, R⁵, R⁷, R⁸ and R⁹ are defined as above and     -   R^(6b) is indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl,         naphthyl, dihydrobenzofuranyl or dihydro-benzodioxinyl,         -   wherein indanyl, 1,2,3,4-tetrahydronaphthalenyl, phenyl,             naphthyl, dihydrobenzofuranyl and di-hydrobenzodioxinyl are             optionally substituted with one or two R^(6S) substituents,         -   wherein         -   R^(6Sb) is independently selected from the group consisting             cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl,             C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or             6-membered heteroaryl, 3- to 7-membered heterocyclyl,             —N(R²⁰)₂ or —C(═O)(OR²⁵),             -   Wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or                 6-membered heteroaryl, 3- to 7-membered heterocyclyl are                 optionally substituted as defined above             -   and R²⁰ and R²⁵ are defined as above,     -   in one or more steps as shown in scheme 9.

A compound of formula (I-a), wherein R^(6Sa) is halogen, can be converted into a compound of formula (I-b) wherein R^(6Sb) is cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R²⁰)₂ or —C(═O)(OR²⁵) by transition metal catalyzed or metallo-photoredox catalyzed processes as described herein.

A compound of formula (I-a) can be prepared by one or more of the processes herein described or by methods known to the person skilled in the art.

Process J

A compound of formula (I-a-1), wherein A¹, L, Q, R³, R⁴, R⁵, R⁶ and R⁷ are defined as above and wherein

-   -   A² is O,     -   T is hydrogen,     -   m is 1 or 2,     -   or     -   a compound of formula (I-a-3), wherein A¹, L, Q, R³, R⁴, R⁵, R⁶         and R⁷ are defined as above and wherein     -   A² is CR¹R²,         -   wherein R¹ and R² are defined as above,     -   T is hydrogen,     -   m is 1 or 2,     -   or     -   a compound of formula (I-a-4), wherein A¹, Q, L, R³, R⁴, R⁵, R⁶         and R⁷ are defined as above and wherein     -   A² is C(═O),     -   T is hydrogen,     -   m is 1 or 2,     -   or     -   a compound of formula (I-a-5), wherein A¹, L, Q, R³, R⁴, R⁵, R⁶         and R⁷ are defined as above and wherein     -   A² is S(═O)₂     -   T is hydrogen,     -   m is 1 or 2,     -   can be prepared by a process comprising the steps of first         treating a compound of formula (16), wherein A¹, Q and R⁷ are         defined as above, with an alkoxide to provide compound of         formula (20), wherein A¹, Q and R⁷ are defined as above and Y is         C₁-C₆-alkyl, which is then reacted with an amine of formula         (9c-1), (9c-2), (9c-3) or (9c-4) respectively, wherein each m,         L, R³, R⁴, R⁵, R⁶ are defined as above and W is hydrogen or         suitable protecting group for amino function and     -   E¹ is NH₂—O— in compound of formula (9c-1),     -   E¹ is NH₂—CR⁴⁴R⁴⁵— in compound of formula (9c-2),         -   wherein         -   R⁴⁴ and R⁴⁵ are hydrogen, C₁-C₆-alkyl, C₃-C₈-cycloalkyl,             C₆-C₁₄-aryl,         -   or         -   R⁴⁴ and R⁴⁵ form together with the carbon atom to which they             are attached, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,     -   E¹ is NH₂—C(═O)— in compound of formula (9c-3),     -   E¹ is NH₂—S(═O)₂— in compound of formula (9c-4),     -   to obtain a compound of formula (I-a-1), (I-a-3), (I-a-4) or         (I-a-5) respectively     -   as shown in scheme 10.

The compound of formula (20), wherein A¹, Q and R⁷ are defined as above and Y is C₁-C₆-alkyl, can be obtained by treating a compound of formula (16), wherein A¹, Q and R⁷ are defined as above, with an alkoxide such as sodium methanolate or sodium ethanolate according to methods described in the literature (Heterocycles, 34, 1992, 929-935).

The compound of formula (20), wherein A¹, Q and R⁷ are defined as above and Y is C₁-C₆-alkyl, is treated with a compound of formula (9-c-1), (9-c-2), (9-c-3) or (9-c-4), wherein m, L, R³, R⁴, R⁵, R⁶ are defined as above, W is hydrogen or suitable protecting group for amino function and

-   -   E¹ is NH₂—O— in compound of formula (9c-1),     -   E is NH₂—CR⁴⁴R⁴⁵— in compound of formula (9c-2),         -   wherein R⁴⁴ and R⁴⁵ are defined as above,     -   E¹ is NH₂—C(═O)— in compound of formula (9c-3),     -   E¹ is NH₂—S(═O)₂— in compound of formula (9c-4),     -   are cyclized under acidic conditions to form respectively a         compound of formula (I-a-1), (I-a-3), (I-a-4) or (I-a-5),         wherein m, A¹, L, Q, T, R³, R⁴, R⁵, R⁶, and R⁷ are defined as         above and     -   A² is O in compound of formula (I-a-1)     -   A² is CR¹R² in compound of formula (I-a-3)     -   A² is C(═O) in compound of formula (I-a-4)     -   A² is S(═O)₂ in compound of formula (I-a-5).

Reaction conditions to perform such transformations based on this methodology have been described in the literature (Heterocycles 2016, 92, 2166-2200).

Amines of formula (9-c-1), (9-c-2), (9-c-3) or (9-c-4) are either commercially available, or may be prepared by methods described in the literature (Molecules, 9 (6), 405-426; 2004, WO2017/203474; J. Med. Chem 1985, 28, 694-698; J. Med. Chem 2006, 49, 4333-4343) and by Process G of this invention.

Reagents of formula (16) are either commercially available or producible by processes described in the literature (WO2010/099279).

Intermediates

The present invention also relates to intermediates for the preparation of compounds of formula (I).

Some of the intermediates of formula (1) as defined herein are known from the prior art, see for example CN106317027A and U.S. Pat. No. 5,420,129A.

Thus, the present invention relates to compounds of formula (1):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sc),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,     -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                     wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,     -   provided that when in formula (1) A is C—R⁸ and R⁸═H, then     -   Q is not 2,5-dichlorophenoxy, if R⁷ is hydrogen,     -   and provided that the compound of formula (1) is not:     -   ethyl 2,6-dichloro-5-phenoxypyrimidine-4-carboxylate (CAS         157415-41-3), further preferably provided that when in         formula (1) A is C—R⁸ and R⁸═H, then     -   R⁷ is not isopropyl if U¹ is hydroxyl.

Thus, the present invention also relates to compounds of formula (1):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R⁸ is hydrogen or halogen,     -   U¹ is hydroxyl, halogen or C₁-C₆-alkoxy,     -   R⁷ is halogen, cyano, isocyano, hydroxyl, mercapto, nitro,         amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,         C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,         C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,         C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,         C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,         C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy,         C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,         C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,         C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,         C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl,         C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,         C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl,         C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered         heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or         6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl,     -   Q is C₆-C₁₄-aryl, C₇-C₁₂-carbocyclyl, 6- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₇-C₁₂-carbocyclyl 6- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S),         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl                     are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl in turn are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,     -   provided that when in formula (1) A is C—R⁸ and R⁸ ═H, then     -   Q is not 2,5-dichlorophenoxy, if R⁷ is hydrogen,     -   and provided that the compound of formula (1) is not:     -   ethyl 2,6-dichloro-5-phenoxypyrimidine-4-carboxylate (CAS         157415-41-3),     -   further preferably provided that when in formula (1) A is C—R⁸         and R⁸ ═H, then     -   R⁷ is not isopropyl if U¹ is hydroxyl.

In advantageous compounds of formula (1), R⁷ is not hydrogen.

The present invention also relates to compounds of formula (2):

-   -   wherein     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen or C₁-C₆-alkyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a C₃-C₈-cycloalkyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,

    -   provided that the compound of formula (2) preferably is not:

2-(2-amino-2-phenylethoxy)-1H-isoindole-1,3(2H)-dione 1640226-54-5 2-{[rac-(1R,2R)-1-amino-1-(4-chlorophenyl)propan-2-yl]oxy}-1H-isoindole- 2085782-61-0 1,3(2H)-dione 2-{[rac-(1S,2S)-1-amino-1-(4-chlorophenyl)propan-2-yl]oxy}-1H-isoindole- 2085782-62-1 1,3(2H)-dione hydrochloride (1:1) 2-{[1-amino-1-(4-fluorophenyl)-2-methylpropan-2-yl]oxy}-1H-isoindole-1,3(2H)- 1227082-96-3 dione tert-butyl {1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-3-phenylpropan-2- 937641-57-1 yl}carbamate tert-butyl {rac-(1R,2R)-1-(4-chlorophenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol- 2085782-59-6 2-yl)oxy]propyl}carbamate tert-butyl {2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-1-(4-fluorophenyl)-2- 1227082-95-2 methylpropyl}carbamate 2-[rac-2-amino-3-(2,4-dimethylphenyl)propoxy]isoindoline-1,3-dione 2446130-64-7 2-[rac-2-amino-3-(2,4-dimethylphenyl)propoxy]isoindoline-1,3-dione 2446130-65-8 2,2,2-trifluoroacetic acid 2-[rac-2-amino-3-(2,4-dichlorophenyl)propoxy]isoindoline-1,3-dione 2446130-81-8 2-[rac-2-amino-3-(2,4-dichlorophenyl)propoxy]isoindoline-1,3-dione 2446130-82-9 2,2,2-trifluoroacetic acid 2-[rac-2-amino-3-(4-bromo-2-chlorophenyl)propoxy]isoindoline-1,3-dione 2446130-89-6 2-[rac-2-amino-3-(4-bromo-2-chlorophenyl)propoxy]isoindoline-1,3-dione 2446130-90-9 2,2,2-trifluoroacetic acid tert-butyl {1-(2-chloro-4-methylpheny1)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2- 2446131-06-0 yl)oxy]propan-2-yl}carbamate 2-[2-amino-3-(2-chloro-4-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446131-05-9 trifluoroacetate (1:1) 2-[2-amino-3-(2-chloro-4-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446131-04-8 2-[2-amino-3-(4-bromo-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-92-1 trifluoroacetate 2-[2-amino-3-(4-bromo-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-91-0 2-[2-amino-3-(3,4-dimethylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-88-5 trifluoroacetate (1:1) 2-[2-amino-3-(3,4-dimethylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-87-4 2-[2-amino-3-(4-isopropyl-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-86-3 trifluoroacetate (1:1) 2-[2-amino-3-(4-isopropyl-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-85-2 2-[2-amino-3-(2-chloro-4-isopropylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-84-1 trifluoroacetate (1:1) 2-[2-amino-3-(2-chloro-4-isopropylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-83-0 2-[2-amino-3-(4-cyclopropyl-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-80-7 trifluoroacetate (1:1) 2-[2-amino-3-(4-cyclopropyl-2-methylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-79-4 2-[2-amino-3-(2-chloro-4-cyclopropylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-78-3 trifluoroacetate (1:1) 2-[2-amino-3-(2-chloro-4-cyclopropylphenyl)propoxy]-1H-isoindole-1,3(2H)-dione 2446130-77-2 tert-butyl {(1S)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-1-phenyl- 2102206-02-8 ethyl}carbamate

The present invention also relates to compounds of formula (3):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy,         C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,         C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3-         to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,             C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,             -   wherein             -   L^(SA) is independently halogen, cyano, hydroxyl,                 carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,                 —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   and/or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,                 formyl, carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to                 7-membered heterocyclyl,             -   and/or             -   two L^(SC) substituents form together with the carbon                 atom to which they are attached to a                 C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of halogen, cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl in turn is optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to four substituents independently                 selected from the group consisting of halogen, cyano,                 nitro, hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₁-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (3):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S), wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl                     are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl in turn are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (4):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy,         C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,         C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3-         to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,             C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,         -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to             7-membered heterocyclyl in turn are optionally substituted             with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,             -   wherein             -   L^(SA) is independently halogen, cyano, hydroxyl,                 carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,                 —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   and/or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,                 formyl, carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to                 7-membered heterocyclyl,             -   and/or             -   two L^(SC) substituents form together with the carbon                 atom to which they are attached to a                 C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of halogen, cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl in turn is optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to four substituents independently                 selected from the group consisting of halogen, cyano,                 nitro, hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (4):

-   -   wherein     -   A¹ is N or CR⁸         -   wherein R⁸ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ or R⁴, together with R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,         -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to             7-membered heterocyclyl in turn are optionally substituted             with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   R⁸ is hydrogen or halogen,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S), wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl                     are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl in turn are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   W represents hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (6a) and (6b):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy,         C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,         C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3-         to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,             C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,             -   wherein             -   L^(SA) is independently halogen, cyano, hydroxyl,                 carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,                 —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   and/or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,                 formyl, carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to                 7-membered heterocyclyl,             -   and/or             -   two L^(SC) substituents form together with the carbon                 atom to which they are attached to a                 C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents, wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of halogen, cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl in turn is optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to                 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to four substituents independently                 selected from the group consisting of halogen, cyano,                 nitro, hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 halogen, cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,         -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are             optionally substituted with one to three R^(7Sa)             substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,

    -   X is halogen.

The present invention also relates to compounds of formula (6a) and (6b):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or         (4-methoxyphenyl)methyl,

    -   X is halogen.

The present invention also relates to compounds of formula (7):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein         -   R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy,         C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl,         C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3-         to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,             C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered             heterocyclyl-ring are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,             -   wherein             -   L^(SA) is independently halogen, cyano, hydroxyl,                 carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,                 —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   and/or             -   two substituents L^(SA) that are bound to the same                 carbon atom form together with the carbon atom which                 they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to                 7-membered heterocyclyl-ring,             -   L^(SC) is independently halogen, cyano, nitro, hydroxyl,                 formyl, carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to                 7-membered heterocyclyl,             -   and/or             -   two L^(SC) substituents form together with the carbon                 atom to which they are attached to a                 C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is independently selected from the group consisting             of halogen, cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of halogen, cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is independently hydrogen, C₁-C₆-alkyl or             C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl in turn is optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to                 7-membered heterocyclyl,                 -   and                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to four substituents                     independently selected from the group consisting of                     halogen, cyano, nitro, hydroxyl, formyl, carboxyl,                     oxo, methylidene, halomethylidene, C₁-C₆-alkyl,                     C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and                     C₃-C₈-halocycloalkyl,             -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,                 C₁-C₆-alkyl or C₁-C₆-haloalkyl,                 -   wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn                     are optionally substituted with one to three                     substituents independently selected from the group                     consisting of halogen, cyano, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                     —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl and 3- to 7-membered                     heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl or 3- to 7-membered heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl in turn are optionally substituted                 with one to three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in                 turn are optionally substituted with one to three                 R^(7Sa) substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are                 optionally substituted with one to three R^(7Sa)                 substituents,             -   and             -   wherein C₃-C₈-cycloalkyl in turn is optionally                 substituted with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,             -   or             -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to                 the same carbon atom form together a                 C₃-C₈-cycloalkyl-ring,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl,

    -   X is halogen.

The present invention also relates to compounds of formula (7):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl,

    -   X is halogen.

The present invention also relates to compounds of formula (9):

-   -   wherein     -   m is 1,     -   L is methylidene or difluoromethylidene,     -   R³ and R⁴ are hydrogen,     -   R⁵ is hydrogen,     -   R⁶ is phenyl,         -   wherein phenyl is optionally substituted with one to four             R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,             C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,             C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,     -   E¹ is chlorine, bromine or iodine,     -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl     -   and salts, solvates or salts of the solvates thereof,     -   provided that the compound of formula (9) preferably is not:

(2RS)-1-chloro-3-phenylpropan-2-amine 749167-08-6 (2RS)-1-chloro-3-phenylpropan-2-amine 776253-38-4 1-chloro-3-phenylpropan-2-amine 748709-78-6 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-28-5 1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 49557-36-0 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-27-4 3-(2-amino-3-chloropropyl)phenol 790605-82-2 3-(2-amino-3-chloropropyl)phenol hydrochloride (1:1) 66033-01-0 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine 2101321-88-2 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride (1:1) 2101321-89-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine 690946-87-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine hydrochloride (1:1) 49557-34-8 5-[(2RS)-2-amino-3-chloropropyl]-2-methoxybenzenesulfonamide 855594-92-2 (2RS)-1-chloro-3-phenylpropan-2-amine 749167-08-6 (2RS)-1-chloro-3-phenylpropan-2-amine 776253-38-4 1-chloro-3-phenylpropan-2-amine 748709-78-6 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-28-5 1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 49557-36-0 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-27-4 3-(2-amino-3-chloropropyl)phenol 790605-82-2 3-(2-amino-3-chloropropyl)phenol hydrochloride (1:1) 66033-01-0 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine 2101321-88-2 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride (1:1) 2101321-89-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine 690946-87-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine hydrochloride (1:1) 49557-34-8 5-[(2RS)-2-amino-3-chloropropyl]-2-methoxybenzenesulfonamide 855594-92-2 rac-(2RS)-1-chloro-3-(2-chloro-4-methyl-phenyl)propan-2-amine 2446132-77-8 rac-(2RS)-1-chloro-3-(2-chloro-4-methyl-phenyl)propan-2-amine hydrochloride 2446132-78-9 rac-(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-amine 2446130-66-9 rac-(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-amine hydrochloride 2446130-67-0 (2S)-1-bromo-3-phenylpropan-2-amine trifluoroacetate (1:1) 2446130-69-2 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine 2446132-79-0 1-(2-bromo-4-methylpheny1)-3-chloropropan-2-amine 2446132-73-4 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine 2446132-71-2 1-chloro-3-(2-cyclopropyl-4-methylphenyl)propan-2-amine hydrochloride (1:1) 2446132-98-3 1-chloro-3-(2-cyclopropyl-4-methylphenyl)propan-2-amine 2446132-97-2 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine hydrochloride (1:1) 2446132-80-3 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine 2446132-79-0 1-(2-bromo-4-methylpheny1)-3-chloropropan-2-amine hydrochloride (1:1) 2446132-74-5 1-(2-bromo-4-methylphenyl)-3-chloropropan-2-amine 2446132-73-4 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine hydrochloride (1:1) 2446132-72-3 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine 2446132-71-2 1-chloro-3-[4-(trifluoromethoxy)phenyl]propan-2-amine hydrochloride (1:1) 2446132-68-7 1-chloro-3-[4-(trifluoromethoxy)phenyl]propan-2-amine 2446132-67-6 3-amino-4-(2,4-dimethylphenyl)butanamide 2446130-71-6 4-(2,4-dimethylphenyl)butane-1,3-diamine 2446130-60-3

The present invention also relates to compounds of formula (9):

-   -   wherein     -   m is 1 or 2,     -   L is a direct bond, methylidene, difluoromethylidene or         ethylidene,     -   R³ and R⁴ are hydrogen,     -   R⁵ is hydrogen,     -   R⁶ is phenyl or thienyl,         -   wherein phenyl and thienyl are optionally substituted with             one to four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl,             C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,             C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,     -   E¹ is chlorine, bromine, iodine, aminooxy, amino, aminomethyl,         aminocarbonyl or aminosulfonyl,     -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl     -   and salts, solvates or salts of the solvates thereof,     -   provided that the compound of formula (9) preferably is not:

(2RS)-1-chloro-3-phenylpropan-2-amine 749167-08-6 (2RS)-1-chloro-3-phenylpropan-2-amine 776253-38-4 1-chloro-3-phenylpropan-2-amine 748709-78-6 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-28-5 1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 49557-36-0 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-27-4 3-(2-amino-3-chloropropyl)phenol 790605-82-2 3-(2-amino-3-chloropropyl)phenol hydrochloride (1:1) 66033-01-0 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine 2101321-88-2 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride (1:1) 2101321-89-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine 690946-87-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine hydrochloride (1:1) 49557-34-8 5-[(2RS)-2-amino-3-chloropropyl]-2-methoxybenzenesulfonamide 855594-92-2 (2RS)-1-chloro-3-phenylpropan-2-amine 749167-08-6 (2RS)-1-chloro-3-phenylpropan-2-amine 776253-38-4 1-chloro-3-phenylpropan-2-amine 748709-78-6 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-28-5 1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 49557-36-0 (2RS)-1-chloro-3-phenylpropan-2-amine hydrochloride (1:1) 100431-27-4 3-(2-amino-3-chloropropyl)phenol 790605-82-2 3-(2-amino-3-chloropropyl)phenol hydrochloride (1:1) 66033-01-0 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine 2101321-88-2 (2RS)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride (1:1) 2101321-89-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine 690946-87-3 1-chloro-3-(3,4,5-trimethoxyphenyl)propan-2-amine hydrochloride (1:1) 49557-34-8 rac-(2RS)-1-chloro-3-(2-chloro-4-methyl-phenyl)propan-2-amine 2446132-77-8 rac-(2RS)-1-chloro-3-(2-chloro-4-methyl-phenyl)propan-2-amine hydrochloride 2446132-78-9 rac-(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-amine 2446130-66-9 rac-(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-amine hydrochloride 2446130-67-0 (2S)-1-bromo-3-phenylpropan-2-amine trifluoroacetate (1:1) 2446130-69-2 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine 2446132-79-0 1-(2-bromo-4-methylpheny1)-3-chloropropan-2-amine 2446132-73-4 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine 2446132-71-2 1-chloro-3-(2-cyclopropyl-4-methylphenyl)propan-2-amine hydrochloride (1:1) 2446132-98-3 1-chloro-3-(2-cyclopropyl-4-methylphenyl)propan-2-amine 2446132-97-2 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine hydrochloride (1:1) 2446132-80-3 1-chloro-3-(3,4-dichlorophenyl)propan-2-amine 2446132-79-0 1-(2-bromo-4-methylphenyl)-3-chloropropan-2-amine hydrochloride (1:1) 2446132-74-5 1-(2-bromo-4-methylphenyl)-3-chloropropan-2-amine 2446132-73-4 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine hydrochloride (1:1) 2446132-72-3 1-chloro-3-[4-(difluoromethyl)phenyl]propan-2-amine 2446132-71-2 1-chloro-3-[4-(trifluoromethoxy)phenyl]propan-2-amine hydrochloride (1:1) 2446132-68-7 1-chloro-3-[4-(trifluoromethoxy)phenyl]propan-2-amine 2446132-67-6 3-amino-4-(2,4-dimethylphenyl)butanamide 2446130-71-6 4-(2,4-dimethylphenyl)butane-1,3-diamine 2446130-60-3

The present invention also relates to compounds of formula (10):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are hydrogen,     -   R⁵ is hydrogen,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,         -   is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   E¹ is hydroxyl or halogen,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (11):

-   -   wherein     -   A¹ is N or CR⁸,         -   wherein R¹ is hydrogen or halogen     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ or R⁴, together with R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered         heterocyclyl or 5- to 14-membered heteroaryl,         -   wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl 3- to 14-membered             heterocyclyl or 5- to 14-membered heteroaryl are optionally             substituted with one to five substituents Q^(S)         -   wherein         -   Q^(S) is independently selected from the group consisting of             halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl,             carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl,             3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to             14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃,             —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³, —NR³⁴C(═O)R³⁵,             —C(═O)N(R³⁶)₂, C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰,             —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂,             -   wherein             -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl,                 C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,                 C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy,                 C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl,                 C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,                 C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl,                 —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are                 optionally substituted with one to three substituents                 independently selected from the group consisting of                 cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to                 7-membered heterocyclyl,             -   said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy,                 C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5-                 to 14-membered heteroaryl in turn are optionally                 substituted with one to three substituents independently                 selected from the group consisting of halogen, cyano,                 amino, nitro, hydroxyl, formyl, carboxyl, oxo,                 methylidene, halomethylidene, C₁-C₆-alkyl,                 C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                 C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl                 and 3- to 7-membered heterocyclyl,                 -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,             -   and wherein             -   R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and                 C₁-C₆-alkoxy,             -   R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are                 independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or                 C₁-C₆-alkoxy,                 -   wherein                 -   said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy                     in turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,             -   and wherein             -   R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or                 C₃-C₈-cycloalkyl,                 -   wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl,                     C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in                     turn are optionally substituted with one to three                     substituents independently selected from the group                     consisting of cyano, amino, nitro, hydroxyl,                     C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,                     C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl,                     C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                     —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,                     wherein said C₃-C₈-cycloalkyl in turn is optionally                     substituted with one to three substituents                     independently selected from the group consisting of                     halogen, cyano, amino, nitro, hydroxyl, formyl,                     carboxyl, oxo, methylidene, halomethylidene,                     C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                     C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                     C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl,                     C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to                     7-membered heterocyclyl,                 -    wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl                     and 3- to 7-membered heterocyclyl furthermore are                     optionally substituted with two substituents forming                     together with the carbon atom to which they are                     attached to a C₃-C₈-cycloalkyl,

    -   E¹ is hydroxyl or halogen,

    -   E² is hydroxyl or amino,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (12):

-   -   wherein     -   A¹ is N or CR⁸         -   wherein R⁸ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are hydrogen,     -   R⁵ is hydrogen,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))₃, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₇-C₁₂-carbocyclyl, C₆-C₁₄-aryl or 7- to 14-membered         heterocyclyl,         -   wherein C₇-C₁₂-carbocyclyl, C₆-C₁₄-aryl and 7- to             14-membered heterocyclyl are optionally substituted with one             to four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   X is halogen,

    -   E¹ is hydroxyl or halogen,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl, provided that the compound of         formula (12) preferably is not:

5-bromo-2-cyclopropyl-N-[1-(2-fluorophenyl)-3-hydroxypropyl]pyrimidine-4- 2249230-71-3 carboxamide 5-chloro-N-(3-hydroxy-1-phenylpropyl)-2-isopropyl-N-methylpyrimidine-4- 2071583-58-7 carboxamide 5-chloro-N-(3-hydroxy-1-phenylpropyl)-2-methylpyrimidine-4-carboxamide 2069692-16-4 5-chloro-N-(3-hydroxy-1-phenylpropyl)-2-isopropylpyrimidine-4-carboxamide 2069116-82-9 5-chloro-N-(3-hydroxy-1-phenylpropyl)pyrimidine-4-carboxamide 2062363-89-5 5-chloro-N-(3-hydroxy-1-phenylpropyl)-N-methylpyrimidine-4-carboxamide 2059513-53-8 5-chloro-N-[2-fluoro-1-(2-methylphenyl)ethyl]-2-isopropylpyrimidine-4-carboxamide 2471404-71-2 5-chloro-2-ethyl-N-[2-fluoro-1-(2-methylphenyl)ethyl]pyrimidine-4-carboxamide 2403155-96-2 5-chloro-N-[(1R)-1-(4-chlorophenyl)-2-hydroxyethyl]-2-ethylpyrimidine-4- 2398016-15-2 carboxamide 5-chloro-2-ethyl-N-[2-fluoro-1-(4-fluorophenyl)ethyl]pyrimidine-4-carboxamide 2393328-52-2 5-chloro-2-ethyl-N-[2-hydroxy-1-(2-methylphenyl)ethyl]-N-methylpyrimidine-4- 2393093-78-0 carboxamide 5-chloro-N-[2-fluoro-1-(2-methylphenyl)ethyl]-2-methylpyrimidine-4-carboxamide 2371110-21-1 5-chloro-N-(2-hydroxy-1-phenylethyl)-2-isopropylpyrimidine-4-carboxamide 2068919-96-8 5-chloro-N-[2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl]pyrimidine-4-carboxamide 2060969-43-7 5-chloro-N-[1-(4-ethylphenyl)-2-hydroxyethyl]-2-methylpyrimidine-4-carboxamide 2060546-01-0 5-chloro-N-[(1S)-2-hydroxy-1-phenylethyl]-2-methylpyrimidine-4-carboxamide 2060348-97-0 5-chloro-N-[1-(4-ethylphenyl)-2-hydroxyethyl]pyrimidine-4-carboxamide 2059923-55-4 5-chloro-N-[(1R)-2-hydroxy-1-phenylethyl]-2-(methylsulfanyl)pyrimidine-4-carboxamide 1920522-99-1 5-chloro-N-[(1S)-2-hydroxy-1-phenylethyl]-2-(methylsulfanyl)pyrimidine-4- 1912038-17-5 carboxamide 5-chloro-N-(2-hydroxy-1-phenylethyl)-2-(methylsulfanyl)pyrimidine-4-carboxamide 1493243-27-8

The present invention also relates to compounds of formula (13):

-   -   wherein     -   A¹ is N or CR⁸         -   wherein R⁸ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ or R⁴, together with R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,             -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3-                 to 7-membered heterocyclyl in turn are optionally                 substituted with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and                 -   wherein C₃-C₈-cycloalkyl is optionally substituted                     with one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   X is halogen,

    -   E¹ is hydroxyl or halogen,

    -   E² is hydroxyl or amino,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl.

The present invention also relates to compounds of formula (14):

-   -   wherein     -   A¹ is N or CR⁸         -   wherein R⁸ is hydrogen or halogen,     -   m is 1 or 2,     -   R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl,         formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered         heteroaryl, 3- to 14-membered heterocyclyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and             —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three substituents independently selected from the group             consisting of halogen, cyano, amino, nitro, hydroxyl,             formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered             heteroaryl and 3- to 14-membered heterocyclyl are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, nitro,             hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,             C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl,     -   or     -   R³ and R⁴ form together with the carbon atom to which they are         attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring         or a 3- to 7-membered heterocyclyl-ring,         -   wherein C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl             are optionally substituted with one to three substituents             independently selected from the group consisting of halogen,             cyano, nitro, hydroxyl, formyl, oxo, methylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy,         C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or         —O—Si(C₁-C₆-alkyl)₃,         -   wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy,             C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally             substituted with one to three substituents independently             selected from the group consisting of halogen, cyano, amino,             nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,         -   and         -   wherein C₃-C₈-cycloalkyl is optionally substituted with one             to three substituents independently selected from the group             consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo,             methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to             7-membered heterocyclyl,     -   or     -   R³ or R⁴, together with R⁵ form together with the carbon atom to         which they are attached to a C₃-C₈-cycloalkyl-ring,     -   L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene,         C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-,         —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—,         —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—,         —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂), —C(═NR^(L8))— or a group of         formula

-   -   -   wherein         -   said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene,             —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are             optionally substituted with one to three substituents             L^(SA),         -   # is the point of attachment to the heterocyclyl-moiety,         -   ## is the point of attachment to R⁶,         -   L¹ is a direct bond or C₁-C₆-alkylene,         -   L² is a direct bond or C₁-C₆-alkylene,         -   E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to             7-membered heterocyclyl,         -   wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to             7-membered heterocyclyl in turn are optionally substituted             with one to three substituents L^(SC),         -   R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen             or C₁-C₆-alkyl,         -   R^(L5), R^(L6), R^(L7) and R^(L8) are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or             C₂-C₆-alkenyl,         -   L^(SA) is independently halogen, cyano, hydroxyl, carboxyl,             methylidene, halomethylidene, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   or         -   two substituents L^(SA) that are bound to the same carbon             atom form together with the carbon atom which they are             attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered             heterocyclyl-ring,         -   L^(Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, carboxyl, oxo, methylidene, halomethylidene,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆ alkenyl, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to             7-membered heterocyclyl,         -   and/or         -   two L^(Sc) substituents form together with the carbon atom             to which they are attached to a C₃-C₈-cycloalkyl-ring,

    -   R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered         heterocyclyl, 5- to 14-membered heteroaryl,         C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered         heteroaryloxy, 3- to 14-membered heterocyclyloxy,         C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to         14-membered heteroarylsulfanyl, 3- to 14-membered         heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,         C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to         14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl,         C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to         14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy,         C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or         C₁-C₃-alkylsulfonyl,         -   wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl,             C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted             with one substituent selected from the group consisting of             C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl and 5- to 14-membered heteroaryl,             -   wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to                 14-membered heterocyclyl and 5- to 14-membered                 heteroaryl in turn are optionally substituted with one                 to four R^(6S) substituents,         -   wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered             heterocyclyl, 5- to 14-membered heteroaryl,             C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered             heteroaryloxy, 3- to 14-membered heterocyclyloxy,             C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to             14-membered heteroarylsulfanyl, 3- to 14-membered             heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl,             C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl,             3- to 14-membered heterocyclylsulfinyl,             C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to             14-membered heteroarylsulfonyl and 3- to 14-membered             heterocyclylsulfonyl are optionally substituted with one to             four R^(6S) substituents,         -   wherein         -   R^(6S) is selected from the group consisting of halogen,             cyano, isocyano, nitro, hydroxyl, mercapto,             pentafluorosulfanyl, oxo, methylidene, halomethylidene,             formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,             C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,             C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,             C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,             C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered             heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷),             —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ or             —Si(C₁-C₆-alkyl)₃,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,                 C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,                 C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy,                 C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl,                 C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl,                 C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,                 C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and                 —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted                 with one to three substituents independently selected                 from the group consisting of cyano, hydroxyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   or             -   two substituents C₁-C₆-alkyl attached to the same carbon                 atom from a C₃-C₈-cycloalkyl-ring,             -   and             -   wherein C₃-C₈-cycloalkylsulfanyl,                 C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl,                 C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy,                 C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered                 heteroaryl and 3- to 7-membered heterocyclyl are                 furthermore optionally substituted with one to four                 substituents independently selected from the group                 consisting of halogen, cyano, nitro, hydroxyl, formyl,                 carboxyl, oxo, methylidene, halomethylidene,                 C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   and wherein         -   R¹⁵ is hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl,             -   wherein said C₁-C₆-alkyl is optionally substituted with                 one to three substituents independently selected from                 the group consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,             -   and             -   wherein said C₃-C₈-cycloalkyl is optionally substituted                 with one to four substituents independently selected                 from the group consisting of halogen, cyano, nitro,                 hydroxyl, formyl, carboxyl, oxo, methylidene,                 halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl,                 C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl,                 C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,                 C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl,         -   R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen,             C₁-C₆-alkyl or C₁-C₆-haloalkyl,             -   wherein said C₁-C₆-alkyl or C₁-C₆-haloalkyl are                 furthermore optionally substituted with one to three                 substituents independently selected from the group                 consisting of cyano, hydroxyl, C₁-C₆-alkoxy,                 C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃,                 —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl,                 C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl,

    -   R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto,         nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl,         C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy,         C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl,         C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl,         C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,         C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,         C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl,         C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl,         C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl,         C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl,         C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl,         C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or         6-membered heteroaryl, 3- to 7-membered heterocyclyl,         C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered         heteroaryloxy, 3- to 7-membered heterocyclyloxy,         —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²²,         —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or         —S(═O)(═NR²⁸)R²⁹,         -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl,             C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl,             C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl,             C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy,             C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy,             C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl,             C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl,             C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl,             C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl,             C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and             —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to             three R^(7Sa) substituents,         -   wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl,             C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl,             C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered             heteroaryl, 3- to 7-membered heterocyclyl,             C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered             heteroaryloxy, 3- to 7-membered heterocyclyloxy are             optionally substituted with one to three R^(7Sc)             substituents,         -   and wherein         -   R²⁰ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl,             C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered             heterocyclyl,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and                 C₂-C₆-haloalkynyl are optionally substituted with one to                 three substituents R^(7Sa),             -   and             -   wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,                 C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to                 7-membered heterocyclyl are optionally substituted with                 one to three substituents R^(7Sc),         -   R²¹ and R²² are independently hydroxyl, amino, cyano,             C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,             mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino,             -   wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy,                 mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino are                 optionally substituted with one to three R^(7Sa)                 substituents,         -   R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently             hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl,             -   wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl are optionally                 substituted with one to three R^(7Sa) substituents,             -   and             -   wherein C₃-C₈-cycloalkyl is optionally substituted with                 one to three R^(7Sc) substituents,         -   wherein         -   R^(7Sa) is independently cyano, hydroxyl, carboxyl,             C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl,             C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl,             —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to             7-membered heterocyclyl,         -   R^(7Sc) is independently halogen, cyano, nitro, hydroxyl,             formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl,             C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆             alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl,             —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl,         -   or         -   two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the             same carbon atom form together a C₃-C₈-cycloalkyl-ring,

    -   X is halogen,

    -   W is hydrogen, tert-butoxycarbonyl, benzyl or         (4-methoxyphenyl)methyl.

The present invention also relates to intermediates of formula (8):

Q-OH  (8),

-   -   wherein     -   Q is a group of formula

-   -   wherein     -   § ¹ is the point of attachment to oxygen,     -   A¹ is CH or N,     -   Q^(S) is C₃-C₄-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl,         C₂-C₆-haloalkenyl or C₂-C₆-alkynyl, provided that the compound         of formula (8) does not represent:

2-fluoro-3-(3,3,3-trifluoroprop-1-en-2-yl)phenol 2168012-00-6 3-(1-ethoxyvinyl)-2-fluorophenol 2137960-04-2 1-(2-fluoro-3-hydroxyphenyl)cyclopropanecarbonitrile 1881320-49-5 3-(1-aminocyclopropyl)-2-fluorophenol 1785193-75-0 1-(2-fluoro-3-hydroxyphenyl)cyclopropanecarboxylic 1507131-96-5 acid 2-fluoro-3-(prop-1-en-2-yl)phenol 1375066-38-8 3-cyclopropyl-2-fluoro-phenol 2290421-25-7 2-fluoro-3-(1-fluorocyclopropyl)phenol 2385918-06-7 3-(2,2-difluorocyclopropyl)-2-fluoro-phenol 2435608-24-3 2-fluoro-3-vinyl-phenol 2290411-18-4 2-fluoro-3-[(E)-prop-1-enyl]phenol 2435608-23-2 2-fluoro-3-isopropenyl-phenol 1375066-38-8 3-ethyl-2-fluoro-phenol 1243456-02-1 2-fluoro-3-propyl-phenol 2284409-52-3 3-butyl-2-fluoro-phenol 2284271-78-7

Compositions and Formulations

The present invention further relates to compositions, in particular compositions for controlling unwanted microorganisms. The composition may be applied to the microorganisms and/or in their habitat.

The composition comprises at least one compound of formula (I) and at least one agriculturally suitable auxiliary, e.g. carrier(s) and/or surfactant(s).

A carrier is a solid or liquid, natural or synthetic, organic or inorganic substance that is generally inert. The carrier generally improves the application of the compounds, for instance, to plants, plants parts or seeds. Examples of suitable solid carriers include, but are not limited to, ammonium salts, in particular ammonium sulfates, ammonium phosphates and ammonium nitrates, natural rock flours, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite and diatomaceous earth, silica gel and synthetic rock flours, such as finely divided silica, alumina and silicates. Examples of typically useful solid carriers for preparing granules include, but are not limited to crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, synthetic granules of inorganic and organic flours and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks. Examples of suitable liquid carriers include, but are not limited to, water, organic solvents and combinations thereof. Examples of suitable solvents include polar and nonpolar organic chemical liquids, for example from the classes of aromatic and nonaromatic hydrocarbons (such as cyclohexane, paraffins, alkylbenzenes, xylene, toluene, tetrahydronaphthalene, alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride), alcohols and polyols (which may optionally also be substituted, etherified and/or esterified, such as ethanol, propanol, butanol, benzylalcohol, cyclohexanol or glycol), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone), esters (including fats and oils) and (poly)ethers, unsubstituted and substituted amines, amides (such as dimethylformamide or fatty acid amides) and esters thereof, lactams (such as N-alkylpyrrolidones, in particular N-methylpyrrolidone) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide), oils of vegetable or animal origin. The carrier may also be a liquefied gaseous extender, i.e. liquid which is gaseous at standard temperature and under standard pressure, for example aerosol propellants such as halohydrocarbons, butane, propane, nitrogen and carbon dioxide.

Preferred solid carriers are selected from clays, talc and silica.

Preferred liquid carriers are selected from water, fatty acid amides and esters thereof, aromatic and nonaromatic hydrocarbons, lactams and carbonic acid esters.

The amount of carrier typically ranges from 1 to 99.99%, preferably from 5 to 99.9%, more preferably from 10 to 99.5%, and most preferably from 20 to 99% by weight of the composition.

Liquid carriers are typically present in a range of from 20 to 90%, for example 30 to 80% by weight of the composition.

Solid carriers are typically present in a range of from 0 to 50%, preferably 5 to 45%, for example 10 to 30% by weight of the composition.

If the composition comprises two or more carriers, the outlined ranges refer to the total amount of carriers.

The surfactant can be an ionic (cationic or anionic), amphoteric or non-ionic surfactant, such as ionic or non-ionic emulsifier(s), foam former(s), dispersant(s), wetting agent(s), penetration enhancer(s) and any mixtures thereof. Examples of suitable surfactants include, but are not limited to, salts of polyacrylic acid, salts of lignosulfonic acid (such as sodium lignosulfonate), salts of phenolsulfonic acid or naphthalenesulfonic acid, polycondensates of ethylene oxide and/or propylene oxide with fatty alcohols, fatty acids or fatty amines (for example, polyoxyethylene fatty acid esters such as castor oil ethoxylate, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers), substituted phenols (preferably alkylphenols or arylphenols) and ethoxylates thereof (such as tristyrylphenol ethoxylate), salts of sulfosuccinic esters, taurine derivatives (preferably alkyl taurates), phosphoric esters of polyethoxylated alcohols or phenols, fatty esters of polyols (such a fatty acid esters of glycerol, sorbitol or sucrose), sulfates (such as alkyl sulfates and alkyl ether sulfates), sulfonates (for example, alkylsulfonates, arylsulfonates and alkylbenzene sulfonates), phosphate esters, protein hydrolysates, lignosulfite waste liquors and methylcellulose. Any reference to salts in this paragraph refers preferably to the respective alkali, alkaline earth and ammonium salts.

Preferred surfactants are selected from polyoxyethylene fatty alcohol ethers, polyoxyethylene fatty acid esters, alkylbenzene sulfonates, such as calcium dodecylbenzenesulfonate, castor oil ethoxylate, sodium lignosulfonate and arylphenol ethoxylates, such as tristyrylphenol ethoxylate.

The amount of surfactants typically ranges from 5 to 40%, for example 10 to 20%, by weight of the composition.

Further examples of suitable auxiliaries include water repellents, siccatives, binders (adhesive, tackifier, fixing agent, such as carboxymethylcellulose, natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, natural phospholipids such as cephalins and lecithins and synthetic phospholipids, polyvinylpyrrolidone and tylose), thickeners and secondary thickeners (such as cellulose ethers, acrylic acid derivatives, xanthan gum, modified clays, e.g. the products available under the name Bentone, and finely divided silica), stabilizers (e.g. cold stabilizers, preservatives (e.g. dichlorophene and benzyl alcohol hemiformal), antioxidants, light stabilizers, in particular UV stabilizers, or other agents which improve chemical and/or physical stability), dyes or pigments (such as inorganic pigments, e.g. iron oxide, titanium oxide and Prussian Blue; organic dyes, e.g. alizarin, azo and metal phthalocyanine dyes), antifoams (e.g. silicone antifoams and magnesium stearate), antifreezes, stickers, gibberellins and processing auxiliaries, mineral and vegetable oils, perfumes, waxes, nutrients (including trace nutrients, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc), protective colloids, thixotropic substances, penetrants, sequestering agents and complex formers.

The choice of the auxiliaries depends on the intended mode of application of compounds of formula (I) and/or on the physical properties of the compound(s). Furthermore, the auxiliaries may be chosen to impart particular properties (technical, physical and/or biological properties) to the compositions or use forms prepared therefrom. The choice of auxiliaries may allow customizing the compositions to specific needs.

The composition of the invention may be provided to the end user as ready-for-use formulation, i.e. the compositions may be directly applied to the plants or seeds by a suitable device, such as a spraying or dusting device. Alternatively, the compositions may be provided to the end user in the form of concentrates which have to be diluted, preferably with water, prior to use.

The composition of the invention can be prepared in conventional manners, for example by mixing the compounds of formula (I) with one or more suitable auxiliaries, such as disclosed herein above.

The composition comprises a fungicidally effective amount of the compound(s) of formula (I). The term “effective amount” is an amount, which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants.

Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound of formula (I) used. Usually, the composition according to the invention contains from 0.01 to 99% by weight, preferably from 0.05 to 98% by weight, more preferred from 0.1 to 95% by weight, even more preferably from 0.5 to 90% by weight, most preferably from 1 to 80% by weight of the compound of formula (I). It is possible that a composition comprises two or more compounds of the invention. In such case the outlined ranges refer to the total amount of compounds of the present invention.

The composition of the invention may be in any customary composition type, such as solutions (e.g aqueous solutions), emulsions, water- and oil-based suspensions, powders (e.g. wettable powders, soluble powders), dusts, pastes, granules (e.g. soluble granules, granules for broadcasting), suspoemulsion concentrates, natural or synthetic products impregnated with the compound of formula (I), fertilizers and also microencapsulations in polymeric substances. The compounds of formula (I) may be present in a suspended, emulsified or dissolved form. Examples of particular suitable composition types are solutions, watersoluble concentrates (e.g. SL, LS), dispersible concentrates (DC), suspensions and suspension concentrates (e.g. SC, OD, OF, FS), emulsifiable concentrates (e.g. EC), emulsions (e.g. EW, EO, ES, ME, SE), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR, FG, GG, MG), insecticidal articles (e.g. LN), as well as gel formulations for the treatment of plant propagation materials such as seeds (e.g. GW, GF). These and further compositions types are defined by the Food and Agriculture Organization of the United Nations (FAO). An overview is given in the “Catalogue of pesticide formulation types and international coding system”, Technical Monograph No. 2,6th Ed. May 2008, Croplife International.

Preferably, the composition of the invention is in form of one of the following types: EC, SC, FS, SE, OD and WG, more preferred EC, SC, OD and WG.

Further details about examples of composition types and their preparation are given below. If two or more compounds of the invention are present, the outlined amount of compound of the invention refers to the total amount of compounds of the present invention. This applies mutatis mutandis for any further component of the composition, if two or more representatives of such component, e.g. wetting agent, binder, are present.

i) Water-Soluble Concentrates (SL, LS)

10-60% by weight of at least one compound of formula (I) and 5-15% by weight surfactant (e.g. polyoxyethylene fatty alcohol ether) are dissolved in such amount of water and/or water-soluble solvent (e.g. alcohols such as propylene glycol or carbonates such as propylene carbonate) to result in a total amount of 100% by weight. Before application the concentrate is diluted with water.

ii) Dispersible Concentrates (DC)

5-25% by weight of at least one compound of formula (I) and 1-10% by weight surfactant and/or binder (e.g. polyvinylpyrrolidone) are dissolved in such amount of organic solvent (e.g. cyclohexanone) to result in a total amount of 100% by weight. Dilution with water gives a dispersion.

iii) Emulsifiable Concentrates (EC)

15-70% by weight of at least one compound of formula (I) and 5-10% by weight surfactant (e.g. a mixture of calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in such amount of water-insoluble organic solvent (e.g. aromatic hydrocarbon or fatty acid amide) and if needed additional water-soluble solvent to result in a total amount of 100% by weight. Dilution with water gives an emulsion.

iv) Emulsions (EW, EO, ES)

5-40% by weight of at least one compound of formula (I) and 1-10% by weight surfactant (e.g. a mixture of calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in 20-40% by weight water-insoluble organic solvent (e.g. aromatic hydrocarbon). This mixture is added to such amount of water by means of an emulsifying machine to result in a total amount of 100% by weight. The resulting composition is a homogeneous emulsion. Before application the emulsion may be further diluted with water.

v) Suspensions and Suspension Concentrates

v-1) Water-Based (SC, FS)

In a suitable grinding equipment, e.g. an agitated ball mill, 20-60% by weight of at least one compound of formula (I) are comminuted with addition of 2-10% by weight surfactant (e.g. sodium lignosulfonate and polyoxyethylene fatty alcohol ether), 0.1-2% by weight thickener (e.g. xanthan gum) and water to give a fine active substance suspension. The water is added in such amount to result in a total amount of 100% by weight. Dilution with water gives a stable suspension of the active substance. For FS type compositions up to 40% by weight binder (e.g. polyvinylalcohol) is added.

v-2) Oil-Based (OD, OF)

In a suitable grinding equipment, e.g. an agitated ball mill, 20-60% by weight of at least one compound of formula (I) are comminuted with addition of 2-10% by weight surfactant (e.g. sodium lignosulfonate and polyoxyethylene fatty alcohol ether), 0.1-2% by weight thickener (e.g. modified clay, in particular Bentone, or silica) and an organic carrier to give a fine active substance oil suspension. The organic carrier is added in such amount to result in a total amount of 100% by weight. Dilution with water gives a stable dispersion of the active substance.

vi) Water-Dispersible Granules and Water-Soluble Granules (WG, SG)

50-80% by weight of at least one compound of formula (I) are ground finely with addition of surfactant (e.g. sodium lignosulfonate and polyoxyethylene fatty alcohol ether) and converted to water-dispersible or water-soluble granules by means of technical appliances (e. g. extrusion, spray tower, fluidized bed). The surfactant is used in such amount to result in a total amount of 100% by weight. Dilution with water gives a stable dispersion or solution of the active substance.

vii) Water-Dispersible Powders and Water-Soluble Powders (WP, SP, WS)

50-80% by weight of at least one compound of formula (I) are ground in a rotor-stator mill with addition of 1-8% by weight surfactant (e.g. sodium lignosulfonate, polyoxyethylene fatty alcohol ether) and such amount of solid carrier, e.g. silica gel, to result in a total amount of 100% by weight. Dilution with water gives a stable dispersion or solution of the active substance.

viii) Gel (GW, GF)

In an agitated ball mill, 5-25% by weight of at least one compound of formula (I) are comminuted with addition of 3-10% by weight surfactant (e.g. sodium lignosulfonate), 1-5% by weight binder (e.g. carboxymethylcellulose) and such amount of water to result in a total amount of 100% by weight. This results in a fine suspension of the active substance. Dilution with water gives a stable suspension of the active substance.

ix) Microemulsion (ME)

5-20% by weight of at least one compound of formula (I) are added to 5-30% by weight organic solvent blend (e.g. fatty acid dimethylamide and cyclohexanone), 10-25% by weight surfactant blend (e.g. polyoxyethylene fatty alcohol ether and arylphenol ethoxylate), and such amount of water to result in a total amount of 100% by weight. This mixture is stirred for 1 h to produce spontaneously a thermodynamically stable microemulsion.

x) Microcapsules (CS)

An oil phase comprising 5-50% by weight of at least one compound of formula (I), 0-40% by weight water-insoluble organic solvent (e.g. aromatic hydrocarbon), 2-15% by weight acrylic monomers (e.g. methylmethacrylate, methacrylic acid and a di- or triacrylate) are dispersed into an aqueous solution of a protective colloid (e.g. polyvinyl alcohol). Radical polymerization initiated by a radical initiator results in the formation of poly(meth)acrylate microcapsules. Alternatively, an oil phase comprising 5-50% by weight of at least one compound of formula (I), 0-40% by weight water-insoluble organic solvent (e.g. aromatic hydrocarbon), and an isocyanate monomer (e.g. diphenylmethene-4,4′-diisocyanatae) are dispersed into an aqueous solution of a protective colloid (e.g. polyvinyl alcohol). The addition of a polyamine (e.g. hexamethylenediamine) results in the formation of polyurea microcapsules. The monomers amount to 1-10% by weight of the total CS composition.

xi) Dustable Powders (DP, DS)

1-10% by weight of at least one compound of formula (I) are ground finely and mixed intimately with such amount of solid carrier, e.g. finely divided kaolin, to result in a total amount of 100% by weight.

xii) Granules (GR, FG)

0.5-30% by weight of at least one compound of formula (I) are ground finely and associated with such amount of solid carrier (e.g. silicate) to result in a total amount of 100% by weight. Granulation is achieved by extrusion, spray-drying or the fluidized bed.

xiii) Ultra-Low Volume Liquids (UL)

1-50% by weight of at least one compound of formula (I) are dissolved in such amount of organic solvent, e.g. aromatic hydrocarbon, to result in a total amount of 100% by weight.

The compositions types i) to xiii) may optionally comprise further auxiliaries, such as 0.1-1% by weight preservatives, 0.1-1% by weight antifoams, 0.1-1% by weight dyes and/or pigments, and 5-10% by weight antifreezes.

Mixtures/Combinations

The compound of formula (I) and the composition of the invention can be mixed with other active ingredients like fungicides, bactericides, acaricides, nematicides, insecticides, biological control agents or herbicides. Mixtures with fertilizers, growth regulators, safeners, nitrification inhibitors, semiochemicals and/or other agriculturally beneficial agents are also possible. This may allow to broaden the activity spectrum or to prevent development of resistance. Examples of known fungicides, insecticides, acaricides, nematicides and bactericides are disclosed in the Pesticide Manual, 17th Edition.

Examples of fungicides which could be mixed with the compound of formula (I) and the composition of the invention are:

-   -   1) Inhibitors of the ergosterol biosynthesis, for example         (1.001) cyproconazole, (1.002) difenoconazole, (1.003)         epoxiconazole, (1.004) fenhexamid, (1.005) fenpropidin, (1.006)         fenpropimorph, (1.007) fenpyrazamine, (1.008) fluquinconazole,         (1.009) flutriafol, (1.010) imazalil, (1.011) imazalil sulfate,         (1.012) ipconazole, (1.013) metconazole, (1.014) myclobutanil,         (1.015) paclobutrazol, (1.016) prochloraz, (1.017)         propiconazole, (1.018) prothioconazole, (1.019) pyrisoxazole,         (1.020) spiroxamine, (1.021) tebuconazole, (1.022)         tetraconazole, (1.023) triadimenol, (1.024) tridemorph, (1.025)         triticonazole, (1.026)         (1R,2S,5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol,         (1.027)         (1S,2R,5R)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol,         (1.028)         (2R)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.029)         (2R)-2-(1-chlorocyclopropyl)-4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.030)         (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol,         (1.031)         (2S)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.032)         (2S)-2-(1-chloro-cyclopropyl)-4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.033)         (2S)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol,         (1.034)         (R)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol,         (1.035)         (S)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol,         (1.036)         [3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol,         (1.037)         1-({(2R,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole,         (1.038)         1-({(2S,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole,         (1.039)         1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl         thiocyanate, (1.040)         1-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl         thiocyanate, (1.041)         1-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl         thiocyanate, (1.042)         2-[(2R,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.043)         2-[(2R,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.044)         2-[(2R,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.045)         2-[(2R,4S,5S)-1-(2,4-dichloro-phenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.046)         2-[(2S,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.047)         2-[(2S,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.048)         2-[(2S,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.049)         2-[(2S,4S,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.050)         2-[1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.051)         2-[2-chloro-4-(2,4-dichlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol,         (1.052)         2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.053)         2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,         (1.054)         2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)pentan-2-ol,         (1.055) mefentrifluconazole, (1.056)         2-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.057)         2-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluoro-phenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.058)         2-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione,         (1.059)         5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol,         (1.060)         5-(allylsulfanyl)-1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole,         (1.061)         5-(allylsulfanyl)-1-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole,         (1.062)         5-(allylsulfanyl)-1-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole,         (1.063)         N′-(2,5-dimethyl-4-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide,         (1.064)         N′-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]sulfanyl}phenyl)N-ethyl-N-methylimidoformamide,         (1.065)         N′-(2,5-dimethyl-4-{[3-(2,2,3,3-tetrafluoropropoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide,         (1.066)         N′-(2,5-dimethyl-4-{[3-(pentafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide,         (1.067)         N′-(2,5-dimethyl-4-{3-[(1,1,2,2-tetrafluoroethyl)sulfanyl]-phenoxy}phenyl)-N-ethyl-N-methylimidoformamide,         (1.068)         N′-(2,5-dimethyl-4-{3-[(2,2,2-trifluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide,         (1.069)         N′-(2,5-dimethyl-4-{3-[(2,2,3,3-tetrafluoropropyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide,         (1.070)         N′-(2,5-dimethyl-4-{3-[(pentafluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide,         (1.071)         N′-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylimidoformamide,         (1.072)         N′-(4-{[3-(difluoromethoxy)phenyl]sulfanyl}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide,         (1.073)         N′-(4-{3-[(difluoromethyl)sulfanyl]phenoxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide,         (1.074)         N′-[5-bromo-6-(2,3-dihydro-1H-inden-2-yloxy)-2-methylpyridin-3-yl]-N-ethyl-N-methylimidoformamide,         (1.075)         N′-{4-[(4,5-dichloro-1,3-thiazol-2-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimidoformamide,         (1.076)         N′-{5-bromo-6-[(1R)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.077)         N′-{5-bromo-6-[(1S)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.078)         N′-{5-bromo-6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.079)         N′-{5-bromo-6-[(trans-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.080)         N′-{5-bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.081) ipfentrifluconazole, (1.082)         2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol,         (1.083)         2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol,         (1.084)         2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol,         (1.085)         3-[2-(1-chlorocyclopropyl)-3-(3-chloro-2-fluoro-phenyl)-2-hydroxypropyl]imidazole-4-carbonitrile,         (1.086)         4-[[6-[rac-(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile,         (1.087)N-isopropyl-N′-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)phenyl]-N-methylimidoformamide,         (1.088)         N′-{5-bromo-2-methyl-6-[(1-propoxypropan-2-yl)oxy]pyridin-3-yl}-N-ethyl-N-methylimidoformamide,         (1.089) hexaconazole, (1.090) penconazole, (1.091)         fenbuconazole, (1.092) methyl         2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3-(1,2,4-triazol-1-yl)propanoate.     -   2) Inhibitors of the respiratory chain at complex I or II, for         example (2.001) benzovindiflupyr, (2.002) bixafen, (2.003)         boscalid, (2.004) carboxin, (2.005) fluopyram, (2.006)         flutolanil, (2.007) fluxapyroxad, (2.008) furametpyr, (2.009)         Isofetamid, (2.010) isopyrazam (anti-epimeric enantiomer         1R,4S,9S), (2.011) isopyrazam (anti-epimeric enantiomer         1S,4R,9R), (2.012) isopyrazam (anti-epimeric racemate         1RS,4SR,9SR), (2.013) isopyrazam (mixture of syn-epimeric         racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR),         (2.014) isopyrazam (syn-epimeric enantiomer 1R,4S,9R), (2.015)         isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.016)         isopyrazam (syn-epimeric racemate 1RS,4SR,9RS), (2.017)         penflufen, (2.018) penthiopyrad, (2.019) pydiflumetofen, (2.020)         Pyraziflumid, (2.021) sedaxane, (2.022)         1,3-dimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide,         (2.023)         1,3-dimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide,         (2.024)         1,3-dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide,         (2.025)         1-methyl-3-(trifluoromethyl)-N-[2′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide,         (2.026)         2-fluoro-6-(trifluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)benzamide,         (2.027)         3-(difluoromethyl)-1-methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide,         (2.028) inpyrfluxam, (2.029)         3-(difluoromethyl)-1-methyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide,         (2.030) fluindapyr, (2.031)         3-(difluoromethyl)-N-[(3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide,         (2.032)         3-(difluoromethyl)-N-[(3S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide,         (2.033)         5,8-difluoro-N-[2-(2-fluoro-4-{[4-(trifluoromethyl)-pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine,         (2.034)N-(2-cyclopentyl-5-fluorobenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.035)N-(2-tert-butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.036)N-(2-tert-butylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.037)N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.038) isoflucypram,         (2.039)N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.040)N-[(1S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.041)N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.042)N-[2-chloro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.043)N-[3-chloro-2-fluoro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.044)N-[5-chloro-2-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.045)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[5-methyl-2-(trifluoromethyl)benzyl]-1H-pyrazole-4-carboxamide,         (2.046)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-fluoro-6-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.047)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropyl-5-methylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.048)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carbothioamide,         (2.049)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.050)N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(5-fluoro-2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide,         (2.051)N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.052)N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-fluorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.053)N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.054)         N-cyclopropyl-N-(2-cyclopropyl-5-fluorobenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.055)N-cyclopropyl-N-(2-cyclopropyl-5-methylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.056)N-cyclopropyl-N-(2-cyclopropylbenzyl)-3-(di-fluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide,         (2.057) pyrapropoyne,         (2.058)N-[rac-(1S,2S)-2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)nicotinamide,         (2.059)N-[(1S,2S)-2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)nicotinamide,         (2.060) flubeneteram.     -   3) Inhibitors of the respiratory chain at complex III, for         example (3.001) ametoctradin, (3.002) amisulbrom, (3.003)         azoxystrobin, (3.004) coumethoxystrobin, (3.005) coumoxystrobin,         (3.006) cyazofamid, (3.007) dimoxystrobin, (3.008) enoxastrobin,         (3.009) famoxadone, (3.010) fenamidone, (3.011)         flufenoxystrobin, (3.012) fluoxastrobin, (3.013)         kresoxim-methyl, (3.014) metominostrobin, (3.015) orysastrobin,         (3.016) picoxystrobin, (3.017) pyraclostrobin, (3.018)         pyrametostrobin, (3.019) pyraoxystrobin, (3.020)         trifloxystrobin, (3.021)         (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylvinyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide,         (3.022)         (2E,3Z)-5-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide,         (3.023)         (2R)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide,         (3.024)         (2S)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide,         (3.025) fenpicoxamid, (3.026) mandestrobin,         (3.027)N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-formamido-2-hydroxybenzamide,         (3.028)         (2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide,         (3.029) methyl         {5-[3-(2,4-dimethylphenyl)-1H-pyrazol-1-yl]-2-methylbenzyl}carbamate,         (3.030) metyltetraprole, (3.031) florylpicoxamid, (3.032)         (2S,3S)-3-(o-tolyl)butan-2-yl         N-{[4-methoxy-3-(propanoyloxy)-2-pyridyl]carbonyl}-L-alaninate.     -   4) Inhibitors of the mitosis and cell division, for example         (4.001) carbendazim, (4.002) diethofencarb, (4.003) ethaboxam,         (4.004) fluopicolide, (4.005) pencycuron, (4.006) thiabendazole,         (4.007) thiophanate-methyl, (4.008) zoxamide, (4.009)         pyridachlometyl, (4.010)         3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine,         (4.011)         3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine,         (4.012)         4-(2-bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.013)         4-(2-bromo-4-fluorophenyl)-N-(2-bromo-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.014)         4-(2-bromo-4-fluorophenyl)-N-(2-bromophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.015)         4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.016)         4-(2-bromo-4-fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.017)         4-(2-bromo-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.018)         4-(2-chloro-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.019)         4-(2-chloro-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.020)         4-(2-chloro-4-fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.021)         4-(2-chloro-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.022)         4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine,         (4.023)N-(2-bromo-6-fluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.024)N-(2-bromophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.025)N-(4-chloro-2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine,         (4.026) fluopimomide.     -   5) Compounds capable to have a multisite action, for example         (5.001) bordeaux mixture, (5.002) captafol, (5.003) captan,         (5.004) chlorothalonil, (5.005) copper hydroxide, (5.006) copper         naphthenate, (5.007) copper oxide, (5.008) copper oxychloride,         (5.009) copper(2+) sulfate, (5.010) dithianon, (5.011) dodine,         (5.012) folpet, (5.013) mancozeb, (5.014) maneb, (5.015)         metiram, (5.016) metiram zinc, (5.017) oxine-copper, (5.018)         propineb, (5.019) sulfur and sulfur preparations including         calcium polysulfide, (5.020) thiram, (5.021) zineb, (5.022)         ziram, (5.023)         6-ethyl-5,7-dioxo-6,7-dihydro-5H-pyrrolo[3′,4′:5,6][1,4]dithiino[2,3-c][1,2]thiazole-3-carbonitrile.     -   6) Compounds capable to induce a host defence, for example         (6.001) acibenzolar-S-methyl, (6.002) isotianil, (6.003)         probenazole, (6.004) tiadinil.     -   7) Inhibitors of the amino acid and/or protein biosynthesis, for         example (7.001) cyprodinil, (7.002) kasugamycin, (7.003)         kasugamycin hydrochloride hydrate, (7.004) oxytetracycline,         (7.005) pyrimethanil, (7.006)         3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline.     -   8) Inhibitors of the ATP production, for example (8.001)         silthiofam.     -   9) Inhibitors of the cell wall synthesis, for example (9.001)         benthiavalicarb, (9.002) dimethomorph, (9.003) flumorph, (9.004)         iprovalicarb, (9.005) mandipropamid, (9.006) pyrimorph, (9.007)         valifenalate, (9.008)         (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one,         (9.009)         (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one.     -   10) Inhibitors of the lipid and membrane synthesis, for example         (10.001) propamocarb, (10.002) propamocarb hydrochloride,         (10.003) tolclofos-methyl.     -   11) Inhibitors of the melanin biosynthesis, for example (11.001)         tricyclazole, (11.002) tolprocarb.     -   12) Inhibitors of the nucleic acid synthesis, for example         (12.001) benalaxyl, (12.002) benalaxyl-M (kiralaxyl), (12.003)         metalaxyl, (12.004) metalaxyl-M (mefenoxam).     -   13) Inhibitors of the signal transduction, for example (13.001)         fludioxonil, (13.002) iprodione, (13.003) procymidone, (13.004)         proquinazid, (13.005) quinoxyfen, (13.006) vinclozolin.     -   14) Compounds capable to act as an uncoupler, for example         (14.001) fluazinam, (14.002) meptyldinocap.     -   15) Further fungicides selected from the group consisting of         (15.001) abscisic acid, (15.002) benthiazole, (15.003)         bethoxazin, (15.004) capsimycin, (15.005) carvone, (15.006)         chinomethionat, (15.007) cufraneb, (15.008) cyflufenamid,         (15.009) cymoxanil, (15.010) cyprosulfamide, (15.011) flutianil,         (15.012) fosetyl-aluminium, (15.013) fosetyl-calcium, (15.014)         fosetyl-sodium, (15.015) methyl isothiocyanate, (15.016)         metrafenone, (15.017) mildiomycin, (15.018) natamycin, (15.019)         nickel dimethyldithiocarbamate, (15.020) nitrothal-isopropyl,         (15.021) oxamocarb, (15.022) oxathiapiprolin, (15.023)         oxyfenthiin, (15.024) pentachlorophenol and salts, (15.025)         phosphorous acid and its salts, (15.026) propamocarb-fosetylate,         (15.027) pyriofenone (chlazafenone), (15.028) tebufloquin,         (15.029) tecloftalam, (15.030) tolnifanide, (15.031)         1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone,         (15.032)         1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone,         (15.033) 2-(6-benzylpyridin-2-yl)quinazoline, (15.034)         dipymetitrone, (15.035)         2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone,         (15.036)         2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-chloro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone,         (15.037)         2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-fluoro-6-(prop-2-yn-1-yloxy)-phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone,         (15.038)         2-[6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]quinazoline,         (15.039)         2-{(5R)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl         methanesulfonate, (15.040)         2-{(5S)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl         methanesulfonate, (15.041) ipflufenoquin, (15.042)         2-{2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]phenyl}propan-2-ol,         (15.043) fluoxapiprolin, (15.044)         2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl         methanesulfonate, (15.045) 2-phenylphenol and salts, (15.046)         3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline,         (15.047) quinofumelin, (15.048) 4-amino-5-fluoropyrimidin-2-ol         (tautomeric form: 4-amino-5-fluoropyrimidin-2(1H)-one), (15.049)         4-oxo-4-[(2-phenylethyl)amino]butanoic acid, (15.050)         5-amino-1,3,4-thiadiazole-2-thiol, (15.051)         5-chloro-N′-phenyl-N′-(prop-2-yn-1-yl)thiophene-2-sulfonohydrazide,         (15.052) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine,         (15.053) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine,         (15.054)         9-fluoro-2,2-dimethyl-5-(quinolin-3-yl)-2,3-dihydro-1,4-benzoxazepine,         (15.055) but-3-yn-1-yl         {6-[({[(Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate,         (15.056) ethyl (2Z)-3-amino-2-cyano-3-phenylacrylate, (15.057)         phenazine-1-carboxylic acid, (15.058) propyl         3,4,5-trihydroxybenzoate, (15.059) quinolin-8-ol, (15.060)         quinolin-8-ol sulfate (2:1), (15.061) tert-butyl         {6-[([{[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate,         (15.062)         5-fluoro-4-imino-3-methyl-1-[(4-methylphenyl)sulfonyl]-3,4-dihydropyrimidin-2(1H)-one,         (15.063) aminopyrifen, (15.064)         (N′-[2-chloro-4-(2-fluorophenoxy)-5-methylphenyl]-N-ethyl-N-methylimidoformamide),         (15.065)         (N′-(2-chloro-5-methyl-4-phenoxyphenyl)-N-ethyl-N-methylimidoformamide),         (15.066)         (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol),         (15.067)         (5-bromo-1-(5,6-dimethylpyridin-3-yl)-3,3-dimethyl-3,4-dihydroisoquinoline),         (15.068)         (3-(4,4-difluoro-5,5-dimethyl-4,5-dihydrothieno[2,3-c]pyridin-7-yl)quinoline),         (15.069)         (1-(4,5-dimethyl-1H-benzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline),         (15.070)         8-fluoro-3-(5-fluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinolone,         (15.071)         8-fluoro-3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinolone,         (15.072)         3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-8-fluoroquinoline,         (15.073)         (N-methyl-N-phenyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide),         (15.074) methyl         {4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}carbamate,         (15.075)         (N-{4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl}cyclopropanecarboxamide),         (15.076)         N-methyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.077)N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.078)N—[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.079)N-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]cyclopropanecarboxamide,         (15.080)N-(2-fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.081)         2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide,         (15.082)N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl]methyl]acetamide,         (15.083)N-[(E)-N-methoxy-C-methyl-carbonimidoyl]-4-(5-(trifluoro-methyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.084)N—[(Z)—N-methoxy-C-methyl-carbonimidoyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.085)N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide,         (15.086)         4,4-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one,         (15.087)N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzenecarbothioamide,         (15.088)         5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one,         (15.089)N-((2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoro-propanamide,         (15.090)         1-methoxy-1-methyl-3-[[4-[5-(trifluoro-methyl}-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.091)         1,1-diethyl-3-[[4-[5-(trifluoromethyl}-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.092)N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide,         (15.093)N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]-methyl]cyclopropanecarboxamide,         (15.094)         1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.095)N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl)cyclopropanecarboxamide,         (15.096)         N,2-dimethoxy-N-[[4-[5-(trifluoromethyl}-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide,         (15.097)N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl]methyl]propanamide,         (15.098)         1-methoxy-3-methyl-1-[[4-[5-(trifluoro-methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.099)         1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.100)         3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea,         (15.101)         1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]-methyl]piperidin-2-one,         (15.102)         4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]-methyl]isooxazolidin-3-one,         (15.103)         5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one,         (15.104)         3,3-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piperidin-2-one,         (15.105)         1-[[3-fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-phenyl]methyl]azepan-2-one,         (15.106)         4,4-dimethyl-2-[[4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-phenyl]methyl]isoxazolidin-3-one,         (15.107)         5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one,         (15.108) ethyl         1-{4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl}-1H-pyrazole-4-carboxylate,         (15.109)         N,N-dimethyl-1-{4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl}-1H-1,2,4-triazol-3-amine,         (15.110)N-{2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl}butanamide,         (15.111)N-(1-methylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.112)N-(2,4-difluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide,         (15.113)         1-(5,6-dimethylpyridin-3-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline,         (15.114)         1-(6-(difluoromethyl)-5-methyl-pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline,         (15.115)         1-(5-(fluoromethyl)-6-methyl-pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline,         (15.116)         1-(6-(difluoromethyl)-5-methoxy-pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline,         (15.117) 4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl         dimethyl-carbamate,         (15.118)N-{4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl}propanamide,         (15.119)         3-[2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-1,5-dihydro-2,4-benzodioxepin-6-yl         methanesulfonate, (15.120)         9-fluoro-3-[2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-1,5-dihydro-2,4-benzodioxepin-6-yl         methanesulfonate, (15.121)         3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-1,5-dihydro-2,4-benzodioxepin-6-yl         methanesulfonate, (15.122)         3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-9-fluoro-1,5-dihydro-2,4-benzodioxepin-6-yl         methanesulfonate, (15.123)         1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinoline,         (15.124)         8-fluoro-N-(4,4,4-trifluoro-2-methyl-1-phenylbutan-2-yl)quinoline-3-carboxamide,         (15.125)         8-fluoro-N-[(2S)-4,4,4-trifluoro-2-methyl-1-phenylbutan-2-yl]quinoline-3-carboxamide,         (15.126)N-(2,4-dimethyl-1-phenylpentan-2-yl)-8-fluoroquinoline-3-carboxamide,         (15.127)N-[(2S)-2,4-dimethyl-1-phenylpentan-2-yl]-8-fluoroquinoline-3-carboxamide         and (15.128) D-tagatose.

All named mixing partners of the classes (1) to (15) as described here above can be present in the form of the free compound or, if their functional groups enable this, an agrochemically active salt thereof.

The compound of formula (I) and the composition of the invention may also be combined with one or more biological control agents.

As used herein, the term “biological control” is defined as control of harmful organisms such as a phytopathogenic fungi and/or insects and/or acarids and/or nematodes by the use or employment of a biological control agent.

As used herein, the term “biological control agent” is defined as an organism other than the harmful organisms and/or proteins or secondary metabolites produced by such an organism for the purpose of biological control. Mutants of the second organism shall be included within the definition of the biological control agent. The term “mutant” refers to a variant of the parental strain as well as methods for obtaining a mutant or variant in which the pesticidal activity is greater than that expressed by the parental strain. The “parent strain” is defined herein as the original strain before mutagenesis. To obtain such mutants the parental strain may be treated with a chemical such as N-methyl-N′-nitro-N-nitrosoguanidine, ethylmethanesulfone, or by irradiation using gamma, x-ray, or UV-irradiation, or by other means well known to those skilled in the art. Known mechanisms of biological control agents comprise enteric bacteria that control root rot by out-competing fungi for space on the surface of the root. Bacterial toxins, such as antibiotics, have been used to control pathogens. The toxin can be isolated and applied directly to the plant or the bacterial species may be administered so it produces the toxin in situ.

A “variant” is a strain having all the identifying characteristics of the NRRL or ATCC Accession Numbers as indicated in this text and can be identified as having a genome that hybridizes under conditions of high stringency to the genome of the NRRL or ATCC Accession Numbers.

“Hybridization” refers to a reaction in which one or more polynucleotides react to form a complex that is stabilized via hydrogen bonding between the bases of the nucleotide residues. The hydrogen bonding may occur by Watson-Crick base pairing, Hoogstein binding, or in any other sequence-specific manner.

The complex may comprise two strands forming a duplex structure, three or more strands forming a multi-stranded complex, a single self-hybridizing strand, or any combination of these. Hybridization reactions can be performed under conditions of different “stringency”. In general, a low stringency hybridization reaction is carried out at about 40° C. in 10×SSC or a solution of equivalent ionic strength/temperature. A moderate stringency hybridization is typically performed at about 50° C. in 6×SSC, and a high stringency hybridization reaction is generally performed at about 60° C. in 1×SSC.

A variant of the indicated NRRL or ATCC Accession Number may also be defined as a strain having a genomic sequence that is greater than 85%, more preferably greater than 90% or more preferably greater than 95% sequence identity to the genome of the indicated NRRL or ATCC Accession Number. A polynucleotide or polynucleotide region (or a polypeptide or polypeptide region) has a certain percentage (for example, 80%, 85%, 90%, or 95%) of “sequence identity” to another sequence means that, when aligned, that percentage of bases (or amino acids) are the same in comparing the two sequences. This alignment and the percent homology or sequence identity can be determined using software programs known in the art, for example, those described in Current Protocols in Molecular Biology (F. M. Ausubel et al., eds., 1987).

NRRL is the abbreviation for the Agricultural Research Service Culture Collection, an international depositary authority for the purposes of deposing microorganism strains under the Budapest treaty on the international recognition of the deposit of microorganisms for the purposes of patent procedure, having the address National Center for Agricultural Utilization Research, Agricultural Research service, U.S. Department of Agriculture, 1815 North university Street, Peroira, Ill. 61604 USA.

ATCC is the abbreviation for the American Type Culture Collection, an international depositary authority for the purposes of deposing microorganism strains under the Budapest treaty on the international recognition of the deposit of microorganisms for the purposes of patent procedure, having the address ATCC Patent Depository, 10801 University Blvd., Manassas, Va. 10110 USA.

Examples of biological control agents which may be combined with the compound of formula (I) and the composition of the invention are:

-   -   (A) Antibacterial agents selected from the group of:     -   (A1) bacteria, such as (A1.1) Bacillus subtilis, in particular         strain QST713/AQ713 (available as SERENADE OPTI or SERENADE ASO         from Bayer CropScience LP, US, having NRRL Accession No. B21661,         U.S. Pat. No. 6,060,051); (A1.2) Bacillus sp., in particular         strain D747 (available as DOUBLE NICKEL® from Kumiai Chemical         Industry Co., Ltd.), having Accession No. FERM BP-8234, U.S.         Pat. No. 7,094,592; (A1.3) Bacillus pumilus, in particular         strain BU F-33, having NRRL Accession No. 50185 (available as         part of the CARTISSA® product from BASF, EPA Reg. No. 71840-19);         (A1.4) Bacillus subtilis var. amyloliquefaciens strain FZB24         having Accession No. DSM 10271 (available from Novozymes as         TAEGRO® or TAEGRO® ECO (EPA Registration No. 70127-5)); (A1.5) a         Paenibacillus sp. strain having Accession No. NRRL B-50972 or         Accession No. NRRL B-67129, WO 2016/154297; (A1.6) Bacillus         subtilis strain BU1814, (available as VELONDIS® PLUS, VELONDIS®         FLEX and VELONDIS® EXTRA from BASF SE); (A1.7) Bacillus         mojavensis strain R3B (Accession No. NCAIM (P) B001389) (WO         2013/034938) from Certis USA LLC, a subsidiary of Mitsui & Co.;         (A1.8) Bacillus subtilis CX-9060 from Certis USA LLC, a         subsidiary of Mitsui & Co.; (A1.9) Paenibacillus polymyxa, in         particular strain AC-1 (e.g. TOPSEED® from Green Biotech Company         Ltd.); (A1.10) Pseudomonas proradix (e.g. PRORADIX® from Sourcon         Padena); (A1.11) Pantoea agglomerans, in particular strain E325         (Accession No. NRRL B-21856) (available as BLOOMTIME BIOLOGICAL™         FD BIOPESTICIDE from Northwest Agri Products); and     -   (A2) fungi, such as (A2.1) Aureobasidium pullulans, in         particular blastospores of strain DSM14940, blastospores of         strain DSM 14941 or mixtures of blastospores of strains DSM14940         and DSM14941 (e.g., BOTECTOR® and BLOSSOM PROTECT® from         bio-ferm, CH); (A2.2) Pseudozyma aphidis (as disclosed in         WO2011/151819 by Yissum Research Development Company of the         Hebrew University of Jerusalem); (A2.3) Saccharomyces         cerevisiae, in particular strains CNCM No. I-3936, CNCM No.         I-3937, CNCM No. I-3938 or CNCM No. I-3939 (WO 2010/086790) from         Lesaffre et Compagnie, FR;     -   (B) biological fungicides selected from the group of:     -   (B1) bacteria, for example (B1.1) Bacillus subtilis, in         particular strain QST713/AQ713 (available as SERENADE OPTI or         SERENADE ASO from Bayer CropScience LP, US, having NRRL         Accession No. B21661 and described in U.S. Pat. No. 6,060,051);         (B1.2) Bacillus pumilus, in particular strain QST2808 (available         as SONATA® from Bayer CropScience LP, US, having Accession No.         NRRL B-30087 and described in U.S. Pat. No. 6,245,551); (B1.3)         Bacillus pumilus, in particular strain GB34 (available as Yield         Shield® from Bayer AG, DE); (B1.4) Bacillus pumilus, in         particular strain BU F-33, having NRRL Accession No. 50185         (available as part of the CARTISSA product from BASF, EPA Reg.         No. 71840-19); (B1.5) Bacillus amyloliquefaciens, in particular         strain D747 (available as Double Nickel™ from Kumiai Chemical         Industry Co., Ltd., having accession number FERM BP-8234, U.S.         Pat. No. 7,094,592); (B1.6) Bacillus subtilis Y1336 (available         as BIOBAC® WP from Bion-Tech, Taiwan, registered as a biological         fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and         5277); (B1.7) Bacillus subtilis strain MBI 600 (available as         SUBTILEX from BASF SE), having Accession Number NRRL B-50595,         U.S. Pat. No. 5,061,495; (B1.8) Bacillus subtilis strain GB03         (available as Kodiak® from Bayer AG, DE); (B1.9) Bacillus         subtilis var. amyloliquefaciens strain FZB24 having Accession         No. DSM 10271 (available from Novozymes as TAEGRO® or TAEGRO®         ECO (EPA Registration No. 70127-5)); (B1.10) Bacillus mycoides,         isolate J, having Accession No. B-30890 (available as BMJ TGAI®         or WG and LifeGard™ from Certis USA LLC, a subsidiary of Mitsui         & Co.); (B1.11) Bacillus licheniformis, in particular strain         SB3086, having Accession No. ATCC 55406, WO 2003/000051         (available as ECOGUARD® Biofungicide and GREEN RELEAF™ from         Novozymes); (B1.12) a Paenibacillus sp. strain having Accession         No. NRRL B-50972 or Accession No. NRRL B-67129, WO 2016/154297;         (B1.13) Bacillus subtilis strain BU1814, (available as VELONDIS®         PLUS, VELONDIS® FLEX and VELONDIS® EXTRA from BASF SE); (B1.14)         Bacillus subtilis CX-9060 from Certis USA LLC, a subsidiary of         Mitsui & Co.; (B1.15) Bacillus amyloliquefaciens strain F727         (also known as strain MBI110) (NRRL Accession No. B-50768; WO         2014/028521) (STARGUS® from Marrone Bio Innovations); (B1.16)         Bacillus amyloliquefaciens strain FZB42, Accession No. DSM 23117         (available as RHIZOVITAL® from ABiTEP, DE); (B1.17) Bacillus         licheniformis FMCH001 and Bacillus subtilis FMCH002 (QUARTZO®         (WG) and PRESENCE® (WP) from FMC Corporation); (B1.18) Bacillus         mojavensis strain R3B (Accession No. NCAIM (P) B001389) (WO         2013/034938) from Certis USA LLC, a subsidiary of Mitsui & Co.;         (B1.19) Paenibacillus polymyxa ssp. plantarum (WO 2016/020371)         from BASF SE; (B1.20) Paenibacillus epiphyticus (WO 2016/020371)         from BASF SE; (B.1.21) Pseudomonas chlororaphis strain AFS009,         having Accession No. NRRL B-50897, WO 2017/019448 (e.g., HOWLER™         and ZIO® from AgBiome Innovations, US); (B1.22) Pseudomonas         chlororaphis, in particular strain MA342 (e.g. CEDOMON®,         CERALL®, and CEDRESS® by Bioagri and Koppert); (B1.23)         Streptomyces lydicus strain WYEC108 (also known as Streptomyces         lydicus strain WYCD108US) (ACTINO-IRON® and ACTINOVATE® from         Novozymes); (B1.24) Agrobacterium radiobacter strain K84 (e.g.         GALLTROL-A® from AgBioChem, CA); (B1.25) Agrobacterium         radiobacter strain K1026 (e.g. NOGALL™ from BASF SE); (B1.26)         Bacillus subtilis KTSB strain (FOLIACTIVE® from Donaghys);         (B1.27) Bacillus subtilis IAB/BS03 (AVIV™ from STK Bio-Ag         Technologies); (B1.28) Bacillus subtilis strain Y1336 (available         as BIOBAC® WP from Bion-Tech, Taiwan, registered as a biological         fungicide in Taiwan under Registration Nos. 4764, 5454, 5096 and         5277); (B1.29) Bacillus amyloliquefaciens isolate B246 (e.g.         AVOGREEN™ from University of Pretoria); (B1.30) Bacillus         methylotrophicus strain BAC-9912 (from Chinese Academy of         Sciences' Institute of Applied Ecology); (B1.31) Pseudomonas         proradix (e.g. PRORADIX® from Sourcon Padena); (B1.32)         Streptomyces griseoviridis strain K61 (also known as         Streptomyces galbus strain K61) (Accession No. DSM 7206)         (MYCOSTOP® from Verdera; PREFENCE® from BioWorks; cf. Crop         Protection 2006, 25, 468-475); (B1.33) Pseudomonas fluorescens         strain A506 (e.g. BLIGHTBAN® A506 by NuFarm); and     -   (B2) fungi, for example: (B2.1) Coniothyrium minitans, in         particular strain CON/M/91-8 (Accession No. DSM-9660; e.g.         Contans® from Bayer CropScience Biologics GmbH); (B2.2)         Metschnikowia fructicola, in particular strain NRRL Y-30752;         (B2.3) Microsphaeropsis ochracea; (B2.5) Trichoderma atroviride,         in particular strain SC1 (having Accession No. CBS 122089, WO         2009/116106 and U.S. Pat. No. 8,431,120 (from Bi-PA)), strain         77B (T77 from Andermatt Biocontrol) or strain LU132 (e.g.         Sentinel from Agrimm Technologies Limited); (B2.6) Trichoderma         harzianum strain T-22 (e.g. Trianum-P from Andermatt Biocontrol         or Koppert) or strain Cepa Simb-T5 (from Simbiose Agro); (B2.14)         Gliocladium roseum (also known as Clonostachys rosea f, rosea),         in particular strain 321U from Adjuvants Plus, strain ACM941 as         disclosed in Xue (Efficacy of Clonostachys rosea strain ACM941         and fungicide seed treatments for controlling the root tot         complex of field pea, Can Jour Plant Sci 83(3): 519-524), or         strain IK726 (Jensen D F, et al. Development of a biocontrol         agent for plant disease control with special emphasis on the         near commercial fungal antagonist Clonostachys rosea strain         ‘IK726’; Australas Plant Pathol. 2007; 36:95-101); (B2.35)         Talaromyces flavus, strain V117b; (B2.36) Trichoderma viride, in         particular strain B35 (Pietr et al., 1993, Zesz. Nauk. A R w         Szczecinie 161: 125-137); (B2.37) Trichoderma asperellum, in         particular strain SKT-1, having Accession No. FERM P-16510 (e.g.         ECO-HOPE® from Kumiai Chemical Industry), strain T34 (e.g. T34         Biocontrol by Biocontrol Technologies S.L., ES) or strain ICC         012 from Isagro; (B2.38) Trichoderma atroviride, strain CNCM         I-1237 (e.g. Esquive® WP from Agrauxine, FR); (B2.39)         Trichoderma atroviride, strain no. V08/002387; (B2.40)         Trichoderma atroviride, strain NMI no. V08/002388; (B2.41)         Trichoderma atroviride, strain NMI no. V08/002389; (B2.42)         Trichoderma atroviride, strain NMI no. V08/002390; (B2.43)         Trichoderma atroviride, strain LC52 (e.g. Tenet by Agrimm         Technologies Limited); (B2.44) Trichoderma atroviride, strain         ATCC 20476 (IMI 206040); (B2.45) Trichoderma atroviride, strain         T11 (IMI352941/CECT20498); (B2.46) Trichoderma harmatum; (B2.47)         Trichoderma harzianum; (B2.48) Trichoderma harzianum rifai T39         (e.g. Trichodex® from Makhteshim, US); (B2.49) Trichoderma         asperellum, in particular, strain kd (e.g. T-Gro from Andermatt         Biocontrol); (B2.50) Trichoderma harzianum, strain ITEM 908         (e.g. Trianum-P from Koppert); (B2.51) Trichoderma harzianum,         strain TH35 (e.g. Root-Pro by Mycontrol); (B2.52) Trichoderma         virens (also known as Gliocladium virens), in particular strain         GL-21 (e.g. SoilGard by Certis, US); (B2.53) Trichoderma viride,         strain TV1(e.g. Trianum-P by Koppert); (B2.54) Ampelomyces         quisqualis, in particular strain AQ 10 (e.g. AQ 10® by         IntrachemBio Italia); (B2.56) Aureobasidium pullulans, in         particular blastospores of strain DSM14940; (B2.57)         Aureobasidium pullulans, in particular blastospores of strain         DSM 14941; (B2.58) Aureobasidium pullulans, in particular         mixtures of blastospores of strains DSM14940 and DSM 14941 (e.g.         Botector® by bio-ferm, CH); (B2.64) Cladosporium         cladosporioides, strain H39, having Accession No. CBS122244, US         2010/0291039 (by Stichting Dienst Landbouwkundig Onderzoek);         (B2.69) Gliocladium catenulatum (Synonym: Clonostachys rosea f         catenulate) strain J1446 (e.g. Prestop® by Lallemand); (B2.70)         Lecanicillium lecanii (formerly known as Verticillium lecanii)         conidia of strain KVO1 (e.g. Vertalec® by Koppert/Arysta);         (B2.71) Penicillium vermiculatum; (B2.72) Pichia anomala, strain         WRL-076 (NRRL Y-30842), U.S. Pat. No. 7,579,183; (B2.75)         Trichoderma atroviride, strain SKT-1 (FERM P-16510), JP Patent         Publication (Kokai) 11-253151 A; (B2.76) Trichoderma atroviride,         strain SKT-2 (FERM P-16511), JP Patent Publication (Kokai)         11-253151 A; (B2.77) Trichoderma atroviride, strain SKT-3 (FERM         P-17021), JP Patent Publication (Kokai) 11-253151 A; (B2.78)         Trichoderma gamsii (formerly T. viride), strain ICC080 (IMI CC         392151 CABI, e.g. BioDerma by AGROBIOSOL DE MEXICO, S.A. DE         C.V.); (B2.79) Trichoderma harzianum, strain DB 103 (available         as T-GRO® 7456 by Dagutat Biolab); (B2.80) Trichoderma         polysporum, strain IMI 206039 (e.g. Binab TF WP by BINAB         Bio-Innovation AB, Sweden); (B2.81) Trichoderma stromaticum,         having Accession No. Ts3550 (e.g. Tricovab by CEPLAC, Brazil);         (B2.83) Ulocladium oudemansii strain U3, having Accession No. NM         99/06216 (e.g., BOTRY-ZEN® by Botry-Zen Ltd, New Zealand and         BOTRYSTOP® from BioWorks, Inc.); (B2.84) Verticillium albo-atrum         (formerly V. dahliae), strain WCS850 having Accession No.         WCS850, deposited at the Central Bureau for Fungi Cultures         (e.g., DUTCH TRIG® by Tree Care Innovations); (B2.86)         Verticillium chlamydosporium; (B2.87) mixtures of Trichoderma         asperellum strain ICC 012 (also known as Trichoderma harzianum         ICC012), having Accession No. CABI CC IMI 392716 and Trichoderma         gamsii (formerly T. viride) strain ICC 080, having Accession No.         IMI 392151 (e.g., BIO-TAM™ from Isagro USA, Inc. and BIODERMA®         by Agrobiosol de Mexico, S.A. de C.V.); (B2.88) Trichoderma         asperelloides JM41R (Accession No. NRRL B-50759) (TRICHO PLUS®         from BASF SE); (B2.89) Aspergillus flavus strain NRRL 21882         (products known as AFLA-GUARD® from Syngenta/ChemChina); (B2.90)         Chaetomium cupreum (Accession No. CABI 353812) (e.g. BIOKUPRUM™         by AgriLife); (B2.91) Saccharomyces cerevisiae, in particular         strain LASO2 (from Agro-Levures et D6riv6s), strain LAS117 cell         walls (CEREVISANE® from Lesaffre; ROMEO® from BASF SE), strains         CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. I-3938, CNCM No.         I-3939 (WO 2010/086790) from Lesaffre et Compagnie, FR; (B2.92)         Trichoderma virens strain G-41, formerly known as Gliocladium         virens (Accession No. ATCC 20906) (e.g., ROOTSHIELD® PLUS WP and         TURFSHIELD® PLUS WP from BioWorks, US); (B2.93) Trichoderma         hamatum, having Accession No. ATCC 28012; (B2.94) Ampelomyces         quisqualis strain AQ10, having Accession No. CNCM I-807 (e.g.,         AQ 10® by IntrachemBio Italia); (B2.95) Phlebiopsis gigantea         strain VRA 1992 (ROTSTOP® C from Danstar Ferment); (B2.96)         Penicillium steckii (DSM 27859; WO 2015/067800) from BASF SE;         (B2.97) Chaetomium globosum (available as RIVADIOM® by Rivale);         (B2.98) Cryptococcus flavescens, strain 3C (NRRL Y-50378);         (B2.99) Dactylaria candida; (B2.100) Dilophosphora alopecuri         (available as TWIST FUNGUS®); (B2.101) Fusarium oxysporum,         strain Fo47 (available as FUSACLEAN® by Natural Plant         Protection); (B2.102) Pseudozyma flocculosa, strain PF-A22 UL         (available as SPORODEX® L by Plant Products Co., CA); (B2.103)         Trichoderma gamsii (formerly T. viride), strain ICC 080 (IMI CC         392151 CABI) (available as BIODERMA® by AGROBIOSOL DE MEXICO,         S.A. DE C.V.); (B2.104) Trichoderma fertile (e.g. product         TrichoPlus from BASF); (B2.105) Muscodor roseus, in particular         strain A3-5 (Accession No. NRRL 30548); (B2.106) Simplicillium         lanosoniveum;     -   biological control agents having an effect for improving plant         growth and/or plant health which may be combined in the compound         combinations according to the invention including     -   (C1) bacteria selected from the group consisting of Bacillus         pumilus, in particular strain QST2808 (having Accession No. NRRL         No. B-30087); Bacillus subtilis, in particular strain         QST713/AQ713 (having NRRL Accession No. B-21661 and described in         U.S. Pat. No. 6,060,051; available as SERENADE® OPTI or         SERENADE® ASO from Bayer CropScience LP, US); Bacillus subtilis,         in particular strain AQ30002 (having Accession Nos. NRRL B-50421         and described in U.S. patent application Ser. No. 13/330,576);         Bacillus subtilis, in particular strain AQ30004 (and NRRL         B-50455 and described in U.S. patent application Ser. No.         13/330,576); Sinorhizobium meliloti strain NRG-185-1 (NITRAGIN®         GOLD from Bayer CropScience); Bacillus subtilis strain BU1814,         (available as TEQUALIS® from BASF SE); Bacillus subtilis rm303         (RHIZOMAX® from Biofilm Crop Protection); Bacillus         amyloliquefaciens pm414 (LOLI-PEPTA® from Biofilm Crop         Protection); Bacillus mycoides BT155 (NRRL No. B-50921),         Bacillus mycoides EE118 (NRRL No. B-50918), Bacillus mycoides         EE141 (NRRL No. B-50916), Bacillus mycoides BT46-3 (NRRL No.         B-50922), Bacillus cereus family member EE128 (NRRL No.         B-50917), Bacillus thuringiensis BT013A (NRRL No. B-50924) also         known as Bacillus thuringiensis 4Q7, Bacillus cereus family         member EE349 (NRRL No. B-50928), Bacillus amyloliquefaciens         SB3281 (ATCC #PTA-7542; WO 2017/205258), Bacillus         amyloliquefaciens TJ1000 (available as QUIKROOTS® from         Novozymes); Bacillus firmus, in particular strain CNMC I-1582         (e.g. VOTIVO® from BASF SE); Bacillus pumilus, in particular         strain GB34 (e.g. YIELD SHIELD® from Bayer Crop Science, DE);         Bacillus amyloliquefaciens, in particular strain IN937a;         Bacillus amyloliquefaciens, in particular strain FZB42 (e.g.         RHIZOVITAL® from ABiTEP, DE); Bacillus amyloliquefaciens BS27         (Accession No. NRRL B-5015); a mixture of Bacillus licheniformis         FMCH001 and Bacillus subtilis FMCH002 (available as QUARTZO®         (WG), PRESENCE® (WP) from FMC Corporation); Bacillus cereus, in         particular strain BP01 (ATCC 55675; e.g. MEPICHLOR® from Arysta         Lifescience, US); Bacillus subtilis, in particular strain MBI         600 (e.g. SUBTILEX® from BASF SE); Bradyrhizobium japonicum         (e.g. OPTIMIZE® from Novozymes); Mesorhizobium cicer (e.g.,         NODULATOR from BASF SE); Rhizobium leguminosarium biovar viciae         (e.g., NODULATOR from BASF SE); Delftia acidovorans, in         particular strain RAY209 (e.g. BIOBOOST® from Brett Young         Seeds); Lactobacillus sp. (e.g. LACTOPLANT® from LactoPAFI);         Paenibacillus polymyxa, in particular strain AC-1 (e.g. TOPSEED®         from Green Biotech Company Ltd.); Pseudomonas proradix (e.g.         PRORADIX® from Sourcon Padena); Azospirillum brasilense (e.g.,         VIGOR® from KALO, Inc.); Azospirillum lipoferum (e.g.,         VERTEX-IF™ from TerraMax, Inc.); a mixture of Azotobacter         vinelandii and Clostridium pasteurianum (available as         INVIGORATE® from Agrinos); Pseudomonas aeruginosa, in particular         strain PN1; Rhizobium leguminosarum, in particular bv. viceae         strain Z25 (Accession No. CECT 4585); Azorhizobium caulinodans,         in particular strain ZB-SK-5; Azotobacter chroococcum, in         particular strain H23; Azotobacter vinelandii, in particular         strain ATCC 12837; Bacillus siamensis, in particular strain KCTC         13613T; Bacillus tequilensis, in particular strain NII-0943;         Serratia marcescens, in particular strain SRM (Accession No.         MTCC 8708); Thiobacillus sp. (e.g. CROPAID® from Cropaid Ltd         UK); and (C2) fungi selected from the group consisting of         Purpureocillium lilacinum (previously known as Paecilomyces         lilacinus) strain 251 (AGAL 89/030550; e.g. BioAct from Bayer         CropScience Biologics GmbH)Penicillium bilaii, strain ATCC 22348         (e.g. JumpStart® from Acceleron BioAg), Talaromyces flavus,         strain V117b; Trichoderma atroviride strain CNCM I-1237 (e.g.         Esquive® WP from Agrauxine, FR), Trichoderma viride, e.g. strain         B35 (Pietr et al., 1993, Zesz. Nauk. A R w Szczecinie 161:         125-137); Trichoderma atroviride strain LC52 (also known as         Trichoderma atroviride strain LU132; e.g. Sentinel from Agrimm         Technologies Limited); Trichoderma atroviride strain SC1         described in International Application No. PCT/IT2008/000196);         Trichoderma asperellum strain kd (e.g. T-Gro from Andermatt         Biocontrol); Trichoderma asperellum strain Eco-T (Plant Health         Products, ZA); Trichoderma harzianum strain T-22 (e.g. Trianum-P         from Andermatt Biocontrol or Koppert); Myrothecium verrucaria         strain AARC-0255 (e.g. DiTera™ from Valent Biosciences);         Penicillium bilaii strain ATCC ATCC20851; Pythium oligandrum         strain M1 (ATCC 38472; e.g. Polyversum from Bioprepraty, CZ);         Trichoderma virens strain GL-21 (e.g. SoilGard® from Certis,         USA); Verticillium albo-atrum (formerly V. dahliae) strain         WCS850 (CBS 276.92; e.g. Dutch Trig from Tree Care Innovations);         Trichoderma atroviride, in particular strain no. V08/002387,         strain no. NMI No. V08/002388, strain no. NMI No. V08/002389,         strain no. NMI No. V08/002390; Trichoderma harzianum strain ITEM         908; Trichoderma harzianum, strain TSTh20; Trichoderma harzianum         strain 1295-22; Pythium oligandrum strain DV74; Rhizopogon         amylopogon (e.g. comprised in Myco-Sol from Helena Chemical         Company); Rhizopogon fulvigleba (e.g. comprised in Myco-Sol from         Helena Chemical Company); and Trichoderma virens strain GI-3;     -   insecticidally active biological control agents selected from     -   (D1) bacteria selected from the group consisting of Bacillus         thuringiensis subsp. aizawai, in particular strain ABTS-1857         (SD-1372; e.g. XENTARI® from Valent BioSciences); Bacillus         mycoides, isolate J. (e.g. BmJ from Certis USA LLC, a subsidiary         of Mitsui & Co.); Bacillus sphaericus, in particular Serotype         H5a5b strain 2362 (strain ABTS-1743) (e.g. VECTOLEX® from Valent         BioSciences, US); Bacillus thuringiensis subsp. kurstaki strain         BMP 123 from Becker Microbial Products, IL; Bacillus         thuringiensis subsp. aizawai, in particular serotype H-7 (e.g.         FLORBAC® WG from Valent BioSciences, US); Bacillus thuringiensis         subsp. kurstaki strain HD-1 (e.g. DIPEL® ES from Valent         BioSciences, US); Bacillus thuringiensis subsp. kurstaki strain         BMP 123 by Becker Microbial Products, IL; Bacillus thuringiensis         israelensis strain BMP 144 (e.g. AQUABAC® by Becker Microbial         Products IL); Burkholderia spp., in particular Burkholderia         rinojensis strain A396 (also known as Burkholderia rinojensis         strain MBI 305) (Accession No. NRRL B-50319; WO 2011/106491 and         WO 2013/032693; e.g. MBI-206 TGAI and ZELTO® from Marrone Bio         Innovations); Chromobacterium subtsugae, in particular strain         PRAA4-1T (MBI-203; e.g. GRANDEVO® from Marrone Bio Innovations);         Paenibacillus popilliae (formerly Bacillus popilliae; e.g. MILKY         SPORE POWDER™ and MILKY SPORE GRANULAR™ from St. Gabriel         Laboratories); Bacillus thuringiensis subsp. israelensis         (serotype H-14) strain AM65-52 (Accession No. ATCC 1276) (e.g.         VECTOBAC® by Valent BioSciences, US); Bacillus thuringiensis         var. kurstaki strain EVB-113-19 (e.g., BIOPROTEC® from AEF         Global); Bacillus thuringiensis subsp. tenebrionis strain NB 176         (SD-5428; e.g. NOVODOR® FC from BioFa DE); Bacillus         thuringiensis var. japonensis strain Buibui; Bacillus         thuringiensis subsp. kurstaki strain ABTS 351; Bacillus         thuringiensis subsp. kurstaki strain PB 54; Bacillus         thuringiensis subsp. kurstaki strain SA 11; Bacillus         thuringiensis subsp. kurstaki strain SA 12; Bacillus         thuringiensis subsp. kurstaki strain EG 2348; Bacillus         thuringiensis var. Colmeri (e.g. TIANBAOBTC by Changzhou         Jianghai Chemical Factory); Bacillus thuringiensis subsp.         aizawai strain GC-91; Serratia entomophila (e.g. INVADE® by         Wrightson Seeds); Serratia marcescens, in particular strain SRM         (Accession No. MTCC 8708); and Wolbachia pipientis ZAP strain         (e.g., ZAP MALES® from MosquitoMate); and (D2) fungi selected         from the group consisting of Isaria fumosorosea (previously         known as Paecilomyces fumosoroseus) strain apopka 97; Beauveria         bassiana strain ATCC 74040 (e.g. NATURALIS® from Intrachem Bio         Italia); Beauveria bassiana strain GHA (Accession No. ATCC74250;         e.g. BOTANIGUARD® ES and MYCONTROL-O® from Laverlam         International Corporation); Zoophtora radicans; Metarhizium         robertsii 15013-1 (deposited under NRRL accession number 67073),         Metarhizium robertsii 23013-3 (deposited under NRRL accession         number 67075), and Metarhizium anisopliae 3213-1 (deposited         under NRRL accession number 67074) (WO 2017/066094; Pioneer         Hi-Bred International); Beauveria bassiana strain ATP02         (Accession No. DSM 24665). Among these, Isaria fumosorosea         (previously known as Paecilomyces fumosoroseus) strain apopka 97         is particularly preferred;     -   (E) viruses selected from the group consisting of Adoxophyes         orana (summer fruit tortrix) granulosis virus (GV), Cydia         pomonella (codling moth) granulosis virus (GV), Helicoverpa         armigera (cotton bollworm) nuclear polyhedrosis virus (NPV),         Spodoptera exigua (beet armyworm) mNPV, Spodoptera frugiperda         (fall armyworm) mNPV, and Spodoptera littoralis (African cotton         leafworm) NPV;     -   (F) bacteria and fungi which can be added as ‘inoculant’ to         plants or plant parts or plant organs and which, by virtue of         their particular properties, promote plant growth and plant         health. Examples are: Agrobacterium spp., Azorhizobium         caulinodans, Azospirillum spp., Azotobacter spp., Bradyrhizobium         spp., Burkholderia spp., in particular Burkholderia cepacia         (formerly known as Pseudomonas cepacia), Gigaspora spp., or         Gigaspora monosporum, Glomus spp., Laccaria spp., Lactobacillus         buchneri, Paraglomus spp., Pisolithus tinctorus, Pseudomonas         spp., Rhizobium spp., in particular Rhizobium trifolii,         Rhizopogon spp., Scleroderma spp., Suillus spp., and         Streptomyces spp.; and     -   (G) plant extracts and products formed by microorganisms         including proteins and secondary metabolites which can be used         as biological control agents, such as Allium sativum, Artemisia         absinthium, azadirachtin, Biokeeper WP, Cassia nigricans,         Celastrus angulatus, Chenopodium anthelminticum, chitin,         Armour-Zen, Dryopteris filix-mas, Equisetum arvense, Fortune         Aza, Fungastop, Heads Up (Chenopodium quinoa saponin extract),         Pyrethrum/Pyrethrins, Quassia amara, Quercus, Quillaja, Regalia,         “Requiem™ Insecticide”, rotenone, ryania/ryanodine, Symphytum         officinale, Tanacetum vulgare, thymol, Triact 70, TriCon,         Tropaeulum majus, Urtica dioica, Veratrin, Viscum album,         Brassicaceae extract, in particular oilseed rape powder or         mustard powder, as well as bioinsecticidal/acaricidal active         substances obtained from olive oil, in particular unsaturated         fatty/carboxylic acids having carbon chain lengths C₁₆-C₂₀ as         active ingredients, such as, for example, contained in the         product with the trade name FLiPPER®.

The compound of formula (I) and the composition of the invention may be combined with one or more active ingredients selected from insecticides, acaricides and nematicides.

“Insecticides” as well as the term “insecticidal” refers to the ability of a substance to increase mortality or inhibit growth rate of insects. As used herein, the term “insects” comprises all organisms in the class “Insecta”.

“Nematicide” and “nematicidal” refers to the ability of a substance to increase mortality or inhibit the growth rate of nematodes. In general, the term “nematode” comprises eggs, larvae, juvenile and mature forms of said organism.

“Acaricide” and “acaricidal” refers to the ability of a substance to increase mortality or inhibit growth rate of ectoparasites belonging to the class Arachnida, sub-class Acari.

Examples of insecticides, acaricides and nematicides, respectively, which could be mixed with the compound of formula (I) and the composition of the invention are:

-   -   (1) Acetylcholinesterase (AChE) inhibitors, such as, for         example, carbamates, for example alanycarb, aldicarb,         bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl,         carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate,         furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb,         oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate,         trimethacarb, XMC and xylylcarb; or organophosphates, for         example acephate, azamethiphos, azinphos-ethyl, azinphos-methyl,         cadusafos, chlorethoxyfos, chlorfenvinphos, chlormephos,         chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl,         diazinon, dichlorvos/DDVP, dicrotophos, dimethoate,         dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur,         fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos,         imicyafos, isofenphos, isopropyl O-(methoxyaminothiophosphoryl)         salicylate, isoxathion, malathion, mecarbam, methamidophos,         methidathion, mevinphos, monocrotophos, naled, omethoate,         oxydemeton-methyl, parathion-methyl, phenthoate, phorate,         phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl,         profenofos, propetamphos, prothiofos, pyraclofos,         pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos,         terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon         and vamidothion.     -   (2) GABA-gated chloride channel blockers, such as, for example,         cyclodiene-organochlorines, for example chlordane and endosulfan         or phenylpyrazoles (fiproles), for example ethiprole and         fipronil.     -   (3) Sodium channel modulators, such as, for example,         pyrethroids, e.g. acrinathrin, allethrin, d-cis-trans allethrin,         d-trans allethrin, bifenthrin, bioallethrin, bioallethrin         s-cyclopentenyl isomer, bioresmethrin, cycloprothrin,         cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin,         gamma-cyhalothrin, cypermethrin, alpha-cypermethrin,         beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin,         cyphenothrin [(1R)-trans-isomer], deltamethrin, empenthrin         [(EZ)-(1R)-isomer], esfenvalerate, etofenprox, fenpropathrin,         fenvalerate, flucythrinate, flumethrin, tau-fluvalinate,         halfenprox, imiprothrin, kadethrin, momfluorothrin, permethrin,         phenothrin [(1R)-trans-isomer], prallethrin, pyrethrins         (pyrethrum), resmethrin, silafluofen, tefluthrin, tetramethrin,         tetramethrin [(1R)-isomer)], tralomethrin and transfluthrin or         DDT or methoxychlor.     -   (4) Nicotinic acetylcholine receptor (nAChR) competitive         modulators, such as, for example, neonicotinoids, e.g.         acetamiprid, clothianidin, dinotefuran, imidacloprid,         nitenpyram, thiacloprid and thiamethoxam or nicotine or         sulfoxaflor or flupyradifurone.     -   (5) Nicotinic acetylcholine receptor (nAChR) allosteric         modulators, such as, for example, spinosyns, e.g. spinetoram and         spinosad.     -   (6) Glutamate-gated chloride channel (GluCl) allosteric         modulators, such as, for example, avermectins/milbemycins, for         example abamectin, emamectin benzoate, lepimectin and         milbemectin.     -   (7) Juvenile hormone mimics, such as, for example, juvenile         hormone analogues, e.g. hydroprene, kinoprene and methoprene or         fenoxycarb or pyriproxyfen.     -   (8) Miscellaneous non-specific (multi-site) inhibitors, such as,         for example, alkyl halides, e.g. methyl bromide and other alkyl         halides; or chloropicrine or sulphuryl fluoride or borax or         tartar emetic or methyl isocyanate generators, e.g. diazomet and         metam.     -   (9) Modulators of Chordotonal Organs, such as, for example         pymetrozine or flonicamid.     -   (10) Mite growth inhibitors, such as, for example clofentezine,         hexythiazox and diflovidazin or etoxazole.     -   (11) Microbial disruptors of the insect gut membrane, such as,         for example Bacillus thuringiensis subspecies israelensis,         Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai,         Bacillus thuringiensis subspecies kurstaki, Bacillus         thuringiensis subspecies tenebrionis, and B.t. plant proteins:         Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A,         Cry3Ab, Cry3Bb, Cry34Ab1/35Ab1.     -   (12) Inhibitors of mitochondrial ATP synthase, such as, ATP         disruptors such as, for example, diafenthiuron or organotin         compounds, for example azocyclotin, cyhexatin and fenbutatin         oxide or propargite or tetradifon.     -   (13) Uncouplers of oxidative phosphorylation via disruption of         the proton gradient, such as, for example, chlorfenapyr, DNOC         and sulfluramid.     -   (14) Nicotinic acetylcholine receptor channel blockers, such as,         for example, bensultap, cartap hydrochloride, thiocylam, and         thiosultap-sodium.     -   (15) Inhibitors of chitin biosynthesis, type 0, such as, for         example, bistrifluron, chlorfluazuron, diflubenzuron,         flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron,         noviflumuron, teflubenzuron and triflumuron.     -   (16) Inhibitors of chitin biosynthesis, type 1, for example         buprofezin.     -   (17) Moulting disruptor (in particular for Diptera, i.e.         dipterans), such as, for example, cyromazine.     -   (18) Ecdysone receptor agonists, such as, for example,         chromafenozide, halofenozide, methoxyfenozide and tebufenozide.     -   (19) Octopamine receptor agonists, such as, for example,         amitraz.     -   (20) Mitochondrial complex III electron transport inhibitors,         such as, for example, hydramethylnone or acequinocyl or         fluacrypyrim.     -   (21) Mitochondrial complex I electron transport inhibitors, such         as, for example from the group of the METI acaricides, e.g.         fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad         and tolfenpyrad or rotenone (Derris).     -   (22) Voltage-dependent sodium channel blockers, such as, for         example indoxacarb or metaflumizone.     -   (23) Inhibitors of acetyl CoA carboxylase, such as, for example,         tetronic and tetramic acid derivatives, e.g. spirodiclofen,         spiromesifen and spirotetramat.     -   (24) Mitochondrial complex IV electron transport inhibitors,         such as, for example, phosphines, e.g. aluminium phosphide,         calcium phosphide, phosphine and zinc phosphide or cyanides,         e.g. calcium cyanide, potassium cyanide and sodium cyanide.     -   (25) Mitochondrial complex II electron transport inhibitors,         such as, for example, beta-ketonitrile derivatives, e.g.         cyenopyrafen and cyflumetofen and carboxanilides, such as, for         example, pyflubumide.     -   (28) Ryanodine receptor modulators, such as, for example,         diamides, e.g. chlorantraniliprole, cyantraniliprole and         flubendiamide,     -   further active compounds such as, for example, Afidopyropen,         Afoxolaner, Azadirachtin, Benclothiaz, Benzoximate, Bifenazate,         Broflanilide, Bromopropylate, Chinomethionat, Chloroprallethrin,         Cryolite, Cyclaniliprole, Cycloxaprid, Cyhalodiamide,         Dicloromezotiaz, Dicofol, epsilon-Metofluthrin,         epsilon-Momfluthrin, Flometoquin, Fluazaindolizine,         Fluensulfone, Flufenerim, Flufenoxystrobin, Flufiprole,         Fluhexafon, Fluopyram, Fluralaner, Fluxametamide, Fufenozide,         Guadipyr, Heptafluthrin, Imidaclothiz, Iprodione,         kappa-Bifenthrin, kappa-Tefluthrin, Lotilaner, Meperfluthrin,         Paichongding, Pyridalyl, Pyrifluquinazon, Pyriminostrobin,         Spirobudiclofen, Tetramethylfluthrin, Tetraniliprole,         Tetrachlorantraniliprole, Tigolaner, Tioxazafen, Thiofluoximate,         Triflumezopyrim and iodomethane; furthermore preparations based         on Bacillus firmus (I-1582, BioNeem, Votivo), and also the         following compounds:         1-{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazole-5-amine         (known from WO2006/043635) (CAS 885026-50-6),         {1′-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]-5-fluorospiro[indol-3,4′-piperidin]-1(2H)-yl}(2-chloropyridin-4-yl)methanone         (known from WO2003/106457) (CAS 637360-23-7),         2-chloro-N-[2-{1-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]piperidin-4-yl}-4-(trifluoromethyl)phenyl]isonicotinamide         (known from WO2006/003494) (CAS 872999-66-1),         3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one         (known from WO 2010052161) (CAS 1225292-17-0),         3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl         ethyl carbonate (known from EP2647626) (CAS 1440516-42-6),         4-(but-2-yn-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluoro-pyrimidine         (known from WO2004/099160) (CAS 792914-58-0), PF1364 (known from         JP2010/018586) (CAS 1204776-60-2),         N-[(2E)-1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide         (known from WO2012/029672) (CAS 1363400-41-2),         (3E)-3-[1-[(6-chloro-3-pyridyl)methyl]-2-pyridylidene]-1,1,1-trifluoro-propan-2-one         (known from WO2013/144213) (CAS 1461743-15-6),         N-[3-(benzylcarbamoyl)-4-chlorophenyl]-1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide         (known from WO2010/051926) (CAS 1226889-14-0),         5-bromo-4-chloro-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazole-3-carboxamide         (known from CN103232431) (CAS 1449220-44-3),         4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)-benzamide,         4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(trans-1-oxido-3-thietanyl)-benzamide         and         4-[(5S)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)benzamide         (known from WO 2013/050317 A1) (CAS 1332628-83-7),         N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]-propanamide,         (+)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]-propanamide         and         (−)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]-propanamide         (known from WO 2013/162715 A2, WO 2013/162716 A2, US         2014/0213448 A1) (CAS 1477923-37-7),         5-[[(2E)-3-chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile         (known from CN 101337937 A) (CAS 1105672-77-2),         3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)thioxomethyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide,         (Liudaibenjiaxuanan, known from CN 103109816 A) (CAS         1232543-85-9);         N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-Pyrazole-5-carboxamide         (known from WO 2012/034403 A1) (CAS 1268277-22-0),         N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide         (known from WO 2011/085575 A1) (CAS 1233882-22-8),         4-[3-[2,6-dichloro-4-[(3,3-dichloro-2-propen-1-yl)oxy]phenoxy]propoxy]-2-methoxy-6-(trifluoromethyl)-pyrimidine         (known from CN 101337940 A) (CAS 1108184-52-6); (2E)- and         2(Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy)phenyl]-hydrazinecarboxamide         (known from CN 101715774 A) (CAS 1232543-85-9);         3-(2,2-dichloroethenyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenyl-cyclopropanecarboxylic         acid ester (known from CN 103524422 A) (CAS 1542271-46-4);         (4aS)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)thio]phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic         acid methyl ester (known from CN 102391261 A) (CAS         1370358-69-2); 6-deoxy-3-O-ethyl-2,4-di-O-methyl-,         1-[N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1H-1,2,4-triazol-3-yl]phenyl]carbamate]-α-L-mannopyranose         (known from US 2014/0275503 A1) (CAS 1181213-14-8);         8-(2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethyl-pyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane         (CAS 1253850-56-4),         (8-anti)-8-(2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethyl-pyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane         (CAS 933798-27-7),         (8-syn)-8-(2-cyclopropylmethoxy-4-trifluoromethyl-phenoxy)-3-(6-trifluoromethyl-pyridazin-3-yl)-3-aza-bicyclo[3.2.1]octane         (known from WO2007/040280 A1, WO 2007040282 A1) (CAS         934001-66-8),         N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]-propanamide         (known from WO 2015/058021 A1, WO 2015/058028 A1) (CAS         1477919-27-9) and         N-[4-(aminothioxomethyl)-2-methyl-6-[(methylamino)carbonyl]phenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide         (known from CN 103265527 A) (CAS 1452877-50-7),         5-(1,3-dioxan-2-yl)-4-[[4-(trifluoromethyl)phenyl]methoxy]-pyrimidine         (known from WO 2013/115391 A1) (CAS 1449021-97-9),         3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-methoxy-1-methyl-1,8-diazaspiro[4.5]dec-3-en-2-one         (known from WO 2010/066780 A1, WO 2011/151146 A1) (CAS         1229023-34-0),         3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-1,8-diazaspiro[4.5]decane-2,4-dione         (known from WO 2014/187846 A1) (CAS 1638765-58-8),         3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl-carbonic         acid ethyl ester (known from WO 2010/066780 A1, WO 2011151146         A1) (CAS 1229023-00-0),         N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoro-acetamide         (known from DE 3639877 A1, WO 2012029672 A1) (CAS 1363400-41-2),         [N(E)]-N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoro-acetamide,         (known from WO 2016005276 A1) (CAS 1689566-03-7),         [N(Z)]—N-[1-[(6-chloro-3-pyridinyl)methyl]-2(1H)-pyridinylidene]-2,2,2-trifluoro-acetamide,         (CAS 1702305-40-5),         3-endo-3-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-9-azabicyclo[3.3.1]nonane         (known from WO 2011/105506 A1, WO 2016/133011 A1) (CAS         1332838-17-1).

Examples of herbicides which could be mixed with the compound of formula (I) and the composition of the invention are:

Acetochlor, acifluorfen, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)pyridine-2-carboxylic acid, aminocyclopyrachlor, aminocyclopyrachlor-potassium, aminocyclopyrachlor-methyl, aminopyralid, amitrole, ammoniumsulfamate, anilofos, asulam, atrazine, azafenidin, azimsulfuron, beflubutamid, benazolin, benazolin-ethyl, benfluralin, benfuresate, bensulfuron, bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap, bicyclopyron, bifenox, bilanafos, bilanafos-sodium, bispyribac, bispyribac-sodium, bixlozone, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil-butyrate, -potassium, -heptanoate, and -octanoate, busoxinone, butachlor, butafenacil, butamifos, butenachlor, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone, carfentrazone-ethyl, chloramben, chlorbromuron, 1-{2-chloro-3-[(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazol-4-yl)carbonyl]-6-(trifluormethyl)phenyl}piperidin-2-on, 4-{2-chloro-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-(methylsulfonyl)benzoyl}-1,3-dimethyl-1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazol-4-carboxylat, chlorfenac, chlorfenac-sodium, chlorfenprop, chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, 2-[2-chloro-4-(methylsulfonyl)-3-(morpholin-4-ylmethyl)benzoyl]-3-hydroxycyclohex-2-en-1-on, 4-{2-chloro-4-(methylsulfonyl)-3-[(2,2,2-trifluoroethoxy)methyl]benzoyl}-1-ethyl-1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazol-4-carboxylat, chlorophthalim, chlorotoluron, chlorthal-dimethyl, 3-[5-chloro-4-(trifluormethyl)pyridine-2-yl]-4-hydroxy-1-methylimidazolidine-2-on, chlorsulfuron, cinidon, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clethodim, clodinafop, clodinafop-propargyl, clomazone, clomeprop, clopyralid, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cycloate, cyclopyranil, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop, cyhalofop-butyl, cyprazine, 2,4-D, 2,4-D-butotyl, -butyl, -dimethylammonium, -diolamin, -ethyl, -2-ethylhexyl, -isobutyl, -isooctyl, -isopropylammonium, -potassium, -triisopropanolammonium, and -trolamine, 2,4-DB, 2,4-DB-butyl, -dimethylammonium, -isooctyl, -potassium, and -sodium, daimuron (dymron), dalapon, dazomet, n-decanol, desmedipham, detosyl-pyrazolate (DTP), dicamba, dichlobenil, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, diclofop-P-methyl, diclosulam, difenzoquat, diflufenican, diflufenzopyr, diflufenzopyr-sodium, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, 3-(2,6-dimethylphenyl)-6-[(2-hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1-methylchinazolin-2,4(1H,3H)-dion, 1,3-dimethyl-4-[2-(methylsulfonyl)-4-(trifluormethyl)benzoyl]-1H-pyrazol-5-yl-1,3-dimethyl-1H-pyrazol-4-carboxylat, dimetrasulfuron, dinitramine, dinoterb, diphenamid, diquat, diquat-dibromid, dithiopyr, diuron, DMPA, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron, etobenzanid, ethyl-[(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetat, F-9960, F-5231, i.e. N-{2-chloro-4-fluoro-5-[4-(3-fluoropropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl]phenyl}ethanesulfonamide, F-7967, i.e. 3-[7-chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fenquinotrione, fentrazamide, flamprop, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac, flumiclorac-pentyl, flumioxazin, fluometuron, flurenol, flurenol-butyl, -dimethylammonium and -methyl, fluoroglycofen, fluoroglycofen-ethyl, flupropanate, flupyrsulfuron, flupyrsulfuron-methyl-sodium, fluridone, flurochloridone, fluroxypyr, fluroxypyr-meptyl, flurtamone, fluthiacet, fluthiacet-methyl, fomesafen, fomesafen-sodium, foramsulfuron, fosamine, glufosinate, glufosinate-ammonium, glufosinate-P-sodium, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-ammonium, -isopropylammonium, -diammonium, -dimethylammonium, -potassium, -sodium, and -trimesium, H-9201, i.e. O-(2,4-dimethyl-6-nitrophenyl)O-ethyl isopropylphosphoramidothioate, halauxifen, halauxifen-methyl, halosafen, halosulfuron, halosulfuron-methyl, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, hexazinone, HW-02, i.e. 1-(dimethoxyphosphoryl) ethyl-(2,4-dichlorophenoxy)acetate, 4-hydroxy-1-methoxy-5-methyl-3-[4-(trifluormethyl)pyridine-2-yl]imidazolidine-2-on, 4-hydroxy-1-methyl-3-[4-(trifluormethyl)pyridine-2-yl]imidazolidine-2-on, (5-hydroxy-1-methyl-1H-pyrazol-4-yl)(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)methanon, 6-[(2-hydroxy-6-oxocyclohex-1-en-1-yl)carbonyl]-1,5-dimethyl-3-(2-methylphenyl)chinazolin-2,4(1H,3H)-dion, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonium, imazethapyr, imazethapyr-immonium, imazosulfuron, indanofan, indaziflam, iodosulfuron, iodosulfuron-methyl-sodium, ioxynil, ioxynil-octanoate, -potassium and -sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, karbutilate, KUH-043, i.e. 3-({[5-(difluoromethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole, ketospiradox, lactofen, lenacil, linuron, MCPA, MCPA-butotyl, -dimethylammonium, -2-ethylhexyl, -isopropylammonium, -potassium, and -sodium, MCPB, MCPB-methyl, -ethy,l and -sodium, mecoprop, mecoprop-sodium, and -butotyl, mecoprop-P, mecoprop-P-butotyl, -dimethylammonium, -2-ethylhexyl, and -potassium, mefenacet, mefluidide, mesosulfuron, mesosulfuron-methyl, mesotrione, methabenzthiazuron, metam, metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron, methiopyrsulfuron, methiozolin, 2-({2-[(2-methoxyethoxy)methyl]-6-(trifluormethyl)pyridin-3-yl}carbonyl)cyclohexan-1,3-dion, methyl isothiocyanate, 1-methyl-4-[(3,3,4-trimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)carbonyl]-1H-pyrazol-5-ylpropan-1-sulfonat, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, metsulfuron-methyl, molinat, monolinuron, monosulfuron, monosulfuron-ester, MT-5950, i.e. N-(3-chloro-4-isopropylphenyl)-2-methylpentan amide, NGGC-011, napropamide, NC-310, i.e. [5-(benzyloxy)-1-methyl-1H-pyrazol-4-yl](2,4-dichlorophenyl)methanone, neburon, nicosulfuron, nonanoic acid (pelargonic acid), norflurazon, oleic acid (fatty acids), orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefon, oxyfluorfen, paraquat, paraquat dichloride, pebulate, pendimethalin, penoxsulam, pentachlorphenol, pentoxazone, pethoxamid, petroleum oils, phenmedipham, picloram, picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate (pyrazolate), pyrazosulfuron, pyrazosulfuron-ethyl, pyrazoxyfen, pyribambenz, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, QYM-201, QYR-301, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, SL-261, sulcotrion, sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosulfuron, SYN-523, SYP-249, i.e. 1-ethoxy-3-methyl-1-oxobut-3-en-2-yl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate, SYP-300, i.e. 1-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA, TCA (trichloroacetic acid), TCA-sodium, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbumeton, terbuthylazin, terbutryn, tetflupyrolimet, thenylchlor, thiazopyr, thiencarbazone, thiencarbazone-methyl, thifensulfuron, thifensulfuron-methyl, thiobencarb, tiafenacil, tolpyralate, topra-mezone, tralkoxydim, triafamone, tri-allate, triasulfuron, triaziflam, tribenuron, tribenuron-methyl, triclopyr, trietazine, trifloxysulfuron, trifloxysulfuron-sodium, trifludimoxazin, trifluralin, triflusulfuron, triflusulfuron-methyl, tritosulfuron, urea sulfate, vernolate, ZJ-0862, i.e. 3,4-dichloro-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}aniline.

Examples for plant growth regulators are:

Acibenzolar, acibenzolar-S-methyl, 5-aminolevulinic acid, ancymidol, 6-benzylaminopurine, Brassinolid, catechine, chlormequat chloride, cloprop, cyclanilide, 3-(cycloprop-1-enyl) propionic acid, daminozide, dazomet, n-decanol, dikegulac, dikegulac-sodium, endothal, endothal-dipotassium, -disodium, and -mono(N,N-dimethylalkylammonium), ethephon, flumetralin, flurenol, flurenol-butyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfide, indol-3-acetic acid (IAA), 4-indol-3-ylbutyric acid, isoprothiolane, probenazole, jasmonic acid, maleic hydrazide, mepiquat chloride, 1-methyl-cyclopropene, methyl jasmonate, 2-(1-naphthyl)acetamide, 1-naphthylacetic acid, 2-naphthyloxyacetic acid, nitrophenolate-mixture, paclobutrazol, N-(2-phenylethyl)-beta-alanine, N-phenylphthalamic acid, prohexadione, prohexadione-calcium, prohydrojasmone, salicylic acid, strigolactone, tecnazene, thidiazuron, triacontanol, trinexapac, trinexapac-ethyl, tsitodef, uniconazole, uniconazole-P.

Examples of safeners which could be mixed with the compound of formula (I) and the composition of the invention are, for example, benoxacor, cloquintocet (-mexyl), cyometrinil, cyprosulfamide, dichlormid, fenchlorazole (-ethyl), fenclorim, flurazole, fluxofenim, furilazole, isoxadifen (-ethyl), mefenpyr (-diethyl), naphthalic anhydride, oxabetrinil, 2-methoxy-N-({4-[(methylcarbamoyl)-amino]phenyl}sulphonyl)benzamide (CAS 129531-12-0), 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane (CAS 71526-07-3), 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine (CAS 52836-31-4).

Examples of nitrification inhibitors which can be mixed with the compound of formula (I) and the composition of the invention are selected from the group consisting of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid, 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, 3,4-dimethyl pyrazolium glycolate, 3,4-dimethyl pyrazolium citrate, 3,4-dimethyl pyrazolium lactate, 3,4-dimethyl pyrazolium mandelate, 1,2,4-triazole, 4-Chloro-3-methylpyrazole, N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, N-((3(5),4-dimethylpyrazole-1-yl)methyl)formamide, N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide; reaction adducts of dicyandiamide, urea and formaldehyde, triazonyl-formaldehyde-dicyandiamide adducts, 2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine, 1-((2-cyanoguanidino)methyl)urea, 2-cyano-1-((2-cyanoguanidino)-methyl)guanidine, 2-chloro-6-(trichloromethyl)-pyridine (nitrapyrin or N-serve), dicyandiamide, 3,4-dimethyl pyrazole phosphate, 4,5-dimethyl pyrazole phosphate, 3,4-dimethylpyrazole, 4,5-dimethyl pyrazole, ammoniumthiosulfate, neem, products based on ingredients of neem, linoleic acid, alpha-linolenic acid, methyl p-coumarate, methyl ferulate, methyl 3-(4-hydroxyphenyl) propionate, karanjin, brachialacton, p-benzoquinone sorgoleone, 4-amino-1,2,4-triazole hydrochloride, 1-amido-2-thiourea, 2-amino-4-chloro-6-methylpyrimidine, 2-mercapto-benzothiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiodiazole (terrazole, etridiazole), 2-sulfanilamidothiazole, 3-methylpyrazol, 1,2,4-triazol thiourea, cyan amide, melamine, zeolite powder, catechol, benzoquinone, sodium tetraborate, allylthiourea, chlorate salts, and zinc sulfate.

The compound of formula (I) and the composition of the invention may be combined with one or more agriculturally beneficial agents.

Examples of agriculturally beneficial agents include biostimulants, plant growth regulators, plant signal molecules, growth enhancers, microbial stimulating molecules, biomolecules, soil amendments, nutrients, plant nutrient enhancers, etc., such as lipo-chitooligosaccharides (LCO), chitooligosaccharides (CO), chitinous compounds, flavonoids, jasmonic acid or derivatives thereof (e.g., jasmonates), cytokinins, auxins, gibberellins, absiscic acid, ethylene, brassinosteroids, salicylates, macro- and micro-nutrients, linoleic acid or derivatives thereof, linolenic acid or derivatives thereof, karrikins, and beneficial microorganisms (e.g., Rhizobium spp., Bradyrhizobium spp., Sinorhizobium spp., Azorhizobium spp., Glomus spp., Gigaspora spp., Hymenoscyphous spp., Oidiodendron spp., Laccaria spp., Pisolithus spp., Rhizopogon spp., Scleroderma spp., Rhizoctonia spp., Acinetobacter spp., Arthrobacter spp., Arthrobotrys spp., Aspergillus spp., Azospirillum spp., Bacillus spp., Burkholderia spp., Candida spp., Chryseomonas spp., Enterobacter spp., Eupenicillium spp., Exiguobacterium spp., Klebsiella spp., Kluyvera spp., Microbacterium spp., Mucor spp., Paecilomyces spp., Paenibacillus spp., Penicillium spp., Pseudomonas spp., Serratia spp., Stenotrophomonas spp., Streptomyces spp., Streptosporangium spp., Swaminathania spp., Thiobacillus spp., Torulospora spp., Vibrio spp., Xanthobacter spp., Xanthomonas spp., etc.), and combinations thereof.

Methods and Uses

The compound of formula (I) and the composition of the invention have potent microbicidal activity and/or plant defense modulating potential. They can be used for controlling unwanted microorganisms, such as unwanted fungi and bacteria, on plants. They can be particularly useful in crop protection (they control microorganisms that cause plants diseases) or for protecting materials (e.g. industrial materials, timber, storage goods) as described in more details herein below. More specifically, the compound of formula (I) and the composition of the invention can be used to protect seeds, germinating seeds, emerged seedlings, plants, plant parts, fruits, harvest goods and/or the soil in which the plants grow from unwanted microorganisms.

Control or controlling as used herein encompasses protective, curative and eradicative treatment of unwanted microorganisms. Unwanted microorganisms may be pathogenic bacteria, pathogenic virus, pathogenic oomycetes or pathogenic fungi, more specifically phytopathogenic bacteria, phytopathogenic virus, phytopathogenic oomycetes or phytopathogenic fungi. As detailed herein below, these phytopathogenic microorganism are the causal agents of a broad spectrum of plants diseases.

More specifically, the compound of formula (I) and the composition of the invention can be used as fungicides. For the purpose of the specification, the term “fungicide” refers to a compound or composition that can be used in crop protection for the control of unwanted fungi, such as Plasmodiophoromycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes and/or for the control of Oomycetes.

The compound of formula (I) and the composition of the invention may also be used as antibacterial agent. In particular, they may be used in crop protection, for example for the control of unwanted bacteria, such as Pseudomonadaceae, Rhizobiaceae, Xanthomonadaceae, Enterobacteriaceae, Corynebacteriaceae and Streptomycetaceae.

The compound of formula (I) and the composition of the invention may also be used as antiviral agent in crop protection. For example the compound of formula (I) and the composition of the invention may have effects on diseases from plant viruses, such as the tobacco mosaic virus (TMV), tobacco rattle virus, tobacco stunt virus (TStuV), tobacco leaf curl virus (VLCV), tobacco nervilia mosaic virus (TVBMV), tobacco necrotic dwarf virus (TNDV), tobacco streak virus (TSV), potato virus X (PVX), potato viruses Y, S, M, and A, potato acuba mosaic virus (PAMV), potato mop-top virus (PMTV), potato leaf-roll virus (PLRV), alfalfa mosaic virus (AMV), cucumber mosaic virus (CMV), cucumber green mottlemosaic virus (CGMMV), cucumber yellows virus (CuYV), watermelon mosaic virus (WMV), tomato spotted wilt virus (TSWV), tomato ringspot virus (TomRSV), sugarcane mosaic virus (SCMV), rice dwarf virus, rice stripe virus, rice black-streaked dwarf virus, strawberry mottle virus (SMoV), strawberry vein banding virus (SVBV), strawberry mild yellow edge virus (SMYEV), strawberry crinkle virus (SCrV), broad beanwilt virus (BBWV), and melon necrotic spot virus (MNSV).

The present invention also relates to a method for controlling unwanted microorganisms, such as unwanted fungi, oomycetes and bacteria, on plants comprising the step of applying at least one compound of formula (I) or at least one composition of the invention to the microorganisms and/or their habitat (to the plants, plant parts, seeds, fruits or to the soil in which the plants grow).

Typically, when the compound of formula (I) and the composition of the invention are used in curative or protective methods for controlling phytopathogenic fungi and/or phytopathogenic oomycetes, an effective and plant-compatible amount thereof is applied to the plants, plant parts, fruits, seeds or to the soil or substrates in which the plants grow. Suitable substrates that may be used for cultivating plants include inorganic based substrates, such as mineral wool, in particular stone wool, perlite, sand or gravel; organic substrates, such as peat, pine bark or sawdust; and petroleum based substrates such as polymeric foams or plastic beads. Effective and plant-compatible amount means an amount that is sufficient to control or destroy the fungi present or liable to appear on the cropland and that does not entail any appreciable symptom of phytotoxicity for said crops. Such an amount can vary within a wide range depending on the fungus to be controlled, the type of crop, the crop growth stage, the climatic conditions and the respective compound or composition of the invention used. This amount can be determined by systematic field trials that are within the capabilities of a person skilled in the art.

Plants and Plant Parts

The compound of formula (I) and the composition of the invention may be applied to any plants or plant parts.

Plants mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the genetically modified plants (GMO or transgenic plants) and the plant cultivars which are protectable and non-protectable by plant breeders' rights.

Plant cultivars are understood to mean plants which have new properties (“traits”) and have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. They can be cultivars, varieties, bio- or genotypes.

Plant parts are understood to mean all parts and organs of plants above and below the ground, such as shoots, leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes. The plant parts also include harvested material and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, slips and seeds.

Plants which may be treated in accordance with the methods of the invention include the following: cotton, flax, grapevine, fruit, vegetables, such as Rosaceae sp. (for example pome fruits such as apples and pears, but also stone fruits such as apricots, cherries, almonds and peaches, and soft fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp. (for example coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example lemons, oranges and grapefruit); Solanaceae sp. (for example tomatoes), Liliaceae sp., Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumber), Alliaceae sp. (for example leek, onion), Papilionaceae sp. (for example peas); major crop plants, such as Gramineae sp. (for example maize, turf, cereals such as wheat, rye, rice, barley, oats, millet and triticale), Asteraceae sp. (for example sunflower), Brassicaceae sp. (for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, kohlrabi, radishes, and oilseed rape, mustard, horseradish and cress), Fabacae sp. (for example bean, peanuts), Papilionaceae sp. (for example soya bean), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. (for example sugar beet, fodder beet, swiss chard, beetroot); useful plants and ornamental plants for gardens and wooded areas; and genetically modified varieties of each of these plants.

Plants and plant cultivars which may be treated by the above disclosed methods include plants and plant cultivars which are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.

Plants and plant cultivars which may be treated by the above disclosed methods include those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.

Plants and plant cultivars which may be treated by the above disclosed methods include those plants characterized by enhanced yield characteristics. Increased yield in said plants may be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield may furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content and composition for example cotton or starch, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.

Plants and plant cultivars which may be treated by the above disclosed methods include plants and plant cultivars which are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses.

Transgenic Plants, Seed Treatment and Integration Events

The compound of formula (I) can be advantageously used to treat transgenic plants, plant cultivars or plant parts that received genetic material which imparts advantageous and/or useful properties (traits) to these plants, plant cultivars or plant parts. Therefore, it is contemplated that the present invention may be combined with one or more recombinant traits or transgenic event(s) or a combination thereof. For the purposes of this application, a transgenic event is created by the insertion of a specific recombinant DNA molecule into a specific position (locus) within the chromosome of the plant genome. The insertion creates a novel DNA sequence referred to as an “event” and is characterized by the inserted recombinant DNA molecule and some amount of genomic DNA immediately adjacent to/flanking both ends of the inserted DNA. Such trait(s) or transgenic event(s) include, but are not limited to, pest resistance, water use efficiency, yield performance, drought tolerance, seed quality, improved nutritional quality, hybrid seed production, and herbicide tolerance, in which the trait is measured with respect to a plant lacking such trait or transgenic event. Concrete examples of such advantageous and/or useful properties (traits) are better plant growth, vigor, stress tolerance, standability, lodging resistance, nutrient uptake, plant nutrition, and/or yield, in particular improved growth, increased tolerance to high or low temperatures, increased tolerance to drought or to levels of water or soil salinity, enhanced flowering performance, easier harvesting, accelerated ripening, higher yields, higher quality and/or a higher nutritional value of the harvested products, better storage life and/or processability of the harvested products, and increased resistance against animal and microbial pests, such as against insects, arachnids, nematodes, mites, slugs and snails.

Among DNA sequences encoding proteins which confer properties of tolerance to such animal and microbial pests, in particular insects, mention will particularly be made of the genetic material from Bacillus thuringiensis encoding the Bt proteins widely described in the literature and well known to those skilled in the art. Mention will also be made of proteins extracted from bacteria such as Photorhabdus (WO97/17432 and WO98/08932). In particular, mention will be made of the Bt Cry or VIP proteins which include the CrylA, CryIAb, CryIAc, CryIIA, CryIIIA, CryIIIB2, Cry9c Cry2Ab, Cry3Bb and CryIF proteins or toxic fragments thereof and also hybrids or combinations thereof, especially the CrylF protein or hybrids derived from a CrylF protein (e.g. hybrid CrylA-CrylF proteins or toxic fragments thereof), the CrylA-type proteins or toxic fragments thereof, preferably the Cry1Ac protein or hybrids derived from the Cry1Ac protein (e.g. hybrid Cry1Ab-Cry1Ac proteins) or the Cry1Ab or Bt2 protein or toxic fragments thereof, the Cry2Ae, Cry2Af or Cry2Ag proteins or toxic fragments thereof, the Cry1A.105 protein or a toxic fragment thereof, the VIP3Aa19 protein, the VIP3Aa20 protein, the VIP3A proteins produced in the COT202 or COT203 cotton events, the VIP3Aa protein or a toxic fragment thereof as described in Estruch et al. (1996), Proc Natl Acad Sci US A. 28; 93(11):5389-94, the Cry proteins as described in WO2001/47952, the insecticidal proteins from Xenorhabdus (as described in WO98/50427), Serratia (particularly from S. entomophila) or Photorhabdus species strains, such as Tc-proteins from Photorhabdus as described in WO98/08932. Also any variants or mutants of any one of these proteins differing in some amino acids (1-10, preferably 1-5) from any of the above named sequences, particularly the sequence of their toxic fragment, or which are fused to a transit peptide, such as a plastid transit peptide, or another protein or peptide, is included herein.

Another and particularly emphasized example of such properties is conferred tolerance to one or more herbicides, for example imidazolinones, sulphonylureas, glyphosate or phosphinothricin. Among DNA sequences encoding proteins which confer properties of tolerance to certain herbicides on the transformed plant cells and plants, mention will be particularly be made to the bar or PAT gene or the Streptomyces coelicolor gene described in WO2009/152359 which confers tolerance to glufosinate herbicides, a gene encoding a suitable EPSPS (5-Enolpyruvylshikimat-3-phosphat-synthase) which confers tolerance to herbicides having EPSPS as a target, especially herbicides such as glyphosate and its salts, a gene encoding glyphosate-n-acetyltransferase, or a gene encoding glyphosate oxidoreductase. Further suitable herbicide tolerance traits include at least one ALS (acetolactate synthase) inhibitor (e.g. WO2007/024782), a mutated Arabidopsis ALS/AHAS gene (e.g. U.S. Pat. No. 6,855,533), genes encoding 2,4-D-monooxygenases conferring tolerance to 2,4-D (2,4-dichlorophenoxyacetic acid) and genes encoding Dicamba monooxygenases conferring tolerance to dicamba (3,6-dichloro-2-methoxybenzoic acid).

Yet another example of such properties is resistance to one or more phytopathogenic fungi, for example Asian Soybean Rust. Among DNA sequences encoding proteins which confer properties of resistance to such diseases, mention will particularly be made of the genetic material from Glycine tomentella, for example from any one of publically available accession lines PI441001, PI483224, PI583970, PI446958, PI499939, PI505220, PI499933, PI441008, PI505256 or PI446961 as described in WO2019/103918.

Further and particularly emphasized examples of such properties are increased resistance against bacteria and/or viruses owing, for example, to systemic acquired resistance (SAR), systemin, phytoalexins, elicitors and also resistance genes and correspondingly expressed proteins and toxins.

Particularly useful transgenic events in transgenic plants or plant cultivars which can be treated with preference in accordance with the invention include Event 531/PV-GHBK04 (cotton, insect control, described in WO2002/040677), Event 1143-14A (cotton, insect control, not deposited, described in WO2006/128569); Event 1143-51B (cotton, insect control, not deposited, described in WO2006/128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002-120964 or WO2002/034946); Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO2010/117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO2010/117735); Event 281-24-236 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in WO2005/103266 or US-A 2005-216969); Event 3006-210-23 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in US-A 2007-143876 or WO2005/103266); Event 3272 (corn, quality trait, deposited as PTA-9972, described in WO2006/098952 or US-A 2006-230473); Event 33391 (wheat, herbicide tolerance, deposited as PTA-2347, described in WO2002/027004), Event 40416 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11508, described in WO 11/075593); Event 43A47 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11509, described in WO2011/075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in WO2010/077816); Event ASR-368 (bent grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US-A 2006-162007 or WO2004/053062); Event B16 (corn, herbicide tolerance, not deposited, described in US-A 2003-126634); Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO2010/080829); Event BLR1 (oilseed rape, restoration of male sterility, deposited as NCIMB 41193, described in WO2005/074671), Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in US-A 2009-217423 or WO2006/128573); Event CE44-69D (cotton, insect control, not deposited, described in US-A 2010-0024077); Event CE44-69D (cotton, insect control, not deposited, described in WO2006/128571); Event CE46-02A (cotton, insect control, not deposited, described in WO2006/128572); Event COT102 (cotton, insect control, not deposited, described in US-A 2006-130175 or WO2004/039986); Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or WO2005/054479); Event COT203 (cotton, insect control, not deposited, described in WO2005/054480); ); Event DAS21606-3/1606 (soybean, herbicide tolerance, deposited as PTA-11028, described in WO2012/033794), Event DAS40278 (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO2011/022469); Event DAS-44406-6/pDAB8264.44.06.1 (soybean, herbicide tolerance, deposited as PTA-11336, described in WO2012/075426), Event DAS-14536-7/pDAB8291.45.36.2 (soybean, herbicide tolerance, deposited as PTA-11335, described in WO2012/075429), Event DAS-59122-7 (corn, insect control—herbicide tolerance, deposited as ATCC PTA 11384, described in US-A 2006-070139); Event DAS-59132 (corn, insect control—herbicide tolerance, not deposited, described in WO2009/100188); Event DAS68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in WO2011/066384 or WO2011/066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in US-A 2009-137395 or WO 08/112019); Event DP-305423-1 (soybean, quality trait, not deposited, described in US-A 2008-312082 or WO2008/054747); Event DP-32138-1 (corn, hybridization system, deposited as ATCC PTA-9158, described in US-A 2009-0210970 or WO2009/103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or WO2008/002872); Event EE-I (brinjal, insect control, not deposited, described in WO 07/091277); Event Fil 17 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006-059581 or WO 98/044140); Event FG72 (soybean, herbicide tolerance, deposited as PTA-11041, described in WO2011/063413), Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or WO98/044140); Event GHB119 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8398, described in WO2008/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A 2010-050282 or WO2007/017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US-A 2005-188434 or WO98/044140); Event GM RZ13 (sugar beet, virus resistance, deposited as NCIMB-41601, described in WO2010/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or WO 2004/074492); Event JOPLIN1 (wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO2006/108674 or US-A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 2006/108675 or US-A 2008-196127); Event LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO2003/013224 or US-A 2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC 203353, described in U.S. Pat. No. 6,468,747 or WO2000/026345); Event LLRice62 (rice, herbicide tolerance, deposited as ATCC 203352, described in WO2000/026345), Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US-A 2008-2289060 or WO2000/026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-5623, described in US-A 2007-028322 or WO2005/061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US-A 2009-300784 or WO2007/142840); Event MIR604 (corn, insect control, not deposited, described in US-A 2008-167456 or WO2005/103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US-A 2004-250317 or WO2002/100163); Event MON810 (corn, insect control, not deposited, described in US-A 2002-102582); Event MON863 (corn, insect control, deposited as ATCC PTA-2605, described in WO2004/011601 or US-A 2006-095986); Event MON87427 (corn, pollination control, deposited as ATCC PTA-7899, described in WO2011/062904); Event MON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, described in WO2009/111263 or US-A 2011-0138504); Event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or WO2009/064652); Event MON87705 (soybean, quality trait —herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or WO2010/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA-9670, described in WO2011/034704); Event MON87712 (soybean, yield, deposited as PTA-10296, described in WO2012/051199), Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in WO2010/024976); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911, described in US-A 2011-0067141 or WO2009/102873); Event MON88017 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or WO2005/059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in WO2004/072235 or US-A 2006-059590); Event MON88302 (oilseed rape, herbicide tolerance, deposited as PTA-10955, described in WO2011/153186), Event MON88701 (cotton, herbicide tolerance, deposited as PTA-11754, described in WO2012/134808), Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO 07/140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or WO2006/130436); Event MS1 1 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO2001/031042); Event MS8 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO2001/041558 or US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A 2007-292854); Event PE-7 (rice, insect control, not deposited, described in WO2008/114282); Event RF3 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO2001/041558 or US-A 2003-188347); Event RT73 (oilseed rape, herbicide tolerance, not deposited, described in WO2002/036831 or US-A 2008-070260); Event SYHT0H2/SYN-000H2-5 (soybean, herbicide tolerance, deposited as PTA-11226, described in WO2012/082548), Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO2002/44407 or US-A 2009-265817); Event T25 (corn, herbicide tolerance, not deposited, described in US-A 2001-029014 or WO2001/051654); Event T304-40 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8171, described in US-A 2010-077501 or WO2008/122406); Event T342-142 (cotton, insect control, not deposited, described in WO2006/128568); Event TC1507 (corn, insect control—herbicide tolerance, not deposited, described in US-A 2005-039226 or WO2004/099447); Event VTP1034 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-3925, described in WO2003/052073), Event 32316 (corn, insect control—herbicide tolerance, deposited as PTA-11507, described in WO2011/084632), Event 4114 (corn, insect control—herbicide tolerance, deposited as PTA-11506, described in WO2011/084621), event EE-GM3/FG72 (soybean, herbicide tolerance, ATCC Accession No PTA-11041) optionally stacked with event EE-GM1/LL27 or event EE-GM2/LL55 (WO2011/063413A2), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession No PTA-10442, WO2011/066360A1), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession No PTA-10442, WO2011/066384A1), event DP-040416-8 (corn, insect control, ATCC Accession No PTA-11508, WO2011/075593A1), event DP-043A47-3 (corn, insect control, ATCC Accession No PTA-11509, WO2011/075595A1), event DP-004114-3 (corn, insect control, ATCC Accession No PTA-11506, WO2011/084621A1), event DP-032316-8 (corn, insect control, ATCC Accession No PTA-11507, WO2011/084632A1), event MON-88302-9 (oilseed rape, herbicide tolerance, ATCC Accession No PTA-10955, WO2011/153186A1), event DAS-21606-3 (soybean, herbicide tolerance, ATCC Accession No. PTA-11028, WO2012/033794A2), event MON-87712-4 (soybean, quality trait, ATCC Accession No. PTA-10296, WO2012/051199A2), event DAS-44406-6 (soybean, stacked herbicide tolerance, ATCC Accession No. PTA-11336, WO2012/075426A1), event DAS-14536-7 (soybean, stacked herbicide tolerance, ATCC Accession No. PTA-11335, WO2012/075429A1), event SYN-000H2-5 (soybean, herbicide tolerance, ATCC Accession No. PTA-11226, WO2012/082548A2), event DP-061061-7 (oilseed rape, herbicide tolerance, no deposit No available, WO2012071039A1), event DP-073496-4 (oilseed rape, herbicide tolerance, no deposit No available, US2012131692), event 8264.44.06.1 (soybean, stacked herbicide tolerance, Accession No PTA-11336, WO2012075426A2), event 8291.45.36.2 (soybean, stacked herbicide tolerance, Accession No. PTA-11335, WO2012075429A2), event SYHT0H2 (soybean, ATCC Accession No. PTA-11226, WO2012/082548A2), event MON88701 (cotton, ATCC Accession No PTA-11754, WO2012/134808A1), event KK179-2 (alfalfa, ATCC Accession No PTA-11833, WO2013/003558A1), event pDAB8264.42.32.1 (soybean, stacked herbicide tolerance, ATCC Accession No PTA-11993, WO2013/010094A1), event MZDT09Y (corn, ATCC Accession No PTA-13025, WO2013/012775A1).

Further, a list of such transgenic event(s) is provided by the United States Department of Agriculture's (USDA) Animal and Plant Health Inspection Service (APHIS) and can be found on their website on the world wide web at aphis.usda.gov. For this application, the status of such list as it is/was on the filing date of this application, is relevant.

The genes/events which impart the desired traits in question may also be present in combinations with one another in the transgenic plants. Examples of transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice, triticale, barley, rye, oats), maize, soya beans, potatoes, sugar beet, sugar cane, tomatoes, peas and other types of vegetable, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes), with particular emphasis being given to maize, soya beans, wheat, rice, potatoes, cotton, sugar cane, tobacco and oilseed rape.

Traits which are particularly emphasized are the increased resistance of the plants to insects, arachnids, nematodes and slugs and snails, as well as the increased resistance of the plants to one or more herbicides.

Commercially available examples of such plants, plant parts or plant seeds that may be treated with preference in accordance with the invention include commercial products, such as plant seeds, sold or distributed under the GENUITY®, DROUGHTGARD®, SMARTSTAX®, RIB COMPLETE®, ROUNDUP READY®, VT DOUBLE PRO®, VT TRIPLE PRO®, BOLLGARD II®, ROUNDUP READY 2 YIELD®, YIELDGARD®, ROUNDUP READY® 2 XTEND™, INTACTA RR2 PRO®, VISTIVE GOLD®, and/or XTENDFLEX™ trade names.

Pathogens

Non-limiting examples of pathogens of fungal diseases which may be treated in accordance with the invention include:

-   -   diseases caused by powdery mildew pathogens, for example         Blumeria species, for example Blumeria graminis; Podosphaera         species, for example Podosphaera leucotricha; Sphaerotheca         species, for example Sphaerotheca fuliginea; Uncinula species,         for example Uncinula necator;     -   diseases caused by rust disease pathogens, for example         Gymnosporangium species, for example Gymnosporangium sabinae;         Hemileia species, for example Hemileia vastatrix; Phakopsora         species, for example Phakopsora pachyrhizi or Phakopsora         meibomiae; Puccinia species, for example Puccinia recondita,         Puccinia graminis oder Puccinia striiformis; Uromyces species,         for example Uromyces appendiculatus;     -   diseases caused by pathogens from the group of the Oomycetes,         for example Albugo species, for example Albugo candida; Bremia         species, for example Bremia lactucae; Peronospora species, for         example Peronospora pisi or P. brassicae; Phytophthora species,         for example Phytophthora infestans; Plasmopara species, for         example Plasmopara viticola; Pseudoperonospora species, for         example Pseudoperonospora humuli or Pseudoperonospora cubensis;         Pythium species, for example Pythium ultimum;     -   leaf blotch diseases and leaf wilt diseases caused, for example,         by Alternaria species, for example Alternaria solani; Cercospora         species, for example Cercospora beticola; Cladiosporium species,         for example Cladiosporium cucumerinum; Cochliobolus species, for         example Cochliobolus sativus (conidial form: Drechslera, syn:         Helminthosporium) or Cochliobolus miyabeanus; Colletotrichum         species, for example Colletotrichum lindemuthanium; Corynespora         species, for example Corynespora cassiicola; Cycloconium         species, for example Cycloconium oleaginum; Diaporthe species,         for example Diaporthe citri; Elsinoe species, for example         Elsinoe fawcettii; Gloeosporium species, for example         Gloeosporium laeticolor; Glomerella species, for example         Glomerella cingulata; Guignardia species, for example Guignardia         bidwelli; Leptosphaeria species, for example Leptosphaeria         maculans; Magnaporthe species, for example Magnaporthe grisea;         Microdochium species, for example Microdochium nivale;         Mycosphaerella species, for example Mycosphaerella graminicola,         Mycosphaerella arachidicola or Mycosphaerella fijiensis;         Phaeosphaeria species, for example Phaeosphaeria nodorum;         Pyrenophora species, for example Pyrenophora teres or         Pyrenophora tritici repentis; Ramularia species, for example         Ramularia collo-cygni or Ramularia areola; Rhynchosporium         species, for example Rhynchosporium secalis; Septoria species,         for example Septoria apii or Septoria lycopersici; Stagonospora         species, for example Stagonospora nodorum; Typhula species, for         example Typhula incarnata; Venturia species, for example         Venturia inaequalis;     -   root and stem diseases caused, for example, by Corticium         species, for example Corticium graminearum; Fusarium species,         for example Fusarium oxysporum; Gaeumannomyces species, for         example Gaeumannomyces graminis; Plasmodiophora species, for         example Plasmodiophora brassicae; Rhizoctonia species, for         example Rhizoctonia solani; Sarocladium species, for example         Sarocladium oryzae; Sclerotium species, for example Sclerotium         oryzae; Tapesia species, for example Tapesia acuformis;         Thielaviopsis species, for example Thielaviopsis basicola;     -   ear and panicle diseases (including corn cobs) caused, for         example, by Alternaria species, for example Alternaria spp.;         Aspergillus species, for example Aspergillus flavus;         Cladosporium species, for example Cladosporium cladosporioides;         Claviceps species, for example Claviceps purpurea; Fusarium         species, for example Fusarium culmorum; Gibberella species, for         example Gibberella zeae; Monographella species, for example         Monographella nivalis; Stagnospora species, for example         Stagnospora nodorum; diseases caused by smut fungi, for example         Sphacelotheca species, for example Sphacelotheca reiliana;         Tilletia species, for example Tilletia caries or Tilletia         controversa; Urocystis species, for example Urocystis occulta;         Ustilago species, for example Ustilago nuda;     -   fruit rot caused, for example, by Aspergillus species, for         example Aspergillus flavus; Botrytis species, for example         Botrytis cinerea; Monilinia species, for example Monilinia laxa;         Penicillium species, for example Penicillium expansum or         Penicillium purpurogenum; Rhizopus species, for example Rhizopus         stolonifer; Sclerotinia species, for example Sclerotinia         sclerotiorum; Verticilium species, for example Verticilium         alboatrum;     -   seed- and soil-borne rot and wilt diseases, and also diseases of         seedlings, caused, for example, by Alternaria species, for         example Alternaria brassicicola; Aphanomyces species, for         example Aphanomyces euteiches; Ascochyta species, for example         Ascochyta lentis; Aspergillus species, for example Aspergillus         flavus; Cladosporium species, for example Cladosporium herbarum;         Cochliobolus species, for example Cochliobolus sativus (conidial         form: Drechslera, Bipolaris Syn: Helminthosporium);         Colletotrichum species, for example Colletotrichum coccodes;         Fusarium species, for example Fusarium culmorum; Gibberella         species, for example Gibberella zeae; Macrophomina species, for         example Macrophomina phaseolina; Microdochium species, for         example Microdochium nivale; Monographella species, for example         Monographella nivalis; Penicillium species, for example         Penicillium expansum; Phoma species, for example Phoma lingam;         Phomopsis species, for example Phomopsis sojae; Phytophthora         species, for example Phytophthora cactorum; Pyrenophora species,         for example Pyrenophora graminea; Pyricularia species, for         example Pyricularia oryzae; Pythium species, for example Pythium         ultimum; Rhizoctonia species, for example Rhizoctonia solani;         Rhizopus species, for example Rhizopus oryzae; Sclerotium         species, for example Sclerotium rolfsii; Septoria species, for         example Septoria nodorum; Typhula species, for example Typhula         incarnata; Verticillium species, for example Verticillium         dahliae;     -   cancers, galls and witches' broom caused, for example, by         Nectria species, for example Nectria galligena;     -   wilt diseases caused, for example, by Verticillium species, for         example Verticillium longisporum; Fusarium species, for example         Fusarium oxysporum;     -   deformations of leaves, flowers and fruits caused, for example,         by Exobasidium species, for example Exobasidium vexans; Taphrina         species, for example Taphrina deformans;     -   degenerative diseases in woody plants, caused, for example, by         Esca species, for example Phaeomoniella chlamydospora,         Phaeoacremonium aleophilum or Fomitiporia mediterranea;         Ganoderma species, for example Ganoderma boninense;     -   diseases of plant tubers caused, for example, by Rhizoctonia         species, for example Rhizoctonia solani; Helminthosporium         species, for example Helminthosporium solani;     -   diseases caused by bacterial pathogens, for example Xanthomonas         species, for example Xanthomonas campestris pv. oryzae;         Pseudomonas species, for example Pseudomonas syringae pv.         lachrymans; Erwinia species, for example Erwinia amylovora;         Liberibacter species, for example Liberibacter asiaticus; Xyella         species, for example Xylella fastidiosa; Ralstonia species, for         example Ralstonia solanacearum; Dickeya species, for example         Dickeya solani; Clavibacter species, for example Clavibacter         michiganensis; Streptomyces species, for example Streptomyces         scabies.

Diseases of Soya Beans:

Fungal diseases on leaves, stems, pods and seeds caused, for example, by Alternaria leaf spot (Alternaria spec. atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot (Septoria glycines), Cercospora leaf spot and blight (Cercospora kikuchii), choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Peronospora manshurica), drechslera blight (Drechslera glycini), frogeye leaf spot (Cercospora sojina), leptosphaerulina leaf spot (Leptosphaerulina trifolii), phyllostica leaf spot (Phyllosticta sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta glycines), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), rust (Phakopsora pachyrhizi, Phakopsora meibomiae), scab (Sphaceloma glycines), stemphylium leaf blight (Stemphylium botryosum), sudden death syndrome (Fusarium virguliforme), target spot (Corynespora cassiicola).

Fungal diseases on roots and the stem base caused, for example, by black root rot (Calonectria crotalariae), charcoal rot (Macrophomina phaseolina), fusarium blight or wilt, root rot, and pod and collar rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), mycoleptodiscus root rot (Mycoleptodiscus terrestris), neocosmospora (Neocosmospora vasinfecta), pod and stem blight (Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var. caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythium rot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola).

Mycotoxins

In addition, the compound of formula (I) and the composition of the invention may reduce the mycotoxin content in the harvested material and the foods and feeds prepared therefrom. Mycotoxins include particularly, but not exclusively, the following: deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2- and HT2-toxin, fumonisins, zearalenon, moniliformin, fusarin, diaceotoxyscirpenol (DAS), beauvericin, enniatin, fusaroproliferin, fusarenol, ochratoxins, patulin, ergot alkaloids and aflatoxins which can be produced, for example, by the following fungi: Fusarium spec., such as F. acuminatum, F. asiaticum, F. avenaceum, F. crookwellense, F. culmorum, F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi, F. musarum, F. oxysporum, F. proliferatum, F. poae, F. pseudograminearum, F. sambucinum, F. scirpi, F. semitectum, F. solani, F. sporotrichoides, F. langsethiae, F. subglutinans, F. tricinctum, F. verticilihoides, and also by Aspergillus spec., such as A. flavus, A. parasiticus, A. nomius, A. ochraceus, A. clavatus, A. terreus, A. versicolor, Penicillium spec., such as P. verrucosum, P. viridicatum, P. citrinum, P. expansum, P. claviforme, P. roqueforti, Claviceps spec., such as C. purpurea, C. fusiformis, C. paspali, C. africana, Stachybotrys spec. and others.

Material Protection

The compound of formula (I) and the composition of the invention may also be used in the protection of materials, especially for the protection of industrial materials against attack and destruction by phytopathogenic fungi.

In addition, the compound of formula (I) and the composition of the invention may be used as antifouling compositions, alone or in combinations with other active ingredients.

Industrial materials in the present context are understood to mean inanimate materials which have been prepared for use in industry. For example, industrial materials which are to be protected from microbial alteration or destruction may be adhesives, glues, paper, wallpaper and board/cardboard, textiles, carpets, leather, wood, fibers and tissues, paints and plastic articles, cooling lubricants and other materials which can be infected with or destroyed by microorganisms. Parts of production plants and buildings, for example cooling-water circuits, cooling and heating systems and ventilation and air-conditioning units, which may be impaired by the proliferation of microorganisms may also be mentioned within the scope of the materials to be protected. Industrial materials within the scope of the present invention preferably include adhesives, sizes, paper and card, leather, wood, paints, cooling lubricants and heat transfer fluids, more preferably wood.

The compound of formula (I) and the composition of the invention may prevent adverse effects, such as rotting, decay, discoloration, decoloration or formation of mould.

In the case of treatment of wood the compound of formula (I) and the composition of the invention may also be used against fungal diseases liable to grow on or inside timber.

Timber means all types of species of wood, and all types of working of this wood intended for construction, for example solid wood, high-density wood, laminated wood, and plywood. In addition, the compound of formula (I) and the composition of the invention may be used to protect objects which come into contact with saltwater or brackish water, especially hulls, screens, nets, buildings, moorings and signalling systems, from fouling.

The compound of formula (I) and the composition of the invention may also be employed for protecting storage goods. Storage goods are understood to mean natural substances of vegetable or animal origin or processed products thereof which are of natural origin, and for which long-term protection is desired. Storage goods of vegetable origin, for example plants or plant parts, such as stems, leaves, tubers, seeds, fruits, grains, may be protected freshly harvested or after processing by (pre)drying, moistening, comminuting, grinding, pressing or roasting. Storage goods also include timber, both unprocessed, such as construction timber, electricity poles and barriers, or in the form of finished products, such as furniture. Storage goods of animal origin are, for example, hides, leather, furs and hairs. The compound of formula (I) and the composition of the invention may prevent adverse effects, such as rotting, decay, discoloration, decoloration or formation of mould.

Microorganisms capable of degrading or altering industrial materials include, for example, bacteria, fungi, yeasts, algae and slime organisms. The compound of formula (I) and the composition of the invention preferably act against fungi, especially moulds, wood-discoloring and wood-destroying fungi (Ascomycetes, Basidiomycetes, Deuteromycetes and Zygomycetes), and against slime organisms and algae. Examples include microorganisms of the following genera: Alternaria, such as Alternaria tenuis; Aspergillus, such as Aspergillus niger; Chaetomium, such as Chaetomium globosum; Coniophora, such as Coniophora puetana; Lentinus, such as Lentinus tigrinus; Penicillium, such as Penicillium glaucum; Polyporus, such as Polyporus versicolor; Aureobasidium, such as Aureobasidium pullulans; Sclerophoma, such as Sclerophoma pityophila; Trichoderma, such as Trichoderma viride; Ophiostoma spp., Ceratocystis spp., Humicola spp., Petriella spp., Trichurus spp., Coriolus spp., Gloeophyllum spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp., Cladosporium spp., Paecilomyces spp. Mucor spp., Escherichia, such as Escherichia coli; Pseudomonas, such as Pseudomonas aeruginosa; Staphylococcus, such as Staphylococcus aureus, Candida spp. and Saccharomyces spp., such as Saccharomyces cerevisae.

Seed Treatment

The compound of formula (I) and the composition of the invention may also be used to protect seeds from unwanted microorganisms, such as phytopathogenic microorganisms, for instance phytopathogenic fungi or phytopathogenic oomycetes. The term seed(s) as used herein include dormant seeds, primed seeds, pregerminated seeds and seeds with emerged roots and leaves.

Thus, the present invention also relates to a method for protecting seeds from unwanted microorganisms which comprises the step of treating the seeds with the compound of formula (I) or the composition of the invention.

The treatment of seeds with the compound of formula (I) or the composition of the invention protects the seeds from phytopathogenic microorganisms, but also protects the germinating seeds, the emerging seedlings and the plants after emergence from the treated seeds. Therefore, the present invention also relates to a method for protecting seeds, germinating seeds and emerging seedlings.

The seeds treatment may be performed prior to sowing, at the time of sowing or shortly thereafter.

When the seeds treatment is performed prior to sowing (e.g. so-called on-seed applications), the seeds treatment may be performed as follows: the seeds may be placed into a mixer with a desired amount of the compound of formula (I) or the composition of the invention, the seeds and the compound of formula (I) or the composition of the invention are mixed until an homogeneous distribution on seeds is achieved. If appropriate, the seeds may then be dried.

The invention also relates to seeds coated with the compound of formula (I) or the composition of the invention.

Preferably, the seeds are treated in a state in which it is sufficiently stable for no damage to occur in the course of treatment. In general, seeds can be treated at any time between harvest and shortly after sowing. It is customary to use seeds which have been separated from the plant and freed from cobs, shells, stalks, coats, hairs or the flesh of the fruits. For example, it is possible to use seeds which have been harvested, cleaned and dried down to a moisture content of less than 15% by weight. Alternatively, it is also possible to use seeds which, after drying, for example, have been treated with water and then dried again, or seeds just after priming, or seeds stored in primed conditions or pre-germinated seeds, or seeds sown on nursery trays, tapes or paper.

The amount of the compound of formula (I) or the composition of the invention applied to the seeds is typically such that the germination of the seed is not impaired, or that the resulting plant is not damaged.

This must be ensured particularly in case the compound of formula (I) would exhibit phytotoxic effects at certain application rates. The intrinsic phenotypes of transgenic plants should also be taken into consideration when determining the amount of the compound of formula (I) to be applied to the seed in order to achieve optimum seed and germinating plant protection with a minimum amount of compound being employed.

The compound of formula (I) can be applied as such, directly to the seeds, i.e. without the use of any other components and without having been diluted. Also the composition of the invention can be applied to the seeds.

The compound of formula (I) and the composition of the invention are suitable for protecting seeds of any plant variety. Preferred seeds are that of cereals (such as wheat, barley, rye, millet, triticale, and oats), oilseed rape, maize, cotton, soybean, rice, potatoes, sunflower, beans, coffee, peas, beet (e.g. sugar beet and fodder beet), peanut, vegetables (such as tomato, cucumber, onions and lettuce), lawns and ornamental plants. More preferred are seeds of wheat, soybean, oilseed rape, maize and rice.

The compound of formula (I) and the composition of the invention may be used for treating transgenic seeds, in particular seeds of plants capable of expressing a polypeptide or protein which acts against pests, herbicidal damage or abiotic stress, thereby increasing the protective effect. Seeds of plants capable of expressing a polypeptide or protein which acts against pests, herbicidal damage or abiotic stress may contain at least one heterologous gene which allows the expression of said polypeptide or protein. These heterologous genes in transgenic seeds may originate, for example, from microorganisms of the species Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. These heterologous genes preferably originate from Bacillus sp., in which case the gene product is effective against the European corn borer and/or the Western corn rootworm. Particularly preferably, the heterologous genes originate from Bacillus thuringiensis.

Application

The compound of formula (I) can be applied as such, or for example in the form of as ready-to-use solutions, emulsions, water- or oil-based suspensions, powders, wettable powders, pastes, soluble powders, dusts, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural products impregnated with the compound of formula (I), synthetic substances impregnated with the compound of formula (I), fertilizers or microencapsulations in polymeric substances.

Application is accomplished in a customary manner, for example by watering, spraying, atomizing, broadcasting, dusting, foaming or spreading-on. It is also possible to deploy the compound of formula (I) by the ultra-low volume method, via a drip irrigation system or drench application, to apply it in-furrow or to inject it into the soil stem or trunk. It is further possible to apply the compound of formula (I) by means of a wound seal, paint or other wound dressing.

The effective and plant-compatible amount of the compound of formula (I) which is applied to the plants, plant parts, fruits, seeds or soil will depend on various factors, such as the compound/composition employed, the subject of the treatment (plant, plant part, fruit, seed or soil), the type of treatment (dusting, spraying, seed dressing), the purpose of the treatment (curative and protective), the type of microorganisms, the development stage of the microorganisms, the sensitivity of the microorganisms, the crop growth stage and the environmental conditions.

When the compound of formula (I) is used as a fungicide, the application rates can vary within a relatively wide range, depending on the kind of application. For the treatment of plant parts, such as leaves, the application rate may range from 0.1 to 10 000 g/ha, preferably from 10 to 1000 g/ha, more preferably from 50 to 300 g/ha (in the case of application by watering or dripping, it is even possible to reduce the application rate, especially when inert substrates such as rockwool or perlite are used). For the treatment of seeds, the application rate may range from 0.1 to 200 g per 100 kg of seeds, preferably from 1 to 150 g per 100 kg of seeds, more preferably from 2.5 to 25 g per 100 kg of seeds, even more preferably from 2.5 to 12.5 g per 100 kg of seeds. For the treatment of soil, the application rate may range from 0.1 to 10 000 g/ha, preferably from 1 to 5000 g/ha.

These application rates are merely examples and are not intended to limit the scope of the present invention.

The compound of formula (I) and the composition of the invention can be used in combination with models e.g. embedded in computer programs for site specific crop management, satellite farming, precision farming or precision agriculture. Such models support the site specific management of agricultural sites with data from various sources such as soils, weather, crops (e.g. type, growth stage, plant health), weeds (e.g. type, growth stage), diseases, pests, nutrients, water, moisture, biomass, satellite data, yield etc. with the purpose to optimize profitability, sustainability and protection of the environment. In particular, such models can help to optimize agronomical decisions, control the precision of pesticide applications and record the work performed.

As an example, the compound of formula (I) can be applied to a crop plant according to appropriate dose regime if a model models the development of a fungal disease and calculates that a threshold has been reached for which it is recommendable to apply the compound of formula (I) to the crop plant.

Commercially available systems which include agronomic models are e.g. FieldScripts™ from The Climate Corporation, Xarvio™ from BASF, AGLogic™ from John Deere, etc.

The compound of formula (I) can also be used in combination with smart spraying equipment such as e.g. spot spraying or precision spraying equipment attached to or housed within a farm vehicle such as a tractor, robot, helicopter, airplane, unmanned aerial vehicle (UAV) such as a drone, etc. Such an equipment usually includes input sensors (such as e.g. a camera) and a processing unit configured to analyze the input data and configured to provide a decision based on the analysis of the input data to apply the compound of the invention to the crop plants (respectively the weeds) in a specific and precise manner. The use of such smart spraying equipment usually also requires positions systems (e.g. GPS receivers) to localize recorded data and to guide or to control farm vehicles; geographic information systems (GIS) to represent the information on intelligible maps, and appropriate farm vehicles to perform the required farm action such as the spraying.

In an example, fungal diseases can be detected from imagery acquired by a camera. In an example fungal diseases can be identified and/or classified based on that imagery. Such identification and/classification can make use of image processing algorithms. Such image processing algorithms can utilize machine learning algorithms, such as trained neutral networks, decision trees and utilize artificial intelligence algorithms. In this manner, the compounds described herein can be applied only where needed.

Aspects of the present teaching may be further understood in light of the following examples, which should not be construed as limiting the scope of the present teaching in any way.

A. EXAMPLES A-1. Generality A-1.1. Measurement of Log P Values

Measurement of Log P values as provided herein was performed according to EEC directive 79/831 Annex V.A8 by HPLC (High Performance Liquid Chromatography) on reversed phase columns with the following methods:

-   -   ^([a])Log P value is determined by measurement of LC-UV, in an         acidic range, with 0.1% formic acid in water and acetonitrile as         eluent (linear gradient from 10% acetonitrile to 95%         acetonitrile).     -   ^([b])Log P value is determined by measurement of LC-UV, in a         neutral range, with 0.001 molar ammonium acetate solution in         water and acetonitrile as eluent (linear gradient from 10%         acetonitrile to 95% acetonitrile).     -   ^([c])Log P value is determined by measurement of LC-UV, in an         acidic range, with 0.1% phosphoric acid and acetonitrile as         eluent (linear gradient from 10% acetonitrile to 95%         acetonitrile).

If more than one Log P value is available within the same method, all the values are given and separated by “+”.

Calibration was done with straight-chain alkan2-ones (with 3 to 16 carbon atoms) with known Log P values (measurement of Log P values using retention times with linear interpolation between successive alkanones). Lambda-max-values were determined using UV-spectra from 200 nm to 400 nm and the peak values of the chromatographic signals

A-1.2. ¹H-NMR Data

¹H-NMR data of selected examples as provided herein are written in form of ¹H-NMR-peak lists. To each signal peak are listed the 6-value in ppm and the signal intensity in round brackets. Between the δ-value—signal intensity pairs are semicolons as delimiters.

The peak list of an example has therefore the form:

-   -   δ₁ (intensity₁); δ₂ (intensity₂); . . . ; δ_(i) (intensity_(i));         . . . ; δ_(n) (intensity_(n))

Intensity of sharp signals correlates with the height of the signals in a printed example of a NMR spectrum in cm and shows the real relations of signal intensities. From broad signals several peaks or the middle of the signal and their relative intensity in comparison to the most intensive signal in the spectrum can be shown.

For calibrating chemical shift for ¹H spectra, we use tetramethylsilane and/or the chemical shift of the solvent used, especially in the case of spectra measured in DMSO. Therefore in NMR peak lists, tetramethylsilane peak can occur but not necessarily.

The ¹H-NMR peak lists are similar to classical ¹H-NMR prints and contains therefore usually all peaks, which are listed at classical NMR-interpretation.

Additionally, they can show like classical ¹H-NMR prints signals of solvents, stereoisomers of the target compounds, which are also object of the invention, and/or peaks of impurities.

To show compound signals in the delta-range of solvents and/or water the usual peaks of solvents, for example peaks of DMSO in DMSO-D₆ and the peak of water are shown in our ¹H-NMR peak lists and have usually on average a high intensity.

The peaks of stereoisomers of the target compounds and/or peaks of impurities have usually on average a lower intensity than the peaks of target compounds (for example with a purity >90%).

Such stereoisomers and/or impurities can be typical for the specific preparation process. Therefore, their peaks can help to recognize the reproduction of our preparation process via “side-products-fingerprints”.

An expert, who calculates the peaks of the target compounds with known methods (MestreC, ACD-simulation, but also with empirically evaluated expectation values) can isolate the peaks of the target compounds as needed optionally using additional intensity filters. This isolation would be similar to relevant peak picking at classical ¹H-NMR interpretation.

Further details of NMR-data description with peak lists you find in the publication “Citation of NMR Peaklist Data within Patent Applications” of the Research Disclosure Database Number 564025.

The following examples illustrate in a non-limiting manner the preparation and biological activity of the compounds of formula (I) according to the invention.

A-3. Synthesis of Compounds of Formula (I) and Intermediates Preparation Example 1: Preparation of (5RS)-3-{2-cyclopropyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl}-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine (compound I-001) Step 1: Preparation of 2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxylic acid (Compound 1-02)

In a microwave vial, a mixture of 5-bromo-2-cyclopropylpyrimidine-4-carboxylic acid (200 mg, 0.82 mmol), 3-(trifluoromethyl)phenol (226 mg, 1.39 mmol), N-(n-butyl)imidazole (30 mg, 0.25 mmol), cesium carbonate (536 mg, 1.64 mmol) and copper(I)iodide (31.3 mg, 0.16 mmol) were dissolved in dioxane (4.5 mL). The tube was sealed and the reaction mixture was heated in a microwave at 130° C. for 30 min. The reaction was diluted with dichloromethane and filtered over Celite®. The organic layers were concentrated under reduced pressure. Purification of the residue by preparative HPLC afforded, after evaporation of the solvents, 23 mg (98% purity, 10% yield) of 2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxylic acid as a white solid.

Step 2: Preparation of 2-cyclopropyl-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide (Compound 3-01)

Under argon, to a mixture of 2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxylic acid (23 mg, 0.07 mmol) and HATU (30 mg, 0.07 mmol) in DMF (1 mL) were added at 0° C., 2-{[(2RS)-2-amino-3-(2,4-dimethylphenyl)propyl]oxy}-1H-isoindole-1,3(2H)-dione.trifluoroacetate (34 mg, 0.07 mmol) and N,N-Diisopropylethylamine (0.04 mL, 0.21 mmol). After 15 min at 0° C., the reaction mixture was stirred for 18 h at room temperature. It was then diluted with water and extracted with ethyl acetate (2×50 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/ethyl aceate) afforded, after evaporation of the solvents, 34 mg (100% purity, 76% yield) of 2-cyclopropyl-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide as a white solid.

Step 3: Preparation of N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide (Compound 4-01)

Under argon, hydrazine monohydrate (0.01 mL, 0.16 mmol) was added to a solution of 2-cyclopropyl-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide (34 mg, 0.05 mmol) in dichloromethane/methanol (1 mL, 1:1). The reaction mixture was stirred for 2 h at room temperature and concentrated. It was then diluted with water and extracted with dichloromethane (2×50 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Evaporation of the solvents afforded 27 mg (100% purity, 98% yield) of N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide as a colorless oil.

Step 4: Preparation of (5RS)-3-{2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl}-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine

Under argon, POCl₃ (0.02 mL, 0.18 mmol) was added at 85° C. to a solution N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidine-4-carboxamide (27 mg, 0.06 mmol) in Acetonitrile (5 mL). The reaction mixture was stirred for 2 h at 85° C. After cooling to room temperature, the mixture was poured into a saturated sodium bicarbonate solution and extracted with ethyl acetate (2×50 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/ethyl acetate) afforded, after evaporation of the solvents, 11.3 mg (100% purity, 39% yield) of (5RS)-3-{2-cyclopropyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl}-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine as a yellow oil.

Preparation Example 2: Preparation of (5RS)-5-(2,4-dimethylbenzyl)-3-{2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl}-5,6-dihydro-4H-1,2,4-oxadiazine (Compound I-002) Step 1: Preparation of 5-bromo-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-2-methylpyrimidine-4-carboxamide

Under argon, to a mixture of 5-bromo-2-methylpyrimidine-4-carboxylic acid (150 mg, 0.07 mmol) and HATU (289 mg, 0.76 mmol) in DMF (6.5 mL) were added at 0° C., 2-{[(2RS)-2-amino-3-(2,4-dimethylphenyl)propyl]oxy}-1H-isoindole-1,3(2H)-dione trifluoroacetate (333 mg, 0.76 mmol) and N,N-Diisopropylethylamine (0.36 mL, 2.07 mmol). After 15 min at 0° C., the reaction mixture was stirred for 18 h at room temperature. It was then diluted with water and extracted with ethyl acetate (2×200 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/ethyl acetate) afforded, after evaporation of the solvents, 211 mg (100% purity, 58% yield) of 5-bromo-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-2-methylpyrimidine-4-carboxamide as a yellow solid.

Step 2: Preparation of N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-5-bromo-2-methylpyrimidine-4-carboxamide

Under argon, hydrazine monohydrate (0.07 mL, 1.2 mmol) was added to a solution of 5-bromo-N-{(2RS)-1-(2,4-dimethylphenyl)-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]propan-2-yl}-2-methylpyrimidine-4-carboxamide (210 mg, 0.40 mmol) in dichloromethane/methanol (6 mL, 1:1). The reaction mixture was stirred for 2 h at room temperature and concentrated. It was then diluted with water and extracted with dichloromethane (2×100 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Evaporation of the solvents afforded 161 mg (76% purity, 77% yield) of N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-5-bromo-2-methylpyrimidine-4-carboxamide as a yellow oil.

Step 3: Preparation of (5RS)-5-(2,4-dimethylbenzyl)-3-{2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl}-5,6-dihydro-4H-1,2,4-oxadiazine (Compound 7-01)

Under argon, POCl₃ (0.11 mL, 1.16 mmol) was added at 85° C. to a solution N-[(2RS)-1-(aminooxy)-3-(2,4-dimethylphenyl)propan-2-yl]-5-bromo-2-methylpyrimidine-4-carboxamide (152 mg, 0.38 mmol) in Acetonitrile (5 mL). The reaction mixture was stirred for 1 h at 85° C. After cooling to room temperature, the mixture was poured into a saturated sodium bicarbonate solution and extracted with ethyl acetate (2×50 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/EtOAc) afforded, after evaporation of the solvents, 32 mg (91% purity, 20% yield) of (5RS)-5-(2,4-dimethylbenzyl)-3-{2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl}-5,6-dihydro-4H-1,2,4-oxadiazine as a yellow oil.

Step 4: Preparation of (5RS)-5-(2,4-dimethylbenzyl)-3-{2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl}-5,6-dihydro-4H-1,2,4-oxadiazine

In a microwave vial, a mixture of (5RS)-3-(5-bromo-2-methylpyrimidin-4-yl)-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine (26 mg, 0.06 mmol), 3-(trifluoromethyl)phenol (16.5 mg, 0.1 mmol), N-(n-butyl)imidazole (4.2 mg, 0.03 mmol), cesium carbonate (44.4 mg, 0.14 mmol) and copper(I)iodide (1.3 mg, 0.007 mmol) were dissolved in dioxane (2.5 mL). The tube was sealed and the reaction mixture was heated in a microwave at 130° C. for 30 min. The reaction was diluted with dichloromethane and filtered over Celite®. The organic layers were concentrated under reduced pressure. Purification of the residue by preparative HPLC afforded, after evaporation of the solvents, 13.7 mg (100% purity, 44% yield) of (5RS)-5-(2,4-dimethylbenzyl)-3-{2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl}-5,6-dihydro-4H-1,2,4-oxadiazine as a brown oil.

Preparation Example 3: Preparation of (5RS)-5-(2,4-dimethylbenzyl)-3-[2-methyl-5-(3-nitro-phenoxy)pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (Compound I-003) Step 1: Preparation of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-2-methyl-pyrimidine-4-carboxamide (Compound 12.01)

Under argon, to a solution of 5-bromo-2-methylpyrimidine-4-carboxylic acid (200 mg, 0.92 mmol) and propylphosphonic anhydride (1.1 g, 3.41 mmol, 50% in THF) in dichloromethane (6 mL) was added N,N-Diisopropylethylamine (0.59 mL, 3.36 mmol) and (2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-aminium chloride (237 mg, 1 mmol). The reaction mixture was stirred at room temperature for 1 h, diluted with water and extracted with dichloromethane (3×200 mL). The organic extracts were washed with a saturated aqueous sodium bicarbonate solution and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/EtOAc) afforded, after evaporation of the solvents, 256 mg (100% purity, 70% yield) of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-2-methylpyrimidine-4-carboxamide.

Step 2: Preparation of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-N′-hydroxy-2-methylpyrimidine-4-carboximidamide (Compound 13.01)

To a solution of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-2-methylpyrimidine-4-carboxamide (233 mg, 0.59 mmol) in toluene (6 mL) was added phosphorous pentachloride (183 mg, 0.54 mmol). The reaction mixture was stirred at 75° C. for 2 h, then concentrated under reduced pressure. The residue was dissolved in Acetonitrile (3 mL) and added to a solution of hydroxylamine (0.72 mL, 11.7 mmol, 50% in water) in Acetonitrile (3 mL). After stirring at room temperature for 15 min, the reaction mixture was diluted with water and extracted with ethyl acetate (3×200 mL). The organic extracts were washed with water and brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by column chromatography on silica gel (gradient heptane/EtOAc) afforded, after evaporation of the solvents, 127 mg (100% purity, 53% yield) of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-N′-hydroxy-2-methylpyrimidine-4-carboximidamide as a yellow oil.

Step 3: Preparation of (5RS)-3-(5-bromo-2-methylpyrimidin-4-yl)-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine (Compound 7.01)

To a solution of 5-bromo-N-[(2RS)-1-chloro-3-(2,4-dimethylphenyl)propan-2-yl]-N′-hydroxy-2-methylpyrimidine-4-carboximidamide (124 mg, 0.3 mmol) in Acetonitrile (2.9 mL) was added potassium phosphate (96 mg, 0.45 mmol). The reaction mixture was stirred at room temperature for 18 h, then diluted with water and extracted with ethyl acetate (3×200 mL). The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Evaporation of the solvents afforded 91.5 mg (100% purity, 81% yield) of (5RS)-3-(5-bromo-2-methylpyrimidin-4-yl)-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine as a yellow oil.

Step 4: Preparation of (5RS)-5-(2,4-dimethylbenzyl)-3-[2-methyl-5-(3-nitrophenoxy)pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine

In a microwave vial, a mixture of (5RS)-3-(5-bromo-2-methylpyrimidin-4-yl)-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine (85 mg, 0.22 mmol), 3-nitrophenol (47 mg, 0.34 mmol), N-(n-butyl)imidazole (14 mg, 0.11 mmol), cesium carbonate (148 mg, 0.45 mmol) and copper(I)iodide (4.3 mg, 0.02 mmol) were dissolved in dioxane (4 mL). The tube was sealed and the reaction mixture was heated in a microwave at 130° C. for 30 min. The reaction was diluted with dichloromethane and filtered over Celite®. The organic layers were concentrated under reduced pressure. Purification of the residue by preparative HPLC afforded, after evaporation of the solvents, 19.6 mg (100% purity, 20% yield) of (5RS)-5-(2,4-dimethylbenzyl)-3-[2-methyl-5-(3-nitrophenoxy)pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine as a brown oil.

Preparation Example 4: Preparation of (5RS)-3-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-5-indan-5-yl-5,6-dihydro-4H-1,2,4-oxadiazine (Compound 1-014) Step 1: Preparation of 5-(3-chlorophenoxy)-N′-hydroxy-2-methyl-pyrimidine-4-carboxamidine (Compound 17-01)

To a solution of 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carbonitrile (59 mg, 0.243 mmol) in ethanol (1.5 mL) was added hydroxylamine-hydrochloride (42 mg, 0.67 mmol) and potassium carbonate (84 mg, 0.67 mmol). The reaction mixture was stirred 2 h at 60° C., then the reaction mixture was cooled down to room temperature and filtered. The filtrate was concentrated, and the residue was diluted with water and extracted with ethyl acetate. The combined organic layers were dried with MgSO₄, filtered and concentrated to give 45 mg (94% purity, 63% yield) of (5-(3-chlorophenoxy)-N′-hydroxy-2-methyl-pyrimidine-4-carboxamidine as a white solid.

Step 2: Preparation of (5-(3-chlorophenoxy)-N′-(2-indan-5-yl-2-oxo-ethoxy)-2-methyl-pyrimidine-4-carboxamidine (Compound 19-01)

To a solution of 5-(3-chlorophenoxy)-N′-hydroxy-2-methyl-pyrimidine-4-carboxamidine (42 mg, 0.151 mmol) in acetonitrile (1.5 mL) was added 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (0.052 mL, 0.181 mmol) at room temperature. After stirring for 15 min, 2-bromo-1-indan-5-yl-ethanone (54 mg, 0.226 mmol) in acetonitrile (1 mL) was added and the mixture was stirred for 15 min at room temperature. The reaction mixture was quenched with saturated aqueous solution of ammonium chloride, then extracted with ethyl acetate. The organic phase was dried with MgSO₄, filtered and concentrated to give 95 mg (61% purity, 88% yield) of (5-(3-chlorophenoxy)-N′-(2-indan-5-yl-2-oxo-ethoxy)-2-methyl-pyrimidine-4-carboxamidine. The product was converted without further purification.

Step 3: Preparation of (5RS)-3-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-5-indan-5-yl-5,6-dihydro-4H-1,2,4-oxadiazine (Compound 1-014)

A solution of (5-(3-chlorophenoxy)-N′-(2-indan-5-yl-2-oxo-ethoxy)-2-methyl-pyrimidine-4-carboxamidine (93 mg, 0, 213 mmol) in a mixture of methanol (1.6 mL) and acetic acid (0.4 mL) was heated for 1 h at 60° C. Then sodium cyanoborohydride (15 mg, 0.234 mmol) was added and the reaction mixture was stirred at 60° C. for an additional 2 h. The reaction mixture was poured into 1N NaOH solution and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over MgSO₄ and concentrated. The residue was purified by preparative HPLC to afford 18 mg (99% purity, 20% yield) of (5RS)-3-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-5-indan-5-yl-5,6-dihydro-4H-1,2,4-oxadiazine as a transparent oil.

Preparation Example 5: Preparation of (5RS)-5-[(4-ethynyl-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (Compound I-026) Step 1: Preparation of trimethyl-[2-[3-methyl-4-[[(5RS)-3-[2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazin-5-yl]methyl]phenyl]ethynyl]silane (Compound 1-010)

In a sealed vial, (5RS)-5-[(4-bromo-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (200 mg, 0.38 mmol) (compound I-021), trimethylsilylacetylene (0.273 mL, 1.92 mmol), tetrakis(triphenylphosphine)palladium (44 mg, 0.04 mmol), zinc dibromide (173 mg, 0.77 mmol) and diisopropylamine (0.27 mL, 1.92 mmol) were suspended in degassed toluene (4 mL). The reaction mixture was stirred at 120° C. under microwave irradiation during 35 min. The reaction mixture was poured over brine and diluted with ethyl acetate. The organic layer was dried over MgSO₄ anhydrous, filtered and then concentrated under reduced pressure. This crude product was purified by flash silica gel chromatography (10% to 80% ethyl acetate in n-heptane) to afford 102 mg (80% purity, 40% yield) of trimethyl-[2-[3-methyl-4-[[(5RS)-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazin-5-yl]methyl]phenyl]ethynyl]silane.

Step 2: Preparation of (5RS)-5-[(4-ethynyl-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (Compound I-026)

To a solution of trimethyl-[2-[3-methyl-4-[[(5RS)-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazin-5-yl]methyl]phenyl]ethynyl]silane (96 mg, 80% purity, 0.143 mmol) in THF (3 mL) at 0° C. was added tetra-n-butylammonium fluoride (0.143 mL, 0.143 mmol, 1 M solution in THF). After 30 min. at 0° C., the reaction mixture was poured into the brine, and extracted with ethyl acetate. The collected organic layer was dried over MgSO₄ anhydrous, filtered then concentrated over reduced pressure. The crude product was purified by preparative HPLC to afford 28 mg (99% purity, 42% yield) of (5RS)-5-[(4-ethynyl-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine as a transparent oil.

Preparation Example 6: Preparation of (5RS)-5-[(4-cyclopropyl-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (Compound I-029)

In a sealed vial(5RS)-5-[(4-bromo-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoro-methyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine (100 mg, 0.19 mmol) (compound I-021), 2-cyclopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (64 mg, 0.38 mmol), cesium carbonate (94 mg, 0.29 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (7.5 mg, 0.009 mmol) were suspended in a mixture of 1,4-dioxane (1 mL) and water (0.5 mL). The reaction mixture was stirred at 130° C. under microwave irradiation during 45 min. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous solution of K₂CO₃. The organic layer was dried over MgSO₄ anhydrous, filtered then concentrated over reduced pressure. This crude product was purified by preparative HPLC to afford 9 mg (96% purity, 9% yield) of (5RS)-5-[(4-cyclopropyl-2-methyl-phenyl)methyl]-3-[2-methyl-5-[3-(trifluoromethyl)phenoxy]pyrimidin-4-yl]-5,6-dihydro-4H-1,2,4-oxadiazine.

Preparation Example 7: Preparation of (6RS)-2-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-6-[(2,4-dimethylphenyl)methyl]-5,6-dihydro-1H-pyrimidin-4-one (Compound I-011) Step 1: Preparation of methyl 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carboximidate (compound 20-01)

To a solution of 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carbonitrile (120 mg, 0.48 mmol) in methanol (1 mL) at 0° C. was added sodium methoxide (29 mg, 0.53 mmol). The reaction was stirred for 2 h at 0° C., and then 30 min at room temperature. The reaction mixture was kept as a solution and used directly without further purification for the following step.

Step 2: Preparation of (6RS)-2-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-6-[(2,4-dimethylphenyl)methyl]-5,6-dihydro-1H-pyrimidin-4-one (Compound I-011)

A solution of methyl 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carboximidate (135 mg, 0.48 mmol) and 3-amino-4-(2,4-dimethylphenyl)butanamide (151 mg, 0.73 mmol) in methanol (1 mL) and acetic acid (28 μL, 0.48 mmol) was stirred at 60° C. during 18 h. The reaction mixture was cooled down to room temperature and concentrated. The crude product was purified directly by flash silica gel chromatography (10% to 80% ethyl acetate in n-heptane) to afford 93 mg (99% purity, 43% yield) of (6RS)-2-[5-(3-chlorophenoxy)-2-methyl-pyrimidin-4-yl]-6-[(2,4-dimethylphenyl)methyl]-5,6-dihydro-1H-pyrimidin-4-one as a white powder.

Preparation Example 8: Preparation of 5-(3-chlorophenoxy)-2-methyl-4-[(6RS)-6-[(2,4-dimethyl-phenyl)methyl]-1,4,5,6-tetrahydropyrimidin-2-yl]pyrimidine (Compound T-022) Step 1: Preparation of methyl 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carboximidate (compound 20-01)

To a solution of 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carbonitrile (120 mg, 0.48 mmol) in methanol (1 mL) at 0° C. was added sodium methoxide (29 mg, 0.53 mmol). The reaction was stirred for 2 h at 0° C., and then 30 min at room temperature. The reaction mixture was kept as a solution and used directly treated for the following step.

Step 2: Preparation of 5-(3-chlorophenoxy)-2-methyl-4-[(6RS)-6-[(2,4-dimethylphenyl)methyl]-1,4,5,6-tetrahydropyrimidin-2-yl]pyrimidine (Compound I-022)

A solution of methyl 5-(3-chlorophenoxy)-2-methyl-pyrimidine-4-carboximidate (135 mg, 0.48 mmol) and 4-(2,4-dimethylphenyl)butane-1,3-diamine (140 mg, 0.72 mmol) in methanol (1.5 mL) and acetic acid (13 μL, 0.24 mmol) was stirred at room temperature during 18 h. The reaction mixture was cooled down to room temperature and concentrated. The crude product was purified directly by flash silica gel chromatography (10% to 80% ethyl acetate in n-heptane) to afford 113 mg (99% purity, 55% yield) of 5-(3-chlorophenoxy)-2-methyl-4-[(6RS)-6-[(2,4-dimethylphenyl)methyl]-1,4,5,6-tetrahydropyrimidin-2-yl]pyrimidine as a yellow oil.

The compounds as shown in Table 1 below were prepared in accordance with the examples provided above or following methods described herein.

TABLE 1 Compounds according to formula (I) Ex No Structure ¹H-NMR Peak List LogP I-001

I-001: ¹H-NMR(500.1 MHz, CDCl3): δ = 8.3657 (6.1); 7.4320 (0.8); 7.4164 (2.0); 7.4007 (1.2); 7.3317 (2.0); 7.3163 (1.4); 7.2591 (20.8); 7.1034 (4.5); 7.0867 (1.4); 7.0681 (1.4); 7.0521 (5.3); 7.0359 (2.4); 7.0201 (0.9); 6.3216 (1.8); 5.2981 (5.9); 4.0471 (1.2); 4.0403 (1.3); 4.0254 (1.3); 4.0185 (1.4); 3.7989 (0.6); 3.7931 (0.8); 3.7874 (0.9); 3.7814 (0.9); 3.7760 (0.8); 3.7699 (0.6); 3.6441 (1.5); 3.6324 (1.3); 3.6224 (1.4); 3.6106 (1.2); 2.9374 (1.0); 2.9259 (1.0); 2.9102 (1.3); 2.8987 (1.3); 2.7473 (1.3); 2.7297 (1.3); 2.7201 (1.1); 2.7023 (1.0); 2.3290 (14.3); 2.3119 (15.1); 2.3014 (0.7); 2.2908 (0.8); 2.2843 (0.9); 2.2747 (1.3); 2.2652 (0.9); 2.2589 (0.8); 2.2491 (0.4); 1.5413 (16.0); 1.2847 (0.3); 1.2556 (1.3); 1.1475 (0.4); 1.1342 (0.6); 1.1216 (1.6); 1.1186 (1.6); 1.1065 (2.0); 1.0940 (1.8); 1.0808 (1.1); 1.0748 (1.2); 1.0640 (1.5); 1.0537 (1.0); 1.0501 (1.1); 1.0394 (1.4); 1.0274 (0.6); 1.0229 (0.8); 0.8807 (0.4); 5.16^([a]) 0.1539 (0.5); 0.0692 (12.6); −0.0002 (27.7) I-002

I-002: ¹H-NMR(500.1 MHz, CDCl3): δ = 8.4314 (3.7); 7.4542 (0.5); 7.4377 (1.0); 7.4207 (0.8); 7.3566 (1.3); 7.3411 (0.9); 7.2596 (8.5); 7.1300 (2.7); 7.1176 (1.0); 7.0612 (1.2); 7.0459 (2.2); 7.0361 (2.0); 7.0076 (1.3); 6.9921 (0.7); 6.4383 (1.1); 5.2980 (1.5); 4.1429 (0.6); 4.1287 (1.7); 4.1144 (1.7); 4.1001 (0.6); 3.9901 (0.8); 3.9833 (0.8); 3.9683 (0.9); 3.9615 (0.9); 3.8113 (0.5); 3.8051 (0.5); 3.8001 (0.6); 3.6697 (1.0); 3.6587 (0.9); 3.6479 (0.9); 3.6370 (0.8); 2.9187 (0.5); 2.9056 (0.6); 2.8913 (1.0); 2.8782 (0.9); 2.8249 (1.0); 2.8088 (0.9); 2.7975 (0.6); 2.7814 (0.6); 2.7464 (11.4); 2.3168 (16.0); 2.0435 (7.2); 2.0043 (0.4); 1.5580 (1.7); 1.2729 (2.0); 1.2586 (4.2); 1.2444 (1.9); 0.0694 (2.8); −0.0002 (11.0) 4.33^([a]) I-003

I-003: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5025 (3.2); 7.9443 (1.5); 7.9251 (1.8); 7.5818 (2.5); 7.5102 (1.0); 7.4904 (1.9); 7.4706 (1.3); 7.3293 (1.7); 7.3110 (1.6); 7.2606 (1.0); 7.0383 (5.2); 7.0137 (3.0); 6.9957 (1.7); 6.4866 (2.1); 5.2950 (2.0); 3.9648 (1.3); 3.9394 (1.5); 3.7880 (1.4); 3.6532 (1.2); 3.6404 (1.3); 3.6275 (1.3); 3.6144 (1.1); 2.9151 (0.7); 2.8987 (0.9); 2.8815 (1.5); 2.8660 (1.5); 2.8223 (1.5); 2.8016 (1.9); 2.7739 (10.5); 2.3143 (16.0); 2.0430 (0.6); 2.0027 (0.3); 1.6337 (0.6); 1.2576 (0.6); 1.2416 (0.4); −0.0002 (1.0) 3.78^([a]) I-004

I-004: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3507 (0.8); 7.2598 (6.3); 7.2177 (0.7); 7.1983 (1.4); 7.1787 (0.8); 7.0686 (1.0); 7.0495 (1.7); 7.0291 (1.9); 6.9946 (1.2); 6.9752 (0.8); 6.9363 (1.1); 6.9176 (0.9); 6.7803 (1.6); 6.7637 (1.0); 6.7428 (0.8); 6.4083 (0.9); 5.2977 (1.0); 4.1306 (0.9); 4.1127 (1.0); 4.0949 (0.4); 4.0651 (0.4); 4.0347 (0.6); 4.0273 (0.6); 4.0073 (0.6); 4.0005 (0.7); 3.8135 (0.5); 3.7152 (0.6); 3.7016 (0.6); 3.6881 (0.6); 3.6741 (0.5); 2.9395 (0.4); 2.9233 (0.4); 2.9054 (0.8); 2.8893 (0.8); 2.8352 (0.8); 2.8148 (0.8); 2.8011 (0.5); 2.7809 (0.4); 2.7082 (5.6); 2.3195 (10.0); 2.3132 (16.0); 2.0436 (5.0); 1.5769 (5.6); 1.2764 (1.2); 1.2585 (2.3); 1.2407 (1.1); 0.9356 (0.6); 0.0695 (1.8); −0.0002 (8.3) 3.95^([a]) I-005

I-005: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3346 (4.0); 7.2600 (13.8); 7.2368 (2.7); 7.1991 (0.8); 7.1954 (0.8); 7.1833 (0.9); 7.1792 (1.6); 7.1750 (1.1); 7.1631 (1.0); 7.1593 (1.0); 7.1382 (1.9); 7.1189 (2.7); 7.0482 (1.7); 7.0338 (1.3); 7.0297 (1.9); 7.0135 (1.7); 7.0092 (1.6); 6.9929 (0.9); 6.9886 (0.9); 6.8965 (1.0); 6.8928 (1.0); 6.8786 (1.2); 6.8754 (1.6); 6.8581 (0.8); 6.8543 (0.7); 6.4425 (1.3); 5.2984 (3.9); 3.9830 (0.9); 3.9751 (1.6); 3.9546 (2.4); 3.9486 (1.8); 3.9309 (0.4); 3.7852 (0.9); 3.7709 (1.3); 3.7558 (1.1); 3.7417 (0.6); 3.0733 (0.5); 3.0563 (0.5); 3.0391 (1.4); 3.0232 (1.4); 3.0013 (1.2); 2.9825 (1.1); 2.9669 (0.6); 2.9494 (0.5); 2.7229 (16.0); 2.3512 (0.3); 2.3327 (11.8); 1.5770 (3.8); 1.2554 (0.4); 0.0694 (2.3); −0.0002 (18.0) 4.19^([a]) I-006

I-006: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4345 (4.8); 7.4618 (0.8); 7.4419 (1.8); 7.4206 (1.4); 7.3624 (2.4); 7.3427 (1.6); 7.2593 (17.6); 7.2340 (2.5); 7.1355 (7.4); 7.1181 (3.7); 6.7222 (1.1); 6.6948 (1.3); 6.6782 (1.3); 6.6510 (1.3); 6.4384 (2.1); 5.7629 (2.5); 5.7191 (2.3); 5.2979 (5.2); 5.2540 (2.5); 5.2267 (2.4); 3.9792 (1.2); 3.9708 (1.3); 3.9519 (1.5); 3.9438 (1.6); 3.8232 (1.2); 3.7044 (1.6); 3.6914 (1.4); 3.6773 (1.4); 3.6646 (1.1); 2.9541 (0.7); 2.9369 (0.7); 2.9198 (1.7); 2.9035 (1.7); 2.8757 (1.7); 2.8557 (1.7); 2.8417 (0.8); 2.8217 (0.7); 2.7426 (16.0); 2.3516 (14.3); 2.3270 (0.7); 2.0435 (1.0); 1.5574 (7.0); 1.2767 (0.5); 1.2584 (1.3); 1.2412 (0.4); 0.0694 (4.2); −0.0002 (15.9) 4.44^([a]) I-007

I-007: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4266 (0.3); 7.3093 (0.8); 7.2886 (1.6); 7.2598 (6.2); 7.0664 (1.0); 7.0470 (2.1); 7.0361 (2.1); 7.0080 (1.4); 6.9890 (0.7); 6.8597 (1.0); 6.8402 (0.9); 6.7736 (1.0); 6.7530 (0.9); 6.7033 (1.8); 6.6727 (0.8); 6.4886 (1.7); 6.4289 (0.8); 6.3045 (0.8); 4.1305 (0.4); 4.1125 (0.4); 3.9993 (0.6); 3.9793 (0.6); 3.8049 (0.6); 3.6896 (0.6); 3.6756 (0.6); 3.6630 (0.6); 3.6497 (0.4); 2.9307 (0.4); 2.9145 (0.4); 2.8967 (0.8); 2.8809 (0.8); 2.8323 (0.8); 2.8125 (0.8); 2.7986 (0.5); 2.7784 (0.5); 2.7290 (3.7); 2.3186 (16.0); 2.0436 (2.1); 1.5667 (5.9); 1.2764 (0.6); 1.2585 (1.2); 1.2408 (0.5); 0.0696 (2.3); −0.0002 (7.9) 3.94^([a]) I-008

I-008: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3966 (0.5); 8.2610 (5.0); 7.2605 (12.4); 7.2321 (4.4); 7.1655 (0.6); 7.1485 (2.4); 7.1296 (3.2); 7.1104 (0.4); 7.0901 (0.3); 7.0314 (2.6); 7.0133 (2.1); 6.9958 (1.4); 6.9754 (2.6); 6.9560 (1.6); 6.9341 (0.3); 6.8654 (1.4); 6.8466 (2.3); 6.8266 (1.2); 6.7104 (1.5); 6.6933 (2.3); 6.6761 (1.2); 6.4399 (2.6); 5.2984 (8.5); 4.0014 (1.7); 3.9769 (3.8); 3.8093 (1.3); 3.7985 (1.6); 3.7834 (1.5); 3.0913 (0.7); 3.0760 (0.8); 3.0581 (1.6); 3.0418 (1.7); 3.0110 (1.7); 2.9928 (1.6); 2.9785 (0.8); 2.9591 (0.7); 2.7892 (1.6); 2.7013 (16.0); 2.3260 (14.9); 2.2767 (1.6); 2.1151 (0.5); 2.0931 (1.1); 2.0806 (1.6); 2.0694 (1.1); 2.0482 (0.5); 1.5741 (24.2); 1.2564 (0.9); 1.0379 (0.4); 1.0096 (3.6); 0.9887 (3.6); 0.7414 (4.5); 0.7283 (4.3); 0.0698 (5.2); −0.0002 (14.9) 4.49^([a]) I-009

I-009: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4127 (3.2); 7.2592 (2.5); 7.2354 (0.6); 7.2154 (1.6); 7.1995 (1.3); 7.1796 (1.7); 7.1597 (0.6); 7.0676 (1.0); 7.0484 (2.0); 7.0331 (2.6); 7.0278 (2.1); 7.0227 (1.4); 7.0089 (1.3); 6.9897 (0.7); 6.9122 (0.9); 6.9095 (0.8); 6.8921 (0.8); 6.4162 (1.1); 4.0111 (0.7); 4.0026 (0.8); 3.9839 (0.8); 3.9755 (0.8); 3.8113 (0.5); 3.8056 (0.6); 3.6858 (0.9); 3.6721 (0.8); 3.6587 (0.8); 3.6449 (0.7); 2.9318 (0.4); 2.9156 (0.5); 2.8977 (0.9); 2.8815 (0.8); 2.8323 (0.9); 2.8122 (0.9); 2.7982 (0.5); 2.7780 (0.5); 2.7330 (10.1); 2.3192 (16.0); 1.5950 (1.0); 0.0706 (0.6); −0.0002 (3.1) 4.44^([a]) I-010

I-010: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4403 (1.3); 8.4373 (1.9); 7.4435 (0.6); 7.4226 (0.5); 7.3647 (1.1); 7.3382 (1.0); 7.2992 (0.6); 7.2792 (0.6); 7.2596 (5.9); 7.1326 (1.5); 7.1048 (0.7); 7.0853 (0.6); 7.0400 (0.4); 6.4021 (0.5); 5.2976 (2.7); 3.9361 (0.3); 3.9283 (0.4); 3.9091 (0.4); 3.9013 (0.5); 3.8095 (0.3); 3.7030 (0.4); 3.6915 (0.4); 3.6758 (0.3); 2.9103 (0.5); 2.8940 (0.5); 2.8849 (0.7); 2.8659 (0.6); 2.8583 (0.3); 2.7495 (7.4); 2.4018 (0.4); 2.3526 (0.4); 2.3253 (2.0); 2.3113 (3.6); 1.5514 (6.9); 0.2988 (2.2); 0.2499 (16.0); 0.2343 (2.0); 0.2070 (1.7); 0.0697 (4.5); −0.0002 (6.1) 5.79^([a]) I-011

I-011: ¹H-NMR(400.1 MHz, CDCl3): δ = 9.3618 (1.0); 8.5704 (5.3); 7.2588 (5.0); 7.2373 (2.7); 7.2168 (1.8); 7.1056 (1.1); 7.1034 (1.3); 7.1008 (1.3); 7.0986 (1.3); 7.0856 (0.9); 7.0833 (1.0); 7.0808 (1.1); 7.0786 (1.0); 6.9243 (3.0); 6.9055 (2.3); 6.8887 (1.6); 6.8832 (2.5); 6.8779 (1.8); 6.8430 (1.2); 6.8238 (0.8); 6.7625 (1.1); 6.7603 (1.2); 6.7564 (1.1); 6.7543 (1.1); 6.7418 (1.0); 6.7396 (1.1); 6.7357 (1.1); 6.7335 (1.0); 5.2963 (1.0); 3.9460 (0.5); 3.9386 (0.4); 3.9323 (0.6); 3.9246 (0.6); 3.9188 (0.6); 3.9111 (0.6); 3.9048 (0.4); 3.8974 (0.6); 2.8976 (0.8); 2.8835 (0.8); 2.8630 (0.9); 2.8490 (0.9); 2.8328 (0.4); 2.7826 (16.0); 2.5798 (1.0); 2.5583 (1.0); 2.5452 (0.8); 2.5238 (0.8); 2.4495 (0.9); 2.4354 (1.0); 2.4076 4.01^([a]) (1.3); 2.3935 (1.2); 2.2596 (9.7); 2.2049 (1.7); 2.1948 (10.7); 2.1778 (1.7); 2.1630 (1.3); 2.1454 (0.3); 2.1358 (1.2); 1.5810 (0.7); 1.2550 (0.5); 0.0704 (0.8); −0.0002 (6.4); −0.0084 (0.3) I-012

I-012: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4365 (5.0); 7.4638 (0.8); 7.4439 (1.7); 7.4228 (1.3); 7.3625 (2.2); 7.3436 (1.5); 7.2611 (8.3); 7.1420 (7.3); 7.1219 (4.2); 6.9718 (2.8); 6.9660 (3.0); 6.8046 (1.7); 6.7987 (1.6); 6.7835 (1.5); 6.7777 (1.4); 6.4705 (1.9); 5.2990 (4.1); 3.9168 (2.7); 3.8957 (2.4); 3.8053 (16.0); 3.7878 (0.9); 3.7552 (0.3); 3.7356 (1.1); 3.7220 (1.5); 3.7063 (1.3); 3.6936 (0.8); 3.0216 (0.5); 3.0058 (0.6); 2.9879 (1.6); 2.9710 (1.7); 2.9601 (1.8); 2.9425 (1.7); 2.9264 (0.6); 2.9073 (0.5); 2.7566 (15.3); 2.0444 (0.8); 1.5732 (3.4); 1.2765 (0.4); 1.2589 (0.8); 0.0699 (3.2); −0.0002 (10.8) 4.08^([a]) I-013

I-013: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4349 (5.1); 7.4639 (0.8); 7.4440 (1.9); 7.4227 (1.3); 7.3628 (2.4); 7.3440 (1.6); 7.2609 (10.2); 7.2372 (3.8); 7.1405 (5.7); 7.1232 (3.9); 7.1035 (3.3); 7.0491 (2.4); 7.0300 (1.5); 6.4816 (2.1); 3.9297 (2.8); 3.9038 (2.1); 3.8970 (1.5); 3.7350 (1.2); 3.7235 (1.5); 3.7078 (1.3); 3.6970 (0.9); 3.0500 (0.6); 3.0327 (0.6); 3.0160 (1.7); 2.9997 (1.7); 2.9841 (1.7); 2.9658 (1.6); 2.9512 (0.7); 2.9322 (0.6); 2.8426 (0.3); 2.7561 (16.0); 2.3541 (0.4); 2.3337 (14.1); 1.5758 (12.4); 1.2582 (0.6); 0.0698 (1.1); −0.0002 (12.7) 4.47^([a]) I-014

I-014: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4634 (5.2); 7.2843 (1.2); 7.2641 (4.3); 7.2593 (12.8); 7.2444 (1.7); 7.0752 (1.2); 7.0731 (1.0); 6.9320 (1.1); 6.9265 (2.4); 6.9214 (1.8); 6.9156 (1.5); 6.9136 (1.5); 6.9096 (0.8); 6.8951 (1.1); 6.8933 (1.1); 6.8891 (0.9); 6.8873 (0.8); 6.6338 (1.3); 5.2981 (11.8); 4.6799 (0.6); 4.6700 (0.7); 4.6650 (0.7); 4.6549 (0.7); 4.2441 (0.7); 4.2416 (0.8); 4.2342 (0.8); 4.2315 (0.7); 4.2168 (0.8); 4.2142 (0.9); 4.2068 (0.8); 4.2042 (0.8); 3.6221 (1.3); 3.6037 (1.3); 3.5948 (1.3); 3.5764 (1.2); 2.9379 (3.0); 2.9193 (5.9); 2.9007 (3.4); 2.7868 (0.4); 2.7366 (16.0); 2.6872 (0.3); 2.1360 (0.6); 2.1173 (1.8); 2.1088 (0.4); 2.0986 (2.6); 2.0803 (1.8); 2.0615 (0.5); 2.0437 (1.3); 1.5497 (7.2); 1.2766 (0.5); 1.2587 (1.1); 1.2409 (0.4); 0.0693 (7.2); 0.0603 (0.4); 0.0502 4.05^([a]) (0.4); 0.0078 (0.6); −0.0002 (17.4); −0.0083 (0.9); −0.0500 (0.3) I-015

I-015: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4461 (5.2); 7.4708 (0.6); 7.4499 (1.3); 7.4291 (1.0); 7.3709 (1.6); 7.3513 (3.5); 7.2601 (11.1); 7.1447 (2.8); 6.5029 (1.2); 5.2983 (3.5); 3.9409 (0.9); 3.9329 (1.1); 3.9137 (1.2); 3.9057 (1.4); 3.8561 (3.1); 7.1917 (2.2); 7.0999 (2.2); 7.0954 (1.5); 7.0930 (1.3); 7.0801 (0.4); 3.8475 (0.6); 3.8391 (0.8); 3.8310 (0.8); 3.8226 (0.6); 3.8121 (0.4); 3.7536 (1.3); 3.7427 (1.1); 3.7264 (1.0); 3.7155 (0.8); 2.9406 (1.6); 2.9269 (2.2); 2.9088 (1.6); 2.7809 (0.3); 2.7495 (16.0); 1.5707 (1.0); 0.0697 (1.3); 0.0078 (0.5); −0.0002 (13.6) 4.17^([a]) I-016

I-016: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3952 (0.8); 8.2538 (4.8); 7.2595 (9.2); 7.0803 (2.4); 7.0622 (3.4); 7.0260 (4.8); 6.9899 (5.1); 6.9701 (6.0); 6.9198 (0.6); 6.9024 (0.4); 6.8579 (1.7); 6.8386 (2.7); 6.8192 (1.5); 6.7065 (2.0); 6.6901 (2.7); 6.4108 (3.2); 5.2978 (1.1); 4.3651 (0.4); 4.1368 (0.4); 4.0594 (1.9); 4.0339 (2.2); 3.8401 (1.9); 3.7518 (1.9); 3.7424 (1.7); 3.7289 (1.7); 3.7155 (1.4); 2.9564 (1.0); 2.9412 (1.2); 2.9227 (2.0); 2.9090 (1.9); 2.8605 (1.9); 2.8426 (1.9); 2.8313 (1.4); 2.7946 (2.6); 2.6921 (15.2); 2.3295 (16.0); 2.3077 (15.7); 2.2728 (3.1); 2.0781 (1.9); 1.5679 (17.8); 1.2545 (0.7); 1.0058 (4.7); 0.9857 (4.2); 0.7381 (5.7); 0.7269 (5.3); 0.0695 (4.8); −0.0002 (11.2) 4.41^([a]) I-017

I-017: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3643 (5.3); 7.4496 (0.8); 7.4296 (1.7); 7.4087 (1.3); 7.3445 (2.2); 7.3251 (1.5); 7.2601 (9.5); 7.1179 (5.1); 7.1022 (2.0); 7.0579 (1.8); 7.0374 (5.0); 7.0045 (2.6); 6.9857 (1.3); 6.2481 (2.1); 5.2981 (1.2); 4.1305 (0.8); 4.1127 (0.8); 4.0949 (0.3); 4.0420 (1.2); 4.0340 (1.3); 4.0151 (1.5); 4.0071 (1.5); 3.8130 (1.0); 3.8066 (1.1); 3.7997 (1.2); 3.7928 (1.1); 3.6697 (1.5); 3.6552 (1.4); 3.6425 (1.4); 3.6281 (1.2); 2.9288 (1.0); 2.9142 (1.0); 2.8947 (1.5); 2.8803 (1.4); 2.7699 (1.4); 2.7477 (1.4); 2.7359 (1.1); 2.7134 (0.9); 2.5791 (0.3); 2.4820 (16.0); 2.3138 (15.4); 2.3041 (15.8); 2.0438 (3.2); 1.5658 (17.2); 1.2765 (1.2); 1.2586 (2.5); 1.2409 (1.1); 0.0698 (4.5); −0.0002 (11.7) 5.09^([a]) I-018

I-018: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5242 (0.7); 8.4198 (5.0); 7.2604 (11.2); 7.2402 (6.3); 7.1553 (0.9); 7.1258 (2.7); 7.1070 (3.9); 7.0842 (3.0); 7.0640 (2.7); 7.0475 (3.4); 7.0291 (2.2); 6.9841 (0.6); 6.9628 (0.6); 6.9163 (0.7); 6.8884 (4.4); 6.8691 (2.8); 6.8473 (2.4); 6.8126 (0.4); 6.4431 (3.0); 5.2975 (1.0); 4.3623 (0.4); 4.0849 (0.4); 3.9413 (4.1); 3.9196 (3.7); 3.7457 (1.6); 3.7343 (2.0); 3.7181 (1.8); 3.7060 (1.3); 3.0556 (1.0); 3.0402 (1.0); 3.0229 (2.1); 3.0076 (2.1); 2.9838 (2.1); 2.9657 (2.1); 2.9339 (0.8); 2.8261 (2.1); 2.7407 (16.0); 2.3325 (15.3); 2.2805 (2.2); 1.5616 (16.9); 1.2599 (0.4); 0.0695 (2.2); −0.0002 (12.3) 4.22^([a]) I-019

I-019: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3693 (3.5); 7.2950 (0.9); 7.2755 (2.1); 7.2590 (8.9); 7.1671 (1.9); 7.1479 (1.4); 7.0667 (1.5); 7.0474 (2.5); 7.0255 (4.2); 6.9956 (2.0); 6.9770 (1.2); 6.8524 (1.4); 6.8320 (1.3); 6.6818 (0.9); 6.6547 (1.0); 6.6377 (1.0); 6.6109 (1.0); 6.4156 (1.8); 5.7236 (2.0); 5.6795 (1.8); 5.2975 (2.7); 5.2730 (2.0); 5.2458 (1.9); 4.1478 (0.4); 4.1301 (1.1); 4.1125 (1.2); 4.0947 (0.4); 4.0223 (1.1); 3.9956 (1.2); 3.8159 (1.0); 3.7081 (1.2); 3.6950 (1.0); 3.6811 (1.0); 3.6677 (0.8); 2.9367 (0.6); 2.9212 (0.6); 2.9034 (1.2); 2.8872 (1.2); 2.8346 (1.2); 2.8144 (1.2); 2.8017 (0.7); 2.7806 (0.6); 2.7155 (11.5); 2.3161 (16.0); 2.0431 (4.6); 2.0038 (0.5); 1.5839 (3.2); 1.2761 (1.5); 1.2584 (2.9); 1.2405 (1.4); 0.0694 (0.9); −0.0002 (11.2) 4.09^([a]) I-020

I-020: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3709 (5.4); 7.4499 (0.7); 7.4305 (1.7); 7.4111 (1.1); 7.3466 (1.8); 7.3273 (1.2); 7.2592 (3.6); 7.2343 (2.9); 7.1252 (4.6); 7.1182 (2.5); 7.0981 (3.7); 7.0507 (1.9); 7.0314 (1.1); 6.2571 (1.6); 5.2957 (0.5); 3.9663 (0.9); 3.9583 (1.5); 3.9481 (0.7); 3.9356 (2.4); 3.9068 (0.4); 3.7270 (0.8); 3.7138 (1.3); 3.6991 (1.2); 3.6847 (0.5); 3.0519 (0.7); 3.0373 (0.7); 3.0181 (1.2); 3.0037 (1.2); 2.9266 (1.1); 2.9063 (1.0); 2.8928 (0.7); 2.8730 (0.7); 2.5190 (16.0); 2.3312 (12.4); 1.5638 (0.9); 1.2573 (0.5); 0.0708 (0.9); −0.0002 (3.9) 5.14^([a]) I-021

I-021: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4411 (5.1); 7.4685 (0.6); 7.4471 (1.2); 7.4262 (0.9); 7.3666 (3.9); 7.3474 (1.1); 7.3262 (1.2); 7.3215 (1.0); 7.3061 (1.3); 7.3013 (1.2); 7.2603 (11.8); 7.1421 (1.4); 7.1267 (3.4); 7.0407 (2.3); 7.0204 (2.0); 6.4208 (1.2); 5.2988 (1.5); 3.9325 (0.9); 3.9244 (1.0); 3.9053 (1.2); 3.8972 (1.3); 3.8185 (0.6); 3.8101 (0.7); 3.8019 (0.8); 3.7934 (0.6); 3.7823 (0.4); 3.7221 (1.4); 3.7104 (1.1); 3.6950 (1.0); 3.6834 (0.8); 2.9195 (0.4); 2.9029 (0.5); 2.8853 (1.5); 2.8685 (1.5); 2.8590 (1.6); 2.8453 (0.6); 2.8393 (1.4); 2.8248 (0.5); 2.8050 (0.4); 2.7500 (16.0); 2.3260 (12.1); 1.5618 (8.2); 1.2542 (0.3); 0.0696 (3.9); 0.0076 (0.6); −0.0002 (14.4); −0.0083 (0.6) 4.48^([a]) I-022

I-022: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3434 (5.6); 7.4024 (1.1); 7.3822 (2.8); 7.3620 (1.9); 7.2982 (1.7); 7.2762 (1.2); 7.2628 (6.0); 7.1484 (1.4); 7.1432 (2.8); 7.1384 (2.0); 7.1257 (1.6); 7.1054 (1.2); 7.1011 (1.0); 7.0236 (1.8); 7.0035 (3.2); 6.8907 (1.4); 6.8720 (1.1); 5.2985 (9.4); 4.0352 (0.4); 4.0239 (0.9); 4.0123 (0.5); 3.9977 (0.6); 3.9864 (1.1); 3.9749 (0.5); 3.9328 (0.6); 3.9210 (0.7); 3.9087 (0.6); 3.7209 (0.3); 3.7151 (0.5); 3.7040 (0.7); 3.6910 (0.6); 3.6791 (0.8); 3.6669 (0.5); 3.6537 (0.5); 3.6429 (0.4); 3.0879 (0.7); 3.0727 (0.7); 3.0527 (1.1); 3.0378 (1.1); 2.9497 (1.1); 2.9272 (1.1); 2.9148 (0.8); 2.8923 (0.7); 2.7140 (16.0); 2.3051 (12.3); 2.2697 (12.1); 2.2529 (1.2); 2.2407 (0.7); 2.2290 (0.9); 2.2186 (1.0); 2.2073 (0.4); 2.1691 (6.2); 1.9680 (1.7); 1.9177 (0.4); 2.59^([a]) 1.9063 (0.5); 1.8950 (0.7); 1.8836 (0.5); 1.8719 (0.6); 1.8607 (0.4); 1.2528 (0.4); 1.2352 (0.4); 0.0700 (1.9); 0.0078 (0.4); −0.0002 (8.4) I-023

I-023: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4175 (0.8); 7.2596 (5.2); 7.2405 (1.6); 7.2203 (1.0); 7.0809 (1.2); 7.0653 (1.6); 7.0473 (2.0); 7.0356 (2.0); 7.0083 (1.3); 6.9893 (0.7); 6.8796 (1.8); 6.8618 (1.1); 6.8412 (0.9); 6.4155 (0.9); 4.0118 (0.6); 4.0040 (0.6); 3.9846 (0.7); 3.9765 (0.7); 3.8049 (0.6); 3.6879 (0.7); 3.6741 (0.6); 3.6608 (0.6); 3.6471 (0.5); 2.9310 (0.4); 2.9150 (0.5); 2.8970 (0.9); 2.8810 (0.8); 2.8312 (0.8); 2.8111 (0.8); 2.7971 (0.5); 2.7770 (0.5); 2.7323 (6.0); 2.3188 (16.0); 1.5786 (2.3); 0.0697 (1.3); −0.0002 (6.1) 4.15^([a]) I-024

I-024: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3315 (5.0); 7.2600 (10.0); 7.2068 (1.1); 7.1867 (2.1); 7.1654 (1.4); 7.0695 (1.9); 7.0503 (3.2); 7.0293 (3.5); 6.9942 (2.3); 6.9752 (1.4); 6.8477 (2.1); 6.8288 (1.9); 6.7105 (5.1); 6.6956 (2.1); 6.4109 (2.0); 5.2981 (2.0); 4.1484 (0.5); 4.1306 (1.5); 4.1126 (1.5); 4.0951 (0.6); 4.0349 (1.2); 4.0266 (1.3); 4.0079 (1.4); 3.9996 (1.5); 3.8163 (1.1); 3.7163 (1.6); 3.7026 (1.3); 3.6892 (1.4); 3.6756 (1.2); 2.9411 (0.8); 2.9250 (0.8); 2.9072 (1.6); 2.8912 (1.5); 2.8372 (1.5); 2.8168 (1.5); 2.8029 (0.9); 2.7827 (0.9); 2.7466 (0.5); 2.7047 (16.0); 2.3219 (15.9); 2.3138 (15.7); 2.0439 (6.3); 2.0046 (0.4); 1.8820 (0.4); 1.8706 (0.7); 1.8617 (0.9); 1.8497 (1.4); 1.8372 (0.9); 1.8289 (0.8); 1.8158 (0.4); 1.5732 (7.2); 1.2766 (1.9); 1.2587 (3.9); 1.2409 (1.9); 0.9711 (0.8); 0.9548 (2.8); 0.9379 (2.8); 0.9227 (1.1); 0.8831 (0.3); 4.55^([a]) 0.6869 (0.9); 0.6745 (3.4); 0.6594 (3.3); 0.6471 (0.9); 0.0697 (3.4); −0.0002 (13.1) I-025

I-025: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3969 (2.6); 7.2993 (0.5); 7.2805 (1.4); 7.2601 (6.9); 7.2360 (2.4); 6.9801 (3.4); 6.4017 (1.3); 5.2983 (4.9); 4.0091 (0.7); 4.0016 (0.8); 3.9820 (0.9); 3.9752 (0.9); 3.8042 (0.7); 3.6825 (0.9); 3.6687 (0.8); 3.6558 (0.8); 3.6418 (0.6); 3.0562 (2.7); 2.9303 (0.4); 2.9138 (0.5); 2.8961 (0.9); 2.8799 (0.9); 2.8292 (0.9); 2.8093 (0.9); 2.7955 (0.5); 2.7751 (0.4); 2.7265 (8.3); 2.3181 (16.0); 1.5555 (5.8); 1.2604 (0.7); 0.8825 (0.4); 0.0695 (1.2); −0.0002 (8.4) 3.85^([a]) I-026

I-026: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4392 (5.2); 7.4671 (0.6); 7.4461 (1.4); 7.4251 (1.0); 7.3616 (3.3); 7.3464 (1.2); 7.3315 (1.3); 7.3119 (1.5); 7.2600 (15.1); 7.1319 (4.6); 7.1129 (2.1); 6.4275 (1.3); 5.2987 (10.8); 3.9488 (0.9); 3.9405 (1.1); 3.9216 (1.2); 3.9134 (1.4); 3.8416 (0.6); 3.8334 (0.7); 3.8251 (0.8); 3.8172 (0.6); 3.8055 (0.4); 3.7214 (1.4); 3.7094 (1.1); 3.6942 (1.1); 3.6823 (0.9); 3.0645 (5.3); 2.9637 (0.5); 2.9472 (0.5); 2.9295 (1.5); 2.9130 (1.4); 2.8993 (1.5); 2.8792 (1.4); 2.8650 (0.5); 2.8458 (0.6); 2.7464 (16.0); 2.3298 (12.2); 2.0442 (1.3); 2.0054 (0.6); 1.5681 (2.0); 1.2768 (0.5); 1.2589 (1.1); 1.2412 (0.4); 0.0694 (2.0); 0.0076 (1.1); −0.0002 (21.2) 3.99^([a]) I-027

I-027: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4451 (5.1); 7.4715 (1.0); 7.4516 (2.1); 7.4309 (1.5); 7.3708 (2.6); 7.3518 (1.8); 7.2612 (14.0); 7.2377 (5.5); 7.2183 (3.5); 7.1364 (5.0); 7.0940 (0.4); 7.0733 (0.4); 7.0430 (2.0); 7.0222 (1.7); 6.6961 (1.3); 6.5134 (2.8); 6.4740 (2.3); 6.3310 (1.4); 5.3002 (1.2); 3.9568 (1.5); 3.9487 (1.6); 3.9414 (1.3); 3.8936 (1.4); 3.8862 (1.3); 3.8657 (2.2); 3.8584 (2.0); 3.7947 (1.8); 3.7852 (1.9); 3.7676 (1.2); 3.7573 (1.1); 3.0868 (0.5); 3.0695 (0.7); 3.0533 (2.2); 3.0355 (3.8); 3.0159 (2.2); 2.9820 (0.7); 2.8449 (0.8); 2.7519 (16.0); 1.5671 (9.0); 1.2553 (0.8); 0.0695 (2.0); −0.0002 (18.3) 4.15^([a]) I-028

I-028: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4847 (5.1); 7.4584 (1.0); 7.4517 (0.7); 7.4362 (8.1); 7.4295 (6.2); 7.4068 (1.1); 7.3093 (0.4); 7.2979 (1.3); 7.2776 (2.8); 7.2596 (14.2); 7.1237 (1.3); 7.1212 (1.4); 7.1010 (1.2); 6.9604 (1.4); 6.9549 (2.6); 6.9498 (1.8); 6.9197 (1.4); 6.9139 (1.1); 6.8990 (1.2); 6.8943 (1.0); 6.6907 (1.5); 5.9713 (1.4); 5.8407 (1.4); 5.2984 (5.4); 4.6366 (1.2); 4.6329 (1.3); 4.5890 (1.2); 4.5852 (1.2); 4.1304 (0.4); 4.1125 (0.4); 2.8034 (0.3); 2.7540 (16.0); 2.0437 (1.6); 1.5449 (12.9); 1.2766 (0.7); 1.2586 (1.4); 1.2408 (0.6); 0.0782 (0.4); 0.0693 (6.5); 0.0496 (0.5); −0.0002 (18.4); −0.0506 (0.3) 3.79^([a]) I-029

I-029: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4305 (5.2); 7.4578 (0.6); 7.4373 (1.4); 7.4161 (1.1); 7.3570 (1.8); 7.3377 (1.2); 7.2592 (5.3); 7.1306 (4.2); 7.1148 (1.5); 7.0566 (1.9); 7.0372 (2.5); 6.9268 (2.7); 6.8958 (1.6); 6.8763 (1.3); 6.4262 (1.6); 5.2965 (5.9); 4.1300 (0.5); 4.1121 (0.5); 3.9836 (1.0); 3.9752 (1.1); 3.9564 (1.2); 3.9481 (1.3); 3.7969 (0.8); 3.7901 (0.8); 3.7696 (0.4); 3.6717 (1.4); 3.6581 (1.2); 3.6445 (1.2); 3.6310 (1.0); 2.9146 (0.7); 2.8982 (0.7); 2.8804 (1.4); 2.8640 (1.4); 2.8218 (1.4); 2.8019 (1.4); 2.7876 (0.8); 2.7768 (0.3); 2.7677 (0.7); 2.7448 (16.0); 2.3127 (12.7); 2.0429 (2.1); 2.0024 (1.3); 1.8794 (0.6); 1.8710 (0.7); 1.8584 (1.2); 1.8459 (0.7); 1.8375 (0.7); 1.8247 (0.4); 1.5738 (2.0); 1.2760 (0.8); 1.2581 (1.8); 1.2404 (0.7); 0.9754 (0.6); 0.9652 (2.0); 0.9607 (2.2); 0.9517 (1.2); 0.9443 (2.1); 0.9397 (2.1); 0.9300 (0.9); 0.6956 4.70^([a]) (0.9); 0.6832 (2.4); 0.6793 (2.0); 0.6716 (2.4); 0.6588 (0.9); 0.0704 (2.5); −0.0002 (5.2) I-030

I-030: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4394 (5.3); 7.6589 (3.0); 7.6387 (3.4); 7.4702 (0.6); 7.4492 (1.2); 7.4362 (0.3); 7.4280 (1.0); 7.3699 (1.5); 7.3508 (1.0); 7.3072 (3.7); 7.2868 (3.3); 7.2597 (11.6); 7.1454 (1.5); 7.1304 (2.7); 6.4490 (1.1); 5.2982 (5.7); 3.9489 (0.9); 3.9408 (1.1); 3.9218 (1.1); 3.9137 (1.4); 3.8684 (0.6); 3.8603 (0.7); 3.8521 (0.7); 3.8437 (0.6); 3.8325 (0.4); 3.7535 (1.3); 3.7422 (1.1); 3.7264 (1.0); 3.7151 (0.8); 2.9848 (0.4); 2.9683 (0.4); 2.9514 (1.5); 2.9340 (2.6); 2.9133 (1.4); 2.8997 (0.4); 2.8800 (0.5); 2.8419 (0.5); 2.7224 (16.0); 1.5447 (7.8); 1.2584 (0.4); 0.0695 (3.4); −0.0002 (18.0); −0.0082 (0.8) 4.62^([a]) I-031

I-031: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4569 (3.2); 7.2798 (1.0); 7.2606 (5.0); 7.2391 (1.4); 7.0949 (1.2); 7.0924 (1.2); 7.0905 (1.1); 7.0768 (0.9); 7.0749 (1.0); 7.0724 (1.0); 7.0705 (0.9); 6.9372 (1.3); 6.9319 (2.2); 6.9268 (1.5); 6.8986 (2.8); 6.8925 (1.3); 6.8906 (1.2); 6.8780 (3.7); 6.8719 (1.3); 6.8452 (2.1); 6.8402 (2.5); 6.8097 (1.6); 6.8047 (1.3); 6.7890 (1.1); 6.7839 (0.9); 6.6034 (1.4); 4.6067 (0.6); 4.5962 (0.8); 4.5922 (0.8); 4.5818 (0.7); 4.2672 (16.0); 4.2172 (1.0); 4.2070 (0.8); 4.1895 (0.9); 4.1873 (0.9); 4.1797 (0.9); 3.5977 (1.0); 3.5795 (1.1); 3.5703 (1.0); 3.5522 (1.0); 2.7431 (11.9); 2.0036 (1.1); 1.2551 (0.5); 0.0705 (0.5); - 0.0002 (4.7) 3.04^([a]) I-032

I-032: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3822 (2.3); 7.2601 (10.2); 7.2249 (1.2); 7.2043 (2.4); 7.1837 (1.3); 7.0677 (1.6); 7.0484 (2.7); 7.0300 (3.0); 6.9984 (2.0); 6.9798 (1.1); 6.6754 (1.4); 6.6715 (1.4); 6.6547 (1.3); 6.6506 (1.3); 6.5522 (2.8); 6.5094 (1.5); 6.4892 (1.4); 6.4105 (1.6); 5.2980 (1.8); 4.1482 (0.5); 4.1306 (1.5); 4.1127 (1.5); 4.0950 (0.6); 4.0652 (0.5); 4.0281 (1.0); 4.0201 (1.0); 4.0012 (1.1); 3.9931 (1.2); 3.8129 (1.0); 3.7729 (15.2); 3.7098 (1.2); 3.6963 (1.0); 3.6827 (1.1); 3.6689 (0.9); 2.9366 (0.7); 2.9210 (0.7); 2.9028 (1.3); 2.8868 (1.2); 2.8346 (1.3); 2.8146 (1.2); 2.8007 (0.8); 2.7803 (0.7); 2.7101 (11.5); 2.3192 (16.0); 2.0437 (7.8); 2.0044 (0.3); 1.6267 (0.4); 1.5764 (7.0); 1.2765 (1.9); 1.2586 (3.8); 1.2408 (1.8); 0.9539 (0.4); 0.9356 (0.8); 0.9174 (0.4); 3.66^([a]) 0.0695 (2.1); −0.0002 (13.6) I-033

I-033: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4461 (5.2); 7.5799 (1.9); 7.4711 (0.5); 7.4512 (1.1); 7.4422 (0.4); 7.4308 (0.9); 7.3929 (0.7); 7.3718 (2.5); 7.3507 (1.0); 7.3401 (2.2); 7.3204 (1.1); 7.2599 (11.0); 7.1462 (1.4); 7.1387 (1.9); 7.1335 (2.1); 6.7626 (1.0); 6.6222 (2.1); 6.4818 (1.2); 6.4702 (0.9); 6.4625 (1.0); 5.2983 (7.5); 4.0030 (0.5); 3.9944 (0.7); 3.9856 (0.8); 3.9765 (0.6); 3.9677 (0.4); 3.8893 (0.8); 3.8814 (0.7); 3.8617 (1.6); 3.8537 (1.4); 3.8123 (1.3); 3.8024 (1.2); 3.7849 (0.7); 3.7749 (0.6); 3.1161 (1.2); 3.0997 (2.3); 3.0816 (1.2); 3.0668 (0.4); 3.0482 (0.3); 2.7475 (16.0); 1.5478 (7.0); 0.0696 (2.5); 0.0080 (0.5); −0.0002 (17.2); - 0.0084 (0.9) 4.02^([a]) I-034

I-034: ¹H-NMR(400.1 MHZ, CDCl3): δ = 9.5693 (1.5); 8.5899 (5.3); 7.2592 (5.4); 7.2033 (1.3); 7.1830 (2.8); 7.1626 (1.8); 7.0758 (1.8); 7.0737 (1.8); 7.0557 (1.3); 6.9268 (2.9); 6.8631 (1.4); 6.8434 (1.8); 6.8183 (2.0); 6.8132 (2.9); 6.8080 (1.9); 6.7345 (2.7); 6.7150 (2.0); 6.6838 (1.5); 6.6785 (1.4); 6.6636 (1.4); 6.6578 (1.3); 5.2971 (1.5); 5.0366 (1.1); 5.0229 (1.2); 5.0043 (1.2); 4.9906 (1.2); 2.8163 (16.0); 2.7454 (1.2); 2.7317 (1.2); 2.7030 (1.4); 2.6894 (1.4); 2.3731 (1.5); 2.3406 (1.6); 2.3307 (1.4); 2.2980 (1.9); 2.2849 (12.8); 2.2189 (13.3); 1.5609 (2.9); 1.2557 (0.4); 0.0700 (1.6); −0.0002 (7.6) 3.80^([a]) I-035

I-035: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4956 (5.2); 7.5391 (0.4); 7.5223 (0.4); 7.2795 (1.0); 7.2601 (13.1); 7.2395 (1.6); 7.2273 (0.7); 7.2058 (1.3); 7.1895 (1.3); 7.1682 (0.7); 7.0932 (1.6); 7.0911 (1.6); 7.0723 (1.4); 6.9154 (0.4); 6.9040 (1.4); 6.9001 (2.0); 6.8806 (4.8); 6.8781 (4.8); 6.8560 (1.4); 6.8341 (0.8); 6.8285 (1.0); 6.8223 (0.8); 6.8027 (1.4); 6.7807 (1.1); 6.7749 (1.0); 6.7559 (0.4); 6.7497 (0.3); 6.7053 (1.3); 6.6979 (1.3); 4.8804 (0.6); 4.8708 (0.6); 4.7657 (2.3); 4.7565 (2.3); 2.7620 (0.7); 2.7467 (16.0); 2.6199 (0.6); 2.6098 (0.6); 2.0049 (1.0); 1.9606 (1.2); 1.5531 (6.3); 1.4010 (0.7); 1.2960 (12.6); 1.2544 (0.7); 1.0992 (3.8); 0.9838 (10.6); 0.0695 (3.6); −0.0002 (15.8) 3.84^([a])

The following compounds of formula (I) may be prepared according to the processes disclosed herein:

-   3-[6-(3-chloro-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5-(2-chloro-4-methylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine -   3-16-(3-chloro-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine -   3-[6-(3-cyclopropyl-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5-(2,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(2-chloro-4-methylbenzyl)-3-[6-(3-cyclopropyl-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(2-chloro-4-methylbenzyl)-3-{3-methyl-6-[3-(trifluoromethyl)phenoxy]-1,2,4-triazin-5-yl}-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(2,4-dimethylbenzyl)-3-{3-methyl-6-[3-(trifluoromethyl)phenoxy]-1,2,4-triazin-5-yl}-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(4-bromo-2-methylbenzyl)-3-{3-methyl-6-[3-(trifluoromethyl)phenoxy]-1,2,4-triazin-5-yl}-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(4-bromo-2-methylbenzyl)-3-[6-(3-cyclopropyl-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(4-bromo-2-methylbenzyl)-3-[6-(3-chloro-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5,6-dihydro-4H-1,2,4-oxadiazine -   3-[6-(3-chloro-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5-(3,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine -   3-[6-(3-cyclopropyl-2-fluorophenoxy)-3-methyl-1,2,4-triazin-5-yl]-5-(3,4-dimethylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine -   5-(3,4-dimethylbenzyl)-3-{3-methyl-6-[3-(trifluoromethyl)phenoxy]-1,2,4-triazin-5-yl}-5,6-dihydro-4H-1,2,4-oxadiazine.

Compounds of Formula (1)

TABLE 2 Compounds according to formula (1), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 1-01

1-01: ¹H-NMR(300.2 MHz, CDCl3): δ = 8.6429 (5.5); 7.5904 (0.6); 7.5646 (1.8); 7.5384 (1.6); 7.5149 (2.1); 7.4891 (0.9); 7.3041 (48.7); 7.2543 (1.3); 7.2302 (1.1); 5.3438 (0.6); 2.8770 (16.0); 1.8227 (0.5); 1.7542 (0.6); 1.7206 (0.6); 1.6818 (0.6); 1.6615 (0.6); 1.4810 (0.4); 1.2972 (1.1); 0.0530 (1.4); 0.0423 (41.8); 0.0313 (1.4) 1.69^([a]) 1-02

1-02: ¹H-NMR(500.1 MHz, d₆-DMSO): δ = 8.7173 (16.0); 7.6068 (2.4); 7.5908 (5.5); 7.5746 (3.6); 7.4986 (5.0); 7.4831 (3.7); 7.3759 (6.5); 7.2830 (3.6); 7.2786 (3.4); 7.2665 (3.3); 7.2621 (3.0); 5.7533 (10.0); 3.3171 (4.3); 2.5006 (40.2); 2.3175 (0.8); 2.3082 (1.8); 2.3008 (2.2); 2.2920 (3.6); 2.2830 (2.2); 2.2760 (1.9); 2.2664 (0.9); 1.2356 (1.3); 1.1240 (1.6); 1.1157 (4.3); 1.1097 (6.7); 1.1028 (4.3); 1.0997 (4.3); 1.0938 (6.0); 1.0876 (2.6); 1.0735 (0.7); 1.0587 (0.6); 1.0430 (2.7); 1.0364 (6.6); 1.0278 (7.7); 1.0222 (5.5); 1.0135 (1.7); −0.0002 (26.6) 2.49^([a]) 1-03

1-03: ¹H-NMR(400.2 MHz, d₆-DMSO): δ = 14.2640 (0.5); 14.0604 (1.1); 8.7553 (3.8); 7.4006 (12.1); 7.2186 (16.0); 7.2009 (15.0); 7.1446 (11.9); 6.9896 (9.1); 6.8525 (0.5); 6.8009 (0.4); 4.0581 (0.6); 4.0401 (1.5); 4.0224 (1.4); 4.0053 (0.6); 3.5546 (0.4); 3.5099 (0.4); 3.4704 (0.4); 3.4393 (0.4); 3.4185 (0.4); 3.3805 (0.4); 3.3407 (0.4); 3.3267 (0.4); 3.2691 (0.4); 3.2579 (0.4); 3.2405 (0.4); 3.2114 (0.4); 3.1952 (0.4); 3.1334 (0.4); 3.1179 (0.4); 3.1057 (0.4); 3.0752 (0.4); 3.0061 (0.9); 2.6805 (12.8); 2.5514 (79.7); 2.5126 (22.9); 2.3772 (1.0); 2.3437 (0.6); 2.2288 (0.3); 1.9935 (7.0); 1.9164 (0.7); 1.2324 (0.4); 1.1943 (1.7); 1.1767 (3.1); 1.1590 (1.6); 0.0003 (10.4) 2.00^([a]) 1-04

1-04: ¹H-NMR(400.2 MHz, d₆-DMSO): δ = 8.5628 (5.6); 7.3290 (1.1); 7.3086 (9.9); 7.3044 (6.4); 7.2957 (12.0); 7.2767 (0.8); 7.1761 (6.6); 7.0085 (0.7); 6.9977 (2.4); 6.9917 (2.6); 6.9863 (3.7); 6.9779 (2.6); 6.9753 (2.4); 6.9688 (2.0); 3.5251 (0.4); 3.5052 (0.5); 3.3435 (1.5); 3.1515 (0.4); 2.7775 (0.4); 2.6717 (2.3); 2.6673 (2.0); 2.6196 (16.0); 2.5071 (175.0); 2.5028 (218.8); 2.4986 (157.8); 2.3337 (1.1); 2.3297 (1.4); 0.0000 (8.0) 2.15^([a]) 1-05

1-05: ¹H-NMR(300.1 MHz, d₆-DMSO): δ = 8.7047 (6.2); 7.4169 (0.9); 7.4078 (0.4); 7.3915 (1.5); 7.3873 (1.3); 7.3817 (0.6); 7.3716 (0.5); 7.3615 (1.6); 7.2660 (2.1); 7.2405 (1.4); 7.0836 (4.0); 7.0716 (1.6); 7.0624 (1.4); 7.0596 (1.4); 7.0540 (0.7); 4.2707 (6.1); 3.3512 (0.6); 2.6734 (16.0); 2.5097 (4.3); 2.5038 (5.6); 2.4980 (3.9); 0.2351 (0.4); 0.1991 (0.8); −0.0004 (1.5); −0.1305 (0.8) 1.77^([a]) 1-06

1-06: ¹H-NMR(300.1 MHz, d₆-DMSO): δ = 8.7319 (3.0); 8.6371 (6.0); 7.3811 (0.9); 7.3551 (2.6); 7.3466 (2.0); 7.3435 (2.1); 7.3370 (1.1); 7.3287 (2.5); 7.2988 (0.4); 7.2864 (2.0); 7.2589 (1.9); 7.2553 (1.6); 7.2486 (0.9); 7.1603 (1.6); 7.1535 (2.1); 7.0388 (0.5); 7.0297 (0.8); 7.0185 (0.7); 7.0082 (0.5); 6.9999 (0.4); 6.9221 (1.1); 6.9169 (1.1); 6.8956 (1.0); 6.8901 (1.0); 6.7652 (1.0); 6.7288 (1.1); 6.7063 (1.2); 6.6699 (1.2); 5.8898 (2.0); 5.8323 (1.7); 5.3169 (2.0); 5.2797 (1.9); 3.3461 (1.1); 2.6771 (8.3); 2.6644 (16.0); 2.5095 (5.8); 2.5037 (7.7); 2.4979 (5.6); 1.9896 (0.4); −0.0003 (1.5) 1.87^([a]) 1-07

1-07: ¹H-NMR(300.1 MHz, d₆-DMSO): δ = 8.5949 (5.4); 7.0746 (0.6); 7.0513 (1.5); 7.0479 (1.6); 7.0248 (1.0); 7.0211 (1.1); 6.8868 (0.8); 6.8818 (1.0); 6.8599 (1.4); 6.8553 (1.6); 6.8332 (0.7); 6.8281 (0.8); 6.8229 (1.0); 6.8179 (0.8); 6.7962 (1.4); 6.7739 (0.8); 3.3294 (1.9); 2.6544 (16.0); 2.5138 (3.7); 2.5081 (7.8); 2.5022 (10.6); 2.4964 (7.7); 2.1023 (0.5); 2.0908 (0.6); 2.0745 (1.0); 2.0572 (0.6); 2.0463 (0.6); 1.9891 (0.7); 1.1744 (0.4); 1.0423 (0.7); 1.0276 (2.0); 1.0201 (2.2); 1.0067 (1.2); 0.9993 (2.0); 0.9919 (2.1); 2.20^([a]) 0.9787 (0.9); 0.7847 (0.9); 0.7711 (2.2); 0.7643 (2.4); 0.7542 (2.2); 0.7473 (2.4); 0.7322 (0.8); −0.0005 (2.1) 1-08

1-08: ¹H-NMR(300.1 MHz, d₆-DMSO): δ = 14.3903 (0.6); 14.3754 (0.6); 14.3570 (0.6); 14.2915 (0.7); 14.2611 (0.6); 14.2262 (0.7); 14.1136 (0.8); 14.0584 (0.8); 14.0448 (0.7); 14.0278 (0.8); 13.9874 (0.7); 13.9793 (0.7); 13.9631 (0.7); 13.9391 (0.6); 13.9085 (0.7); 13.8304 (0.6); 13.8039 (0.6); 13.7190 (0.6); 13.6818 (0.6); 13.6109 (0.5); 12.2188 (2.7); 10.4179 (0.7); 10.3529 (5.6); 9.2084 (0.6); 9.1381 (2.0); 9.0430 (0.6); 8.9501 (1.2); 8.8078 (3.4); 8.7775 (3.2); 8.7364 (2.5); 8.6655 (1.5); 8.6130 (1.1); 8.5996 (1.0); 8.5157 (0.6); 8.4798 (0.6); 8.2939 (0.6); 7.8826 (2.3); 7.8604 (2.4); 7.8245 (0.7); 7.6469 (0.5); 7.4451 (2.5); 7.3724 (16.0); 7.3023 (1.8); 7.1866 (13.1); 7.0688 (6.9); 7.0347 (7.4); 7.0092 (8.6); 6.9828 (10.4); 6.9574 (12.1); 6.9430 (15.3); 6.9306 (11.2); 6.9197 (11.0); 6.8393 (1.0); 6.8087 (0.7); 6.7649 (0.8); 4.0682 (0.6); 4.0424 (1.6); 4.0173 (1.8); 3.9946 (5.4); 3.9768 (5.6); 1.91^([a]) 3.9200 (0.7); 3.8879 (0.7); 3.8615 (0.8); 3.8425 (0.6); 3.6561 (1.1); 3.5695 (5.0); 3.5187 (1.4); 3.4690 (1.3); 3.4449 (1.5); 3.4271 (1.4); 3.3755 (1.4); 3.3126 (1.2); 3.2266 (1.0); 3.1840 (0.9); 3.1686 (0.8); 3.1389 (0.8); 3.0900 (0.6); 3.0560 (0.7); 3.0202 (0.6); 2.9951 (0.6); 2.9616 (0.8); 2.6906 (9.5); 2.5070 (191.5); 2.3890 (4.6); 2.2791 (3.4); 2.1831 (1.9); 2.0976 (1.4); 2.0236 (1.2); 1.9906 (8.7); 1.9118 (1.2); 1.8578 (0.9); 1.8281 (0.9); 1.8003 (0.8); 1.7742 (0.9); 1.6946 (0.7); 1.6278 (0.6); 1.5835 (0.7); 1.5496 (0.6); 1.5343 (0.6); 1.4365 (0.6); 1.4011 (0.6); 1.3809 (0.6); 1.3530 (0.6); 1.2353 (0.8); 1.1985 (1.7); 1.1754 (3.3); 1.1508 (1.8); 1.1207 (0.6); 0.9980 (0.5); 0.7819 (0.5); - 0.0004 (15.0)

Compounds of Formula (2)

TABLE 3 Compounds according to formula (2), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 2-01

2-01: ¹H-NMR(300.1 MHz, d₆-DMSO): δ = 8.4567 (2.3); 7.8866 (16.0); 7.1956 (1.5); 7.1703 (1.8); 6.9824 (2.5); 6.9715 (1.6); 6.9447 (1.0); 4.3276 (0.5); 4.3060 (0.6); 4.2909 (1.0); 4.2697 (1.0); 4.2311 (1.0); 4.2196 (1.1); 4.1945 (0.6); 4.1830 (0.5); 3.7230 (0.6); 3.7140 (0.6); 3.0236 (0.4); 2.9970 (1.1); 2.9786 (1.7); 2.9487 (0.9); 2.9341 (0.3); 2.5156 (1.9); 2.5101 (2.4); 2.5047 (1.8); 2.3112 (0.3); 2.2747 (8.8); 2.2526 (0.6); 2.2218 (8.4) 1.55^([a])

Compounds of Formula (3)

TABLE 4 Compounds according to formula (2), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 3-01

3-01: ¹H-NMR(500.1 MHz, CDCl3): δ = 8.5619 (1.3); 8.5457 (1.3); 8.4307 (7.6); 7.8398 (3.0); 7.8336 (3.3); 7.8289 (3.4); 7.8228 (4.7); 7.8145 (0.6); 7.7712 (0.6); 7.7629 (4.6); 7.7567 (3.5); 7.7520 (3.4); 7.7458 (3.2); 7.7386 (0.4); 7.4408 (1.0); 7.4249 (2.3); 7.4088 (1.5); 7.3490 (2.1); 7.3335 (1.5); 7.2591 (16.8); 7.2396 (2.6); 7.2041 (2.7); 7.1166 (1.5); 7.1122 (1.4); 7.1002 (1.3); 7.0958 (1.2); 6.9854 (5.8); 6.9696 (1.6); 5.2977 (1.3); 4.4436 (0.4); 4.4354 (0.6); 4.4282 (1.0); 4.4207 (0.9); 4.4123 (0.9); 4.4059 (2.8); 4.3995 (1.1); 4.3868 (2.1); 4.3801 (1.4); 4.1425 (1.4); 4.1359 (1.7); 4.1235 (1.6); 4.1167 (1.2); 3.1330 (4.1); 3.1181 (4.1); 2.5649 (1.5); 2.4959 (1.4); 2.4345 (0.4); 2.4250 (0.8); 2.4184 (0.9); 2.4091 (1.7); 2.3994 (1.1); 2.3853 (16.0); 2.3348 (0.6); 2.2836 (15.1); 2.2009 (0.6); 1.5472 (13.8); 1.3019 (0.6); 1.2944 (1.0); 1.2863 (1.2); 1.2774 (1.7); 1.2684 (1.2); 1.2563 (0.6); 1.2487 (0.4); 1.2267 (0.6); 1.2175 (1.2); 1.2079 (0.9); 1.2009 (0.8); 1.1981 (0.7); 1.1927 (1.1); 1.1785 (3.3); 1.1729 (1.6); 1.1705 (1.6); 1.1623 (2.7); 1.1540 (1.7); 0.0697 (7.7); 0.0626 (0.4); 0.0060 (0.9); −0.0002 (22.7); −0.0065 (1.1) 5.40^([a]) 3-02

3-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.6256 (1.7); 8.6060 (1.7); 8.4559 (5.1); 8.0181 (1.1); 7.8343 (4.1); 7.8243 (4.3); 7.7651 (4.6); 7.7569 (4.2); 7.3133 (1.0); 7.2932 (2.7); 7.2607 (18.0); 7.2455 (3.7); 7.0786 (3.5); 7.0339 (2.1); 7.0145 (2.0); 6.9868 (6.3); 6.9645 (2.3); 4.4601 (1.2); 4.4523 (1.3); 4.4315 (2.7); 4.4067 (2.1); 4.1617 (1.7); 4.1547 (1.8); 4.1382 (1.7); 3.7141 (0.4); 3.1567 (4.8); 3.1387 (4.0); 3.0482 (5.0); 2.9562 (5.3); 2.9340 (0.6); 2.8835 (6.2); 2.8176 (16.0); 2.8032 (6.7); 2.4068 (15.0); 2.3684 (0.4); 2.3418 (0.4); 2.3257 (0.5); 2.2842 (15.2); 2.2118 (0.5); 1.5789 (8.4); 1.5200 (1.3); 1.4925 (3.1); 1.4763 (2.9); 1.4478 (2.8); 1.4308 (2.7); 1.2576 (1.2); 0.2067 (0.5); 0.0699 (7.0); −0.0002 (15.1); −0.0875 (0.5) 4.41^([a]) 3-03

3-03: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7200 (5.6); 8.3767 (0.9); 8.3568 (0.9); 7.8451 (2.2); 7.8373 (2.5); 7.8314 (2.5); 7.8237 (3.6); 7.8136 (0.6); 7.7735 (0.5); 7.7635 (3.5); 7.7559 (2.5); 7.7499 (2.6); 7.7421 (2.3); 7.3768 (2.0); 7.3574 (2.3); 7.2601 (16.1); 7.1837 (2.5); 7.0555 (1.3); 7.0359 (1.2); 4.6562 (0.4); 4.6467 (0.8); 4.6366 (0.7); 4.6266 (0.8); 4.6171 (0.5); 4.4620 (1.0); 4.4519 (1.0); 4.4365 (1.4); 4.4263 (1.3); 4.2830 (1.3); 4.2728 (1.3); 4.2574 (1.1); 4.2472 (1.0); 3.3855 (0.6); 3.3661 (0.4); 3.3510 (1.4); 3.3308 (1.9); 3.3091 (1.4); 3.2929 (0.5); 3.2747 (0.4); 2.8032 (4.8); 2.6423 (0.3); 2.6217 (16.0); 2.3013 (11.0); 2.2365 (0.6); 1.5505 (7.4); 1.2558 (0.6); 0.0694 (3.5); −0.0002 (21.0) 4.62^([a])

Compounds of Formula (4)

TABLE 4 Compounds according to formula (4), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 4-01

4-01: ¹H-NMR(500.1 MHz, CDCl3): δ = 8.4385 (6.9); 8.2182 (1.0); 8.2008 (1.0); 7.4464 (0.9); 7.4305 (2.2); 7.4144 (1.4); 7.3554 (2.0); 7.3399 (1.4); 7.2591 (15.2); 7.1665 (2.5); 7.1090 (1.4); 7.1044 (1.3); 7.0925 (1.2); 7.0880 (1.2); 7.0644 (2.4); 7.0489 (2.9); 6.9639 (3.0); 6.9246 (1.7); 6.9091 (1.4); 5.5142 (1.8); 5.2978 (6.8); 4.4775 (0.5); 4.4707 (0.5); 4.4656 (0.6); 4.4592 (0.8); 4.4530 (0.6); 4.4480 (0.6); 4.4411 (0.5); 3.7424 (1.2); 3.7354 (1.3); 3.7202 (1.9); 3.7132 (1.8); 3.6375 (1.8); 3.6255 (1.8); 3.6153 (1.2); 3.6033 (1.2); 2.8845 (4.2); 2.8700 (4.5); 2.8082 (0.7); 2.6180 (0.5); 2.3584 (0.4); 2.3439 (0.8); 2.3322 (1.9); 2.3248 (16.0); 2.3070 (0.5); 2.2923 (0.6); 2.2811 (0.6); 2.2698 (15.0); 1.5704 (1.0); 1.2544 (1.1); 1.1649 (0.5); 1.1524 (3.6); 1.1460 (2.6); 1.1370 (7.1); 1.1322 (2.4); 1.1269 (1.7); 1.1209 (1.2); 1.1136 (0.4); 0.0697 (11.0); 0.0062 (0.6); −0.0002 (20.7); −0.0064 (1.0) 3.70^([a]) 4-02

4-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4616 (5.1); 8.1493 (1.5); 8.1269 (1.5); 7.8719 (0.4); 7.7502 (0.6); 7.3179 (1.0); 7.2982 (2.8); 7.2781 (2.7); 7.2604 (25.1); 7.0714 (2.5); 7.0525 (3.2); 7.0275 (3.7); 7.0133 (2.4); 6.9936 (2.0); 6.9637 (4.5); 6.9206 (2.7); 6.9030 (2.1); 5.5263 (4.6); 5.2989 (3.5); 4.5142 (1.3); 4.1450 (0.6); 3.7584 (1.3); 3.7514 (1.3); 3.7306 (2.1); 3.7243 (2.0); 3.6562 (1.9); 3.6396 (1.9); 3.6288 (1.4); 3.6134 (1.1); 3.0745 (4.9); 2.9561 (0.5); 2.9365 (0.4); 2.8970 (3.6); 2.8851 (3.3); 2.8410 (0.4); 2.8157 (1.2); 2.8034 (3.4); 2.7680 (16.0); 2.5652 (0.7); 2.4969 (0.7); 2.4492 (1.0); 2.3405 (15.7); 2.2691 (16.0); 2.2024 (0.5); 1.5568 (18.8); 1.3102 (0.6); 1.2546 (1.8); 0.8800 (0.4); 0.2172 (0.4); 0.0695 (7.8); −0.0002 (26.9); −0.0780 (0.6) 2.53^([a]) 4-03

4-03: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7373 (5.3); 8.0315 (0.6); 8.0100 (0.6); 7.2599 (11.6); 7.2090 (1.9); 7.1896 (2.3); 7.1697 (2.3); 7.0076 (1.3); 6.9883 (1.0); 5.2979 (1.2); 4.6728 (0.4); 4.6635 (0.4); 4.6570 (0.5); 4.6481 (0.6); 4.6413 (0.5); 4.6346 (0.5); 4.6254 (0.4); 3.8497 (0.9); 3.8404 (1.0); 3.8218 (1.5); 3.8126 (1.4); 3.7242 (1.4); 3.7084 (1.3); 3.6963 (0.9); 3.6806 (0.9); 3.0707 (3.4); 3.0525 (3.4); 2.8026 (1.4); 2.5571 (16.0); 2.2870 (10.4); 1.2553 (0.5); 0.0693 (2.3); −0.0002 (15.1); −0.0083 (0.9) 2.58^([a])

Compounds of Formula (6a)

TABLE 5 Compounds according to formula (6a), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 6a-01

6a-01: ¹H-NMR(400.1 MHz, d₆-DMSO): δ = 8.9720 (1.3); 8.9509 (1.3); 8.8942 (4.4); 7.8660 (16.0); 7.1714 (1.6); 7.1523 (1.9); 6.9638 (2.5); 6.9176 (1.4); 6.9005 (1.3); 4.4427 (0.7); 4.4288 (0.8); 4.3345 (0.7); 4.3207 (0.6); 4.3103 (1.2); 4.2972 (1.0); 4.2545 (1.1); 4.2403 (1.1); 4.2301 (0.8); 4.2156 (0.6); 3.3269 (68.9); 3.2946 (0.8); 3.1224 (0.6); 3.1089 (0.7); 3.0872 (0.9); 3.0728 (0.9); 2.9211 (0.8); 2.8930 (1.5); 2.8651 (0.7); 2.7321 (1.0); 2.5488 (11.4); 2.5040 (23.4); 2.3248 (9.7); 2.2197 (9.3); −0.0002 (4.5) 4.55^([a])

Compounds of Formula (6b)

TABLE 6 Compounds according to formula (6b), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 6b-01

6b-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7484 (5.2); 8.1656 (0.9); 8.1450 (0.9); 7.8626 (0.3); 7.8549 (0.4); 7.7493 (0.4); 7.7416 (0.4); 7.7360 (0.4); 7.2591 (6.9); 7.0963 (2.0); 7.0772 (2.5); 6.9820 (2.9); 6.9446 (1.8); 6.9249 (1.4); 5.5718 (1.3); 5.2963 (0.7); 4.5290 (0.6); 4.5219 (0.7); 4.5146 (0.8); 4.5081 (0.8); 4.5012 (0.7); 4.4934 (0.6); 4.1438 (0.4); 3.7873 (0.9); 3.7787 (1.0); 3.7594 (1.7); 3.7509 (1.6); 3.6915 (1.6); 3.6771 (1.6); 3.6637 (1.0); 3.6492 (1.0); 2.9869 (0.4); 2.9706 (0.4); 2.9522 (1.7); 2.9355 (3.2); 2.9144 (1.8); 2.9004 (0.6); 2.8798 (0.5); 2.8147 (0.4); 2.5506 (16.0); 2.3781 (12.9); 2.3476 (0.4); 2.2779 (12.6); 2.2523 (0.6); 1.5655 (2.0); 1.2555 (0.4); 0.0696 (2.4); −0.0002 (8.3) 2.49^([a])

Compounds of Formula (7)

TABLE 7 Compounds according to formula (7), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 7-01

7-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.8302 (4.9); 7.2597 (10.0); 7.0828 (2.1); 7.0638 (3.5); 7.0404 (3.9); 7.0138 (2.6); 6.9956 (1.8); 6.3403 (2.0); 5.2986 (6.3); 4.0988 (1.3); 4.0905 (1.5); 4.0719 (1.7); 4.0638 (1.8); 3.8397 (1.4); 3.7825 (1.9); 3.7688 (1.5); 3.7555 (1.7); 3.7417 (1.3); 2.9716 (0.9); 2.9559 (1.1); 2.9381 (1.8); 2.9217 (1.8); 2.8668 (1.7); 2.8468 (1.8); 2.8328 (1.3); 2.8132 (1.0); 2.7122 (0.6); 2.6709 (16.0); 2.3349 (14.7); 2.3179 (15.9); 1.5472 (9.4); 1.2865 (0.3); 1.2555 (0.6); 0.0692 (3.7); −0.0002 (13.7) 3.05^([a]) 7-02

7-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7370 (0.9); 8.7274 (0.4); 8.6958 (5.1); 7.2588 (10.5); 7.0696 (2.0); 7.0507 (3.2); 7.0315 (3.4); 7.0033 (2.6); 6.9851 (1.7); 6.9437 (0.4); 6.9366 (0.4); 6.1583 (1.8); 4.1475 (1.3); 4.1393 (1.4); 4.1204 (1.6); 4.1125 (1.8); 3.8584 (0.9); 3.8514 (1.0); 3.8442 (1.1); 3.8367 (1.0); 3.7928 (1.7); 3.7788 (1.2); 3.7663 (1.4); 3.7521 (1.0); 2.9699 (1.0); 2.9555 (1.1); 2.9354 (1.7); 2.9216 (1.5); 2.8192 (1.4); 2.7975 (1.4); 2.7850 (1.0); 2.7632 (0.9); 2.4986 (1.8); 2.4827 (1.0); 2.4788 (1.1); 2.4696 (0.9); 2.4300 (16.0); 2.4097 (1.6); 2.3932 (0.9); 2.3617 (2.0); 2.3447 (0.9); 2.3195 (15.4); 2.3105 (15.3); 2.2919 (2.3); 2.2808 (2.8); 2.0417 (0.8); 1.5489 (17.2); 1.2651 (1.9); 1.2402 (0.5); 0.8977 4.05^([a]) (0.7); 0.8817 (1.5); 0.8644 (0.7); 0.0694 (2.3); −0.0002 (12.8) 7-03

7-03: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7364 (0.4); 8.7223 (0.6); 8.7060 (5.1); 7.6130 (0.3); 7.2602 (9.1); 7.2381 (2.8); 7.1851 (0.3); 7.1441 (1.9); 7.1249 (2.8); 7.0582 (1.7); 7.0390 (1.2); 6.1794 (1.3); 5.2984 (0.9); 4.0813 (1.0); 4.0730 (1.2); 4.0540 (1.2); 4.0458 (1.4); 3.9845 (0.7); 3.9770 (0.8); 3.9696 (0.8); 3.9635 (0.7); 3.9497 (0.4); 3.8467 (1.4); 3.8344 (1.2); 3.8195 (1.2); 3.8074 (1.0); 3.1701 (0.3); 3.1524 (0.3); 3.1049 (0.9); 3.0898 (0.9); 3.0712 (1.4); 3.0561 (1.3); 2.9715 (1.3); 2.9514 (1.3); 2.9378 (0.9); 2.9178 (0.8); 2.5656 (1.0); 2.4964 (1.4); 2.4710 (16.0); 2.3323 (12.1); 2.3192 (1.1); 2.2927 (1.4); 1.5516 (4.7); 1.2560 (0.6); 0.0695 (2.2); −0.0002 (11.4) 4.08^([a])

Compounds According to Formula (9)

TABLE 8 Compounds according to formula (9), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 9-01

9-01: ¹H-NMR(300.2 MHz, CDCl3): δ = 7.6438 (0.5); 7.3661 (0.6); 7.3167 (0.5); 7.2990 (107.3); 7.2639 (0.4); 7.2354 (0.5); 7.1375 (1.2); 7.1101 (1.9); 7.0359 (2.6); 7.0282 (2.3); 7.0171 (1.6); 6.9904 (1.0); 6.9484 (0.8); 4.5372 (0.5); 4.5099 (0.4); 4.2226 (0.4); 4.2061 (0.5); 4.0962 (0.4); 3.8770 (0.7); 3.8498 (0.8); 3.8306 (0.6); 3.8113 (0.5); 3.7436 (16.0); 3.7105 (1.5); 3.6820 (1.5); 3.2699 (0.5); 3.2302 (0.7); 3.1379 (0.5); 3.1032 (0.6); 3.0910 (0.7); 3.0610 (0.4); 2.9134 (0.4); 2.8926 (0.7); 2.8630 (0.4); 2.3783 (9.4); 2.3379 (3.1); 2.3211 (13.5); 2.0640 (0.3); 1.7885 (0.7); 1.7676 (0.8); 1.7013 (2.1); 1.6039 (3.8); 1.3928 (1.2); 1.3716 (2.1); 1.3493 (1.3); 1.3233 (0.6); 1.2923 (1.1); 1.2598 (2.2); 1.2395 (1.4); 0.2335 1.13^([a]) (0.6); 0.1071 (9.8); 0.0771 (0.4); 0.0551 (0.5); 0.0487 (3.2); 0.0380 (131.2); 0.0275 (5.8); −0.0108 (0.4); −0.0221 (0.5); −0.0306 (0.5); −0.1608 (0.5) 9-02

9-02: ¹H-NMR(400.1 MHz, d₆-DMSO): δ = 8.5369 (10.2); 7.7228 (12.5); 7.7026 (15.7); 7.4889 (16.0); 7.4684 (14.2); 3.9139 (3.1); 3.9056 (4.5); 3.8763 (6.9); 3.8630 (3.3); 3.8515 (3.4); 3.6681 (3.8); 3.6575 (5.0); 3.6384 (4.5); 3.6282 (3.3); 3.5681 (0.5); 3.3321 (6.5); 3.1498 (2.5); 3.1352 (2.6); 3.1154 (3.7); 3.1006 (3.8); 3.0210 (4.4); 3.0005 (4.4); 2.9864 (2.8); 2.9660 (2.6); 2.5072 (13.7); 2.5027 (19.4); 2.4983 (15.0); 0.0080 (0.4); −0.0002 (10.5) 1.68^([a]) 9-03

9-03: ¹H-NMR(400.1 MHz, d₆-DMSO): δ = 8.4567 (16.0); 7.7978 (15.8); 7.7497 (0.3); 7.6970 (14.4); 3.9218 (5.5); 3.8926 (10.8); 3.7250 (4.9); 3.7143 (5.7); 3.6951 (4.8); 3.6857 (3.8); 3.5684 (2.3); 3.3192 (17.2); 3.0687 (1.7); 3.0356 (13.2); 3.0190 (8.1); 2.9814 (1.3); 2.5014 (28.9); 1.1062 (1.7); −0.0002 (16.4) 1.29^([a]) 9-04

9-04: ¹H-NMR(300.2 MHz, d₆-DMSO): δ = 7.5393 (0.9); 7.0418 (1.3); 7.0161 (3.2); 7.0024 (3.1); 6.9744 (1.6); 6.9489 (0.8); 3.4134 (0.4); 3.3897 (0.9); 3.3662 (1.1); 3.3473 (0.9); 3.3240 (0.5); 2.7093 (2.1); 2.7044 (2.6); 2.6803 (2.1); 2.5345 (1.6); 2.5286 (3.5); 2.5226 (4.9); 2.5166 (3.6); 2.5107 (1.8); 2.2552 (16.0); 2.2263 (2.8); 2.2095 (1.8); 2.2005 (1.6); 2.0094 (0.4); 0.0204 (6.1) 0.69^([a]) 9-05

9-05: ¹H-NMR(300.2 MHz, CDCl3): δ = 7.3292 (0.5); 7.2991 (1.7); 7.0887 (0.4); 7.0622 (0.4); 7.0162 (0.6); 4.5819 (0.5); 2.8373 (16.0); 2.5265 (1.0); 2.5033 (1.5); 2.3677 (3.6); 2.3333 (3.4); 1.8587 (1.5); 0.0347 (1.9) 0.55^([b]) 9-06

9-06: ¹H-NMR(300.2 MHz, d₆-DMSO): δ = 7.0363 (1.8); 7.0110 (3.3); 6.9851 (3.0); 6.9558 (2.0); 6.9305 (1.1); 5.0883 (0.3); 4.9774 (0.4); 4.9157 (0.4); 4.8595 (0.4); 4.7461 (0.3); 3.0967 (2.8); 2.9721 (0.6); 2.9616 (0.8); 2.9408 (1.0); 2.9301 (0.7); 2.9184 (0.7); 2.9001 (0.9); 2.8765 (1.8); 2.8532 (1.7); 2.8320 (0.8); 2.8133 (0.4); 2.6178 (3.0); 2.5934 (2.2); 2.5340 (2.2); 2.5283 (4.4); 2.5224 (5.8); 2.5164 (4.3); 2.2549 (16.0); 2.2456 (14.8); 1.6161 (0.4); 1.6044 (0.4); 1.5929 (0.6); 1.5808 (0.6); 1.5715 (0.6); 1.5589 (0.6); 0.23^([a]) 1.5475 (0.4); 1.4592 (0.7); 1.4289 (0.7); 1.4141 (0.5); 1.4054 (0.5); 1.3825 (0.4); 1.1264 (8.5); 0.0204 (5.2)

Compounds of Formula (10)

TABLE 9 Compounds according to formula (10), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 10- 01

10-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5111 (4.9); 8.1701 (1.1); 8.1498 (1.1); 7.4709 (0.8); 7.4507 (2.0); 7.4306 (1.4); 7.3834 (2.2); 7.3644 (1.3); 7.2599 (10.4); 7.2226 (2.4); 7.2014 (2.6); 7.1735 (2.7); 7.1115 (1.5); 7.0915 (1.4); 6.9078 (2.6); 6.9018 (2.8); 6.7563 (1.5); 6.7502 (1.4); 6.7350 (1.4); 6.7290 (1.3); 5.2979 (0.4); 4.6235 (0.3); 4.6143 (0.6); 4.6050 (0.9); 4.5954 (0.9); 4.5855 (0.9); 4.5764 (0.6); 3.7693 (16.0); 3.7540 (1.5); 3.7359 (1.8); 3.7256 (1.6); 3.6385 (1.6); 3.6300 (1.6); 3.6101 (1.1); 3.6017 (1.0); 3.1707 (0.5); 3.1520 (0.5); 3.1358 (1.8); 3.1155 (2.5); 3.0943 (1.8); 3.0778 (0.6); 3.0597 (0.5); 2.8117 (15.2); 1.5520 (15.0); 1.3043 (1.1); 1.2652 (4.9); 0.8980 (2.0); 0.8820 (4.5); 0.8645 (2.2); 0.0695 (2.4); −0.0002 (13.6) 4.47^([a]) 10- 02

10-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5085 (5.0); 8.1818 (1.1); 8.1621 (1.1); 7.4706 (0.8); 7.4510 (2.0); 7.4310 (1.5); 7.3838 (2.2); 7.3650 (1.4); 7.2599 (8.7); 7.1983 (2.3); 7.1763 (4.7); 7.1202 (1.6); 7.0996 (1.4); 6.9962 (1.9); 6.9777 (1.6); 5.2980 (0.7); 4.6416 (0.3); 4.6312 (0.6); 4.6219 (0.9); 4.6125 (1.0); 4.6027 (1.0); 4.5933 (0.7); 4.5843 (0.4); 3.7674 (1.0); 3.7567 (1.1); 3.7392 (1.6); 3.7286 (1.6); 3.6428 (1.6); 3.6342 (1.7); 3.6145 (1.1); 3.6059 (1.1); 3.2008 (0.5); 3.1824 (0.5); 3.1662 (1.7); 3.1470 (2.0); 3.1411 (2.1); 3.1223 (1.8); 3.1058 (0.6); 3.0873 (0.5); 2.8111 (16.0); 2.3203 (0.4); 2.3107 (0.4); 2.2868 (13.2); 1.5594 (3.4); 1.2549 (0.5); 0.0697 (2.7); −0.0002 (10.8) 4.74^([a]) 10- 03

10-03: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3394 (4.7); 8.1350 (1.3); 8.1152 (1.3); 7.2604 (11.7); 7.2288 (2.4); 7.2093 (2.8); 7.1727 (3.8); 7.0099 (1.1); 6.9932 (3.6); 6.9747 (2.5); 6.8463 (1.2); 6.8278 (2.0); 6.8088 (1.0); 6.7326 (1.2); 6.7152 (1.9); 6.6983 (1.0); 5.2985 (4.8); 4.7094 (0.7); 4.6998 (1.1); 4.6904 (1.1); 4.6809 (1.1); 4.6720 (0.8); 3.8283 (1.1); 3.8178 (1.2); 3.7999 (1.7); 3.7896 (1.7); 3.6881 (1.8); 3.6799 (1.8); 3.6594 (1.2); 3.6518 (1.2); 3.2302 (0.6); 3.2118 (0.6); 3.1957 (1.8); 3.1773 (1.9); 3.1654 (2.0); 3.1472 (1.8); 3.1306 (0.7); 3.1128 (0.6); 2.7554 (16.0); 2.3170 (0.4); 2.2857 (13.9); 2.1250 (0.4); 2.1117 (0.8); 2.1029 (0.9); 2.0907 (1.4); 2.0789 (1.0); 2.0703 (0.8); 2.0571 (0.4); 1.5625 (24.7); 1.2570 (0.8); 1.0381 (0.8); 1.0227 (3.0); 1.0049 (3.0); 0.7635 (1.0); 0.7508 (3.7); 0.7378 (3.6); 0.0695 (5.2); −0.0002 (14.2) 4.93^([a]) 10- 04

10-04: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4923 (5.1); 8.1528 (1.7); 8.1341 (1.7); 7.2580 (7.8); 7.2353 (2.0); 7.1986 (2.7); 7.1748 (6.2); 7.1091 (2.8); 7.0892 (2.2); 6.9972 (2.7); 6.9794 (2.3); 6.9107 (3.8); 6.8501 (2.4); 6.8303 (2.1); 5.2972 (0.8); 4.6252 (1.6); 4.6148 (1.6); 3.7689 (1.5); 3.7498 (2.0); 3.7406 (2.1); 3.6442 (2.4); 3.6162 (1.5); 3.2027 (0.7); 3.1683 (2.2); 3.1437 (3.2); 3.1251 (2.2); 3.0900 (0.6); 2.7956 (16.0); 2.2877 (14.9); 1.5600 (13.4); 1.2547 (0.4); 0.0698 (3.4); −0.0002 (6.8) 4.61^([a]) 10- 05

10-05: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4158 (4.2); 8.1428 (0.8); 8.1219 (0.8); 7.2598 (17.8); 7.2139 (2.3); 7.2040 (1.2); 7.1997 (2.0); 7.1948 (3.2); 7.1788 (2.9); 7.0423 (0.8); 7.0378 (0.8); 7.0216 (1.6); 7.0171 (1.7); 7.0014 (2.0); 6.9968 (1.2); 6.9860 (1.2); 6.8723 (0.9); 6.8687 (0.9); 6.8513 (1.5); 6.8338 (0.7); 6.8301 (0.6); 5.2986 (8.8); 4.6656 (0.5); 4.6556 (0.7); 4.6460 (0.7); 4.6362 (0.7); 4.6262 (0.5); 3.7971 (1.0); 3.7865 (1.0); 3.7688 (1.5); 3.7583 (1.4); 3.6678 (1.6); 3.6591 (1.6); 3.6394 (1.0); 3.6307 (1.0); 3.2169 (0.5); 3.1982 (0.5); 3.1824 (1.5); 3.1636 (1.5); 3.1518 (1.5); 3.1336 (1.5); 3.1170 (0.5); 3.0990 (0.5); 2.8019 (0.5); 2.7791 (16.0); 2.3225 (0.4); 2.3104 (0.8); 2.2910 (11.6); 1.5528 (1.7); 1.2561 (0.4); 0.0692 (4.2); −0.0002 (24.1) 4.70^([a]) 10- 06

10-06: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5279 (5.2); 8.1633 (0.9); 8.1426 (0.9); 7.4875 (0.7); 7.4677 (1.8); 7.4476 (1.3); 7.3989 (1.8); 7.3797 (1.1); 7.3110 (2.5); 7.2589 (13.1); 7.2396 (1.6); 7.2351 (1.4); 7.1978 (2.2); 7.1260 (1.2); 7.0964 (3.0); 7.0758 (2.0); 5.2969 (0.6); 4.5188 (0.6); 4.5105 (0.7); 4.5026 (0.7); 4.4942 (0.5); 3.7174 (0.9); 3.7075 (0.9); 3.6890 (1.4); 3.6791 (1.4); 3.5951 (1.6); 3.5875 (1.6); 3.5666 (1.1); 3.5590 (1.0); 3.0431 (0.5); 3.0217 (0.4); 3.0083 (1.6); 2.9866 (2.1); 2.9662 (1.6); 2.9478 (0.5); 2.9316 (0.4); 2.8145 (16.0); 2.3646 (12.8); 1.5404 (14.6); 1.2578 (0.4); 0.0695 (2.4); −0.0002 (14.9) 4.86^([a]) 10- 07

10-07: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5549 (5.1); 8.1177 (0.8); 8.0958 (0.8); 7.4908 (0.7); 7.4711 (1.7); 7.4511 (1.2); 7.3993 (1.7); 7.3799 (1.1); 7.3614 (2.5); 7.2849 (2.8); 7.2599 (11.9); 7.1734 (2.0); 7.1303 (1.2); 7.1099 (1.0); 5.2987 (1.5); 4.5664 (0.5); 4.5563 (0.6); 4.5469 (0.6); 4.5361 (0.6); 4.5259 (0.4); 3.6904 (0.8); 3.6794 (0.9); 3.6619 (1.7); 3.6509 (1.6); 3.6086 (1.6); 3.6000 (1.7); 3.5800 (0.9); 3.5714 (0.8); 3.0768 (3.7); 3.0591 (3.6); 2.8123 (16.0); 1.5512 (1.2); 0.0695 (0.5); −0.0002 (16.6) 4.55^([a]) 10- 08

10-08: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5193 (5.2); 8.1960 (1.4); 8.1751 (1.3); 7.4774 (1.0); 7.4576 (2.2); 7.4378 (1.6); 7.3913 (2.5); 7.3725 (1.5); 7.3221 (2.5); 7.3008 (2.9); 7.2609 (12.4); 7.1674 (6.1); 7.1131 (1.8); 7.0927 (1.6); 6.9840 (1.8); 6.9638 (1.6); 6.6569 (1.3); 6.4740 (2.7); 6.2911 (1.3); 5.3001 (2.4); 4.6461 (1.1); 4.6367 (1.1); 4.6275 (1.1); 3.7748 (1.2); 3.7644 (1.2); 3.7464 (1.8); 3.7363 (1.7); 3.6491 (1.9); 3.6409 (1.9); 3.6206 (1.2); 3.6124 (1.2); 3.2229 (0.6); 3.2038 (0.7); 3.1878 (2.1); 3.1686 (3.8); 3.1503 (2.0); 3.1336 (0.6); 3.1151 (0.5); 2.8144 (16.0); 1.5518 (10.3); 1.2565 (0.7); 0.0695 (3.4); −0.0002 (17.2) 4.51^([a]) 10- 09

10-09: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5435 (5.2); 8.1562 (0.7); 8.1348 (0.8); 7.6048 (2.7); 7.5846 (3.4); 7.4882 (0.6); 7.4683 (1.5); 7.4483 (1.2); 7.3996 (1.5); 7.3802 (1.0); 7.3437 (3.6); 7.3232 (3.3); 7.2599 (8.5); 7.1763 (1.8); 7.1300 (1.1); 7.1246 (1.0); 7.1096 (1.0); 7.1043 (0.9); 5.2979 (1.2); 4.5818 (0.4); 4.5717 (0.6); 4.5632 (0.6); 4.5519 (0.6); 4.5434 (0.4); 3.6961 (0.9); 3.6857 (0.9); 3.6676 (1.4); 3.6571 (1.4); 3.5713 (1.4); 3.5630 (1.5); 3.5427 (1.0); 3.5345 (1.0); 3.0844 (2.9); 3.0686 (1.9); 3.0643 (2.1); 2.8091 (16.0); 1.5509 (3.6); 0.0699 (3.7); 0.0079 (0.4); −0.0002 (9.8); −0.0084 (0.7) 4.92^([a]) 10- 10

10-10: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5158 (5.1); 8.2045 (0.7); 8.1839 (0.7); 7.5154 (2.0); 7.4727 (0.6); 7.4529 (1.5); 7.4328 (1.2); 7.4260 (1.4); 7.4062 (1.9); 7.3891 (1.6); 7.3697 (1.0); 7.3354 (1.4); 7.3157 (1.0); 7.2598 (12.4); 7.1632 (1.7); 7.1100 (1.0); 7.1048 (0.9); 7.0896 (0.9); 7.0844 (0.8); 6.7150 (1.0); 6.5745 (2.0); 6.4340 (1.0); 5.2982 (0.6); 4.6951 (0.4); 4.6855 (0.6); 4.6750 (0.6); 4.6648 (0.6); 4.6555 (0.5); 3.7810 (0.9); 3.7704 (0.9); 3.7525 (1.4); 3.7420 (1.4); 3.6566 (1.4); 3.6479 (1.5); 3.6281 (1.0); 3.6194 (1.0); 3.2545 (1.1); 3.2327 (1.7); 3.2136 (1.2); 3.1966 (0.4); 3.1786 (0.4); 2.8126 (16.0); 1.5452 (10.4); 0.0695 (2.2); 0.0080 (0.6); −0.0002 (15.2); −0.0084 (0.8) 4.37^([a]) 10- 11

10-11: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3512 (5.1); 8.1423 (2.0); 8.1230 (2.0); 7.2606 (8.8); 7.1404 (2.6); 7.1223 (3.2); 7.0203 (1.5); 6.9871 (6.1); 6.9462 (2.9); 6.9298 (2.6); 6.8742 (1.8); 6.8561 (2.7); 6.8375 (1.4); 6.7410 (1.7); 6.7244 (2.6); 6.7079 (1.5); 5.2979 (2.6); 4.5792 (1.7); 3.7599 (1.6); 3.7319 (2.4); 3.6498 (2.7); 3.6229 (1.8); 3.0414 (5.4); 3.0240 (5.5); 2.7601 (16.0); 2.3876 (15.7); 2.2796 (15.5); 2.0942 (1.9); 1.5606 (19.6); 1.2568 (0.5); 1.0252 (4.3); 1.0058 (4.4); 0.7519 (5.2); 0.7418 (5.4); 0.0703 (3.5); −0.0002 (10.0) 4.86^([a])

Compounds of Formula (11)

TABLE 10 Compounds according to formula (11), their ¹H-NMR data and LogP values (mixture of stereoisomers) Ex No Structure ¹H-NMR Peak List LogP 11- 01

11-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3528 (1.8); 7.4583 (0.9); 7.4385 (0.8); 7.4166 (1.0); 7.3981 (0.6); 7.3849 (0.4); 7.2618 (6.4); 7.1807 (1.6); 7.1597 (1.5); 6.8214 (1.0); 6.8156 (1.2); 6.7633 (0.7); 6.7575 (0.7); 6.7422 (0.6); 6.7359 (0.7); 3.7703 (1.3); 3.7557 (6.1); 3.7036 (16.0); 3.6728 (0.9); 3.6627 (0.8); 3.6381 (0.3); 3.6302 (0.3); 3.5413 (0.6); 3.5336 (0.6); 3.5132 (0.5); 3.5057 (0.5); 3.0027 (0.7); 2.9846 (1.2); 2.9681 (0.7); 2.8124 (1.0); 2.8033 (0.4); 2.7421 (5.4); 0.0697 (0.6); −0.0002 (7.2) 4.01^([a]) 11- 02

11-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3661 (2.4); 7.4516 (0.5); 7.4321 (1.1); 7.4126 (0.9); 7.3891 (1.4); 7.3709 (0.7); 7.2610 (6.0); 7.2164 (1.5); 7.1581 (1.3); 7.1387 (1.4); 7.0919 (2.5); 7.0013 (1.1); 6.9823 (0.9); 5.8182 (0.7); 5.7921 (0.7); 5.2993 (0.6); 4.0953 (0.4); 4.0873 (0.4); 3.7030 (16.0); 3.6735 (0.7); 3.6641 (0.6); 3.6456 (0.8); 3.6357 (0.8); 3.5019 (0.8); 3.4948 (0.8); 3.4740 (0.6); 3.4670 (0.6); 3.0090 (1.0); 2.9968 (1.3); 2.9903 (1.3); 2.9806 (1.1); 2.8106 (0.7); 2.7516 (7.3); 2.3093 (0.3); 2.2777 (6.5); 1.6333 (0.3); 1.2580 (0.4); 0.0696 (2.2); −0.0002 (7.5) 4.31^([a]) 11- 03

11-03: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3398 (0.5); 8.1908 (1.7); 7.3823 (0.7); 7.3635 (0.5); 7.2604 (6.2); 7.1619 (1.0); 7.1423 (1.1); 7.0714 (1.6); 6.9878 (1.7); 6.9706 (1.2); 6.8526 (0.6); 6.8346 (0.9); 6.8165 (0.4); 6.7077 (0.9); 6.6891 (0.4); 5.8864 (0.5); 5.8614 (0.5); 5.2978 (0.8); 4.5949 (1.0); 4.0262 (0.4); 3.7589 (0.5); 3.7500 (0.5); 3.7305 (0.7); 3.7031 (16.0); 3.5282 (0.7); 3.4995 (0.6); 3.0258 (1.6); 3.0080 (1.6); 2.7547 (1.6); 2.6990 (5.5); 2.3095 (0.4); 2.2841 (1.7); 2.2707 (5.3); 2.2409 (0.4); 2.0680 (1.0); 1.7214 (0.3); 1.6696 (0.3); 1.2569 (0.4); 1.0227 (1.6); 1.0029 (1.6); 0.7424 (1.9); 0.7309 (1.7); 0.0693 (2.6); −0.0002 (7.4) 4.62^([a]) 11- 04

11-04: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3510 (0.9); 8.2035 (2.8); 8.1386 (0.3); 8.1201 (0.4); 7.3830 (0.5); 7.3608 (0.4); 7.2594 (7.8); 7.1406 (0.6); 7.1213 (0.8); 7.0830 (0.4); 7.0203 (1.7); 7.0012 (3.1); 6.9844 (2.8); 6.9649 (1.3); 6.9477 (0.9); 6.9122 (4.2); 6.8575 (1.3); 6.8409 (1.6); 6.7241 (1.4); 6.7070 (1.8); 5.8690 (1.0); 5.8584 (0.7); 5.8440 (1.0); 5.2973 (5.7); 4.5938 (0.8); 3.8621 (0.8); 3.7571 (0.4); 3.7024 (16.0); 3.6743 (1.1); 3.6646 (1.1); 3.6467 (1.7); 3.5189 (1.4); 3.4921 (1.0); 3.0405 (1.0); 3.0226 (1.2); 2.9779 (1.2); 2.9563 (1.1); 2.9258 (1.1); 2.9131 (1.3); 2.8927 (0.6); 2.8792 (0.6); 2.7595 (3.2); 2.7135 (8.9); 2.3866 (2.9); 2.3336 (0.5); 2.3078 (0.8); 2.2784 (3.4); 2.2552 (8.8); 2.0839 (9.1); 2.0553 (1.6); 1.9914 (0.4); 1.9559 (0.3); 1.9259 (0.4); 1.2574 (0.7); 1.0148 (3.0); 0.9964 (2.8); 0.7360 (3.6); 0.7248 (3.2); 0.0696 (5.2); −0.0002 (8.6) 4.51^([a]) 11- 05

11-05: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4915 (1.3); 8.3554 (4.6); 8.1542 (0.5); 8.1345 (0.5); 7.2596 (13.3); 7.2351 (3.4); 7.2147 (1.9); 7.1991 (1.3); 7.1758 (2.4); 7.1603 (3.0); 7.1398 (3.4); 7.1137 (3.8); 7.0932 (6.7); 6.9989 (3.5); 6.9822 (2.8); 6.9455 (3.8); 6.9118 (1.3); 6.8501 (0.8); 6.8267 (2.7); 6.8058 (2.1); 5.8251 (1.7); 5.8012 (1.7); 5.2972 (1.4); 4.6242 (0.4); 4.0730 (1.3); 3.9405 (0.3); 3.7671 (0.5); 3.7415 (0.8); 3.7019 (12.0); 3.6448 (2.6); 3.5060 (2.3); 3.4777 (1.6); 3.1687 (0.6); 3.1453 (0.9); 3.1247 (0.6); 3.0510 (0.6); 3.0148 (2.4); 2.9995 (4.0); 2.9866 (2.6); 2.9492 (0.6); 2.7945 (4.5); 2.7380 (14.4); 2.2811 (16.0); 2.2411 (0.8); 2.2203 (0.4); 2.2009 (0.4); 2.1761 (0.4); 2.1266 (0.4); 2.0659 (1.6); 2.0302 (0.4); 1.9876 (0.4); 1.8801 (0.5); 1.8339 (0.5); 1.7930 (0.5); 1.7638 (0.5); 1.7383 (0.5); 1.6228 (0.4); 1.6039 (0.4); 1.5819 (0.4); 1.5596 (0.4); 1.2559 (0.7); 0.0692 (3.5); −0.0002 (15.2) 4.28^([a]) 11- 06

11-06: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.2592 (4.1); 7.2600 (16.2); 7.2313 (0.8); 7.2276 (0.8); 7.2153 (1.0); 7.2113 (1.5); 7.2072 (1.0); 7.1950 (1.0); 7.1914 (0.9); 7.1556 (2.1); 7.1362 (2.6); 7.0754 (2.7); 7.0486 (0.9); 7.0443 (0.9); 7.0279 (1.7); 7.0237 (1.7); 7.0073 (1.0); 7.0029 (1.2); 6.9962 (1.7); 6.9769 (1.3); 6.9152 (1.0); 6.9115 (0.9); 6.8941 (1.6); 6.8767 (0.7); 6.8730 (0.7); 5.8627 (1.0); 5.8367 (1.1); 5.2986 (6.8); 4.1306 (0.5); 4.1128 (0.5); 4.0952 (0.4); 4.0883 (0.4); 4.0802 (0.6); 4.0709 (0.6); 4.0624 (0.6); 4.0535 (0.6); 4.0458 (0.4); 3.7398 (1.1); 3.7300 (1.1); 3.7119 (1.5); 3.7021 (1.3); 3.5339 (1.5); 3.5267 (1.5); 3.5061 (1.2); 3.4987 (1.1); 3.0131 (3.0); 2.9947 (3.2); 2.7525 (0.5); 2.7424 (0.6); 2.7250 (16.0); 2.2741 (11.9); 2.0438 (2.1); 1.2765 (0.8); 1.2587 (1.6); 1.2409 (0.7); 0.0692 (4.7); −0.0002 (21.8); −0.0081 (1.4) 4.16^([a]) 11- 07

11-07: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3677 (2.4); 7.4472 (0.4); 7.4275 (0.8); 7.4076 (0.8); 7.3873 (1.1); 7.3681 (0.5); 7.2594 (7.2); 7.2329 (0.6); 7.2281 (0.5); 7.2124 (0.7); 7.2073 (0.6); 7.1953 (1.0); 7.0478 (0.5); 7.0276 (0.4); 7.0062 (1.1); 6.9859 (0.9); 5.7770 (0.4); 5.7515 (0.5); 4.5946 (0.4); 3.7006 (16.0); 3.6217 (0.4); 3.6098 (0.4); 3.5938 (0.7); 3.5822 (0.6); 3.5334 (0.7); 3.5255 (0.7); 3.5057 (0.4); 3.4978 (0.4); 2.9948 (0.3); 2.9759 (0.3); 2.9598 (0.6); 2.9411 (0.6); 2.8761 (0.5); 2.8597 (0.5); 2.8413 (0.3); 2.8128 (0.4); 2.7541 (7.1); 2.1743 (5.4); 0.0694 (2.2); −0.0002 (7.5) 11- 08

11-08: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3983 (5.4); 7.4671 (0.8); 7.4473 (1.9); 7.4274 (1.6); 7.4048 (2.1); 7.3854 (1.2); 7.2700 (6.1); 7.2597 (17.6); 7.2140 (2.2); 7.1027 (1.2); 7.0819 (1.0); 5.8016 (0.8); 5.7756 (0.8); 5.2984 (3.9); 4.5953 (0.5); 4.0884 (0.6); 4.0761 (0.6); 4.0635 (0.5); 3.7016 (8.5); 3.5831 (0.4); 3.5646 (2.8); 3.5602 (2.9); 3.5554 (2.5); 3.5472 (2.2); 3.5194 (0.3); 3.0131 (3.8); 2.9970 (3.7); 2.8259 (0.4); 2.8099 (0.6); 2.7791 (0.8); 2.7675 (16.0); 2.7472 (0.4); 1.2563 (0.4); 0.0694 (1.1); −0.0002 (24.1) 4.12^([a]) 11- 09

11-09: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3665 (2.0); 7.4596 (0.6); 7.4402 (1.0); 7.4209 (0.9); 7.3968 (1.3); 7.3771 (0.7); 7.2934 (1.2); 7.2611 (5.5); 7.2098 (1.4); 7.1672 (0.5); 7.0878 (2.2); 7.0691 (0.7); 6.9926 (0.8); 6.9705 (0.7); 6.6515 (0.5); 6.4687 (1.1); 6.2859 (0.5); 5.8253 (0.6); 5.7994 (0.6); 4.1513 (0.5); 3.7032 (16.0); 3.6722 (0.7); 3.6627 (0.6); 3.5256 (0.8); 3.5192 (0.8); 3.4971 (0.5); 3.4901 (0.5); 3.0890 (0.3); 3.0696 (0.4); 3.0543 (0.7); 3.0363 (0.7); 3.0107 (0.7); 2.9925 (0.6); 2.8121 (0.8); 2.7472 (6.0); 2.0539 (0.4); 1.2589 (0.5); 0.0697 (2.1); −0.0002 (7.2) 4.08^([a]) 11- 10

11-10: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3908 (1.6); 7.5792 (0.9); 7.5590 (1.0); 7.4258 (0.5); 7.4060 (0.5); 7.3881 (0.6); 7.2600 (3.2); 7.2475 (1.2); 7.2270 (1.0); 7.1966 (0.7); 7.0764 (0.3); 5.2979 (0.4); 3.7009 (16.0); 3.5476 (0.5); 3.5351 (0.5); 3.5163 (0.5); 3.5077 (0.6); 3.0218 (0.7); 3.0077 (0.6); 3.0031 (0.6); 2.7671 (4.6); 0.0696 (2.2); −0.0002 (3.2) 4.66^([a]) 11- 11

11-11: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.3649 (2.2); 7.4425 (0.9); 7.4301 (0.7); 7.4101 (0.6); 7.4038 (0.6); 7.3843 (1.4); 7.3683 (0.4); 7.3454 (0.6); 7.3267 (0.4); 7.2596 (8.8); 7.1913 (0.8); 7.0662 (0.4); 7.0460 (0.4); 6.7099 (0.4); 6.5694 (0.9); 6.4290 (0.4); 5.8179 (0.4); 5.7918 (0.4); 5.2984 (1.9); 3.7019 (16.0); 3.6935 (0.9); 3.6756 (0.6); 3.6650 (0.6); 3.5250 (0.6); 3.5172 (0.6); 3.4969 (0.4); 3.4892 (0.4); 3.1182 (0.4); 3.1003 (0.4); 3.0722 (0.4); 3.0540 (0.4); 2.7420 (6.7); 0.0691 (1.9); 0.0080 (0.4); −0.0002 (13.9); −0.0085 (0.8) 4.02^([a])

Compounds According to Formula (12)

TABLE 11 Compounds according to formula (11), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 12-01

12-01: ¹H-NMR(500.1 MHz, CDCl3): δ = 8.9031 (4.9); 8.2428 (0.8); 8.2264 (0.8); 7.2594 (7.2); 7.1474 (2.1); 7.1321 (2.5); 7.0069 (2.9); 6.9709 (1.6); 6.9555 (1.4); 5.2980 (3.4); 4.5750 (0.5); 4.5672 (0.7); 4.5596 (0.7); 4.5524 (0.8); 4.5447 (0.5); 4.5363 (0.3); 3.7640 (1.0); 3.7560 (1.0); 3.7414 (1.6); 3.7334 (1.5); 3.6595 (1.6); 3.6534 (1.6); 3.6369 (1.1); 3.6307 (1.0); 3.0474 (2.4); 3.0432 (2.3); 3.0306 (3.7); 2.7486 (16.0); 2.4014 (14.0); 2.2908 (13.2); 1.5485 (9.8); 1.2543 (0.3); 0.0695 (2.8); −0.0002 (9.0) 3.66^([a])

Compounds According to Formula (13)

TABLE 12 Compounds according to formula (13), their ¹H-NMR data and LogP values (mixture of stereoisomers) Ex No Structure ¹H-NMR Peak List LogP 13-01

13-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.7981 (5.0); 7.2581 (9.2); 6.9720 (1.8); 6.9523 (3.5); 6.9113 (5.8); 6.8594 (0.6); 5.7311 (1.6); 5.7063 (1.6); 5.2966 (4.7); 3.6154 (1.4); 3.5980 (1.9); 3.5894 (1.8); 3.4844 (3.8); 3.4590 (2.1); 3.0043 (0.8); 2.9704 (1.7); 2.9493 (1.6); 2.8938 (1.7); 2.8812 (1.8); 2.8598 (1.0); 2.8463 (0.9); 2.7348 (0.6); 2.7110 (16.0); 2.3641 (0.4); 2.2935 (0.5); 2.2574 (14.6); 2.0538 (14.9); 1.5667 (1.4); 1.2589 (0.7); 0.0689 (0.6); −0.0002 (12.7); −0.0024 (11.8) 3.26^([a])

Compounds of Formula (16)

TABLE 13 Compounds according to formula (16), their ¹H-NMR data and LogP values Ex No Structure ¹H-NMR Peak List LogP 16-01

16-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4682 (4.4); 7.4002 (1.1); 7.3800 (2.4); 7.3595 (1.6); 7.2830 (1.3); 7.2807 (1.5); 7.2783 (1.4); 7.2760 (1.4); 7.2603 (7.5); 7.2559 (1.3); 7.1139 (1.6); 7.1086 (2.3); 7.1033 (1.4); 7.0024 (1.2); 7.0001 (1.2); 6.9964 (1.1); 6.9941 (1.0); 6.9819 (1.0); 6.9795 (1.0); 6.9758 (1.0); 6.9735 (0.8); 2.8214 (0.4); 2.7713 (16.0); 2.7216 (0.4); 1.6387 (0.6); 1.2550 (0.3); 0.0694 (3.6); 0.0077 (0.8); −0.0002 (9.8); −0.0084 (0.7) 3.07^([a])

Compounds of Formula (17)

TABLE 14 Compounds according to formula (17), their ¹H-NMR data and LogP values (mixture of stereoisomers) Ex No Structure ¹H-NMR Peak List LogP 17-01

17-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.8771 (0.4); 8.4668 (0.4); 8.3376 (5.2); 7.2734 (1.4); 7.2599 (8.1); 7.2532 (3.6); 7.2326 (1.8); 7.1216 (1.6); 7.1193 (1.7); 7.1171 (1.7); 7.1017 (1.4); 7.0993 (1.4); 7.0972 (1.3); 6.9862 (1.5); 6.9810 (2.9); 6.9762 (1.9); 6.8672 (1.5); 6.8614 (1.5); 6.8466 (1.3); 6.8408 (1.3); 5.6095 (2.6); 2.7822 (1.1); 2.7697 (1.6); 2.7529 (16.0); 2.7092 (0.4); 1.5592 (0.9); 1.2540 (0.7); 0.0692 (2.0); −0.0002 (11.6) 1.66^([a])

Compounds of Formula (19)

TABLE 15 Compounds according to formula (19), their ¹H-NMR data and LogP values (mixture of stereoisomers) Ex No Structure ¹H-NMR Peak List LogP 19- 01

19-01: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.5224 (0.6); 8.4525 (5.0); 8.3724 (1.6); 7.8415 (0.9); 7.8164 (0.5); 7.7883 (0.6); 7.7686 (0.7); 7.7563 (0.4); 7.7366 (0.4); 7.6634 (2.1); 7.6077 (1.2); 7.5883 (1.2); 7.3310 (1.1); 7.3106 (1.4); 7.2939 (0.6); 7.2742 (2.1); 7.2599 (33.7); 7.2423 (1.3); 7.2219 (0.9); 7.2101 (0.6); 7.2051 (0.4); 7.1950 (0.4); 7.1753 (0.3); 7.1617 (0.4); 7.1510 (0.4); 7.1412 (0.5); 7.1276 (0.4); 7.1230 (0.4); 7.1029 (0.6); 7.1005 (0.6); 7.0980 (0.6); 7.0958 (0.6); 7.0826 (0.4); 7.0804 (0.5); 7.0781 (0.5); 7.0758 (0.5); 7.0639 (1.3); 7.0435 (2.6); 7.0231 (1.7); 6.9959 (0.4); 6.9548 (0.4); 6.9493 (0.5); 6.9437 (0.4); 6.9387 (0.7); 6.9335 (0.9); 6.9282 (0.5); 6.8867 (0.4); 6.8680 (0.5); 6.8577 (1.3); 6.8555 (1.3); 6.8530 (1.4); 6.8509 (1.2); 6.8377 (1.0); 6.8356 (1.1); 6.8330 (1.3); 6.8308 (1.3); 6.8248 (0.6); 6.8098 (0.5); 6.8040 (0.4); 6.7588 (1.5); 6.7534 (2.3); 6.7480 (1.5); 6.6053 (1.0); 6.6032 (1.0); 6.5991 (1.0); 6.5972 (1.0); 6.5845 (1.0); 6.5824 (0.9); 6.5784 (1.0); 6.5763 (0.8); 4.15^([a]) 5.6614 (1.4); 5.5875 (0.8); 5.5327 (0.5); 5.2983 (7.4); 5.2540 (0.7); 5.0328 (10.2); 4.6917 (2.5); 4.4376 (4.7); 4.1305 (0.3); 4.1126 (0.4); 3.0020 (0.5); 2.9867 (2.3); 2.9686 (5.6); 2.9513 (6.3); 2.9333 (3.2); 2.9199 (1.3); 2.9021 (0.7); 2.8846 (0.9); 2.8661 (0.5); 2.8603 (0.6); 2.8534 (0.6); 2.8488 (0.6); 2.8329 (1.3); 2.8207 (0.6); 2.8076 (1.6); 2.7957 (0.6); 2.7852 (3.0); 2.7785 (16.0); 2.7665 (5.8); 2.7468 (1.0); 2.7289 (0.5); 2.6904 (0.6); 2.6719 (0.6); 2.4845 (0.5); 2.1674 (0.5); 2.1576 (0.8); 2.1485 (1.6); 2.1387 (2.4); 2.1298 (2.4); 2.1200 (3.4); 2.1113 (1.9); 2.1015 (2.5); 2.0923 (0.9); 2.0829 (1.0); 2.0629 (0.4); 2.0437 (1.8); 2.0050 (0.4); 1.5685 (2.2); 1.4433 (1.8); 1.4411 (1.8); 1.3100 (0.4); 1.3006 (0.4); 1.2835 (0.5); 1.2765 (0.9); 1.2586 (1.9); 1.2436 (0.5); 1.2408 (0.6); 1.2271 (0.5); 1.2093 (0.9); 1.1913 (0.5); 0.8805 (0.4); 0.0782 (0.4); 0.0693 (13.6); 0.0600 (0.7); 0.0499 (0.8); 0.0080 (1.4); −0.0002 (48.6); −0.0084 (2.4); −0.0389 (0.3); −0.0501 (0.8) 19- 02

19-02: ¹H-NMR(400.1 MHz, CDCl3): δ = 8.4521 (5.1); 7.5351 (0.4); 7.5074 (2.0); 7.4870 (0.8); 7.4816 (0.5); 7.4649 (0.3); 7.3732 (2.4); 7.3682 (3.3); 7.3554 (2.0); 7.3502 (1.2); 7.3344 (1.8); 7.3292 (1.5); 7.3115 (0.4); 7.2738 (0.4); 7.2612 (18.1); 7.0861 (1.3); 7.0658 (2.7); 7.0454 (1.7); 6.9454 (0.9); 6.9354 (0.4); 6.9243 (0.8); 6.9176 (0.5); 6.8888 (3.0); 6.8799 (1.4); 6.8780 (1.5); 6.8754 (1.5); 6.8734 (1.4); 6.8678 (2.9); 6.8601 (1.1); 6.8580 (1.2); 6.8555 (1.2); 6.7353 (1.5); 6.7299 (2.4); 6.7245 (1.5); 6.6129 (1.1); 6.6111 (1.1); 6.6068 (1.0); 6.5922 (1.0); 6.5903 (1.0); 6.5861 (1.0); 5.6511 (1.5); 5.2989 (4.6); 4.9713 (10.3); 4.6238 (4.1); 4.3809 (0.4); 4.3718 (0.5); 4.3444 (0.8); 4.3384 (2.1); 4.3354 (2.0); 4.3301 (3.5); 4.3262 (3.2); 4.3214 (3.0); 4.3170 (3.7); 4.2970 (4.5); 4.2920 (3.7); 4.2874 (3.0); 4.2834 (4.2); 4.2782 (2.1); 4.2567 (0.5); 4.1304 (0.4); 4.1125 (0.4); 3.2881 (0.5); 3.2824 (0.6); 3.2704 (1.6); 3.2641 (0.6); 3.2607 (0.6); 3.2526 (1.9); 3.2423 (1.7); 3.2349 (0.9); 3.2246 (1.7); 3.12^([a]) 3.2069 (0.9); 3.1989 (0.5); 3.1880 (0.5); 2.8284 (0.4); 2.8095 (6.2); 2.7841 (6.9); 2.7778 (16.0); 2.7536 (1.0); 2.7295 (0.4); 2.5295 (0.9); 2.0437 (1.5); 1.5761 (7.5); 1.4950 (0.3); 1.4445 (11.7); 1.4427 (11.2); 1.2765 (0.6); 1.2587 (1.2); 1.2409 (0.5); 1.2280 (2.6); 1.2102 (5.3); 1.1923 (2.6); 0.0692 (2.0); 0.0502 (0.4); 0.0078 (0.8); −0.0002 (27.2); −0.0084 (1.6); −0.0497 (0.5) 19- 03

3.41& 4.35^([a]) 19- 04

3.40& 4.01^([a])

Compounds of Formula (20)

TABLE 16 Compounds according to formula (20), their LogP values Ex No Structure LogP 20-01

2.19^([a])

B. Biological Examples B-1. Alternaria alternata In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 14.6 g anhydrous D-glucose (VWR), 7.1 g         Mycological Peptone (Oxoid), 1.4 g granulated Yeast Extract         (Merck), QSP 1 liter     -   Inoculum: spore suspension

Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was <1%.

A spore suspension of A. alternata was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 5 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 20 ppm of active ingredient: I-007; I-015; I-017

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 20 ppm of active ingredient: I-030

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-008; 1-009; I-013; I-014; I-016; I-018; I-019; I-021; I-023; I-024; I-025; I-026; I-027; I-028; I-029; I-031; I-032; I-033; I-034

B-2. Pyricularia oryzae In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 14.6 g anhydrous D-glucose (VWR), 7.1 g         Mycological Peptone (Oxoid), 1.4 g granulated Yeast Extract         (Merck), QSP 1 liter     -   Inoculum: spore suspension

Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was <1%.

A spore suspension of P. oryzae was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 5 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 20 ppm of active ingredient: I-006; I-033

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 20 ppm of active ingredient: I-001; I-005; I-032

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-002; I-003; I-004; I-008; I-009; I-014; I-016; 1-018; I-019; I-021; I-023; I-024; I-025; I-026; I-028; I-029; I-031

B-3. Colletotrichum lindemuthianum In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 14.6 g anhydrous D-glucose (VWR), 7.1 g         Mycological Peptone (Oxoid), 1.4 g granulated Yeast Extract         (Merck), QSP 1 liter     -   Inoculum: spore suspension

Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was <1%.

A spore suspension of C. lindemuthianum was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spores germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 6 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 20 ppm of active ingredient: I-034

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-007; 1-008; I-009; I-013; I-014; I-015; I-016; I-017; I-018; I-019; I-020; I-021; I-023; I-024; I-025; I-026; I-029; I-030; I-031; I-032; I-033

B-4. Pyrenophora teres In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 14.6 g anhydrous D-glucose (VWR), 7.1 g         Mycological Peptone (Oxoid), 1.4 g granulated Yeast Extract         (Merck), QSP 1 liter     -   Inoculum: spore suspension

Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was ≤□1%.

A spore suspension of P. teres was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 6 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-007; 1-008; I-009; I-012; I-013; I-014; I-015; I-016; I-017; I-018; I-019; I-020; I-021; I-023; I-024; I-025; I-026; I-027; I-028; I-029; I-030; I-031; I-032; I-033; I-034

B-5. Botrytis cinerea In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 1 g KH₂PO₄ (VWR), 1 g K₂HPO₄ (VWR), 0.5 g Urea         (VWR), 3 g KNO₃ (Prolabo), 10 g saccharose (VWR), 0.5 g MgSO₄,         7H₂O (Sigma), 0.07 g CaCl₂, 2H₂O (Prolabo), 0.2 mg MnSO₄, H₂O         (Sigma), 0.6 mg CuSO₄, 5H₂O (Sigma), 7.9 mg ZnSO₄, 7H₂O (Sigma),         0.1 mg H₃BO₃ (Merck), 0.14 mg NaMoO₄, 2H₂O (Sigma), 2 mg         thiamine (Sigma), 0.1 mg biotine (VWR), 4 mg FeSO₄, 7H₂O         (Sigma), QSP 1 liter     -   Inoculum: spore suspension

Fungicides were solubilized in DMSO and the solution used to prepare the required range of concentrations. The final concentration of DMSO used in the assay was <1%.

A spore suspension of B. cinerea was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 6 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-007; 1-008; I-009; I-012; I-013; I-014; I-015; I-016; I-017; I-018; I-019; I-020; I-021; I-023; I-024; I-025; I-026; I-027; I-028; I-029; I-030; I-031; I-032; I-033; I-034

B-6. Septoria tritici In Vitro Cell Test

-   -   Solvent: DMSO     -   Culture medium: 1 g KH₂PO₄ (VWR), 1 g K₂HPO₄ (VWR), 0.5 g Urea         (VWR), 3 g KNO₃ (Prolabo), 10 g saccharose (VWR), 0.5 g MgSO₄,         7H₂O (Sigma), 0.07 g CaCl₂, 2H₂O (Prolabo), 0.2 mg MnSO₄, H₂O         (Sigma), 0.6 mg CuSO₄, 5H₂O (Sigma), 7.9 mg ZnSO₄, 7H₂O (Sigma),         0.1 mg H₃BO₃ (Merck), 0.14 mg NaMoO₄, 2H₂O (Sigma), 2 mg         thiamine (Sigma), 0.1 mg biotine (VWR), 4 mg FeSO₄, 7H₂O         (Sigma), QSP 1 liter     -   Inoculum: spore suspension     -   Fungicides were solubilized in DMSO and the solution used to         prepare the required range of concentrations. The final         concentration of DMSO used in the assay was <1%.

A spore suspension of S. tritici was prepared and diluted to the desired spore density.

Fungicides were evaluated for their ability to inhibit spore germination and mycelium growth in liquid culture assay. The compounds were added in the desired concentration to the culture medium with spores. After 7 days incubation, fungi-toxicity of compounds was determined by spectrometric measurement of mycelium growth. Inhibition of fungal growth was determined by comparing the absorbance values in wells containing the fungicides with the absorbance in control wells without fungicides.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 20 ppm of active ingredient: I-017; I-020; I-030

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 20 ppm of active ingredient: I-023 In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 20 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-008; 1-009; 1-013; I-014; 1-016; I-018; 1-019; I-021; 1-024; I-025; 1-026; I-027; 1-028; I-029; I-032; 1-033

B-7. In Vivo Preventive Test on Alternaria brassicae (Leaf Spot on Radish or Cabbage)

-   -   Solvent: 5% by volume of Dimethyl sulfoxide         -   10% by volume of Acetone     -   Emulsifier: 1 μl of Tween® 80 per mg of active ingredient

The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween®80 and then diluted in water to the desired concentration.

The young plants of radish or cabbage were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween® 80.

After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Alternaria brassicae spores. The contaminated radish or cabbage plants were incubated for 3 to 4 days at 20° C. and at 100% relative humidity.

The test was evaluated 6 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-015; I-030 In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-006; I-007; I-008; I-009; I-012; I-013; I-014; I-016; I-017; I-018; I-019; I-020; I-021; I-023; I-024; I-025; I-026; I-027; I-029; I-032; I-033

B-8. In Vivo Preventive Test on Botrytis cinerea (Grey Mould)

-   -   Solvent: 5% by volume of Dimethyl sulfoxide         -   10% by volume of Acetone     -   Emulsifier: 1 μl of Tween® 80 per mg of active ingredient

The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween®80 and then diluted in water to the desired concentration.

The young plants of gherkin or cabbage were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween® 80.

After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants were incubated for 4 to 5 days at 17° C. and at 90% relative humidity. The contaminated cabbage plants were incubated for 4 to 5 days at 20° C. and at 100% relative humidity.

The test was evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-015

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-006

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-001; I-002; I-003; I-004; I-005; I-007; I-008; I-009; I-012; I-013; I-014; I-016; I-017; I-018; I-019; I-020; I-021; I-023; I-024; I-025; I-026; I-027; I-029; I-030; I-032; I-033

B-9. In Vivo Preventive Test on Sphaerotheca fuliginea (Powdery Mildew on Cucurbits)

-   -   Solvent: 5% by volume of Dimethyl sulfoxide         -   10% by volume of Acetone     -   Emulsifier: 1 μl of Tween® 80 per mg of active ingredient

The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween®80 and then diluted in water to the desired concentration.

The young plants of gherkin were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween® 80.

After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Sphaerotheca fuliginea spores. The contaminated gherkin plants were incubated for 8 days at 20° C. and at 70-80% relative humidity.

The test was evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-003; I-015; I-019

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-001; I-002; I-004; I-005; I-006; I-007; I-008; I-009; I-012; I-013; I-014; I-016; I-017; I-018; I-020; I-021; I-023; I-024; I-025; I-026; I-027; I-029; I-030; I-032; I-033

B-10. In Vivo Preventive Test on Colletotrichum lindemuthianum (Leaf Spot on Bean)

-   -   Solvent: 5% by volume of Dimethyl sulfoxide         -   10% by volume of Acetone     -   Emulsifier: 1 μl of Tween® 80 per mg of active ingredient

The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween®80 and then diluted in water to the desired concentration.

The young plants of bean were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween® 80.

After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Colletotrichum lindemuthianum spores. The contaminated bean plants were incubated for 24 hours at 20° C. and at 100% relative humidity and then for 6 days at 20° C. and at 90% relative humidity.

The test was evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

In this test the following compounds according to the invention showed efficacy between 70% and 79% at a concentration of 500 ppm of active ingredient: I-030

In this test the following compounds according to the invention showed efficacy between 80% and 89% at a concentration of 500 ppm of active ingredient: I-017; I-033

In this test the following compounds according to the invention showed efficacy between 90% and 100% at a concentration of 500 ppm of active ingredient: I-001; I-002; I-004; I-005; I-006; I-007; I-008; I-009; I-012; I-013; I-015; I-016; I-018; I-019; I-021; I-023; I-024; I-025; I-026; I-027; I-029; I-032 

1: A compound of formula (I):

wherein A¹ is N or CR⁸, wherein R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl, A² is O, S, C(═O), S(═O), S(═O)₂, NR¹ or CR^(2A)R^(R2B), wherein R¹ is hydrogen, formyl, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R^(2A) and R^(2B) are independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R^(2A) and R^(2B) form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, m is 0, 1 or 2, T is hydrogen, hydroxyl, C₁-C₆-alkyl, —C(═O)R¹¹, —C(═O)(OR¹²), —C(═O)N(R¹³)₂, —S(═O)R¹⁴, —S(═O)₂R¹⁴ or —S(═O)₂N(R¹⁴)₂, wherein R¹¹ and R¹² are independently C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, R¹³ and R¹⁴ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3- to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl and 3- to 14-membered heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered heterocyclyl-ring are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-, —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—, —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—, —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of formula

wherein said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC), R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen or C₁-C₆-alkyl, R^(L5), R^(L6), R^(L7) and R^(L8) are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, wherein L^(SA) is independently halogen, cyano, hydroxyl, carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, L^(SC) is independently halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two L^(SC) substituents form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to 14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or C₁-C₃-alkylsulfonyl, wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted with one substituent selected from the group consisting of C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl, wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to four R^(6S) substituents, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl and 3- to 14-membered heterocyclylsulfonyl are optionally substituted with one to four R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷), —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, or two substituents C₁-C₆-alkyl attached to the same carbon atom from a C₃-C₈-cycloalkyl-ring, and wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, and wherein R¹⁵ is independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, and wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl, wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto, nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered heterocyclyl, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and C₂-C₆-haloalkynyl in turn are optionally substituted with one to three substituents R^(7Sa), and wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents R^(7Sc), R²¹ and R²² are independently hydroxyl, amino, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in turn are optionally substituted with one to three R^(7Sa) substituents, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three R^(7Sa) substituents, and wherein C₃-C₈-cycloalkyl in turn is optionally substituted with one to three R^(7Sc) substituents, wherein R^(7Sa) is independently cyano, hydroxyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to 7-membered heterocyclyl, R^(7Sc) is independently halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, or two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the same carbon atom form together a C₃-C₈-cycloalkyl-ring, Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl are optionally substituted with one to five substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³ NR³⁴C(═O)R³⁵, —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰, —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, and wherein R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy, R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or C₁-C₆-alkoxy, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl,  wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, as well as N-oxides, salts, hydrates and hydrates of the salts and N-oxides thereof. 2: The compound of formula (I) according to claim 1, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, fluoro, chloro or methyl A² is O, C(═O), NR¹ or CR^(2A)R^(R2B), wherein R¹ is hydrogen, formyl, C₁-C₄-alkyl or C₃-C₆-cycloalkyl, R^(2A) and R^(2B) are independently hydrogen or C₁-C₄-alkyl, m is 0, 1 or 2, T is hydrogen or C₁-C₄-alkyl R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen or C₁-C₄-alkyl, L is a direct bond, C₁-C₄-alkylene or a group of formula

wherein said C₁-C₄-alkylene is optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC) wherein L^(SA) is independently fluoro, chloro or hydroxyl, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to 7-membered heterocyclyl-ring, L^(SC) is independently fluoro, chloro hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy, R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl, 5- to 10-membered heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy, wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted with one substituent selected from the group consisting of C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl, wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl in turn are optionally substituted with one to three R^(6S) substituents, wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and 5- to 10-membered heterocyclylsulfanyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶, —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl and C₁-C₄-haloalkylsulfanyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy, and wherein R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy and 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl, R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₁-C₄-alkoxy, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl, wherein R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃, R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy or C₃-C₈-cycloalkyl, Q is phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, wherein phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl, phenyl, 5- or 6-membered heteroaryl, —O—C(═O)R³³, and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₃-C₆-cycloalkyl, C₃-C₆-halocycloalkyl and 3- to 7-membered heterocyclyl, said C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl and C₃-C₆-cycloalkyl, R³³ is C₁-C₄-alkyl or C₁-C₆-haloalkyl, R⁴³ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₃-C₆-cycloalkyl, as well as salts, hydrates and hydrates of the salts thereof. 3: The compound of formula (I) according to claim 1, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, A² is O, C(═O) or CR^(2A)R^(R2B), wherein R^(2A) and R^(2B) are independently hydrogen, m is 1, T is hydrogen, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen, L is a direct bond, methylene or ethylene, wherein said methylene and ethylene are optionally substituted with one or two substituents L^(SA), wherein L^(SA) is independently fluoro, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a cyclopropyl- or a cyclobutyl-ring, R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or pyrimidinyl, wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl and pyrimidinyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl, trifluoromethylsulfanyl, C₃-C₆-cycloalkyl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl, tetrahydrofuranyl or —C(═O)R¹⁶, wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl and wherein R¹⁶ is C₁-C₄-alkyl, R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl, Q is phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydronaphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl or quinolinyl, wherein phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydro-naphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl and quinolinyl, are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₃-C₆-cycloalkyl oxetanyl, pyrrolidinyl, tetrahydrofuranyl, phenyl, thienyl, furanyl, pyrrolyl, pyridyl, —O(C═O)R³³ and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl and C₁-C₄-alkylsulfanyl in turn are optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy and C₁-C₄-alkoxycarbonyl R³³ is C₁-C₄-alkyl, R⁴³ is independently hydrogen or C₁-C₄-alkyl, as well as salts, hydrates and hydrates of the salts thereof. 4: The compound of formula (I) according to claim 1, wherein Q is phenyl, wherein phenyl is substituted with one or two substituents Q^(S) independently selected from the group consisting of halogen, nitro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl. 5: The compound of formula (I) according to claim 1, wherein R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, di-hydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said C₂-C₄-alkynyl is optionally substituted with one substituent —Si(CH₃)₃. 6: The compound of formula (I) according to claim 1, wherein R⁷ is methyl, methylsulfanyl or cyclopropyl, and R⁸ is hydrogen. 7: A composition comprising at least one compound of formula (I) according to claim 1 and at least one carrier and/or surfactant. 8: A method for controlling harmful microorganisms in crop protection and in the protection of materials, comprising applying at least one compound of formula (I) according to claim 1; and/or a composition comprising at least one compound of formula (I) according to claim 1 and at least one carrier and/or surfactant to the harmful microorganisms and/or their habitat. 9: The method of claim 8, wherein the harmful microorganisms comprise phytopathogenic harmful fungi. 10: A process for preparing a compound of formula (I-a-1):

wherein A¹, Q, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as in claim 1 and A² is O, T is hydrogen, m is 1 or 2, may be prepared by reacting a compound of formula (1):

wherein A¹, Q and R⁷ are defined as before and U¹ is hydroxyl, halogen or C₁-C₆-alkoxy, with a compound of formula (2):

wherein m, L, R³, R⁴, R⁵ and R⁶ are defined as before and W is hydrogen, or an aminoprotecting group, to yield a compound of formula (3):

wherein m, A¹, Q, L, W, R³, R⁴, R⁵, R⁶ and R⁷ are defined as before, from which the phthalimide group is removed to yield a compound of formula (4):

wherein m, A¹, Q, L, W, R³, R⁴, R⁵, R⁶ and R⁷ are defined as before, which is then cyclized either when W is hydrogen, by treating the compound of formula (4) with a dehydrating agent, optionally in the presence of a base to obtain directly the compound of formula (I-a-1) or when W is an aminoprotecting group, by treating the compound of formula (4) with a dehydrating agent, optionally in the presence of a base, and then performing a deprotection step to obtain the compound of formula (I-a-1). 11: A process for preparing a compound of formula (I-a-1):

wherein A¹, Q, L, R³, R⁴, R⁵, R⁶ and R⁷ are defined as in claim 1 and A² is O, T is hydrogen, m is 1 or 2, may be prepared by first reacting a compound of formula (5):

wherein A¹ and R⁷ are defined as before and X is halogen, U¹ is hydroxyl, halogen or C₁-C₆-alkoxy, with a compound of formula (2):

wherein m, L, R³, R⁴, R⁵ and R⁶ are defined as before and W is hydrogen, an aminoprotecting group preferably tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl, to result in a compound of formula (6a):

wherein m, A¹, L, W, X, R³, R⁴, R⁵ and R⁶ are defined as before, from which the phthalimide group is removed and the resulting amine is cyclized to yield a compound of formula (7);

wherein m, A¹, A², L, W, X, R³, R⁴, R⁵, R⁶ and R⁷ are defined as before, which is reacted with a compound of formula (8):

wherein Q is defined as above, in the presence of a base (e.g. organic or inorganic base) and optionally in the presence of a suitable copper salt or complex to give a compound of formula (I-a-1). 12: A compound of formula (3):

wherein A¹ is N or CR⁸, wherein R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl, m is 1 or 2, R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3- to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl and 3- to 14-membered heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered heterocyclyl-ring are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-, —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—, —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—, —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of formula

wherein said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC), R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen or C₁-C₆-alkyl, R^(L5), R^(L6), R^(L7) and R^(L8) are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, wherein L^(SA) is independently halogen, cyano, hydroxyl, carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, L^(SC) is independently halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two L^(SC) substituents form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to 14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or C₁-C₃-alkylsulfonyl, wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted with one substituent selected from the group consisting of C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl, wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to four R^(6S) substituents, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl and 3- to 14-membered heterocyclylsulfonyl are optionally substituted with one to four R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷), —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, or two substituents C₁-C₆-alkyl attached to the same carbon atom from a C₃-C₈-cycloalkyl-ring, and wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, and wherein R¹⁵ is independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, and wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl, wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto, nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered heterocyclyl, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and C₂-C₆-haloalkynyl in turn are optionally substituted with one to three substituents R^(7Sa), and wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents R^(7Sc), R²¹ and R²² are independently hydroxyl, amino, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in turn are optionally substituted with one to three R^(7Sa) substituents, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three R^(7Sa) substituents, and wherein C₃-C₈-cycloalkyl in turn is optionally substituted with one to three R^(7Sc) substituents, wherein R^(7Sa) is independently cyano, hydroxyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to 7-membered heterocyclyl, R^(7Sc) is independently halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, or two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the same carbon atom form together a C₃-C₈-cycloalkyl-ring, Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl are optionally substituted with one to five substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³ NR³⁴C(═O)R³⁵, —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰, —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, and wherein R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy, R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or C₁-C₆-alkoxy, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl,  wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl. 13: A compound of formula (4):

wherein A¹ is N or CR⁸, wherein R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl, m is 1 or 2, R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3- to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl and 3- to 14-membered heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered heterocyclyl-ring are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-, —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—, —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—, —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of formula

wherein said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC), R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen or C₁-C₆-alkyl, R^(L5), R^(L6), R^(L7) and R^(L8) are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, wherein L^(SA) is independently halogen, cyano, hydroxyl, carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, L^(SC) is independently halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two L^(SC) substituents form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to 14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or C₁-C₃-alkylsulfonyl, wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted with one substituent selected from the group consisting of C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl, wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to four R^(6S) substituents, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl and 3- to 14-membered heterocyclylsulfonyl are optionally substituted with one to four R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷), —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, or two substituents C₁-C₆-alkyl attached to the same carbon atom from a C₃-C₈-cycloalkyl-ring, and wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, and wherein R¹⁵ is independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, and wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl, wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto, nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered heterocyclyl, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and C₂-C₆-haloalkynyl in turn are optionally substituted with one to three substituents R^(7Sa), and wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents R^(7Sc), R²¹ and R²² are independently hydroxyl, amino, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in turn are optionally substituted with one to three R^(7Sa) substituents, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three R^(7Sa) substituents, and wherein C₃-C₈-cycloalkyl in turn is optionally substituted with one to three R^(7Sc) substituents, wherein R^(7Sa) is independently cyano, hydroxyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to 7-membered heterocyclyl, R^(7Sc) is independently halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, or two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the same carbon atom form together a C₃-C₈-cycloalkyl-ring, Q is C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl, wherein C₆-C₁₄-aryl, C₃-C₁₂-carbocyclyl, 3- to 14-membered heterocyclyl or 5- to 14-membered heteroaryl are optionally substituted with one to five substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —O—C(═O)R³³ NR³⁴C(═O)R³⁵, —C(═O)N(R³⁶)₂, —C(═S)R³⁷, —C(═S)N(R³⁸)₂, —C(═NR³⁹)R⁴⁰, —C(═NOR⁴¹)R⁴² and —N(R⁴³)₂, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkoxy, C₃-C₆-cycloalkenyl, 3- to 7-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, and wherein R³³ is hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy, R³⁴, R³⁵, R³⁶ R³⁷ R³⁸ R³⁹ R⁴⁰ R⁴¹ and R⁴² are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl or C₁-C₆-alkoxy, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₁-C₆-alkoxy in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein R⁴³ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl and C₂-C₆-haloalkenyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₂-C₆-alkenyl and 3- to 7-membered heterocyclyl,  wherein said C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl furthermore are optionally substituted with two substituents forming together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl, W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl. 14: A compound of formula (6a) or (6b):

wherein A¹ is N or CR⁸, wherein R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl, m is 1 or 2, R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3- to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl and 3- to 14-membered heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered heterocyclyl-ring are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-, —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—, —C(═O)NR^(L3), —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—, —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of formula

wherein said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC), R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen or C₁-C₆-alkyl, R^(L5), R^(L6), R^(L7) and R^(L8) are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, wherein L^(SA) is independently halogen, cyano, hydroxyl, carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, L^(SC) is independently halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two L^(SC) substituents form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to 14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or C₁-C₃-alkylsulfonyl, wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted with one substituent selected from the group consisting of C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl, wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to four R^(6S) substituents, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl and 3- to 14-membered heterocyclylsulfonyl are optionally substituted with one to four R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷), —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, or two substituents C₁-C₆-alkyl attached to the same carbon atom from a C₃-C₈-cycloalkyl-ring, and wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, and wherein R¹⁵ is independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, and wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl, wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto, nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered heterocyclyl, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and C₂-C₆-haloalkynyl in turn are optionally substituted with one to three substituents R^(7Sa), and wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents R^(7Sc), R²¹ and R²² are independently hydroxyl, amino, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in turn are optionally substituted with one to three R^(7Sa) substituents, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three R^(7Sa) substituents, and wherein C₃-C₈-cycloalkyl in turn is optionally substituted with one to three R^(7Sc) substituents, wherein R^(7Sa) is independently cyano, hydroxyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to 7-membered heterocyclyl, R^(7Sc) is independently halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, or two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the same carbon atom form together a C₃-C₈-cycloalkyl-ring, W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl, X is halogen. 15: A compound of formula (7):

wherein A¹ is N or CR⁸, wherein R⁸ is hydrogen, halogen, cyano or C₁-C₄-alkyl, m is 1 or 2, R³ and R⁴ are independently hydrogen, halogen, cyano, hydroxyl, formyl, carboxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl, 3- to 14-membered heterocyclyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl, C₆-C₁₄-aryl, 5- to 14-membered heteroaryl and 3- to 14-membered heterocyclyl are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁴ form together with the carbon atom to which they are attached to a carbonyl, a methylidene, a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, wherein C₃-C₈-cycloalkyl-ring and 3- to 7-membered heterocyclyl-ring are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, R⁵ is hydrogen, hydroxyl, C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl, C₃-C₈-cycloalkyl or —O—Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-alkoxy, C₁-C₆-alkylcarbonyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-alkylsulfonyl and —O—Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, amino, nitro, hydroxyl, formyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, and wherein C₃-C₈-cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ and 3- to 7-membered heterocyclyl, or R³ and R⁵ or R⁴ and R⁵ form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, L is a direct bond, carbonyl, C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene-, —C₁-C₆-alkylene-C(═O)—, —NR^(L1)—, —NR^(L2)(C═O)—, —C(═O)NR^(L3)—, —NR^(L4)S(═O)₂—, —S(═O)₂NR^(L5)—, —C(═NOR^(L6))—, —C(═N—N(R^(L7))₂)—, —C(═NR^(L8))— or a group of formula

wherein said C₁-C₆-alkylene, C₂-C₆-alkenylene, C₂-C₆-alkynylene, —C(═O)—C₁-C₆-alkylene- and —C₁-C₆-alkylene-C(═O)— are optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl, C₃-C₈-cycloalkenyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC), R^(L1), R^(L2), R^(L3) and R^(L4) are independently hydrogen or C₁-C₆-alkyl, R^(L5), R^(L6), R^(L7) and R^(L8) are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₃-C₈-cycloalkyl or C₂-C₆-alkenyl, wherein L^(SA) is independently halogen, cyano, hydroxyl, carboxyl, methylidene, halomethylidene, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₈-cycloalkyl-ring or a 3- to 7-membered heterocyclyl-ring, L^(SC) is independently halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, and/or two L^(SC) substituents form together with the carbon atom to which they are attached to a C₃-C₈-cycloalkyl-ring, R⁶ is C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl, 3- to 14-membered heterocyclylsulfonyl, C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl or C₁-C₃-alkylsulfonyl, wherein C₁-C₃-alkoxy, C₁-C₃-haloalkoxy, C₁-C₃-alkylsulfanyl, C₁-C₃-alkylsulfinyl and C₁-C₃-alkylsulfonyl are substituted with one substituent selected from the group consisting of C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl, wherein said C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl in turn are optionally substituted with one to four R^(6S) substituents, wherein C₃-C₁₂-carbocyclyl, C₆-C₁₄-aryl, 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C₃-C₁₂-carbocyclyloxy, C₆-C₁₄-aryloxy, 5- to 14-membered heteroaryloxy, 3- to 14-membered heterocyclyloxy, C₃-C₁₂-carbocyclylsulfanyl, C₆-C₁₄-arylsulfanyl, 5- to 14-membered heteroarylsulfanyl, 3- to 14-membered heterocyclylsulfanyl, C₃-C₁₂-carbocyclylsulfinyl, C₆-C₁₄-arylsulfinyl, 5- to 14-membered heteroarylsulfinyl, 3- to 14-membered heterocyclylsulfinyl, C₃-C₁₂-carbocyclylsulfonyl, C₆-C₁₄-arylsulfonyl, 5- to 14-membered heteroarylsulfonyl and 3- to 14-membered heterocyclylsulfonyl are optionally substituted with one to four R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, isocyano, nitro, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —N(R¹⁵)₂, —O(C═O)R¹⁶, —C(═O)R¹⁶, —C(═O)(OR¹⁷), —C(═O)N(R¹⁸)₂, —S(═O)₂N(R¹⁹)₂, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkylnyloxy, C₂-C₆-haloalkylnyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, or two substituents C₁-C₆-alkyl attached to the same carbon atom from a C₃-C₈-cycloalkyl-ring, and wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkyloxy, C₃-C₈-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, and wherein R¹⁵ is independently hydrogen, C₁-C₆-alkyl or C₃-C₈-cycloalkyl, wherein said C₁-C₆-alkyl in turn is optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, and wherein said C₃-C₈-cycloalkyl in turn is optionally substituted with one to four substituents independently selected from the group consisting of halogen, cyano, nitro, hydroxyl, formyl, carboxyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl and C₃-C₈-halocycloalkyl, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are independently hydrogen, C₁-C₆-alkyl or C₁-C₆-haloalkyl, wherein said C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, cyano, hydroxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl and 3- to 7-membered heterocyclyl, R⁷ is hydrogen, halogen, cyano, isocyano, hydroxyl, mercapto, nitro, amino, formyl, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₃-C₈-cycloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₃-C₈-cycloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₁-C₆-alkylcarbonyl, C₁-C₆-haloalkylcarbonyl, C₁-C₆-alkoxycarbonyl, C₁-C₆-haloalkoxycarbonyl, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₂-C₆-alkenyloxy, C₂-C₆-haloalkenyloxy, C₂-C₆-alkynyloxy, C₂-C₆-haloalkynyloxy, C₁-C₆-alkylsulfanyl, C₁-C₆-haloalkylsulfanyl, C₂-C₆-alkenylsulfanyl, C₂-C₆-alkynylsulfanyl, C₁-C₆-alkylsulfinyl, C₁-C₆-haloalkylsulfinyl, C₁-C₆-alkylsulfonyl, C₁-C₆-haloalkylsulfonyl, —O—Si(C₁-C₆-alkyl)₃ and —Si(C₁-C₆-alkyl)₃ are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₈-cycloalkylsulfanyl, C₃-C₈-cycloalkylsulfinyl, C₃-C₈-cycloalkylsulfonyl, C₃-C₈-cycloalkyl, C₃-C₆-cycloalkenyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₈-cycloalkyloxy, C₆-C₁₄-aryloxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl, C₂-C₆-haloalkynyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl or 3- to 7-membered heterocyclyl, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, C₂-C₆-alkenyl, C₂-C₆-haloalkenyl, C₂-C₆-alkynyl and C₂-C₆-haloalkynyl in turn are optionally substituted with one to three substituents R^(7Sa), and wherein C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₆-C₁₄-aryl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents R^(7Sc), R²¹ and R²² are independently hydroxyl, amino, cyano, C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino or di-(C₁-C₆-alkyl)amino, wherein C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆-alkoxy, mono-(C₁-C₆-alkyl)amino and di-(C₁-C₆-alkyl)amino in turn are optionally substituted with one to three R^(7Sa) substituents, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₆-alkyl, C₁-C₆-haloalkyl and C₃-C₈-cycloalkyl, wherein C₁-C₆-alkyl and C₁-C₆-haloalkyl in turn are optionally substituted with one to three R^(7Sa) substituents, and wherein C₃-C₈-cycloalkyl in turn is optionally substituted with one to three R^(7Sc) substituents, wherein R^(7Sa) is independently cyano, hydroxyl, carboxyl, C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, C₁-C₆-alkoxycarbonyl, —O—Si(C₁-C₆-alkyl)₃, —Si(C₁-C₆-alkyl)₃, C₆-C₁₄-aryl or 3- to 7-membered heterocyclyl, R^(7Sc) is independently halogen, cyano, nitro, hydroxyl, formyl, oxo, methylidene, halomethylidene, C₁-C₆-alkyl, C₁-C₆-haloalkyl C₁-C₆-alkoxy, C₁-C₆-haloalkoxy, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₃-C₈-halocycloalkyl, —O—Si(C₁-C₆-alkyl)₃ or 3- to 7-membered heterocyclyl, or two R^(7Sc) substituents C₁-C₆-alkyl that are bound to the same carbon atom form together a C₃-C₈-cycloalkyl-ring, W is hydrogen, tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl, X is halogen. 16: The compound of formula (3) according to claim 12, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, fluoro, chloro or methyl m is 0, 1 or 2, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen or C₁-C₄-alkyl, L is a direct bond, C₁-C₄-alkylene or a group of formula

wherein said C₁-C₄-alkylene is optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC) wherein L^(SA) is independently fluoro, chloro or hydroxyl, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to 7-membered heterocyclyl-ring, L^(SC) is independently fluoro, chloro hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy, R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl, 5- to 10-membered heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy, wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted with one substituent selected from the group consisting of C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl, wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl in turn are optionally substituted with one to three R^(6S) substituents, wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and 5- to 10-membered heterocyclylsulfanyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶, —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl and C₁-C₄-haloalkylsulfanyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy, and wherein R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy and 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl, R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₁-C₄-alkoxy, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl, wherein R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃, R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy or C₃-C₈-cycloalkyl, Q is phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, wherein phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl, phenyl, 5- or 6-membered heteroaryl, —O—C(═O)R³³, and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₃-C₆-cycloalkyl, C₃-C₆-halocycloalkyl and 3- to 7-membered heterocyclyl, said C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl and C₃-C₆-cycloalkyl, R³³ is C₁-C₄-alkyl or C₁-C₆-haloalkyl, R⁴³ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₃-C₆-cycloalkyl. 17: The compound of formula (3) according to claim 12, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, m is 1, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen, L is a direct bond, methylene or ethylene, wherein said methylene and ethylene are optionally substituted with one or two substituents L^(SA), wherein L^(SA) is independently fluoro, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a cyclopropyl- or a cyclobutyl-ring, R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or pyrimidinyl, wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl and pyrimidinyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl, trifluoromethylsulfanyl, C₃-C₆-cycloalkyl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl, tetrahydrofuranyl or —C(═O)R¹⁶, wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl and wherein R¹⁶ is C₁-C₄-alkyl, R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl, Q is phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydronaphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl or quinolinyl, wherein phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydro-naphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl and quinolinyl, are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₃-C₆-cycloalkyl oxetanyl, pyrrolidinyl, tetrahydrofuranyl, phenyl, thienyl, furanyl, pyrrolyl, pyridyl, —O(C═O)R³³ and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl and C₁-C₄-alkylsulfanyl in turn are optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy and C₁-C₄-alkoxycarbonyl R³³ is C₁-C₄-alkyl, R⁴³ is independently hydrogen or C₁-C₄-alkyl. 18: The compound of formula (3) according to claim 12, wherein Q is phenyl, wherein phenyl is substituted with one or two substituents Q^(S) independently selected from the group consisting of halogen, nitro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl. 19: The compound of formula (3) according to claim 12, wherein R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, di-hydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said C₂-C₄-alkynyl is optionally substituted with one substituent —Si(CH₃)₃. 20: The compound of formula (3) according claim to 12, wherein R⁷ is methyl, methylsulfanyl or cyclopropyl, and R⁸ is hydrogen. 21: The compound of formula (4) according to claim 13, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, fluoro, chloro or methyl m is 0, 1 or 2, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen or C₁-C₄-alkyl, L is a direct bond, C₁-C₄-alkylene or a group of formula

wherein said C₁-C₄-alkylene is optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC) wherein L^(SA) is independently fluoro, chloro or hydroxyl, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to 7-membered heterocyclyl-ring, L^(SC) is independently fluoro, chloro hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy, R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl, 5- to 10-membered heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy, wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted with one substituent selected from the group consisting of C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl, wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl in turn are optionally substituted with one to three R^(6S) substituents, wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and 5- to 10-membered heterocyclylsulfanyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶, —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl and C₁-C₄-haloalkylsulfanyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy, and wherein R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy and 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl, R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₁-C₄-alkoxy, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl, wherein R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃, R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy or C₃-C₈-cycloalkyl, Q is phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, wherein phenyl, naphthyl, C₅-C₁₀-carbocyclyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl, phenyl, 5- or 6-membered heteroaryl, —O—C(═O)R³³, and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of cyano, amino, nitro, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl, C₃-C₆-cycloalkyl, C₃-C₆-halocycloalkyl and 3- to 7-membered heterocyclyl, said C₃-C₆-cycloalkyl, 3- to 7-membered heterocyclyl and 5- or 6-membered heteroaryl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkoxycarbonyl, C₁-C₄-haloalkoxycarbonyl and C₃-C₆-cycloalkyl, R³³ is C₁-C₄-alkyl or C₁-C₆-haloalkyl, R⁴³ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₃-C₆-cycloalkyl. 22: The compound of formula (4) according to claim 13, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, m is 1, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen, L is a direct bond, methylene or ethylene, wherein said methylene and ethylene are optionally substituted with one or two substituents L^(SA), wherein L^(SA) is independently fluoro, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a cyclopropyl- or a cyclobutyl-ring, R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or pyrimidinyl, wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl and pyrimidinyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl, trifluoromethylsulfanyl, C₃-C₆-cycloalkyl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl, tetrahydrofuranyl or —C(═O)R¹⁶, wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl and wherein R¹⁶ is C₁-C₄-alkyl, R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl, Q is phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydronaphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl or quinolinyl, wherein phenyl, naphthyl, 3-bicyclo[4.2.0]octa-1,3,5-trienyl, indanyl, tetrahydro-naphthalenyl, dihydrobenzofuranyl, indenyl, dihydronaphthalenyl, indolinyl, 1,3-benzodioxolyl, chromanyl, dihydro-1,4-benzodioxinyl, [1,3]dioxolo[4,5-b]pyridinyl, tetrahydroquinolinyl, 6,7-dihydro-5H-cyclopenta[b]pyridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzoxazolyl and quinolinyl, are optionally substituted with one to three substituents Q^(S) wherein Q^(S) is independently selected from the group consisting of halogen, cyano, nitro, formyl, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₃-C₆-cycloalkyl oxetanyl, pyrrolidinyl, tetrahydrofuranyl, phenyl, thienyl, furanyl, pyrrolyl, pyridyl, —O(C═O)R³³ and —N(R⁴³)₂, wherein said C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl and C₁-C₄-alkylsulfanyl in turn are optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy and C₁-C₄-alkoxycarbonyl R³³ is C₁-C₄-alkyl, R⁴³ is independently hydrogen or C₁-C₄-alkyl. 23: The compound of formula (4) according to claim 13, wherein Q is phenyl, wherein phenyl is substituted with one or two substituents Q^(S) independently selected from the group consisting of halogen, nitro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl. 24: The compound of formula (4) according to claim 13, wherein R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, di-hydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said C₂-C₄-alkynyl is optionally substituted with one substituent —Si(CH₃)₃. 25: The compound of formula (4) according to claim 13, wherein R⁷ is methyl, methylsulfanyl or cyclopropyl, and R⁸ is hydrogen. 26: The compound of formula (6a) or (6b) according to claim 14, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, fluoro, chloro or methyl m is 0, 1 or 2, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen or C₁-C₄-alkyl, L is a direct bond, C₁-C₄-alkylene or a group of formula

wherein said C₁-C₄-alkylene is optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC) wherein L^(SA) is independently fluoro, chloro or hydroxyl, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to 7-membered heterocyclyl-ring, L^(SC) is independently fluoro, chloro hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy, R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl, 5- to 10-membered heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy, wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted with one substituent selected from the group consisting of C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl, wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl in turn are optionally substituted with one to three R^(6S) substituents, wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and 5- to 10-membered heterocyclylsulfanyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶, —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl and C₁-C₄-haloalkylsulfanyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy, and wherein R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy and 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl, R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₁-C₄-alkoxy, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl, wherein R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃, R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy or C₃-C₈-cycloalkyl. 27: The compound of formula (6a) or (6b) according to claim 14, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, m is 1, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen, L is a direct bond, methylene or ethylene, wherein said methylene and ethylene are optionally substituted with one or two substituents L^(SA), wherein L^(SA) is independently fluoro, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a cyclopropyl- or a cyclobutyl-ring, R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or pyrimidinyl, wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl and pyrimidinyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl, trifluoromethylsulfanyl, C₃-C₆-cycloalkyl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl, tetrahydrofuranyl or —C(═O)R¹⁶, wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl and wherein R¹⁶ is C₁-C₄-alkyl, R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl. 28: The compound of formula (6a) or (6b) according to claim 14, wherein R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, di-hydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said C₂-C₄-alkynyl is optionally substituted with one substituent —Si(CH₃)₃. 29: The compound of formula (6a) or (6b) according to claim 14, wherein R⁷ is methyl, methylsulfanyl or cyclopropyl, and R⁸ is hydrogen. 30: The compound of formula (7) according to claim 15, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, fluoro, chloro or methyl m is 0, 1 or 2, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl C₁-C₄-alkylcarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen or C₁-C₄-alkyl, L is a direct bond, C₁-C₄-alkylene or a group of formula

wherein said C₁-C₄-alkylene is optionally substituted with one to three substituents L^(SA), # is the point of attachment to the heterocyclyl-moiety, ## is the point of attachment to R⁶, L¹ is a direct bond or C₁-C₆-alkylene, L² is a direct bond or C₁-C₆-alkylene, E is C₃-C₈-cycloalkyl or 3- to 7-membered heterocyclyl, wherein said C₃-C₈-cycloalkyl and 3- to 7-membered heterocyclyl in turn are optionally substituted with one to three substituents L^(SC) wherein L^(SA) is independently fluoro, chloro or hydroxyl, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a C₃-C₆-cycloalkyl-ring or a 4- to 7-membered heterocyclyl-ring, L^(SC) is independently fluoro, chloro hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy or C₁-C₄-haloalkoxy, R⁶ is C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl, 5- to 10-membered heterocyclylsulfanyl, C₁-C₃-alkoxy or C₁-C₃-haloalkoxy, wherein C₁-C₃-alkoxy and C₁-C₃-haloalkoxy are substituted with one substituent selected from the group consisting of C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl, wherein said C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl in turn are optionally substituted with one to three R^(6S) substituents, wherein C₅-C₁₀-carbocyclyl, phenyl, naphthyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, C₅-C₁₀-carbocyclyloxy, phenoxy, naphthyloxy, 5- to 10-membered heteroaryloxy, 5- to 10-membered heterocyclyloxy, C₅-C₁₀-carbocyclylsulfanyl, phenylsulfanyl, naphthylsulfanyl, 5- to 10-membered heteroarylsulfanyl and 5- to 10-membered heterocyclylsulfanyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, hydroxyl, mercapto, pentafluorosulfanyl, oxo, methylidene, halomethylidene, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, —C(═O)R¹⁶, —C(═O)(OR¹⁷) or —C(═O)N(R¹⁸)₂, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl and C₁-C₄-haloalkylsulfanyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, and wherein C₃-C₆-cycloalkylsulfanyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyloxy, phenyl, naphthyl, 5- or 6-membered heteroaryl and 3- to 7-membered heterocyclyl are furthermore optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy and C₁-C₄-haloalkoxy, and wherein R¹⁶, R¹⁷ and R¹⁸ are independently hydrogen, C₁-C₄-alkyl or C₁-C₄-haloalkyl, wherein said C₁-C₄-alkyl and C₁-C₄-haloalkyl in turn are optionally substituted with one to three substituents independently selected from the group consisting of halogen, hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl and C₃-C₆-halocycloalkyl, R⁷ is hydrogen, halogen, cyano, hydroxyl, mercapto, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy, 3- to 7-membered heterocyclyloxy, —N(R²⁰)₂, —C(═NR²¹)R²², —NR²³C(═O)R²⁴, —C(═O)(OR²⁵), —C(═O)N(R²⁶)₂, —S(═O)₂N(R²⁷)₂ or —S(═O)(═NR²⁸)R²⁹, wherein C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-hydroxyalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₁-C₄-alkylcarbonyl, C₁-C₄-haloalkylcarbonyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl, C₁-C₄-alkylsulfanyl, C₁-C₄-haloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₁-C₄-alkylsulfonyl and C₁-C₄-haloalkylsulfonyl are optionally substituted with one to three R^(7Sa) substituents, wherein C₃-C₆-cycloalkylsulfanyl, C₁-C₄-alkylsulfinyl, C₁-C₄-haloalkylsulfinyl, C₃-C₆-cycloalkylsulfinyl, C₁-C₄-alkylsulfonyl, C₁-C₄-haloalkylsulfonyl, C₃-C₆-cycloalkylsulfonyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkenyl, phenyl, 5- or 6-membered heteroaryl, 3- to 7-membered heterocyclyl, C₃-C₆-cycloalkyloxy, phenoxy, 5- or 6-membered heteroaryloxy and 3- to 7-membered heterocyclyloxy are optionally substituted with one to three R^(7Sc) substituents, and wherein R²⁰ is independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₂-C₄-alkenyl, C₂-C₄-haloalkenyl, C₂-C₄-alkynyl, C₂-C₄-haloalkynyl or C₃-C₆-cycloalkyl, R²¹ and R²² are independently hydroxyl, C₁-C₄-alkyl, C₁-C₄-haloalkyl or C₁-C₄-alkoxy, R²³, R²⁴, R²⁵, R²⁶, R²⁷, R²⁸ and R²⁹ are independently hydrogen, C₁-C₄-alkyl, C₁-C₄-haloalkyl and C₃-C₆-cycloalkyl, wherein R^(7Sa) is independently hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl or —Si(C₁-C₄-alkyl)₃, R^(7Sc) is independently fluoro, chloro, hydroxyl, oxo, C₁-C₄-alkyl, C₁-C₄-haloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy or C₃-C₈-cycloalkyl. 31: The compound of formula (7) according to claim 15, wherein A¹ is CR⁸, wherein R⁸ is hydrogen, m is 1, R³ and R⁴ are independently hydrogen, fluoro, chloro, C₁-C₄-alkyl, C₁-C₄-alkylcarbonyl, C₁-C₄-alkoxycarbonyl, C₁-C₄-alkylcarbonyloxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl or C₃-C₆-cycloalkyl, R⁵ is hydrogen, L is a direct bond, methylene or ethylene, wherein said methylene and ethylene are optionally substituted with one or two substituents L^(SA), wherein L^(SA) is independently fluoro, or two substituents L^(SA) that are bound to the same carbon atom form together with the carbon atom which they are attached to a cyclopropyl- or a cyclobutyl-ring, R⁶ is indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl or pyrimidinyl, wherein indanyl, tetrahydronaphthalenyl, phenyl, naphthyl, 1,3-benzodioxolyl, 1,2,3,4-tetrahydroquinolinyl, chromanyl, isochromanyl, thiochromanyl, 2,3-dihydro-1,4-benzodioxinyl, tetrahydroquinolinyl, furanyl, thienyl, pyrazolyl, pyridinyl and pyrimidinyl are optionally substituted with one to three R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of halogen, cyano, oxo, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, C₁-C₄-alkylsulfanyl, difluoromethylsulfanyl, trifluoromethylsulfanyl, C₃-C₆-cycloalkyl, furanyl, thienyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, oxetanyl, tetrahydrofuranyl or —C(═O)R¹⁶, wherein C₁-C₄-alkyl, C₁-C₄-alkoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl and C₁-C₄-alkylsulfanyl are furthermore optionally substituted with one or two substituents independently selected from the group consisting of hydroxyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, —Si(C₁-C₄-alkyl)₃ and C₃-C₆-cycloalkyl and wherein R¹⁶ is C₁-C₄-alkyl, R⁷ is hydrogen, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₁-C₄-alkylsulfanyl or C₃-C₆-cycloalkyl. 32: The compound of formula (7) according to claim 15, wherein R⁶ is indanyl, phenyl, dihydrobenzodioxinyl or thienyl, wherein indanyl, phenyl, di-hydrobenzodioxinyl and thienyl are optionally substituted with one or two R^(6S) substituents, wherein R^(6S) is independently selected from the group consisting of fluoro, chloro, C₁-C₄-alkyl, difluoromethyl, trifluoromethyl, C₁-C₄-alkoxy, difluoromethoxy, trifluoromethoxy, C₂-C₄-alkenyl, C₂-C₄-alkynyl, cyclopropyl and cyclobutyl, wherein said C₂-C₄-alkynyl is optionally substituted with one substituent —Si(CH₃)₃. 33: The compound of formula (7) according to claim 15, wherein R⁷ is methyl, methylsulfanyl or cyclopropyl, and R⁸ is hydrogen. 34: The process of claim 10, wherein the aminoprotecting group is tert-butoxycarbonyl, benzyl, allyl or (4-methoxyphenyl)methyl. 35: The process of claim 11, wherein X is bromo. 